Inflammation in prostate carcinogenesis

Inflammation and cancer

2002 • 14,174 citations

Innate Immune Recognition

2002 • 8,157 citations

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

1998 • 7,541 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

Cancer Statistics, 2005

2005 • 5,487 citations

Gout-associated uric acid crystals activate the NALP3 inflammasome

2006 • 4,851 citations

J. Submicrosc. Cytol. Pathol.

2000 • 2,783 citations

Macrophages: Obligate Partners for Tumor Cell Migration, Invasion, and Metastasis

2006 • 2,597 citations

Paradoxical roles of the immune system during cancer development

2006 • 2,213 citations

Distinct Role of Macrophages in Different Tumor Microenvironments

2006 • 2,130 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Cytokines in cancer pathogenesis and cancer therapy

2004 • 1,465 citations

Th17: An Effector CD4 T Cell Lineage with Regulatory T Cell Ties

2006 • 1,403 citations

The causes and prevention of cancer.

1995 • 1,326 citations

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

2002 • 1,309 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Discrimination of bacterial lipoproteins by Toll-like receptor 6

2001 • 1,222 citations

Zonal Distribution of Prostatic Adenocarcinoma

1988 • 1,158 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

IL-23 promotes tumour incidence and growth

2006 • 968 citations

Prostate Cancer

2003 • 900 citations

Proliferative Inflammatory Atrophy of the Prostate

1999 • 868 citations

Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

1996 • 834 citations

International trends and patterns of prostate cancer incidence and mortality

2000 • 834 citations

Histology for Pathologists

1992 • 820 citations

A Prospective Study of Dietary Fat and Risk of Prostate Cancer

1993 • 805 citations

A common variant associated with prostate cancer in European and African populations

2006 • 784 citations

Cancer epidemiology in the last century and the next decade

2001 • 675 citations

Normal Histology of the Prostate

1988 • 658 citations

Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish

2004 • 625 citations

Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men

2006 • 613 citations

Identification of a Novel Gammaretrovirus in Prostate Tumors of Patients Homozygous for R462Q RNASEL Variant

2006 • 567 citations

Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

2002 • 525 citations

Cutting Edge: Functional Interactions Between Toll-Like Receptor (TLR) 2 and TLR1 or TLR6 in Response to Phenol-Soluble Modulin

2001 • 477 citations

CD4+CD25high T Cells Are Enriched in the Tumor and Peripheral Blood of Prostate Cancer Patients

2006 • 416 citations

Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

2002 • 394 citations

Epidemiologic association between prostatitis and prostate cancer

2002 • 393 citations

Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells

2001 • 388 citations

Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas.

2003 • 374 citations

Urologic Surgical Pathology

2020 • 367 citations

The complex genetic epidemiology of prostate cancer

2004 • 364 citations

Asymptomatic Gonorrhea in Men

1974 • 355 citations

TIR domain-containing adaptors define the specificity of TLR signaling

2003 • 345 citations

Influence of cytokine gene polymorphisms on the development of prostate cancer.

2002 • 342 citations

CD4+ CD25+ Regulatory T Lymphocytes Inhibit Microbially Induced Colon Cancer in Rag2-Deficient Mice

2003 • 300 citations

Hypermethylation of the Human Glutathione S-Transferase-π Gene (GSTP1) CpG Island Is Present in a Subset of Proliferative Inflammatory Atrophy Lesions but Not in Normal or Hyperplastic Epithelium of the Prostate

2003 • 298 citations

High Prevalence of Human Cytomegalovirus in Prostatic Intraepithelial Neoplasia and Prostatic Carcinoma

2003 • 296 citations

Viruses, Immunity, and Cancer: Lessons from Hepatitis B

2000 • 294 citations

Estrogen imprinting of the developing prostate gland is mediated through stromal estrogen receptor alpha: studies with alphaERKO and betaERKO mice.

2001 • 292 citations

LOW P27 EXPRESSION PREDICTS POOR DISEASE-FREE SURVIVAL IN PATIENTS WITH PROSTATE CANCER

1998 • 275 citations

Meta-Analysis of Measures of Sexual Activity and Prostate Cancer

2002 • 274 citations

A dominant negative mutant of 2-5A-dependent RNase suppresses antiproliferative and antiviral effects of interferon.

1993 • 273 citations

Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma.

2001 • 267 citations

On The Frequency of Occurrence of Occult Carcinoma of the Prostate

1935 • 255 citations

Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia

2000 • 249 citations

Epidemiology of Inflammation and Prostate Cancer

2004 • 241 citations

Intra-prostatic Urinary Reflux: an Aetiological Factor in Abacterial Prostatitis

1982 • 240 citations

Expression and function of pro‐inflammatory interleukin IL‐17 and IL‐17 receptor in normal, benign hyperplastic, and malignant prostate

2003 • 230 citations

PROPIONIBACTERIUM ACNES ASSOCIATED WITH INFLAMMATION IN RADICAL PROSTATECTOMY SPECIMENS: A POSSIBLE LINK TO CANCER EVOLUTION?

2005 • 227 citations

Prostate Stem Cell Compartments

1998 • 224 citations

Similarities of prostate and breast cancer: Evolution, diet, and estrogens

2001 • 222 citations

Sequence Variants ofToll-Like Receptor 4Are Associated with Prostate Cancer Risk

2004 • 217 citations

A prospective study on intake of animal products and risk of prostate cancer.

2001 • 215 citations

Consensus development of a histopathological classification system for chronic prostatic inflammation

2001 • 209 citations

Intermediate Cells in Human Prostate Epithelium Are Enriched in Proliferative Inflammatory Atrophy

2003 • 205 citations

Atrophy and hyperplasia in the prostate proper

1954 • 204 citations

Loss of the cyclin-dependent kinase inhibitor p27(Kip1) protein in human prostate cancer correlates with tumor grade.

1997 • 200 citations

Phenotypic characterization of infiltrating leukocytes in benign prostatic hyperplasia.

1992 • 199 citations

Cip/Kip proteins: more than just CDKs inhibitors: Figure 1.

2004 • 193 citations

Role of estrogens in development of prostate cancer

2004 • 191 citations

Pathological and molecular mechanisms of prostate carcinogenesis: Implications for diagnosis, detection, prevention, and treatment

2003 • 189 citations

Histology for Pathologists

2008 • 189 citations

Urologic Surgical Pathology

1997 • 185 citations

A Large Cohort Study of Aspirin and Other Nonsteroidal Anti-inflammatory Drugs and Prostate Cancer Incidence

2005 • 184 citations

Heterocyclic Amine Content of Cooked Meat and Risk of Prostate Cancer

1999 • 177 citations

Cytokine Expression Pattern in Benign Prostatic Hyperplasia Infiltrating T Cells and Impact of Lymphocytic Infiltration on Cytokine mRNA Profile in Prostatic Tissue

2003 • 176 citations

Plasma Antibodies against Trichomonas vaginalis and Subsequent Risk of Prostate Cancer

2006 • 175 citations

Prostate cancer and use of nonsteroidal anti-inflammatory drugs: systematic review and meta-analysis

2004 • 172 citations

Implications for RNase L in Prostate Cancer Biology

2003 • 172 citations

Formation and Human Risk of Carcinogenic Heterocyclic Amines Formed from Natural Precursors in Meat

2005 • 163 citations

Sequence Variants of Toll-Like Receptor 4 and Susceptibility to Prostate Cancer

2005 • 163 citations

Prostate cancer and sexually transmitted diseases: a meta-analysis.

2005 • 161 citations

The Role of Androgens and Estrogens in the Pathogenesis of Experimental Nonbacterial Prostatitis

1988 • 158 citations

Sequence Variants in Toll-Like Receptor Gene Cluster (TLR6-TLR1-TLR10) and Prostate Cancer Risk

2005 • 157 citations

Loss-of-Function of Nkx3.1 Promotes Increased Oxidative Damage in Prostate Carcinogenesis

2005 • 156 citations

Postatrophic Hyperplasia of the Prostate Gland

2001 • 143 citations

The Class A Macrophage Scavenger Receptor Is a Major Pattern Recognition Receptor for Neisseria meningitidis Which Is Independent of Lipopolysaccharide and Not Required for Secretory Responses

2002 • 142 citations

Histology and Cellular Kinetics of Prostatic Atrophy

1998 • 142 citations

Detection of human polyomaviruses and papillomaviruses in prostatic tissue reveals the prostate as a habitat for multiple viral infections

2002 • 142 citations

Mouse models of prostate carcinogenesis

2002 • 136 citations

Design of the Prostate Cancer Prevention Trial (PCPT)

1995 • 135 citations

Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: Association with Gleason score and chromosome 8p deletion

2008 • 134 citations

Genetic Polymorphisms of Interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and Risk of Prostate Cancer

2006 • 131 citations

Molecular Pathways to Prostate Cancer

2003 • 130 citations

Trichomonas vaginalis in the prostate gland.

1986 • 128 citations

H6D Polymorphism in Macrophage-Inhibitory Cytokine-1 Gene Associated With Prostate Cancer

2004 • 124 citations

A naturally occurring isoform of the human macrophage scavenger receptor (SR-A) gene generated by alternative splicing blocks modified LDL uptake

1998 • 123 citations

Ejaculation Frequency and Subsequent Risk of Prostate Cancer

2004 • 121 citations

PSA is a candidate self-antigen in autoimmune chronic prostatitis/chronic pelvic pain syndrome

2000 • 117 citations

Role of metabolism and viruses in aflatoxin-induced liver cancer

2005 • 112 citations

GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue

2001 • 108 citations

A transcriptional signaling pathway in the IFN system mediated by 2′-5′-oligoadenylate activation of RNase L

2005 • 106 citations

Common Sequence Variants of the Macrophage Scavenger Receptor 1 Gene Are Associated with Prostate Cancer Risk

2003 • 105 citations

The Dietary Charred Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]Pyridine Acts as Both a Tumor Initiator and Promoter in the Rat Ventral Prostate

2007 • 103 citations

Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis

2003 • 98 citations

Evidence for a Mechanistic Association Between Nonbacterial Prostatitis and Levels of Urate and Creatinine in Expressed Prostatic Secretion

1996 • 96 citations

Isolation of Chlamydia Trachomatis from the Prostatic Cells in Patients Affected by Nonacute Abacterial Prostatitis

1985 • 95 citations

Genetic Analysis of the RNASEL Gene in Hereditary, Familial, and Sporadic Prostate Cancer

2004 • 94 citations

Prostatic structure and function in relation to the etiology of prostatic cancer

1983 • 92 citations

Gonorrhea, Syphilis, Clinical Prostatitis, and the Risk of Prostate Cancer

2006 • 88 citations

Association of Susceptibility Alleles in ELAC2/HPC2, RNASEL/HPC1, and MSR1 with Prostate Cancer Severity in European American and African American Men

2005 • 87 citations

The role of Fgf10 signaling in branching morphogenesis and gene expression of the rat prostate gland: lobe-specific suppression by neonatal estrogens

2004 • 85 citations

Sexual Behavior, Sexually Transmitted Diseases and Prostatitis: The Risk of Prostate Cancer in Black Men

2006 • 85 citations

Molecular biology of prostate-cancer pathogenesis

2006 • 84 citations

Sexual Behavior and Evidence for an Infectious Cause of Prostate Cancer

2001 • 84 citations

Mutation screening and association study of RNASEL as a prostate cancer susceptibility gene

2005 • 84 citations

Nonsteroidal Anti-inflammatory Drugs and Risk of Prostate Cancer in the Baltimore Longitudinal Study of Aging

2005 • 82 citations

Development of dextran sulphate sodium-induced experimental colitis is suppressed in genetically mast cell-deficient Ws/Ws rats

2000 • 78 citations

Intraepithelial and stromal lymphocytes in the normal human prostate

2003 • 78 citations

Ki-67 expression in early prostate cancer and associated pathological lesions.

1996 • 75 citations

Estrogenic Regulation of Signaling Pathways and Homeobox Genes During Rat Prostate Development

2004 • 75 citations

Infection stones of prostate gland

1974 • 75 citations

Telomeres and telomerase in prostatic intraepithelial neoplasia and prostate cancer biology

2006 • 74 citations

Survey of genetically engineered mouse models for prostate cancer: Analyzing the molecular basis of prostate cancer development, progression, and metastasis

2004 • 73 citations

Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men.

2003 • 71 citations

Diverse and Related 16S rRNA-Encoding DNA Sequences in Prostate Tissues of Men with Chronic Prostatitis

1998 • 70 citations

8p22> loss concurrent with 8c gain is associated with poor outcome in prostate cancer

2000 • 69 citations

Sexually Transmitted Infections and Prostatic Inflammation/Cell Damage as Measured by Serum Prostate Specific Antigen Concentration

2006 • 66 citations

No association of germline alteration of MSR1 with prostate cancer risk

2003 • 65 citations

Inflammation and Atrophy Precede Prostatic Neoplasia in a PhIP-Induced Rat Model

2006 • 64 citations

Germ-line alterations in MSR1 gene and prostate cancer risk.

2003 • 61 citations

Prostate Cancer : Biology, Genetics, and the New Therapeutics

2007 • 61 citations

Precancerous Lesions and Conditions of the Prostate

2002 • 58 citations

The Class A Macrophage Scavenger Receptor Attenuates CXC Chemokine Production and the Early Infiltration of Neutrophils in Sterile Peritonitis

2004 • 56 citations

Interleukin-1 receptor antagonist haplotype associated with prostate cancer risk

2005 • 54 citations

A comprehensive association study for genes in inflammation pathway provides support for their roles in prostate cancer risk in the CAPS study

2006 • 53 citations

The Role of Prolactin in the Prostatic Inflammatory Response to Neonatal Estrogen

2003 • 53 citations

A Large Cohort Study of Aspirin and Other Nonsteroidal Anti-Inflammatory Drugs and Prostate Cancer Incidence

2005 • 48 citations

The picture of the prostatic lymphokine network is becoming increasingly complex.

2002 • 47 citations

Postatrophic hyperplasia of the prostate in Japan: Histologic and immunohistochemical features and p53 gene mutation analysis

2002 • 44 citations

Macrophage scavenger receptor down-regulates mycobacterial cord factor-induced proinflammatory cytokine production by alveolar and hepatic macrophages

2006 • 43 citations

TNF-blocking therapies: an alternative mode of action?

2005 • 42 citations

Meta-analysis of association of rare mutations and common sequence variants in theMSR1 gene and prostate cancer risk

2006 • 38 citations

Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer

2003 • 32 citations

In situ shortening of CAG repeat length within the androgen receptor gene in prostatic cancer and its possible precursors

2003 • 30 citations

Pathology and Pathobiology of the Urinary Bladder and Prostate

1992 • 30 citations

An update on chemoprevention strategies in prostate cancer for 2006

2006 • 28 citations

Assessment of aberrations on chromosome 8 in prostatic atrophy

2006 • 23 citations

Macrophage Scavenger Receptor 1 999C>T (R293X) Mutation and Risk of Prostate Cancer

2005 • 22 citations

THE INCIDENCE OF COINCIDENT PROSTATIC CALCULI, PROSTATIC HYPERPLASIA AND CARCINOMA OF THE PROSTATE GLAND

1944 • 22 citations

Prostatic corpora amylacea and crystalloids: similarities and differences on ultrastructural and histochemical studies.

1996 • 21 citations

Gonorrhea in the Male and Female: A Book for Practitioners.

1933 • 18 citations

High susceptibility of the ACI and spontaneously hypertensive rat (SHR) strains to 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine (PhIP) prostate carcinogenesis

2003 • 17 citations

Intraprostatic spermatozoa: zonal distribution and association with atrophy

2006 • 12 citations

Regulation of Hepatocyte Activator Inhibitor-1 Expression by Androgen and Oncogenic Transformation in the Prostate

2005 • 12 citations

The Epidemiology of Prostate Cancer—with a Focus on Nonsteroidal Anti-inflammatory Drugs

2006 • 11 citations

PROSTATIC CALCULI

1987 • 9 citations

826: The Dietary Charred Meat Carcinogen 2-Amino-1-Methyl-6-Phenylimidazo[4,5-B]Pyridine (Phip) Acts as an Initiator and Tumor Promoter in the Rat Ventral Prostate

2006 • 3 citations

Deleted Work

1955 • 0 citations