Molecular Pathways to Prostate Cancer

The fundamental role of epigenetic events in cancer

2002 • 5,532 citations

PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

1997 • 4,753 citations

Cancer Statistics, 2003

2003 • 3,302 citations

Cancer Risks in BRCA2 Mutation Carriers

1999 • 1,477 citations

Epigenetic inactivation of a RAS association domain family protein from the lung tumour suppressor locus 3p21.3

2000 • 1,073 citations

Proliferative Inflammatory Atrophy of the Prostate

1999 • 868 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

Major Susceptibility Locus for Prostate Cancer on Chromosome 1 Suggested by a Genome-Wide Search

1996 • 834 citations

Worms gang up on bacteria

2002 • 828 citations

Mendelian inheritance of familial prostate cancer.

1992 • 803 citations

Family history and the risk of prostate cancer

1990 • 729 citations

Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer

1998 • 672 citations

Roles for Nkx3.1 in prostate development and cancer

1999 • 660 citations

Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression

1998 • 640 citations

α-Methylacyl Coenzyme A Racemase as a Tissue Biomarker for Prostate Cancer

2002 • 633 citations

Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.

1999 • 631 citations

Association of Prostate Cancer Risk With Genetic Polymorphisms in Vitamin D Receptor and Androgen Receptor

1997 • 599 citations

Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

2000 • 569 citations

A candidate prostate cancer susceptibility gene at chromosome 17p

2001 • 558 citations

Germline mutations in the ribonuclease L gene in families showing linkage with HPC1

2002 • 525 citations

5-alpha-reductase activity and risk of prostate cancer among Japanese and US white and black males

1992 • 505 citations

Pten and p27KIP1 cooperate in prostate cancer tumor suppression in the mouse

2001 • 495 citations

Alpha-methylacyl-CoA racemase: a new molecular marker for prostate cancer.

2002 • 478 citations

KLF6 , a Candidate Tumor Suppressor Gene Mutated in Prostate Cancer

2001 • 426 citations

Prostate stem cell antigen (PSCA) expression increases with high gleason score, advanced stage and bone metastasis in prostate cancer

2000 • 422 citations

Aberrant promoter methylation profile of bladder cancer and its relationship to clinicopathological features.

2001 • 419 citations

Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping.

1996 • 398 citations

Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk

2002 • 394 citations

Epidemiologic association between prostatitis and prostate cancer

2002 • 393 citations

Increased AKT Activity Contributes to Prostate Cancer Progression by Dramatically Accelerating Prostate Tumor Growth and Diminishing p27Kip1 Expression

2000 • 381 citations

P504S

2001 • 366 citations

Two Percent of Men with Early-Onset Prostate Cancer Harbor Germline Mutations in the BRCA2 Gene

2003 • 360 citations

Aberrant promoter methylation profile of prostate cancers and its relationship to clinicopathological features.

2002 • 324 citations

Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression

2001 • 320 citations

Association of mis-sense substitution in SRD5A2 gene with prostate cancer in African-American and Hispanic men in Los Angeles, USA

1999 • 313 citations

Quantitation of GSTP1 Methylation in Non-neoplastic Prostatic Tissue and Organ-Confined Prostate Adenocarcinoma

2001 • 309 citations

Association of prostate cancer with vitamin D receptor gene polymorphism.

1996 • 306 citations

Molecular detection of prostate cancer in urine by GSTP1 hypermethylation.

2001 • 299 citations

Mutations in CHEK2 Associated with Prostate Cancer Risk

2003 • 296 citations

Prevalence of a Physician-Assigned Diagnosis of Prostatitis: The Olmsted County Study of Urinary Symptoms and Health Status Among Men

1998 • 291 citations

Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids.

2000 • 275 citations

Telomere shortening is an early somatic DNA alteration in human prostate tumorigenesis.

2002 • 269 citations

Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia

2000 • 249 citations

A prevalent missense substitution that modulates activity of prostatic steroid 5alpha-reductase.

1997 • 248 citations

Diet: Fat, Meat, and Prostate Cancer

2001 • 239 citations

Germline Alterations of the RNASEL Gene, a Candidate HPC1 Gene at 1q25, in Patients and Families with Prostate Cancer

2002 • 235 citations

Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia

2002 • 235 citations

Vitamin D receptor polymorphisms, circulating vitamin D metabolites, and risk of prostate cancer in United States physicians.

1998 • 214 citations

Methylation and Inactivation of Estrogen, Progesterone, and Androgen Receptors in Prostate Cancer

2002 • 205 citations

Association of p27Kipl Levels With Recurrence and Survival in Patients With Stage C Prostate Carcinoma

1998 • 194 citations

Anti-PSCA mAbs inhibit tumor growth and metastasis formation and prolong the survival of mice bearing human prostate cancer xenografts

2001 • 185 citations

Genetic variability of the human SRD5A2 gene: implications for prostate cancer risk.

1995 • 184 citations

Association of vitamin D receptor gene polymorphism with prostate cancer and benign prostatic hyperplasia in a Japanese population.

2000 • 181 citations

Allelic imbalance and microsatellite instability in prostatic adenocarcinoma.

1996 • 176 citations

Prostate cancer detection by GSTP1 methylation analysis of postbiopsy urine specimens.

2003 • 170 citations

Frequent hypermethylation of the RASSF1A gene in prostate cancer

2002 • 167 citations

Combined Analysis of Hereditary Prostate Cancer Linkage to 1q24-25: Results from 772 Hereditary Prostate Cancer Families from the International Consortium for Prostate Cancer Genetics

2000 • 166 citations

The RASSF1A tumor suppressor gene is inactivated in prostate tumors and suppresses growth of prostate carcinoma cells.

2002 • 161 citations

Distinct regions of allelic loss on 13q in prostate cancer.

1996 • 140 citations

Association of prostate cancer with vitamin D receptor haplotypes in African-Americans.

1998 • 138 citations

Hypermethylation of the caveolin‐1 gene promoter in prostate cancer

2001 • 122 citations

METHYLATION OF THE E-CADHERIN GENE PROMOTER CORRELATES WITH PROGRESSION OF PROSTATE CANCER

2001 • 120 citations

Vitamin D receptor polymorphisms as markers in prostate cancer

1999 • 110 citations

Common Sequence Variants of the Macrophage Scavenger Receptor 1 Gene Are Associated with Prostate Cancer Risk

2003 • 105 citations

V89L polymorphism of type-2, 5-alpha reductase enzyme gene predicts prostate cancer presence and progression

2001 • 100 citations

Hypermethylation of the caveolin-1 gene promoter in prostate cancer

2001 • 98 citations

BIOLOGICAL AGGRESSIVENESS OF HEREDITARY PROSTATE CANCER: LONG-TERM EVALUATION FOLLOWING RADICAL PROSTATECTOMY

1998 • 90 citations

The V89L polymorphism in the 5alpha-reductase type 2 gene and risk of prostate cancer.

1999 • 88 citations

Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk

2002 • 88 citations

Focus on prostate cancer

2002 • 83 citations

Genetic and Environmental Factors in Prostate Cancer Genesis:Identifying High-Risk Cohorts

1999 • 76 citations

Radiation-induced apoptosis mediated by retinoblastoma protein.

1998 • 75 citations

Allelic loss on chromosome 13q in human prostate carcinoma.

1997 • 72 citations

VITAMIN D RECEPTOR POLYMORPHISMS AND LETHAL PROSTATE CANCER

1998 • 67 citations

Polymorphisms in the prostate cancer susceptibility gene HPC2/ELAC2 in multiplex families and healthy controls.

2001 • 61 citations

A polymorphism of the 5 alpha-reductase gene and its association with prostate cancer: a case-control analysis.

1997 • 60 citations

Sequence variants of alpha-methylacyl-CoA racemase are associated with prostate cancer risk.

2002 • 60 citations

PREOPERATIVE PROSTATE NEEDLE BIOPSY p27 CORRELATES WITH SUBSEQUENT RADICAL PROSTATECTOMY p27, GLEASON GRADE AND PATHOLOGICAL STAGE

2000 • 50 citations

New concepts in the pathology of prostatic epithelial carcinogenesis

2001 • 48 citations

A 6-Mb High-Resolution Physical and Transcription Map Encompassing the Hereditary Prostate Cancer 1 (HPC1) Region

2000 • 32 citations