Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish

A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

1994 • 5,994 citations

Environmental and Heritable Factors in the Causation of Cancer — Analyses of Cohorts of Twins from Sweden, Denmark, and Finland

2000 • 4,020 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1981 • 3,794 citations

The Causes of Cancer: Quantitative Estimates of Avoidable Risks of Cancer in the United States Today

1983 • 3,602 citations

Identification of the breast cancer susceptibility gene BRCA2

1995 • 3,581 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Global cancer statistics in the year 2000

2001 • 2,471 citations

Mutations of Chromosome 5q21 Genes in FAP and Colorectal Cancer Patients

1991 • 1,890 citations

E-cadherin germline mutations in familial gastric cancer

1998 • 1,629 citations

The Age Distribution of Cancer and a Multi-stage Theory of Carcinogenesis

1954 • 1,475 citations

The age distribution of cancer and a multi-stage theory of carcinogenesis

2004 • 1,306 citations

Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals: discussion.

1976 • 850 citations

Activation of chemically diverse procarcinogens by human cytochrome P-450 1B1.

1996 • 793 citations

Genetic identification of Mom-1, a major modifier locus affecting Min-induced intestinal neoplasia in the mouse

1993 • 664 citations

Overall evaluations of carcinogenicity: an updating of IARC Monographs volumes 1 to 42.

1987 • 610 citations

The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasia

1995 • 566 citations

Salmonella mutagenicity tests: V. Results from the testing of 311 chemicals

1992 • 562 citations

A new colon and mammary carcinogen in cooked food, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)

1991 • 538 citations

Food-derived mutagens and carcinogens.

1992 • 450 citations

The prostate: a target for carcinogenicity of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) derived from cooked foods.

1997 • 392 citations

Soy, Isoflavones, and Breast Cancer Risk in Japan

2003 • 387 citations

Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases

1993 • 356 citations

Mutagenicities of smoke condensates and the charred surface of fish and meat

1977 • 354 citations

ENVIRONMENTAL MUTAGENS AND CARCINOGENS

1978 • 315 citations

Inhibitory effect of Bifidobacterium longum on colon, mammary, and liver carcinogenesis induced by 2-amino-3-methylimidazo[4,5-f]quinoline, a food mutagen.

1993 • 313 citations

Protection of conjugated linoleic acids against 2-amino-3-methylimidazo[4,5-f]quinoline-induced colon carcinogenesis in the F344 rat: a study of inhibitory mechanisms

1995 • 289 citations

Protein adducts in the molecular dosimetry of chemical carcinogens

1990 • 284 citations

The isolation and identification of a new mutagen from fried ground beef: 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP)

1986 • 283 citations

Mutagenic Principle(s) in Tryptophan and Phenylalanine Pyrolysis Products

1977 • 282 citations

Dietary heterocyclic amines and cancer of the colon, rectum, bladder, and kidney: a population-based study

1999 • 282 citations

Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose

2001 • 271 citations

Formation of Mutagens in Beef and Beef Extract During Cooking

1978 • 264 citations

Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers

2002 • 260 citations

N- and O-acetylation of aromatic and heterocyclic amine carcinogens by human monomorphic and polymorphic acetyltransferases expressed in COS-1 cells

1992 • 248 citations

Carcinogenicity of 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline in Nonhuman Primates: Induction of Tumors in Three Macaques

1990 • 224 citations

Heterocyclic Amines, Meat Intake, and Association with Colon Cancer in a Population-based Study

2003 • 219 citations

Studies on Environmental Chemical Carcinogenesis in Japan

1986 • 214 citations

Carcinogenic Activity of Bracken

1965 • 196 citations

Mutagenicity of flavone derivatives.

1977 • 193 citations

Induction of Lymphoma in CDF₁ Mice by the Food Mutagen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1989 • 186 citations

Presence of carcinogenic heterocyclic amines in urine of healthy volunteers eating normal diet, but not of inpatients receiving parenteral alimentation

1991 • 184 citations

Carcinogenicity in mice of a mutagenic compound, 2-amino-3-methylimidazo[4,5-f]quinoline, from broiled sardine, cooked beef and beef extract

1984 • 180 citations

Carcinogenicity in Mice of Mutagenic Compounds from a Tryptophan Pyrolyzate

1981 • 178 citations

Cancer susceptibility in the mouse: genetics, biology and implications for human cancer

2003 • 166 citations

Potent novel mutagens produced by broiling fish under normal conditions.

1980 • 154 citations

Mutagenicity of amino-α-carbolines in pyrolysis products of soybean globulin

1978 • 154 citations

Well-done red meat, metabolic phenotypes and colorectal cancer in Hawaii

2002 • 152 citations

Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) from cooked foods

1987 • 152 citations

Analysis of total meat intake and exposure to individual heterocyclic amines in a case-control study of colorectal cancer: contribution of metabolic variation to risk

2002 • 148 citations

STRUCTURE OF A POTENT MUTAGEN ISOLATED FROM FRIED BEEF

1981 • 146 citations

Demonstration of carcinogenicity in F344 rats of 2-amino-3-methyl-imidazo[4,5-f]quinoline from broiled sardine, fried beef and beef extract.

1984 • 146 citations

Characterization of DNA adducts formed in vitro by reaction of N-hydroxy-2-amino-3-methylimidazo[4,5-f]quinoline and N-hydroxy-2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline at the C-8 and N2 atoms of guanine

1992 • 145 citations

Demonstration of mutagenicity of aniline and o-toluidine by norharman.

1977 • 144 citations

MOLECULAR EPIDEMIOLOGY AND CANCER PREVENTION: Protection by green tea, black tea, and indole-3-carbinol against 2-amino-3-methylimidazo[4,5-f]quinoline-induced DNA adducts and colonic aberrant crypts in the F344 rat

1996 • 141 citations

Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline

1988 • 141 citations

Isolation and structure determination of mutagenic substances in L-glutamic acid pyrolysate.

1978 • 139 citations

Expression of arylamine N-acetyltransferase in human intestine

1998 • 138 citations

Food borne carcinogens : heterocyclic amines

2000 • 135 citations

High frequency of beta-catenin (ctnnb1) mutations in the colon tumors induced by two heterocyclic amines in the F344 rat.

1998 • 129 citations

Genotoxicity of compounds from cooked beef in repair-deficient CHO cells versus Salmonella mutagenicity

1987 • 127 citations

Metabolism of carcinogenic heterocyclic and aromatic amines by recombinant human cytochrome P450 enzymes

1997 • 124 citations

Induction of mammary tumors in female Sprague—Dawley rats by the food-derived carcinogen 2-amino-1-methyl-6-phenyliniidazo [4,5-b]pyridine and effect of dietary fat

1994 • 122 citations

Protection by chlorophyllin and indole-3-carbinol against 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced DNA adducts and colonic aberrant crypts in the F344 rat

1995 • 117 citations

Aquilide A, a new mutagenic compound isolated from bracken fern (Pteridium aquilinum (L.) Kuhn)

1983 • 113 citations

Genetic polymorphisms in heterocyclic amine metabolism and risk of colorectal adenomas

2002 • 113 citations

Inhibitory effects of antioxidants on formation of heterocyclic amines

1998 • 108 citations

CARCINOGENIC EFFECTS OF CYCAD MEAL AND CYCASIN, METHYLAZOXYMETHANOL GLYCOSIDE, IN RATS AND EFFECTS OF CYCASIN IN GERMFREE RATS.

1964 • 105 citations

Creatin(in)e and Maillard reaction products as precursors of mutagenic compounds: Effects of various amino acids

1983 • 105 citations

Microsomal activation of 2-amino-3-methylimidazo[4,5-f]quinoline, a pyrolysate of sardine and beef extracts, to a mutagenic intermediate.

1983 • 104 citations

Natural mutation rates in the house mouse estimates for five specific loci and dominant mutations

1971 • 102 citations

Multipotential carcinogenicity of the fried food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline in rats.

1985 • 102 citations

Carcinogen–DNA adducts in human breast epithelial cells

2002 • 101 citations

Modulation of heterocyclic amine-induced mutagenicity and carcinogenicity: an 'A-to-Z' guide to chemopreventive agents, promoters, and transgenic models

2002 • 97 citations

Inhibitory effects of Bifidobacterium-fermented soy milk on 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced rat mammary carcinogenesis, with a partial contribution of its component isoflavones

2000 • 95 citations

Genetic changes induced by heterocyclic amines

1997 • 95 citations

Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates

1984 • 93 citations

Mutagenicities of nitrofuran derivatives on a bacterial tester strain with an R factor plasmid

1976 • 93 citations

A new approach to risk estimation of food-borne carcinogens — heterocyclic amines — based on molecular information

1999 • 91 citations

Red meat intake, CYP2E1 genetic polymorphisms, and colorectal cancer risk.

2002 • 91 citations

<i>ESCHERICHIA COLI</i> MUTAGENICITY OF FURYLFURAMIDE

1973 • 87 citations

STRUCTURE AND CHEMICAL SYNTHESIS OF ME-IQ, A POTENT MUTAGEN ISOLATED FROM BROILED FISH

1980 • 86 citations

Human exposure to heterocyclic amine food mutagens/carcinogens: Relevance to breast cancer

2002 • 84 citations

Effect of High Water-Holding Capacity on the Formation of Heterocyclic Amines in Fried Beefburgers

2003 • 79 citations

Reaction of N-hydroxylamine and N-acetoxy derivatives of 2-amino-3-methylimidazolo[4,5-f]quinoline with DNA. Synthesis and identification of N-(deoxyguanosin-8-yl)-IQ

1988 • 78 citations

Fundamentals of Cancer Prevention

2005 • 77 citations

Activation of amino-alpha-carboline, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and a copper phthalocyanine cellulose extract of cigarette smoke condensate by cytochrome P-450 enzymes in rat and human liver microsomes.

1991 • 76 citations

Formation of mutagens in cooked foods. III. Isolation of a potent mutagen from beef

1980 • 76 citations

Influence of pro- and antioxidants on the formation of mutagenic-carcinogenic heterocyclic amines in a model system

1996 • 75 citations

TESTING AND CLASSIFICATION OF MUTAGENICITY OF FURYLFURAMIDE IN <i>ESCHERICHIA COLI</i>

1973 • 73 citations

Inhibitory effect of chlorophyllin on PhIP-induced mammary carcinogenesis in female F344 rats

1995 • 72 citations

DNA Modification by 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine in Rats

1989 • 71 citations

Solution structure of the 2-amino-1- methyl-6-phenylimidazo[4,5- b ]pyridine C8-deoxyguanosine adduct in duplex DNA

2001 • 67 citations

Presence of Cancer-producing Substances in Roasted Food

1939 • 66 citations

Agreement of mutational characteristics of heterocyclic amines in lacI of the Big Blue mouse with those in tumor related genes in rodents

1997 • 65 citations

Quantitative analysis of mutagenic heterocyclic aromatic amines in cooked meat using liquid chromatography–atmospheric pressure chemical ionisation tandem mass spectrometry

2000 • 64 citations

Chemoprevention of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]-pyridine (PhIP)-induced mammary gland carcinogenesis by antioxidants in F344 female rats

1995 • 64 citations

Inhibitory effects of 1-O-hexyl-2,3,5-trimethylhydroquinone (HTHQ), green tea catechins and other antioxidants on 2-amino-6-methyldipyrido[l,2-a: 3′ ,2′ -d]imidazole (Glu-P-1)-induced rat hepatocarcinogenesis and dose-dependent inhibition by HTHQ of lesion induction by Glu-P-1 or 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx)

1995 • 63 citations

Induction of cancers in the intestine, liver and various other organs of rats by feeding mutagens from glutamic acid pyrolysate.

1984 • 63 citations

Induction of tumors in the Zymbal gland, oral cavity, colon, skin and mammary gland of F344 rats by a mutagenic compound, 2-amino_-3, 4-dimethylimidazo[4, 5-f)quinoline

1989 • 62 citations

Inhibition by chlorophyllin of 2-amino-3-methylimidazo-[4,5-f] quinoline-induced tumorigenesis in the male F344 rat

1995 • 61 citations

Factors affecting human heterocyclic amine intake and the metabolism of PhIP

2002 • 61 citations

Preferential induction of guanine deletion at 5′-GGGA-3′ in rat mammary glands by 2-amino- 1-methyl-6-phenylimidazo[4,5-b]pyridine

1999 • 61 citations

Genetic control of susceptibility of rats to gastric carcinoma.

1983 • 60 citations

Estimation of dietary HCA intakes in a large-scale population-based prospective study in Japan

2002 • 58 citations

Adduct Formation at C‐8 of Guanine on in vitro Reaction f the Ultimate Form of 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine with 2′‐Deoxyguanosine and Its Phosphate Esters

1992 • 58 citations

Minimization of Heterocyclic Amines and Thermal Inactivation of Escherichia coli in Fried Ground Beef

2000 • 58 citations

Effect of diet on serum albumin and hemoglobin adducts of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) in humans

2000 • 58 citations

Effects of edible oils and fatty acids on the formation of mutagenic heterocyclic amines in a model system

1993 • 55 citations

Structural determination of a mutagenic aminophenylnorharman produced by the co-mutagen norharman with aniline

1998 • 55 citations

A cohort study on the possible association between broiled fish intake and cancer.

1983 • 51 citations

Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2

1999 • 49 citations

Contents in foods, beverages and tobacco.

2000 • 49 citations

Use of nitrite and hypochlorite treatments in determination of the contributions of IQ-type and non-IQ-type heterocyclic amines to the mutagenicities in crude pyrolyzed materials

1985 • 46 citations

Detection of PhIP (2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine) in the Milk of Healthy Women

2001 • 45 citations

Induction of Intestinal Tumors and Lymphomas in C57BL/6N Mice by a Food‐borne Carcinogen, 2‐Amino‐l‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

2002 • 44 citations

Induction of hepatocellular carcinoma and highly metastatic squamous cell carcinomas in the forestomach of mice by feeding 2-amino-3, 4-dimethylimidazo[4, 5-f]quinoline

1986 • 42 citations

How we should deal with unavoidable exposure of man to environmental mutagens: cooked food mutagen discovery, facts and lessons for cancer prevention

2000 • 41 citations

Analysis of heterocyclic amines as their N-dimethylaminomethylene derivatives by gas chromatography with nitrogen-phosphorus selective detection

1997 • 40 citations

The NAT1 C1095A polymorphism, maternal multivitamin use and smoking, and the risk of spina bifida

2005 • 39 citations

Angiosarcoma of the liver in vinyl chloride/polyvinyl chloride workers.

1974 • 38 citations

Development of a short questionnaire to assess the dietary intake of heterocyclic aromatic amines

2002 • 37 citations

Synergistic enhancement of small and large intestinal carcinogenesis by combined treatment of rats with five heterocycic amines in a medium-term multi-organ bioassay

1994 • 37 citations

Efficient induction of rat large intestinal tumors with a new spectrum of mutations by intermittent administration of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine in combination with a high fat diet

2002 • 37 citations

Mutagenic activation of environmental carcinogens by microsomes of gastric mucosa with intestinal metaplasia.

1999 • 34 citations

Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats

1999 • 33 citations

Acrylamide.

1994 • 33 citations

Reduction in formation of 2-amino-1-methyl-6-phenylimidazo[4,5- b]pyridine (PhIP)-induced aberrant crypt foci in the rat colon by docosahexaenoic acid (DHA)

1997 • 32 citations

Carcinogenicity in rats of a mutagenic compound, 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole, from tryptophan pyrolysate.

1985 • 27 citations

Analysis of Mutagenic Heterocyclic Amines in Cooked Food Samples by Gas Chromatography with Nitrogen-Phosphorus Detector

2002 • 26 citations

Single nucleotide instability without microsatellite instability in rat mammary carcinomas.

2001 • 26 citations

Carcinogenicity of a food additive, AF-2, in hamsters and mice

1977 • 25 citations

In vitro and in vivo formation of aminophenylnorharman from norharman and aniline

2002 • 25 citations

Carcinogenicity of a mutagenic compound from food, 2-amino-3-methyl-9H-pyrido[2, 3-b]indole (MeAαC), in male F344 rats

1994 • 25 citations

Mutagenic activities of heterocyclic amines in Chinese hamster lung cells in culture.

1986 • 25 citations

Atrophy of salivary glands and pancreas of rats fed on diet with amino-methyl-.ALPHA.-carboline.

1985 • 24 citations

Difference in Target Organs in Carcinogenesis with a Heterocyclic Amine, 2‐Amino‐3,4‐dimethylimidazo[4,5‐f]quinoline, in Different Strains of Mice

1999 • 24 citations

The Rat Urinary Bladder as a New Target of Heterocyclic Amine Carcinogenicity: Tumor Induction by 3‐Amino‐l‐methyl‐5H‐pyrido[4,3‐β]indole Acetate

1993 • 23 citations

Early detection of 2-amino-1-methyl-6-phenylimidazo (4,5-b)pyridine(PhIP)-induced mutations within the Apc gene of rat colon

2001 • 21 citations

Strain differences of rats in the susceptibility to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo- [4,5-b]pyridine: no implication of Apc and Pla2g2a genetic polymorphisms in differential susceptibility

1999 • 21 citations

H-ras oncogene mutations during development of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)-induced rat mammary gland cancer

2002 • 20 citations

Chromosomal mapping of genes controlling development, histological grade, depth of invasion, and size of rat stomach carcinomas.

2000 • 20 citations

Angiosarcoma of the liver in vinyl chloride/polyvinyl chloride workers. 1977 update of the NIOSH register.

1978 • 19 citations

Deregulation of the cyclin D1/Cdk4 retinoblastoma pathway in rat mammary gland carcinomas induced by the food-derived carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine.

2003 • 16 citations

Structure of DNA Adduct Formed with Aminophenylnorharman, Being Responsible for the Comutagenic Action of Norharman with Aniline

2002 • 16 citations

3-Amino-1-methyl-5H-pyrido[4,3-b]-indole initiates two-stage carcinogenesis in mouse skin but is not a complete carcinogen.

1986 • 15 citations

Single nucleotide instability: a wide involvement in human and rat mammary carcinogenesis?

2002 • 13 citations

Genetic analysis of the susceptibility in rats to aberrant crypt foci formation by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, PhIP

1999 • 11 citations

Oxidation of the 2-hydroxyamino derivative of 2-amino-6-methyldipyrido[1,2-a:3′,2′-d]imidazole (Glu-P-1) to its 2-nitroso form, an ultimate form reacting with hemoglobin thiol groups

1988 • 9 citations

Cancer Today: Origins, Prevention and Treatment

1985 • 9 citations

Mutagenic activity and heterocyclic amine carcinogens in commercial pet foods

2003 • 9 citations

Food-Borne Carcinogens

2016 • 5 citations

Complex factors pertinent to human hazard risk.

2000 • 4 citations

A New Concept of Co-Mutagenicity from a Phenomenon Forgotten for the Past Two Decades: Is It More Important than Previously Expected?

1998 • 3 citations

Mutagenic Activities of Heterocyclic Amines in Chinese Hamster Lung Cells in Culture

1986 • 1 citations