Prostate Stem Cell Compartments

Cancer Cell Cycles

1996 • 5,379 citations

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1994 • 2,154 citations

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21

1994 • 2,071 citations

Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt

1990 • 1,793 citations

Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer.

1992 • 1,063 citations

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

1997 • 1,055 citations

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer

1997 • 861 citations

Cytidine methylation of regulatory sequences near the pi-class glutathione S-transferase gene accompanies human prostatic carcinogenesis.

1994 • 840 citations

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

1994 • 742 citations

Activation of Programmed Cell Death in the Rat Ventral Prostate after Castration*

1988 • 730 citations

The zonal anatomy of the prostate

1981 • 684 citations

Requirement of p27 ^Kip1 for Restriction Point Control of the Fibroblast Cell Cycle

1996 • 683 citations

Normal Histology of the Prostate

1988 • 658 citations

Topological control of p21WAF1/CIP1 expression in normal and neoplastic tissues.

1995 • 593 citations

Intraductal dysplasia: A premalignant lesion of the prostate

1986 • 584 citations

Etiology and disease process of benign prostatic hyperplasia

1989 • 557 citations

Immunohistochemical Localization of the Androgen Receptor in Rat and Human Tissues*

1990 • 492 citations

Regional Morphology and Pathology of The Prostate

1968 • 477 citations

Epithelial stem cells in vivo

1988 • 446 citations

Prognostic role of the cyclin-dependent kinase inhibitor p27 in non-small cell lung cancer.

1997 • 428 citations

Differentiation pathways and histogenetic aspects of normal and abnormal prostatic growth: A stem cell model

1996 • 409 citations

The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas.

1997 • 354 citations

Loss of cyclin-dependent kinase inhibitor p27Kip1 is a novel prognostic factor in localized human prostate adenocarcinoma.

1998 • 329 citations

Keratin immunoreactivity in the benign and neoplastic human prostate.

1985 • 288 citations

LOW P27 EXPRESSION PREDICTS POOR DISEASE-FREE SURVIVAL IN PATIENTS WITH PROSTATE CANCER

1998 • 275 citations

The proliferative function of basal cells in the normal and hyperplastic human prostate

1994 • 251 citations

Multidirectional differentiation in the normal, hyperplastic, and neoplastic human prostate: Simultaneous demonstration of cell-specific epithelial markers

1994 • 230 citations

Tumor angiogenesis correlates with progression after radical prostatectomy but not with pathologic stage in gleason sum 5 to 7 adenocarcinoma of the prostate

1997 • 208 citations

Loss of the cyclin-dependent kinase inhibitor p27(Kip1) protein in human prostate cancer correlates with tumor grade.

1997 • 200 citations

Colocalization of basal and luminal cell-type cytokeratins in human prostate cancer.

1992 • 200 citations

Differential expression of keratins in the basal and luminal compartments of rat prostatic epithelium during degeneration and regeneration

1988 • 183 citations

Biochemical and Pathological Effects of 8 Months of Neoadjuvant Androgen Withdrawal Therapy Before Radical Prostatectomy in Patients with Clinically Confined Prostate Cancer

1996 • 162 citations

Regulation of the cyclin-dependent kinase inhibitor p27 by degradation and phosphorylation

1997 • 159 citations

Effect of Neoadjuvant Endocrine Therapy (Combined Androgen Blockade) on Normal Prostate and Prostatic Carcinoma

1996 • 151 citations

Reduced Expression of Cyclin–dependent Kinase Inhibitor p27^Kipl Is Associated with Advanced Stage and Invasiveness of Gastric Carcinomas

1997 • 132 citations

Widespread distribution of nuclear androgen receptors in the basal cell layer of the normal and hyperplastic human prostate

1993 • 127 citations

Differential Cytokeratin Expression in Normal, Hyperplastic and Malignant Epithelial Cells From Human Prostate

1990 • 127 citations

Cyclin-dependent kinase inhibitor p27KIP1 in lymphoid tissue: p27KIP1 expression is inversely proportional to the proliferative index.

1997 • 126 citations

Early alteration of cell-cycle-regulated gene expression in colorectal neoplasia.

1996 • 118 citations

Identification of intermediate cell types by keratin expression in the developing human prostate

1998 • 108 citations

Quantitative determination of prostatic epithelial and stromal hyperplasia by a new technique. Biomorphometrics.

1978 • 97 citations

Cyclins, Cdks, and Cyclin Kinase Inhibitors

1994 • 91 citations

PSA AND PAP AS IMMUNOHISTOCHEMICAL MARKERS IN PROSTATE CANCER

1993 • 75 citations

The fine structure of the basal cell of human prostate.

1966 • 72 citations

Relation between Bcl-2, cell proliferation, and the androgen receptor status in prostate tissue and precursors of prostate cancer

1998 • 66 citations

Differential expression of cytokeratin mRNA and protein in normal prostate, prostatic intraepithelial neoplasia, and invasive carcinoma.

1997 • 59 citations

Androgen Receptor Expression in Prostatic Dysplasia (Prostatic lntraepithelial Neoplasia) in the Human Prostate: An Immunohistochemical and In Situ Hybridization Study

1996 • 58 citations

Cell proliferation in dysplasia of the prostate: Analysis by PCNA immunostaining

1995 • 55 citations

A novel M(r) 32,000 nuclear phosphoprotein is selectively expressed in cells competent for self-renewal.

1993 • 54 citations

Novel nuclear phosphoprotein pp32 is highly expressed in intermediate- and high-grade prostate cancer

1998 • 53 citations

Immunohistochemical determination of age related proliferation rates in normal and benign hyperplastic human prostates

1993 • 41 citations

Differentiation of rat neonatal ventral prostates grown in a serum-free organ culture system

1997 • 40 citations

Androgen Receptors in Untreated and Treated Prostatic Intraepithelial Neoplasia

1996 • 36 citations

Pathology of prostatic intraepithelial neoplasia and adenocarcinoma of the prostate: prognostic influences of stage, tumor volume, grade, and margins of resection.

1994 • 24 citations

Proteins of the Rat Prostate. III Effect of Testosterone on Protein Synthesis by the Ventral Prostate of Castrated Rats

1990 • 20 citations