TNF-blocking therapies: an alternative mode of action?

A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells

1997 • 3,094 citations

Cytokine Pathways and Joint Inflammation in Rheumatoid Arthritis

2001 • 2,229 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Mice lacking the tumour necrosis factor receptor 1 are resistant to IMF-mediated toxicity but highly susceptible to infection by Listeria monocytogenes

1993 • 1,267 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

The Tumor Necrosis Factor Ligand and Receptor Families

1996 • 1,239 citations

Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response.

1996 • 1,167 citations

Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-α

1996 • 1,121 citations

Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis.

1992 • 1,002 citations

Critical protective role of mast cells in a model of acute septic peritonitis

1996 • 942 citations

Mast Cells: A Cellular Link Between Autoantibodies and Inflammatory Arthritis

2002 • 764 citations

Chimeric anti-TNF-α monoclonal antibody cA2 binds recombinant transmembrane TNF-α and activates immune effector functions

1995 • 693 citations

Binding and Functional Comparisons of Two Types of Tumor Necrosis Factor Antagonists

2002 • 667 citations

New Drugs for Rheumatoid Arthritis

2004 • 643 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Infliximab induces apoptosis in monocytes from patients with chronic active Crohn's disease by using a caspase-dependent pathway

2001 • 601 citations

Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease

2002 • 552 citations

Very early treatment with infliximab in addition to methotrexate in early, poor‐prognosis rheumatoid arthritis reduces magnetic resonance imaging evidence of synovitis and damage, with sustained benefit after infliximab withdrawal: Results from a twelve‐month randomized, double‐blind, placebo‐controlled trial

2005 • 532 citations

The structure of tumor necrosis factor-alpha at 2.6 A resolution. Implications for receptor binding.

1989 • 511 citations

Biological functions of tumor necrosis factor cytokines and their receptors

2003 • 410 citations

Reduction of chemokine levels and leukocyte traffic to joints by tumor necrosis factor α blockade in patients with rheumatoid arthritis

2000 • 394 citations

Mast Cells Control Neutrophil Recruitment during T Cell–Mediated Delayed-Type Hypersensitivity Reactions through Tumor Necrosis Factor and Macrophage Inflammatory Protein 2

2000 • 384 citations

Decrease in cellularity and expression of adhesion molecules by anti–tumor necrosis factor α monoclonal antibody treatment in patients with rheumatoid arthritis

1996 • 377 citations

Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses.

1991 • 369 citations

Critical Roles for Interleukin 1 and Tumor Necrosis Factor α in Antibody-induced Arthritis

2002 • 327 citations

Modulation of angiogenic vascular endothelial growth factor by tumor necrosis factor ? and interleukin-1 in rheumatoid arthritis

1998 • 326 citations

Distinct roles for lymphotoxin‐α and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue

1997 • 318 citations

Mast cell–derived tumor necrosis factor induces hypertrophy of draining lymph nodes during infection

2003 • 312 citations

Mast cells in autoimmune disease

2002 • 311 citations

Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures. Comparison of monoclonal anti TNF-alpha antibody with the interleukin-1 receptor antagonist.

1995 • 286 citations

Evidence that anti–tumor necrosis factor therapy with both etanercept and infliximab induces apoptosis in macrophages, but not lymphocytes, in rheumatoid arthritis joints: Extended report

2005 • 257 citations

Tumour necrosis factor in synovial exudates.

1988 • 242 citations

The Benefit/Risk Profile of TNF-Blocking Agents: Findings of a Consensus Panel

2005 • 211 citations

Mast cells, cytokines, and metalloproteinases at the rheumatoid lesion: dual immunolocalisation studies.

1995 • 197 citations

Signaling by the TNF Receptor Superfamily and T Cell Homeostasis

2000 • 194 citations

Visualizing the First 50 Hr of the Primary Immune Response to a Soluble Antigen

2004 • 175 citations

Mast cells are an important cellular source of tumour necrosis factor α in human intestinal tissue

1999 • 160 citations

Genetic Influences on the End-Stage Effector Phase of Arthritis

2001 • 149 citations

Severe inflammatory arthritis and lymphadenopathy in the absence of TNF

2001 • 147 citations

Anopheles Mosquito Bites Activate Cutaneous Mast Cells Leading to a Local Inflammatory Response and Lymph Node Hyperplasia

2005 • 132 citations

Beneficial effects of tumour necrosis factor-alpha (TNF-α) blockade in rheumatoid arthritis (RA)

1995 • 132 citations

Chemokines Determine Local Lymphoneogenesis and a Reduction of Circulating CXCR4+ T and CCR7 B and T Lymphocytes in Thyroid Autoimmune Diseases

2003 • 107 citations

Anti-TNF- therapies: they are all the same (aren't they?)

2004 • 99 citations

Different distribution of mast cells and macrophages in colonic mucosa of patients with collagenous colitis and inflammatory bowel disease.

2002 • 74 citations

Effects of Tumor Necrosis Factor Alpha on Dendritic Cell Accumulation in Lymph Nodes Draining the Immunization Site and the Impact on the Anticryptococcal Cell-Mediated Immune Response

2002 • 73 citations

Tumor Necrosis Factor-Alpha in Ileal Mast Cells in Patients with Crohn’s Disease

2000 • 55 citations

Molecular targets in immune‐mediated diseases: the case of tumour necrosis factor and rheumatoid arthritis

2003 • 43 citations

Potential of tumor necrosis factor neutralization strategies in rheumatologic disorders other than rheumatoid arthritis

2003 • 41 citations

Why do anti-tumor necrosis factor antibodies work in Crohn's disease?

2004 • 28 citations

ACUTE SEPTIC PERITONITIS

1906 • 3 citations

[Lymph node hyperplasia].

1994 • 1 citations