Decreased NKX3.1 protein expression in focal prostatic atrophy, prostatic intraepithelial neoplasia, and adenocarcinoma: Association with Gleason score and chromosome 8p deletion

Cancer Statistics, 2005

2005 • 5,487 citations

Proliferative Inflammatory Atrophy of the Prostate

1999 • 868 citations

Roles for Nkx3.1 in prostate development and cancer

1999 • 660 citations

Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization.

1997 • 443 citations

Loss of NKX3.1 expression in human prostate cancers correlates with tumor progression.

2000 • 377 citations

High-grade prostatic intraepithelial neoplasia

2004 • 339 citations

Cooperativity of Nkx3.1 and Pten loss of function in a mouse model of prostate carcinogenesis

2002 • 320 citations

Hypermethylation of the Human Glutathione S-Transferase-π Gene (GSTP1) CpG Island Is Present in a Subset of Proliferative Inflammatory Atrophy Lesions but Not in Normal or Hyperplastic Epithelium of the Prostate

2003 • 298 citations

Allelic loss on chromosome 8p12-21 in microdissected prostatic intraepithelial neoplasia.

1995 • 289 citations

Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma.

2001 • 267 citations

Analysis of 99 microdissected prostate carcinomas reveals a high frequency of allelic loss on chromosome 8p12-21.

1996 • 254 citations

Morphologic transitions between proliferative inflammatory atrophy and high-grade prostatic intraepithelial neoplasia

2000 • 249 citations

Nkx3.1 mutant mice recapitulate early stages of prostate carcinogenesis.

2002 • 242 citations

Conditional Loss of Nkx3.1 in Adult Mice Induces Prostatic Intraepithelial Neoplasia

2002 • 235 citations

Intermediate Cells in Human Prostate Epithelium Are Enriched in Proliferative Inflammatory Atrophy

2003 • 205 citations

Atrophy and hyperplasia in the prostate proper

1954 • 204 citations

Allelic loss in locally metastatic, multisampled prostate cancer.

1994 • 170 citations

Deletion, Methylation, and Expression of the NKX3.1 Suppressor Gene in Primary Human Prostate Cancer

2005 • 158 citations

Loss-of-Function of Nkx3.1 Promotes Increased Oxidative Damage in Prostate Carcinogenesis

2005 • 156 citations

Coding region of NKX3.1, a prostate-specific homeobox gene on 8p21, is not mutated in human prostate cancers.

1997 • 148 citations

Postatrophic Hyperplasia of the Prostate Gland

2001 • 143 citations

Histology and Cellular Kinetics of Prostatic Atrophy

1998 • 142 citations

Haploinsufficiency at the Nkx3.1 locus

2003 • 142 citations

A Working Group Classification of Focal Prostate Atrophy Lesions

2006 • 133 citations

A critical role for p27 ^kip1 gene dosage in a mouse model of prostate carcinogenesis

2004 • 122 citations

Targeted disruption of the Nkx3.1 gene in mice results in morphogenetic defects of minor salivary glands: parallels to glandular duct morphogenesis in prostate

2000 • 109 citations

Preneoplastic Prostate Lesions

2001 • 109 citations

GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue

2001 • 108 citations

Trefoil factor 3 overexpression in prostatic carcinoma: Prognostic importance using tissue microarrays

2004 • 100 citations

EXPRESSION PROFILE OF AN ANDROGEN REGULATED PROSTATE SPECIFIC HOMEOBOX GENE NKX3.1 IN PRIMARY PROSTATE CANCER

2000 • 99 citations

Nkx3.1, a murine homolog of Drosophila bagpipe, regulates epithelial ductal branching and proliferation of the prostate and palatine glands

2000 • 98 citations

Roles of the Nkx3.1 homeobox gene in prostate organogenesis and carcinogenesis

2003 • 98 citations

ATROPHY AND REGENERATION IN THE PATHOGENESIS OF PROSTATIC CARCINOMA

1968 • 93 citations

EXPRESSION STUDIES AND MUTATIONAL ANALYSIS OF THE ANDROGEN REGULATED HOMEOBOX GENE NKX3.1 IN BENIGN AND MALIGNANT PROSTATE EPITHELIUM

2001 • 84 citations

Allelic loss of 8p sequences in prostatic intraepithelial neoplasia and carcinoma

1997 • 76 citations

8p22> loss concurrent with 8c gain is associated with poor outcome in prostate cancer

2000 • 69 citations

Precancerous Lesions and Conditions of the Prostate

2002 • 58 citations

Clinical significance of chromosome 8p, 10q, and 16q deletions in prostate cancer

2002 • 56 citations

Statistical dissection of genetic pathways involved in prostate carcinogenesis

2005 • 55 citations

NKX3.1 Is Regulated by Protein Kinase CK2 in Prostate Tumor Cells

2006 • 49 citations

ANALYSIS OF ANDROGEN REGULATED HOMEOBOX GENE NKX3.1 DURING PROSTATE CARCINOGENESIS

2004 • 44 citations

Structural and functional analysis of domains mediating interaction between NKX‐3.1 and PDEF

2004 • 27 citations

Surgical margin and gleason score as predictors of postoperative recurrence in prostate cancer with or without chromosome 8p allelic imbalance

2004 • 13 citations

Regulation of Hepatocyte Activator Inhibitor-1 Expression by Androgen and Oncogenic Transformation in the Prostate

2005 • 12 citations