Angiogenesis inhibition: A review

Tumor Angiogenesis: Therapeutic Implications

1971 • 9,898 citations

Angiogenic Factors

1987 • 3,702 citations

Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo

1993 • 3,605 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Cancer metastasis and angiogenesis: An imbalance of positive and negative regulation

1991 • 2,774 citations

Role of cell shape in growth control

1978 • 2,434 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

1993 • 1,391 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

The role of angiogenesis in tumor growth.

1992 • 1,267 citations

Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant

1994 • 1,249 citations

Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures.

1988 • 1,209 citations

Anti-Angiogenesis

1972 • 1,167 citations

Angiogenesis Induced by Degradation Products of Hyaluronic Acid

1985 • 1,128 citations

Interferon Alfa-2a Therapy for Life-Threatening Hemangiomas of Infancy

1992 • 1,076 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Tumor Angiogenesis

1985 • 1,038 citations

Mast cells as a source of both preformed and immunologically inducible TNF-α/cachectin

1990 • 975 citations

Regulators of Angiogenesis

1991 • 959 citations

TUMOR DORMANCY IN VIVO BY PREVENTION OF NEOVASCULARIZATION

1972 • 898 citations

A simple, quantitative method for assessing angiogenesis and antiangiogenic agents using reconstituted basement membrane, heparin, and fibroblast growth factor.

1992 • 807 citations

Genistein, a dietary-derived inhibitor of in vitro angiogenesis.

1993 • 777 citations

Two different laminin domains mediate the differentiation of human endothelial cells into capillary-like structures in vitro

1989 • 746 citations

How is blood vessel growth regulated in normal and neoplastic tissue? G.H.A. Clowes memorial Award lecture.

1986 • 744 citations

The endogenous oestrogen metabolite 2-methoxyoestradiol inhibits angiogenesis and suppresses tumour growth

1994 • 743 citations

Tumor necrosis factor type alpha, a potent inhibitor of endothelial cell growth in vitro, is angiogenic in vivo.

1987 • 718 citations

Inhibition of Angiogenesis by Recombinant Human Platelet Factor-4 and Related Peptides

1990 • 710 citations

Scatter factor induces blood vessel formation in vivo.

1993 • 704 citations

Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: expression patterns suggest multiple roles during embryonic development.

1991 • 677 citations

Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

1992 • 624 citations

Angiogenesis Inhibition and Tumor Regression Caused by Heparin or a Heparin Fragment in the Presence of Cortisone

1983 • 622 citations

Inhibition of capillary endothelial cell growth by pericytes and smooth muscle cells.

1987 • 607 citations

Protamine is an inhibitor of angiogenesis

1982 • 582 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Phenotypic modulation of endothelial cells by transforming growth factor-beta depends upon the composition and organization of the extracellular matrix.

1988 • 571 citations

Aminoguanidine treatment inhibits the development of experimental diabetic retinopathy.

1991 • 522 citations

Fibronectin controls capillary endothelial cell growth by modulating cell shape.

1990 • 498 citations

A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment

1985 • 492 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

Biologic Therapy of Cancer

1992 • 476 citations

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

1989 • 475 citations

Tumor-promoting phorbol esters induce angiogenesis in vitro

1985 • 470 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

How does extracellular matrix control capillary morphogenesis?

1989 • 466 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

Treatment of Pulmonary Hemangiomatosis with Recombinant Interferon Alfa-2a

1989 • 444 citations

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti‐cancer therapeutic agents

1991 • 441 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Platelet thrombospondin modulates endothelial cell adhesion, motility, and growth: a potential angiogenesis regulatory factor.

1990 • 407 citations

Tissue inhibitor of metalloproteinases‐2 inhibits bFGF‐induced human microvascular endothelial cell proliferation

1993 • 362 citations

Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy

1993 • 362 citations

Inhibition of tumor angiogenesis mediated by cartilage.

1975 • 361 citations

The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity

1989 • 357 citations

Thrombospondins: structure and regulation of expression

1992 • 345 citations

Dual role of tumor necrosis factor-alpha in angiogenesis.

1992 • 342 citations

Embryonic Origins and Assembly of Blood Vessels

1989 • 340 citations

Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis

1993 • 338 citations

Inhibition of Cell Motility by Interferon

1980 • 331 citations

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

1991 • 324 citations

Inhibitory action of transforming growth factor beta on endothelial cells.

1987 • 324 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis.

1993 • 321 citations

Transforming growth factor-beta inhibits endothelial cell proliferation

1986 • 313 citations

Inhibition of endothelial cell proliferation by type β-transforming growth factor: Interactions with acidic and basic fibroblast growth factors

1986 • 312 citations

Isolations of a Cartilage Factor That Inhibits Tumor Neovascularization

1976 • 308 citations

Actions of Tumor Necrosis Factor on Cultured Vascular Endothelial Cells: Morphologic Modulation, Growth Inhibition, and Cytotoxicity

1986 • 300 citations

Inhibition of endothelial cell proliferation by gamma-interferon.

1987 • 292 citations

Control of Angiogenesis with Synthetic Heparin Substitutes

1989 • 292 citations

Lymphocyte-induced angiogenesis: a quantitative and sensitive assay of the graft-vs.-host reaction.

1975 • 285 citations

Endothelial cell proliferation during angiogenesis. In vitro modulation by basement membrane components.

1986 • 277 citations

Thrombospondin exerts an antiangiogenic effect on cord formation by endothelial cells in vitro.

1991 • 273 citations

Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor.

1991 • 268 citations

Angiostatic Steroids

1987 • 267 citations

Vascular attack as a therapeutic strategy for cancer

1990 • 267 citations

ANGIOGENESIS: INITIATION AND CONTROL*

1982 • 264 citations

Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.

1992 • 259 citations

Transforming growth factor-beta complexes with thrombospondin.

1992 • 256 citations

Angiogenesis inhibition by minocycline.

1991 • 254 citations

Specificity of adhesion between murine tumor cells and capillary endothelium: an in vitro correlate of preferential metastasis in vivo.

1987 • 250 citations

Extracellular matrix and cell shape: Potential control points for inhibition of angiogenesis

1991 • 247 citations

Quantitation of Angiogenesis and Antiangiogenesis in the Chick Embryo Chorioallantoic Membrane

1994 • 246 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.

1990 • 230 citations

Suramin: a novel antineoplastic agent with multiple potential mechanisms of action.

1993 • 229 citations

Control of Angiogenesis by Heparin and Other Sulfated Polysaccharides

1992 • 225 citations

The Ca2(+)-binding glycoprotein SPARC modulates cell cycle progression in bovine aortic endothelial cells.

1991 • 223 citations

Sphingosine 1-phosphate, a specific endogenous signaling molecule controlling cell motility and tumor cell invasiveness.

1992 • 223 citations

Transforming growth factor-beta inhibits E-selectin expression on human endothelial cells.

1993 • 217 citations

The 16K Fragment of Prolactin Specifically Inhibits Basal or Fibroblast Growth Factor Stimulated Growth of Capillary Endothelial Cells

1991 • 217 citations

Heparin and Related Polysaccharides

1992 • 217 citations

Vascular Endothelium as the Vulnerable Element in Tumours

1984 • 215 citations

A Possible Mechanism for Inhibition of Angiogenesis by Angiostatic Steroids: Induction of Capillary Basement Membrane Dissolution*

1986 • 214 citations

A role for sialyl Lewis-X/A glycoconjugates in capillary morphogenesis

1993 • 211 citations

Inhibitory effect of angiogenesis inhibitor TNP-470 on tumor growth and metastasis of human cell lines in vitro and in vivo.

1993 • 207 citations

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.

1992 • 205 citations

Shark Cartilage Contains Inhibitors of Tumor Angiogenesis

1983 • 204 citations

Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature.

1993 • 203 citations

Antiinflammatory steroid action: Basic and clinical aspects

1990 • 202 citations

Assays for angiogenesis: A review

1991 • 202 citations

Expression of organ-specific antigens on capillary endothelial cells

1985 • 200 citations

Role of heparan sulfate in immune system-blood vessel interactions

1993 • 200 citations

Regulation of in vitro capillary tube formation by anti-integrin antibodies.

1993 • 194 citations

Site-directed mutagenesis of histidine-13 and histidine-114 of human angiogenin. Alanine derivatives inhibit angiogenin-induced angiogenesis

1989 • 191 citations

Growth Inhibition of Murine Melanoma and Human Colon Carcinoma by Recombinant Human Platelet Factor 4

1990 • 190 citations

Human placental ribonuclease inhibitor abolishes both angiogenic and ribonucleolytic activities of angiogenin.

1987 • 189 citations

Angiogenesis inhibition suppresses collagen arthritis.

1992 • 188 citations

In vivo patterns of expression of urokinase and its inhibitor PAI-1 suggest a concerted role in regulating physiological angiogenesis.

1992 • 187 citations

Insulin-like growth factor I acts as an angiogenic agent in rabbit cornea and retina: comparative studies with basic fibroblast growth factor

1993 • 185 citations

Inhibition of angiogenesis by antiestrogens.

1993 • 184 citations

Retinal Pigment Epithelial Cells Release an Inhibitor of Neovascularization

1985 • 180 citations

Prolonged tumor dormancy by prevention of neovascularization in the vitreous.

1976 • 176 citations

Matrix-bound thrombospondin promotes angiogenesis in vitro

1994 • 173 citations

Specific inhibition of endothelial cell proliferation by thrombospondin

1990 • 168 citations

Monoclonal antibodies against heparin-binding growth factor II/basic fibroblast growth factor that block its biological activity: invalidity of the antibodies for tumor angiogenesis.

1989 • 166 citations

Inhibition of tumor growth and metastasis of rodent tumors by the angiogenesis inhibitor O-(chloroacetyl-carbamoyl)fumagillol (TNP-470; AGM-1470).

1993 • 164 citations

Angiogenesis inhibitor TNP-470 (AGM-1470) potently inhibits the tumor growth of hormone-independent human breast and prostate carcinoma cell lines.

1993 • 163 citations

Inhibition of angiogenesis and tumor growth by a synthetic laminin peptide, CDPGYIGSR-NH2.

1991 • 157 citations

Inhibition of vascular endothelial cell growth by activin-A.

1993 • 157 citations

[A role of the retinal pigment epithelium in the involution of subretinal neovascularization].

1990 • 157 citations

Modulation of endothelial cell proliferation, adhesion, and motility by recombinant heparin‐binding domain and synthetic peptides from the type I repeats of thrombospondin

1993 • 155 citations

Treatment of prostate cancer in the rat with the synthetic retinoid fenretinide.

1993 • 155 citations

Control of tumor growth in animals by infusion of an angiogenesis inhibitor.

1980 • 154 citations

Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2)

1990 • 154 citations

Fibronectin promotes the elongation of microvessels during angiogenesis in vitro

1993 • 150 citations

Suramin Blockade of Insulinlike Growth Factor I-Stimulated Proliferation of Human Osteosarcoma Cells

1990 • 149 citations

Pathogenesis and Inhibition

1987 • 148 citations

Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity.

1991 • 148 citations

Calcium alginate beads as a slow‐release system for delivering angiogenic molecules In Vivo and In Vitro

1992 • 147 citations

Mechanism of action of angiostatic steroids: Suppression of plasminogen activator activity via stimulation of plasminogen activator inhibitor synthesis

1993 • 144 citations

Tumor Cell Collagenase and Its Inhibition by a Cartilage-Derived Protease Inhibitor

1977 • 143 citations

Diabetic-like retinopathy in rats prevented with an aldose reductase inhibitor.

1989 • 143 citations

A highly potent antiangiogenic activity of retinoids

1989 • 143 citations

Heterogeneity of mouse vascular endothelium. In vitro studies of lymphatic, large blood vessel and microvascular endothelial cells.

1987 • 143 citations

SPARC antagonizes the effect of basic fibroblast growth factor on the igration of bovine aortic endothelial cells

1992 • 142 citations

Vascular cells respond differentially to transforming growth factors beta 1 and beta 2 in vitro.

1991 • 137 citations

In vitro endothelial wound repair. Interaction of cell migration and proliferation.

1990 • 136 citations

Inhibition of tumor growth, vascularization, and collagenolysis in the rabbit cornea by medroxyprogesterone.

1981 • 136 citations

Histotypic angiogenesis in vitro: Light microscopic, ultrastructural, and radioautographic studies

1982 • 135 citations

The resistance of certain tissues to invasion: penetrability of explanted tissues by vascularized mesenchyme.

1973 • 135 citations

Tumor angiogenesis: the role of oncogenes and tumor suppressor genes.

1990 • 135 citations

Stimulation of angiogenesis by substance P and interleukin‐1 in the rat and its inhibition by NK₁ or interleukin‐1 receptor antagonists

1993 • 133 citations

Actin is a binding protein for angiogenin.

1993 • 132 citations

Inhibition of Neovascularization by an Extract Derived from Vitreous

1977 • 132 citations

Atrial natriuretic polypeptide as a novel antigrowth factor of endothelial cells.

1992 • 131 citations

A hemangioendothelioma-derived cell line: its use as a model for the study of endothelial cell biology.

1990 • 131 citations

Inhibition by Pentosan Polysulfate (PPS) of Heparin-Binding Growth Factors Released From Tumor Cells and Blockage by PPS of Tumor Growth in Animals

1992 • 127 citations

Inhibition of human endothelial cell proliferation in vitro and neovascularization in vivo by D-penicillamine.

1989 • 123 citations

Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin.

1990 • 123 citations

Vascular endothelial growth factor is inactivated by binding to alpha 2-macroglobulin and the binding is inhibited by heparin.

1993 • 122 citations

Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor.

1992 • 122 citations

Inhibition of angiogenesis by vitamin D3 analogues

1990 • 122 citations

Platelet endothelial cell adhesion molecule, PECAM‐1, modulates cell migration

1992 • 120 citations

Haemodynamic and Transport Barriers to the Treatment of Solid Tumours

1991 • 120 citations

Characterization of the receptor to vasculotropin on bovine adrenal cortex-derived capillary endothelial cells.

1990 • 120 citations

Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth.

1985 • 118 citations

The microvascular extracellular matrix. Developmental changes during angiogenesis in the aortic ring-plasma clot model.

1987 • 118 citations

Retinoic acid counteracts both the downregulation of thrombomodulin and the induction of tissue factor in cultured human endothelial cells exposed to tumor necrosis factor

1992 • 117 citations

Heparinase inhibitsneovascularization.

1994 • 117 citations

Inhibition by sulfated chitin derivatives of invasion through extracellular matrix and enzymatic degradation by metastatic melanoma cells.

1990 • 116 citations

Inhibition of angiogenesis.

1992 • 116 citations

Thrombin promotes angiogenesis by a mechanism independent of fibrin formation

1993 • 114 citations

Extracellular matrix as a solid-state regulator in angiogenesis: identification of new targets for anti-cancer therapy.

1992 • 113 citations

Somatostatin analogues inhibit angiogenesis in the chick chorioallantoic membrane

1991 • 112 citations

Hypoxia-induced angiogenesis in chick chorioallantoic membranes: a role for adenosine

1988 • 111 citations

The combination of antiagniogenic agents to inhibit primary tumor growth and metastasis

1993 • 111 citations

Angiogenic macrophages produce the angiogenic inhibitor thrombospondin 1.

1993 • 111 citations

Inhibition of IGF-I and b-FGF stimulated growth of human retinal endothelial cells by the somatostatin analogue, octreotide: a potential treatment for ocular neovascularization

1993 • 109 citations

Regression of Experimental Iris Neovascularization with Systemic Alpha-interferon

1993 • 109 citations

Obligatory wounding requirement for tumorigenesis in v-jun transgenic mice

1990 • 109 citations

Vasculature as a Target for Tumour Therapy

2015 • 109 citations

The effects of intravitreal triamcinolone acetonide on experimental pre-retinal neovascularization

1993 • 108 citations

Inactivation of human fibroblast growth factor-1 (FGF-1) activity by interaction with copper ions involves FGF-1 dimer formation induced by copper-catalyzed oxidation.

1992 • 108 citations

A metalloproteinase inhibitor as an inhibitor of neovascularization

1991 • 106 citations

Differential adhesion of tumor cells to capillary endothelial cells in vitro.

1984 • 106 citations

Tumor Growth Dependent on Kaposi's Sarcoma-Derived Fibroblast Growth Factor Inhibited by Pentosan Polysulfate

1991 • 106 citations

The Laminins: A Family of Basement Membrane Glycoproteins Important in Cell Differentiation and Tumor Metastases

1993 • 105 citations

Regulation of angiogenesis: A new function of heparin

1985 • 104 citations

Antiangiogenic effects of the quinoline-3-carboxamide linomide.

1993 • 104 citations

Inhibition of Angiogenesis by Somatostatin and Somatostatin-like Compounds Is Structurally Dependent

1993 • 103 citations

Tumor necrosis factor bifunctionally regulates matrix metalloproteinases and tissue inhibitor of metalloproteinases (TIMP) production by human fibroblasts

1990 • 103 citations

Inhibitors of Angiogenesis

1991 • 102 citations

The Role of Basement Membranes in Vascular Development

1990 • 101 citations

Human corneal interleukin-8. IL-1 and TNF-induced gene expression and secretion.

1991 • 100 citations

1992 MACK FORSTER AWARD LECTURE REVIEW

1992 • 100 citations

Production of two variant laminin forms by endothelial cells and shift of their relative levels by angiostatic steroids.

1990 • 99 citations

Induction of vascular endothelial tubular morphogenesis by human glioma cells. A model system for tumor angiogenesis.

1993 • 98 citations

Protein kinase C activators suppress stimulation of capillary endothelial cell growth by angiogenic endothelial mitogens.

1987 • 97 citations

AGM-1470, a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle.

1994 • 97 citations

Morphometric measurements of chorioallantoic membrane vascularity: effects of hypoxia and hyperoxia

1991 • 97 citations

Transforming growth factor‐β1 stimulates macrophage urokinase expression and release of matrix‐bound basic fibroblast growth factor

1993 • 97 citations

Regulation of gene expression by SPARC during angiogenesis in vitro. Changes in fibronectin, thrombospondin-1, and plasminogen activator inhibitor-1.

1992 • 96 citations

The 16-kilodalton N-terminal fragment of human prolactin is a potent inhibitor of angiogenesis

1993 • 96 citations

Macrovascular and microvascular endothelium during long‐term hypoxia: Alterations in cell growth, monolayer permeability, and cell surface coagulant properties

1991 • 95 citations

Differential effects of interferon gamma and alpha on in vitro model of angiogenesis

1991 • 94 citations

Isolation and characterization of an inhibitor of neovascularization from scapular chondrocytes.

1992 • 93 citations

Tumor necrosis factor inhibits the proliferation of cultured capillary endothelial cells

1987 • 91 citations

Interferon-alpha and interleukin 2 synergistically enhance basic fibroblast growth factor synthesis and induce release, promoting endothelial cell growth.

1993 • 91 citations

Inhibition of angiogenesis by suramin.

1992 • 89 citations

Inhibition of Development of Kaposi's Sarcoma-Related Lesions by a Bacterial Cell Wall Complex

1992 • 88 citations

Analysis of experimental antiangiogenic therapy

1993 • 87 citations

Protamine sulfate inhibits mitogenic activities of the extracellular matrix and fibroblast growth factor, but potentiates that of epidermal growth factor

1987 • 86 citations

Isolation and identification of stimulatory and inhibitory cell growth factors in bovine vitreous

1982 • 85 citations

Inhibition of angiogenesis and growth of human nerve-sheath tumors by AGM-1470

1993 • 85 citations

Actions of TNF and INF-γ on Angiogenesis In Vitro

1990 • 84 citations

Pharmacodynamics, Clinical Indications, and Adverse Effects of Heparin

1992 • 84 citations

The disc angiogenesis system.

1988 • 83 citations

Platelet factor 4 blocks the binding of basic fibroblast growth factor to the receptor and inhibits the spontaneous migration of vascular endothelial cells

1990 • 83 citations

Interaction of human placental ribonuclease with placental ribonuclease inhibitor

1991 • 83 citations

Angiogenesis and its inhibitors.

1985 • 83 citations

Rapamycin inhibits spontaneous and fibroblast growth factor beta-stimulated proliferation of endothelial cells and fibroblasts.

1991 • 82 citations

Inhibition of Tumor-Induced Angiogenesis by Sulfated Chitin Derivatives

1992 • 82 citations

A model system for tumor angiogenesis: Involvement of transforming growth factor-α in tube formation of human microvascular endothelial cells induced by esophageal cancer cells

1992 • 82 citations

Inhibition of in vitro angiogenesis by lymphotoxin and interferon-γ

1988 • 81 citations

Tumor Angiogenesis and Polyamines: α-Difluoromethylornithine, an Irreversible Inhibitor of Ornithine Decarboxylase, Inhibits B16 Melanoma-induced Angiogenesis in Ovo and the Proliferation of Vascular Endothelial Cells in Vitro

1990 • 80 citations

An angiogenin-binding protein from endothelial cells.

1991 • 79 citations

Vitreous: an inhibitor of retinal extract-induced neovascularization.

1983 • 78 citations

Suramin inhibits bFGF-induced endothelial cell proliferation and angiogenesis in the chick chorioallantoic membrane

1993 • 78 citations

Heparin and Angiogenesis: A Low-Molecular-Weight Fraction Inhibits and a High-Molecular-Weight Fraction Stimulates Angiogenesis Systemically

1993 • 77 citations

Myeloid expression of the human c-fps/fes proto-oncogene in transgenic mice.

1990 • 77 citations

Inhibition of angiogenesis in vitro by Arg-Gly-Asp-containing synthetic peptide.

1991 • 77 citations

Differential inhibition of various deoxyribonucleic and ribonucleic acid polymerases by suramin

1988 • 77 citations

Microcirculation in Cancer Metastasis

2024 • 76 citations

Angiogenesis can be stimulated or repressed in vivo by a change in GM3:GD3 ganglioside ratio.

1992 • 75 citations

Chondrocytes inhibit endothelial sprout formation in vitro: Evidence for involvement of a transforming growth factor‐beta

1991 • 75 citations

Diabetes-related histopathologies of the rat retina prevented with an aldose reductase inhibitor

1990 • 75 citations

Cell-cell signaling between adult rat ventricular myocytes and cardiac microvascular endothelial cells in heterotypic primary culture.

1993 • 74 citations

[Leu⁸]des‐Arg⁹‐bradykinin inhibits the angiogenic effect of bradykinin and interleukin‐1 in rats

1993 • 73 citations

Suppression of Corneal Neovascularization With Cyclosporine

1992 • 73 citations

Assay and purification of naturally occurring inhibitor of angiogenesis

1991 • 73 citations

Monoclonal antibodies directed against basic fibroblast growth factor which inhibit its biological activity in vitro and in vivo

1989 • 72 citations

Effect of inhibitors of arachidonic acid metabolism on corneal neovascularization in the rat.

1989 • 71 citations

Identification of functional arginines in human angiogenin by site-directed mutagenesis

1992 • 71 citations

A novel angiogenic inhibitor derived from Japanese shark cartilage (I). Extraction and estimation of inhibitory activities toward tumor and embryonic angiogenesis

1990 • 70 citations

Inhibition of human endothelial cell proliferation by gold compounds.

1987 • 66 citations

Hyperthermia Inhibits Angiogenesis

1988 • 65 citations

Vascular endothelial cell differentiation: organ-specificity and selective affinities as the basis for developing anti-cancer strategies

1991 • 65 citations

Anticancer strategies involving the vasculature: vascular targeting and the inhibition of angiogenesis.

1992 • 65 citations

Eicosapentaenoic acid inhibits tube formation of vascular endothelial cellsin vitro

1991 • 64 citations

Myocardial angiogenesis and coronary perfusion in left ventricular pressure-overload hypertrophy in the young lamb. Evidence for inhibition with chronic protamine administration.

1991 • 63 citations

Antitumor effects of an antiangiogenic polysaccharide from an Arthrobacter species with or without a steroid.

1989 • 62 citations

Inhibition of basement membrane biosynthesis prevents angiogenesis.

1988 • 61 citations

Modulation of vascular cell behavior by transforming growth factors β

1992 • 61 citations

Inhibition of Vascular Permeability Factor (Vascular Endothelial Growth Factor) with Antipeptide Antibodies

1993 • 61 citations

Cytotoxicity of tumor necrosis factor-alpha for human umbilical vein endothelial cells.

1989 • 61 citations

Selective endothelial growth inhibition by tetracyclines that inhibit collagenase

1992 • 60 citations

Effect of inflammatory cytokines on human endothelial cell proliferation

1990 • 59 citations

Regulation of cell growth by vitreous humour

1985 • 58 citations

Tryptophan fluorescence as a probe of placental ribonuclease inhibitor binding to angiogenin

1989 • 58 citations

Cultivation of human dermal microvascular endothelial cells in vitro: Immunocytochemical and ultrastructural characterization and effect of treatment with three synthetic retinoids

1991 • 57 citations

Dexamethasone reduces vascular density and plasminogen activator activity in 9L rat brain tumors

1993 • 57 citations

Interaction of gangliosides with fibronectin in the mobilization of capillary endothelium. Possible influence on the growth of metastasis.

1986 • 56 citations

Inhibition of angiogenesis by staurosporine, a potent protein kinase inhibitor.

1992 • 56 citations

Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation

1993 • 56 citations

Basement membrane biosynthesis as a target for developing inhibitors of angiogenesis with anti-tumor properties

1993 • 55 citations

Eponemycin, a novel antibiotic, is a highly powerful angiogenesis inhibitor

1991 • 54 citations

Tumor necrosis factor inhibiting angiogenesis in vitro.

1987 • 53 citations

Heparin-binding fragments of fibronectin are potent inhibitors of endothelial cell growth: structure-function correlations

1986 • 53 citations

Tumor angiogenesis inhibition by prostaglandin synthetase inhibitors.

1986 • 53 citations

Inhibitor of Vascular Endothelial Cell Growth in the Lens

1984 • 53 citations

Medroxyprogesterone acetate, an anti‐cancer and anti‐angiogenic steroid, inhibits the plasminogen activator in bovine endothelial cells

1989 • 53 citations

Heparin-steroid conjugates: new angiogenesis inhibitors with antitumor activity in mice.

1993 • 52 citations

Angiogenesis under normal and pathological conditions.

1991 • 52 citations

An in vitro model for cell-cell interactions

1992 • 52 citations

Motility of human carcinoma cells in response to thrombospondin: relationship to metastatic potential and thrombospondin structural domains.

1993 • 51 citations

Modulation of endothelial cell shape and growth by retinoids

1991 • 51 citations

Inhibition of Angiogenesis with Combination Treatments of Angiostatic Steroids and Suramin

1991 • 50 citations

Chemical Modification of Fumagillin. I. 6-O-Acyl, 6-O-Sulfonyl, 6-O-Alkyl, and 6-O-(N-Substituted-carbamoyl)fumagillols.

1992 • 50 citations

Antitumor effects of angiogenesis inhibitor TNP-470 in rabbits bearing VX-2 carcinoma by arterial administration of microspheres and oil solution.

1993 • 50 citations

Angiogenic activity of rat mammary carcinomas induced by 7, 12-dimethylbenz[a]anthracene and its inhibition by medroxyprogesterone acetate: possible involvement of antiangiogenic action of medroxyprogesterone acetate in its tumor growth inhibition

1988 • 50 citations

Inhibitory effects of nicotinamide on recombinant human interferon-gamma-induced intercellular adhesion molecule-1 (ICAM-1) and HLA-DR antigen expression on cultured human endothelial cells

1992 • 49 citations

Effects of interleukin-1, -2, -4, -6, interferon-gamma and granulocyte/macrophage colony stimulating factor on human vascular endothelial cells

1993 • 48 citations

Does Hyaluronan have a role in endothelial cell proliferation of the synovium?

1992 • 48 citations

Lymphocyte-Induced Angiogenesis in Tumor-Bearing Mice

1976 • 48 citations

Systemic Amiloride Inhibits Experimentally Induced Neovascularization

1990 • 47 citations

Powerful antiangiogenic activity of herbimycin A (named angiostatic antibiotic).

1989 • 47 citations

Angiostatic steroids potentiated by sulfated cyclodextrins inhibit corneal neovascularization.

1991 • 47 citations

The sulfated polysaccharide-peptidoglycan complex potently inhibits embryonic angiogenesis and tumor growth in the presence of cortisone acetate

1988 • 47 citations

Inhibitory effect of human recombinant interleukin-1 α and β on growth of human vascular endothelial cells

1987 • 47 citations

Regulation of angiogenesis in vitro by collagen metabolism

1991 • 47 citations

Interferon Alpha-2a for Subfoveal Neovascularization in Age-related Macular Degeneration

1993 • 46 citations

Suramin inhibits proliferation of rat glioma cells and alters N‐cam cell surface expression

1990 • 45 citations

Protein Kinase C Involvement in the Regulation of Angiogenesis

1993 • 45 citations

Three novel synthetic retinoids, Re 80, Am 580 and Am 80, all exhibit anti-angiogenic activity in vivo

1993 • 45 citations

Aldose reductase and pericyte-endothelial cell contacts in retina and optic nerve.

1989 • 45 citations

Reduction of Glutathione Is Associated with Growth Restriction and Enlargement of Bovine Pulmonary Artery Endothelial Cells Produced by Transforming Growth Factor-β₁

1992 • 44 citations

Radicol, a microbial cell differentiation modulator, inhibits in vivo angiogenesis

1993 • 43 citations

A ribonuclease inhibitor expresses anti-angiogenic properties and leads to reduced tumor growth in mice.

1993 • 43 citations

Angiogenesis: Modulation with opioids

1991 • 43 citations

Oncogenes and tumor suppressor genes in human malignancies

1993 • 43 citations

Characterization and applications of the disc angiogenesis system

1992 • 43 citations

Effects of prostaglandin synthesis inhibitors on tumor growth and vascularization. Experimental studies in the rat.

1983 • 42 citations

Inhibition of production of macrophage-derived angiogenic activity by the anti-rheumatic agents gold sodium thiomalate and auranofin

1988 • 42 citations

Inhibition of angiogenesis by the antineoplastic agents mitoxantrone and bisantrene

1986 • 41 citations

Modulation of endothelial cells growth induced by heparin

1986 • 41 citations

The Current Status of Targeting Tumour Vasculature as a Means of Cancer Therapy: An Overview

1991 • 41 citations

Inhibition of endothelial cell growth by a factor isolated from cartilage

1980 • 41 citations

Steroid Inhibition of Neural Micro vessel Morphogenesis In Vitro: Receptor Mediation and Astroglial Dependence

1992 • 40 citations

Partial purification of a 5.7K glycoprotein from bovine vitreous which inhibits both angiogenesis and collagenase activity

1985 • 40 citations

Inhibition of growth and angiogenesis of human neurofibrosarcoma by heparin and hydrocortisone

1990 • 40 citations

Inhibition of tumor‐induced angiogenesis by the administration of recombinant interferon‐γ followed by a synthetic lipid‐a subunit analogue (GLA‐60)

1992 • 39 citations

Migration Inhibition of Endothelial Cells by Lymphokine-Containing Supernatants

1982 • 39 citations

Inhibition of Tumor Angiogenesis by a Synthetic Cell‐adhesive Polypeptide Containing the Arg‐Gly‐Asp (RGD) Sequence of Fibronectin, Poly(RGD)

1990 • 39 citations

Angiogenesis and its inhibition: potential new therapies in oncology and non-neoplastic diseases.

1991 • 38 citations

Amiloride inhibition of angiogenesis in vitro

1993 • 38 citations

Inhibition of human endothelial cell proliferation by heparin and steroids

1988 • 38 citations

Development of angiogenesis inhibitors for clinical applications

1990 • 37 citations

Antiangiogenic action of heparin plus cortisone is associated with decreased collagenous protein synthesis in the chick chorioallantoic membrane system.

1989 • 37 citations

Antiangiogenic effect of sulphated and nonsulphated glycosaminoglycans and polysaccharides in the chick embryo chorioallantoic membrane

1991 • 37 citations

Inhibition of Tumor-Induced Migration of Bovine Capillary Endothelial Cells by Mouse and Rabbit Tumor Necrosis Factor

1987 • 37 citations

Angiogenesis inhibitors and their delivery systems

1983 • 36 citations

Irsogladine is a potent inhibitor of angiogenesis

1993 • 36 citations

Vascular Smooth Muscle Cells Inhibit the Plasminogen Activators Secreted by Endothelial Cells

1985 • 36 citations

Inhibitory effect of medroxyprogesterone acetate on angiogenesis induced by human endometrial cancer

1992 • 35 citations

Angiogenesis, Key principles, Science, Technology, Medicine

1992 • 35 citations

Growth inhibitory effects of dimethyl sulfoxide and dimethyl sulfone on vascular smooth muscle and endothelial cells in vitro

1987 • 35 citations

Inhibitory effects of anti-angiogenic agents on neovascularization and growth of the chorioallantoic membrane (CAM). — The possibility of a new CAM assay for angiogenesis inhibition

1986 • 34 citations

The Combination of a Bacterial Polysaccharide and Tamoxifen Inhibits Angiogenesis and Tumour Growth

1991 • 34 citations

Antiangiogenesis as a Strategy for Antimetastasis

1988 • 34 citations

Interferon alpha‐2a treatment of patients with subfoveal neovascular macular degeneration

1993 • 34 citations

Is the beneficial effect of sulfasalazine due to inhibition of synovial neovascularization?

1991 • 33 citations

Antibodies against basic fibroblast growth factor inhibit the autocrine growth of pulmonary artery endothelial cells

1988 • 32 citations

Inhibition of microvascular endothelial cell migration by β-cyclodextrin tetradecasulfate and hydrocortisone

1990 • 32 citations

Inhibitory Effects of Heparin Plus Cortisone Acetate on Endothelial Cell Growth Both in Cultures and in Tumor Masses

1987 • 31 citations

Angiogenesis: A mechanism by which oncogenes and tumor suppressor genes regulate tumorigenesis

1993 • 31 citations

Growth and motility of microvascular endothelium are modulated by the relative concentration of gangliosides in the medium

1992 • 31 citations

Efficacy of antitumor chemotherapy in C3H mice enhanced by the antiangiogenesis steroid, cortisone acetate.

1987 • 31 citations

Effects of cortisone with and without heparin on angiogenesis induced by prostaglandin e1 and by s180 cells, and on growth of murine transplantable tumours

1985 • 30 citations

Anti‐angiogenic activity of arachidonic acid metabolism inhibitors in angiogenesis model systems involving human microvascular endothelial cells and neovascularization in mice

1993 • 30 citations

Thiol-containing compounds inhibit the production of monocyte/macrophage-derived angiogenic activity

1991 • 29 citations

Recombinant Truncated Thrombospondin-1 Monomer Modulates Endothelial Cell Plasminogen Activator Inhibitor 1 Accumulation and Proliferation in Vitro

1993 • 29 citations

Tumour-associated Hyaluronan: A Potential Regulator of Tumour Angiogenesis

1991 • 28 citations

Retinol-induced modification of the extracellular matrix of endothelial cells: Its role in growth control

1991 • 28 citations

Response of microvascular endothelial cells to biological response modifiers

1989 • 28 citations

The role of fibroblast growth factors and related oncogenes in tumor growth

1993 • 28 citations

Induction of avascular yolk sac due to reduction of basic fibroblast growth factor by retinoic acid in mice

1992 • 28 citations

Effect of purinergic receptor antagonists suramin and theobromine on tumor-induced angiogenesis in BALB/c mice.

1993 • 27 citations

Inhibition of tumor angiogenesis activity by medroxyprogesterone acetate in gynecologic malignant tumors.

1989 • 27 citations

Early partial excision of major burns in children

1968 • 26 citations

A quantitative in vivo mouse model used to assay inhibitors of tumor-induced angiogenesis.

1991 • 26 citations

Inhibition of angiogenesis in vitro and in ovo with an inhibitor of cellular protein kinases, MDL 27032

1992 • 24 citations

Inhibition of angiogenesis by bleomycin and its copper complex.

1990 • 24 citations

A new angiogenesis inhibitor, FR-111142.

1992 • 24 citations

Macrophages secrete a heparin-binding inhibitor of endothelial cell growth

1991 • 23 citations

Protein Kinase C-Mediated Inhibition of Cyclin A Expression in Human Vascular Endothelial Cells

1993 • 22 citations

Growth‐inhibiting effect of tumor necrosis factor on human umbilical vein endothelial cells is enhanced with advancing age in vitro

1990 • 22 citations

Inhibition of Neovascularization by a Cartilage Factor

1983 • 22 citations

Suramin: The discovery of an old anticancer drug

1990 • 21 citations

Carboxyl‐terminal Heparin‐binding Fragments of Platelet Factor 4 Retain the Blocking Effect on the Receptor Binding of Basic Fibroblast Growth Factor

1993 • 21 citations

Spontaneous corneal neovascularization in nude mice. Local imbalance between angiogenic and anti-angiogenic factors.

1993 • 21 citations

Endothelial-Pericyte Interdigitations in Rat Subcutaneous Disc Implanted Angiogenesis

1993 • 21 citations

Cortisone inhibition of tumor angiogenesis measured by a quantitative colorimetric assay in mice

1990 • 21 citations

Secretion of SPARC by endothelial cells transformed by polyoma middle T oncogene inhibits the growth of normal endothelial cells in vitro

1992 • 21 citations

Growth inhibitory activities in avascular tissues are recognized by anti-transforming growth factor β antibodies

1991 • 21 citations

Angiogenesis and angiogenesis inhibitors in paediatric diseases

1992 • 20 citations

Cartilage-derived anti-tumor factor (CATF) inhibits the proliferation of endothelial cells in culture

1985 • 20 citations

TAN-1120, a new anthracycline with potent angiostatic activity.

1993 • 20 citations

Vitreous: Inhibitor retinal extract induced neovascularization

1984 • 19 citations

Suramin inhibits the stimulation of acute phase plasma protein genes by IL-6-type cytokines in rat hepatoma cells.

1993 • 19 citations

Modulation of Human Endothelial Cell Activation by Antiproliferative Cytokines: Exploration of Arachidonic Acid and Intracellular Cytokine Pathways as Possible Mechanisms of Action

1993 • 19 citations

Basement membrane biosynthesis as a target to tumor therapy.

1990 • 19 citations

Antiangiogenic Effect of Heparin and Other Sulphated Glycosaminoglyycans in the Chick Embryo Chorioallantoic Membrane

1991 • 19 citations

Inhibition of tumor angiogenesis by hexuronyl hexosaminoglycan sulfate

1986 • 18 citations

Inhibitory Effects of Cytokines on Vascular Endothelial Cells, Synergistic Interactions Among Interferon-γ, Tumor Necrosis Factor-α, and Interleukin-1

1992 • 18 citations

Potentiation of angiostatic steroids by a synthetic inhibitor of arylsulfatase.

1988 • 16 citations

Inhibition of basal and tumor necrosis factor-enhanced binding of murine tumor cells to murine endothelium by transforming growth factor-beta 1.

1992 • 16 citations

Cyclosporine is angiostatic

1992 • 16 citations

Prevention of Diabetes-Related Retinal Microangiopathy with Aldose Reductase Inhibitors

1988 • 16 citations

Selective Inhibition by Magnosalin and Magnoshinin, Compounds from ‘Shin-i’ (Flos magnoliae), of Adjuvant-Induced Angiogenesis and Granuloma Formation in the Mouse Pouch

1990 • 16 citations

Collagenase Inhibition with Penicillamine

1973 • 15 citations

Protamine and mast-cell-mediated angiogenesis in the rat.

1990 • 15 citations

Extracellular modulating factors and the control of intraocular neovascularization: An overview

1990 • 15 citations

Acidic fibroblast growth factor-Pseudomonas exotoxin chimeric protein elicits antiangiogenic effects on endothelial cells.

1992 • 14 citations

Effects of nicardipine on tube formation of bovine vascular endothelial cells in vitro.

1992 • 14 citations

Opposing effects of heparin with TGF‐β or aFGF during repair of a mechanical wound of human endothelium. Influence of cAMP on cell migration

1992 • 14 citations

Effect of 15-deoxyspergualin, a microbial angiogenesis inhibitor, on the biological activities of bovine vascular endothelial cells

1992 • 14 citations

In vivo and in vitro studies of angiogenin--a potent angiogenic factor.

1990 • 13 citations

Chloroquine's modulation of endothelial cell activity induced with basic fibroblast growth factor and human serum: Effect on mitogenesis, protease production and cell migration

1990 • 12 citations

The resistance of epithelia to vascularization: Proteinase and endothelial cell growth inhibitory activities in urinary bladder epithelium

1982 • 12 citations

Factors that define the susceptibility of endothelial cells to tumor necrosis factor and lipid A

1992 • 12 citations

Suramin inhibits growth and yet promotes insulin-like growth factor II expression in HepG2 cells.

1993 • 12 citations

The angiogenesis inhibitor beta-cyclodextrin tetradecasulfate inhibits ecto-protein kinase activity.

1992 • 12 citations

A clonal human chondrosarcoma cell line produces an anti-angiogenic antitumor factor.

1990 • 12 citations

Inhibition of angiogenesis by erbstatin, an inhibitor of tyrosine kinase.

1993 • 12 citations

Tumor necrosis factor alpha and interleukin 1 alpha induce anchorage independence in v-jun transgenic murine cells.

1993 • 11 citations

Tumor growth regulation by modulation of basic fibroblast growth factor

1992 • 11 citations

A factor in conditioned medium of rabbit costal chondrocytes inhibits the proliferation of cultured endothelial cells and angiogenesis induced by B16 melanoma: its relation with cartilage-derived anti-tumor factor (CATF).

1987 • 11 citations

Alterations in tumor angiogenesis associated with stable expression of the HIV tat gene

1992 • 10 citations

In vitro activity of novel sulphonic derivatives of distamicyn A

1992 • 10 citations

Modulation of T lymphocyte function by the angiogenesis inhibitor AGM-1470

1993 • 10 citations

Antitumor Action of Retinoids: Inhibition of Tumor Cell Line-Induced Angiogenesis and Prevention of Tumors in Mice

1992 • 9 citations

Inhibition of microvascular endothelial cell proliferation by vitreous following retinal scatter photocoagulation.

1990 • 9 citations

The mode of action of anti-angiogenic steroid and heparin

1992 • 8 citations

The Effects of Total Lymphoid Irradiation upon Corneal Vascularization in the Rat Following Chemical Cautery

1989 • 8 citations

Enhancement by androgen of the angiogenic ability of androgen-responsive Shionogi carcinoma 115.

1992 • 7 citations

Absence of Angiogenesis-lnhibitory Activity in Aqueous Humor of Diabetic Rabbits

1990 • 7 citations

Protamine Sulfate Inhibition of Serum-Induced Mitogenic Responses: Differential Effects on Normal and Neoplastic Cells<xref ref-type="fn" rid="FN2">2</xref>

1984 • 6 citations

Angiogenesis, Tumor Vascularization, and Potential Interference with Tumor Growth

1985 • 6 citations

Combined treatments of heat, radiation, or cytokines with flavone acetic acid on the growth of cultured endothelial cells

1993 • 6 citations

The yeast RNA1 protein, necessary for RNA processing, is homologous to the human ribonuclease/angiogenin inhibitor (RAI)

1992 • 6 citations

Antiangiogenesis strategies in cancer therapy with special reference to Krestin

1992 • 6 citations

The proline analog L-azetidine-2-carboxylic acid modifies the neovascularization pattern by inhibiting branching or tortuosity and stimulating spatial expansion in the rat mesentery.

1993 • 6 citations

The Development of Therapeutic Angiosuppression: Problems and Progress

1992 • 6 citations

Serum-induced proliferation of retinal capillary endothelial cells is inhibited in the presence of retinal extract.

1989 • 5 citations

Inhibition of tumor angiogenesis activity in C3H mouse mammary tumor by medroxyprogesterone acetate.

1989 • 5 citations

Prophylactic antiangiogenic tumor treatment.

1989 • 5 citations

Absence of angiogenesis-inhibitory activity in aqueous humor of diabetic rabbits

1990 • 4 citations

Partial purification and characterization of an endothelial cell growth regulator from the bovine ovary

1990 • 3 citations

Adenosine 3':5'-Cyclic Monophosphate Inhibits in Vitro Angiogenesis Induced by Endothelial Cell Growth Factor.

1992 • 3 citations

Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro

1992 • 3 citations

Retinal pigment epithelial cells release an inhibitor of neovascularization.

1988 • 2 citations

Characterization of the Murine Monoclonal Antibody NL07 Specific for the Human Thrombospondin Receptor (CD36 Molecule)1

2015 • 2 citations

Chapter 15. Inhibitors of Angiogenesis

1992 • 2 citations

Experimental Antiangiogenesis Therapy Using Cortisone Acetate in Murine Bladder Cancer: Independence from "Tumor Volume Effect"

1993 • 1 citations

Modulation of Anti-Tumor Cytotoxicity of Cultured Mast Cells by Metabolic Inhibitors

1992 • 1 citations

Retinal pigment epithelial cells in culture secrete angiogenic inhibitors: in vitro study.

1990 • 1 citations

[Regulation of angiogenesis and tumor growth].

1985 • 1 citations

Deleted Work

1955 • 0 citations