The role of fibroblast growth factors and related oncogenes in tumor growth

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

Angiogenic Factors

1987 • 3,702 citations

Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

1991 • 2,437 citations

THE HEPARIN-BINDING (FIBROBLAST) GROWTH FACTOR FAMILY OF PROTEINS

1989 • 1,948 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

Requirement of Heparan Sulfate for bFGF-Mediated Fibroblast Growth and Myoblast Differentiation

1991 • 1,507 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis.

1989 • 1,282 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth Factor

1986 • 1,032 citations

Human KGF is FGF-Related with Properties of a Paracrine Effector of Epithelial Cell Growth

1989 • 989 citations

Regulators of Angiogenesis

1991 • 959 citations

Heparin Affinity: Purification of a Tumor-Derived Capillary Endothelial Cell Growth Factor

1984 • 937 citations

A heparin-binding angiogenic protein--basic fibroblast growth factor--is stored within basement membrane.

1988 • 892 citations

Heparin protects basic and acidic FGF from inactivation

1986 • 856 citations

Basic fibroblast growth factor induces angiogenesis in vitro.

1986 • 828 citations

Localisation of a fibroblast growth factor and its effect alone and with hydrocortisone on 3T3 cell growth

1974 • 786 citations

Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth

1987 • 764 citations

Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF.

1985 • 710 citations

PDGF and FGF stimulate wound healing in the genetically diabetic mouse.

1990 • 689 citations

Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome Localization

1986 • 679 citations

Tumor interactions with the vasculature: angiogenesis and tumor metastasis

1990 • 598 citations

Basic fibroblast growth factor binds to subendothelial extracellular matrix and is released by heparitinase and heparin-like molecules

1989 • 597 citations

A dual receptor system is required for basic fibroblast growth factor activity

1991 • 589 citations

Human basic fibroblast growth factor gene encodes four polypeptides: three initiate translation from non-AUG codons.

1989 • 527 citations

An oncogene isolated by transfection of Kaposi's sarcoma DNA encodes a growth factor that is a member of the FGF family

1987 • 525 citations

Neovascularization is associated with a switch to the export of bFGF in the multistep development of fibrosarcoma

1991 • 523 citations

A New Class of Steroids Inhibits Angiogenesis in the Presence of Heparin or a Heparin Fragment

1985 • 492 citations

Identification of an Inhibitor of Neovascularization from Cartilage

1990 • 481 citations

AIDS-Kaposi's Sarcoma-Derived Cells Express Cytokines with Autocrine and Paracrine Growth Effects

1989 • 476 citations

High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons.

1989 • 469 citations

In vitro angiogenesis on the human amniotic membrane: requirement for basic fibroblast growth factor-induced proteinases.

1989 • 462 citations

The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors.

1988 • 425 citations

Expression of the FGF-related proto-oncogene int-2 during gastrulation and neurulation in the mouse.

1988 • 384 citations

Basic fibroblast growth factor fused to a signal peptide transforms cells

1988 • 379 citations

Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.

1990 • 368 citations

The fibroblast growth factor family: Structural and biological properties

1989 • 362 citations

Tumorigenesis by mouse mammary tumor virus: Proviral activation of a cellular gene in the common integration region int-2

1984 • 356 citations

Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent

1991 • 324 citations

Correlation between long-term survival in breast cancer patients and amplification of two putative oncogene-coamplification units: hst-1/int-2 and c-erbB-2/ear-1.

1989 • 321 citations

Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development

1989 • 309 citations

Interaction of heparin with human basic fibroblast growth factor: Protection of the angiogenic protein from proteolytic degradation by a glycosaminoglycan

1989 • 304 citations

Characterization of the HST-related FGF.6 gene, a new member of the fibroblast growth factor gene family.

1989 • 294 citations

Control of Angiogenesis with Synthetic Heparin Substitutes

1989 • 292 citations

Discovery of a New Mechanism and Development of Angiogenic Therapy That Accelerates Healing

1991 • 282 citations

Gene expression of fibroblast growth factors in human gliomas and meningiomas: demonstration of cellular source of basic fibroblast growth factor mRNA and peptide in tumor tissues.

1990 • 279 citations

Transforming gene from human stomach cancers and a noncancerous portion of stomach mucosa.

1986 • 277 citations

Purification from a human hepatoma cell line of a basic fibroblast growth factor-like molecule that stimulates capillary endothelial cell plasminogen activator production, DNA synthesis, and migration.

1986 • 272 citations

Proliferation of human malignant melanomas is inhibited by antisense oligodeoxynucleotides targeted against basic fibroblast growth factor.

1989 • 270 citations

Recombinant basic fibroblast growth factor accelerates wound healing

1988 • 269 citations

Extracellular matrix‐resident basic fibroblast growth factor: Implication for the control of angiogenesis

1991 • 268 citations

Suppression of solid tumor growth by immunoneutralizing monoclonal antibody against human basic fibroblast growth factor.

1991 • 268 citations

Purification and characterization of acidic fibroblast growth factor from bovine brain.

1984 • 267 citations

Isolation of cDNAs encoding four mouse FGF family members and characterization of their expression patterns during embryogenesis

1990 • 266 citations

The int-2 gene product acts as an epithelial growth factor in transgenic mice.

1990 • 263 citations

Increased capillary endothelial cell protease activity in response to angiogenic stimuli in vitro.

1983 • 261 citations

Angiogenesis inhibition by minocycline.

1991 • 254 citations

Both normal and tumor cells produce basic fibroblast growth factor

1986 • 250 citations

Genomic sequence of hst, a transforming gene encoding a protein homologous to fibroblast growth factors and the int-2-encoded protein.

1987 • 247 citations

Human tumor cells synthesize an endothelial cell growth factor that is structurally related to basic fibroblast growth factor.

1986 • 247 citations

First steps of tumor-related angiogenesis.

1991 • 241 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

BEK and FLG, two receptors to members of the FGF family, are amplified in subsets of human breast cancers.

1991 • 238 citations

Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.

1990 • 230 citations

Aortic endothelial cells synthesize basic fibroblast growth factor which remains cell associated and platelet‐derived growth factor‐like protein which is secreted

1987 • 229 citations

Basic fibroblast growth factor and nerve growth factor administered in gel foam rescue medial septal neurons after fimbria fornix transection

1989 • 224 citations

Accelerated wound repair, cell proliferation, and collagen accumulation are produced by a cartilage-derived growth factor.

1985 • 221 citations

Basic Fibroblast Growth Factor Levels in the Vitreous of Patients With Proliferative Diabetic Retinopathy

1990 • 217 citations

Heparin affinity of anionic and cationic capillary endothelial cell growth factors: analysis of hypothalamus-derived growth factors and fibroblast growth factors.

1985 • 214 citations

Two proto-oncogenes implicated in mammary carcinogenesis, int-1 and int-2, are independently regulated during mouse development.

1986 • 211 citations

Angiogenesis is stimulated by a tumor‐derived endothelial cell growth factor

1985 • 203 citations

Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix.

1990 • 203 citations

Monospecific antibodies implicate basic fibroblast growth factor in normal wound repair.

1989 • 199 citations

Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements.

1991 • 192 citations

Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints.

1990 • 185 citations

Growth factors and oncogenes in human gastrointestinal carcinomas

1990 • 185 citations

Induction of angiogenesis by bovine brain derived class 1 heparin-binding growth factor

1985 • 180 citations

Expression of the hst-1 and c-kit protooncogenes in human testicular germ cell tumors.

1991 • 180 citations

The affinity of fibroblast growth factors (FGFs) for heparin; FGF-heparan sulfate interactions in cells and extracellular matrix

1990 • 177 citations

Effects of Fibroblast and Epidermal Growth Factors on Ovarian Cell Proliferationin Vitro. I. Characterization of the Response of Granulosa Cells to FGF and EGF

1977 • 174 citations

Growth of normal human keratinocytes and fibroblasts in serum‐free medium is stimulated by acidic and basic fibroblast growth factor

1989 • 174 citations

Processing, secretion, and biological properties of a novel growth factor of the fibroblast growth factor family with oncogenic potential.

1988 • 171 citations

Modes of FGF release in vivo and in vitro

1990 • 169 citations

Specific inhibition of endothelial cell proliferation by thrombospondin

1990 • 168 citations

In situ detection of basic fibroblast growth factor by highly specific antibodies.

1990 • 168 citations

High incidence of coamplification of hst-1 and int-2 genes in human esophageal carcinomas.

1989 • 162 citations

The mouse homolog of the hst/k-FGF gene is adjacent to int-2 and is activated by proviral insertion in some virally induced mammary tumors.

1989 • 160 citations

Inhibition of angiogenesis and tumor growth by a synthetic laminin peptide, CDPGYIGSR-NH2.

1991 • 157 citations

Mesoderm-inducing properties of INT-2 and kFGF: two oncogene-encoded growth factors related to FGF

1989 • 154 citations

Basic fibroblast growth factor in human rhabdomyosarcoma cells: implications for the proliferation and neovascularization of myoblast-derived tumors.

1987 • 151 citations

Inhibition of tumor growth in mice by an analogue of platelet factor 4 that lacks affinity for heparin and retains potent angiostatic activity.

1991 • 148 citations

Increased levels of fibroblast growth factor-like activity in urine from patients with bladder or kidney cancer.

1988 • 146 citations

Basic Fibroblast Growth Factor Stimulation of Epidermal Wound Healing in Pigs

1990 • 145 citations

Basic fibroblast growth factor is released from endothelial extracellular matrix in a biologically active form

1989 • 143 citations

Transformation of NIH 3T3 cells with basic fibroblast growth factor or the hst/K-fgf oncogene causes downregulation of the fibroblast growth factor receptor: reversal of morphological transformation and restoration of receptor number by suramin.

1989 • 143 citations

RETRACTED: Heparin-binding growth factor 1 induces the formation of organoid neovascular structures in vivo.

1989 • 142 citations

Amplification of the int-2 gene in human head and neck squamous cell carcinomas.

1990 • 140 citations

Significance of int-2/hst-1 coamplification as a prognostic factor in patients with esophageal squamous carcinoma.

1991 • 137 citations

Tumor angiogenesis: the role of oncogenes and tumor suppressor genes.

1990 • 135 citations

Amplification of FGF-related genes in human tumors: possible involvement of HST in breast carcinomas.

1989 • 134 citations

Mr 25,000 heparin-binding protein from guinea pig brain is a high molecular weight form of basic fibroblast growth factor.

1987 • 134 citations

Effects of acidic and basic fibroblast growth factors on proliferation and maturation of cultured rat oligodendrocytes

1989 • 133 citations

Amplification of human int-2 in breast cancers and squamous carcinomas.

1988 • 125 citations

Inhibition of human endothelial cell proliferation in vitro and neovascularization in vivo by D-penicillamine.

1989 • 123 citations

Autocrine transformation by chimeric signal peptide-basic fibroblast growth factor: reversal by suramin.

1990 • 123 citations

Increased serum levels of basic fibroblast growth factor in patients with renal cell carcinoma

1991 • 112 citations

Human HST1 (HSTF1) gene maps to chromosome band 11q13 and coamplifies with the INT2 gene in human cancer.

1988 • 111 citations

Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma.

1988 • 107 citations

A metalloproteinase inhibitor as an inhibitor of neovascularization

1991 • 106 citations

Growth Stimulation of Rat Calvaria Osteoblastic Cells by Acidic Fibroblast Growth Factor

1987 • 106 citations

Conditioned Medium from Mouse Sarcoma 180 Cells Contains Vascular Endothelial Growth Factor

1990 • 101 citations

Chemotaxis of human microvessel endothelial cells in response to acidic fibroblast growth factor.

1990 • 99 citations

Localization of basic fibroblast growth factor, a mitogen and angiogenic factor, in human brain tumors

1990 • 95 citations

Basic fibroblast growth factor-like activity and receptors are expressed in a human glioma cell line.

1990 • 92 citations

Clinical and experimental approaches to dermal and epidermal repair: Normal and chronic wounds

1992 • 89 citations

Effects of Recombinant Human Basic Fibroblast Growth Factor and Its Modified Protein CS23 on Survival of Primary Cultured Neurons from Various Regions of Fetal Rat Brain

1990 • 86 citations

Expression of the murine fibroblast growth factor 5 gene in the adult central nervous system.

1990 • 86 citations

Oncogene Amplification in Squamous Cell Carcinoma of the Head and Neck

1990 • 84 citations

BCL-1 participates in the 11q13 amplification found in breast cancer.

1990 • 78 citations

Expression of Acidic and Basic Fibroblast Growth Factors in Human and Bovine Vascular Smooth Muscle Cells

1990 • 78 citations

Deletion of 17p and amplification of the int-2 gene in esophageal carcinomas.

1991 • 75 citations

Expression of and Response to Growth Regulatory Peptides by Two Human Pancreatic Carcinoma Cell Lines

1990 • 75 citations

Retinoic acid induces down-regulation of several growth factors and proto-oncogenes in a human embryonal cancer cell line.

1990 • 74 citations

Growth inhibition of the 9L glioma using polymers to release heparin and cortisone acetate

1990 • 73 citations

Oncogene amplification correlates with dense lymphocyte infiltration in human breast cancers: A role for hematopoietic growth factor release by tumor cells?

1990 • 72 citations

Protooncogene amplification and tumor ploidy in human ovarian neoplasms

1990 • 72 citations

Heterogeneous protooncogene amplification correlates with tumor progression and presence of metastases in gastric cancer patients.

1990 • 71 citations

An Endothelial Cell Growth Factor from the Mouse Neuroblastoma Cell Line NB41

1989 • 71 citations

Fibroblast growth factor gene expression in AIDS-Kaposi's sarcoma detected by in situ hybridization.

1991 • 71 citations

A sensitive enzyme immunoassay for human basic fibroblast growth factor

1991 • 70 citations

Biosynthesis of human fibroblast growth factor-5.

1991 • 68 citations

Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells.

1989 • 67 citations

Structure, chromosome mapping and expression of the murine Fgf-6 gene.

1990 • 67 citations

Detection and Characterization of the Fibroblast Growth Factor-Related Oncoprotein INT-2

1989 • 66 citations

Angiogenesis

1988 • 66 citations

Clinical And Experimental Approaches To Dermal And Epidermal Repair: NORMAL AND CHRONIC WOUNDS

1991 • 65 citations

Human oncogenes detected by a defined medium culture assay.

1987 • 61 citations

Fibroblast Growth Factor Release by Bovine Endothelial Cells and Human Astrocytoma Cells in Culture is Density Dependent

1989 • 59 citations

Expression of the K-fgf protooncogene is repressed during differentiation of F9 cells.

1989 • 59 citations

Elevated Expression of Basic Fibroblast Growth Factor Messenger Ribonucleic Acid in Acoustic Neuromas

1989 • 56 citations

Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier.

1988 • 49 citations

Amplification of the proto-oncogenes int-2, c-erbB-2 and c-myc in human breast cancer

1989 • 48 citations

Basic fibroblast growth factor accelerates tissue repair in models of impaired wound healing.

1991 • 47 citations

Analysis of the int-1, int-2, c-myc, and neu oncogenes in human breast carcinomas.

1990 • 47 citations

Effect of bFGF on the inhibition of contraction caused by bacteria

1991 • 46 citations

Ovarian Germinal Epithelial Cells Respond to Basic Fibroblast Growth Factor and Express Its Gene: Implications for Early Folliculogenesis

1989 • 45 citations

Immunohistochemical analysis of N-myc protein expression in neuroblastoma: Correlation with prognosis of patients

1991 • 44 citations

AMPLIFICATION OF THE hst‐1 GENE IN HUMAN ESOPHAGEAL CARCINOMAS

1988 • 42 citations

The Pathobiology of Neoplasia

1989 • 40 citations

Affinity of fibroblast growth factors for β-cyclodextrin tetradecasulfate

1990 • 39 citations

Advances in neuro-oncology

1989 • 39 citations

Immunobiochemical evidence for the loss of sperm specific histones during male pronucleus formation in monospermic zygotes of sea urchins

1991 • 39 citations

Angiogenesis

1990 • 39 citations

Modulation of plasminogen activator activity in human endometrial adenocarcinoma cells by basic fibroblast growth factor and transforming growth factor beta.

1988 • 38 citations

A transforming gene, hst, found in NIH 3T3 cells transformed with DNA from three stomach cancers and a colon cancer.

1987 • 36 citations

Detection and characterization of the fibroblast growth factor-related oncoprotein INT-2.

1989 • 33 citations

Expression and developmental regulation of the k-FGF oncogene in human and murine embryonal carcinoma cells

1989 • 33 citations

Characterization of INT-2: A member of the fibroblast growth factor family

1990 • 30 citations

Oncogene amplification in breast cancer.

1991 • 29 citations

BASIC FIBROBLAST GROWTH FACTOR IN HUMAN PITUITARY TUMOURS

1990 • 25 citations

Chromosome assignment by polymerase chain reaction techniques: assignment of the oncogene FGF-5 to human chromosome 4.

1990 • 24 citations

Neuron localization and neuroblastoma cell expression of brain-derived growth factor

1987 • 24 citations

Expression of Basic Fibroblast Growth Factor (bFGF) in Kaposi's Sarcoma: An Immunohistologic Study

1990 • 22 citations

Lysates of two established human tumor lines contain heparin-binding growth factors related to bovine acidic brain fibroblast growth factor

1986 • 21 citations

Biosynthesis and storage of basic fibroblast growth factor (bFGF) by endothelial cells: implication for the mechanism of action of angiogenesis.

1988 • 20 citations

Expression and Activation of the K‐fgf Oncogene^a

1989 • 17 citations

Analysis of growth factors in renal cell carcinoma

1988 • 17 citations

A paradigm for oncogene complementation in human breast cancer

1989 • 15 citations

Growth stimulation by androgens, glucocorticoids or fibroblast growth factors and the blocking of the stimulated growth by antibody against basic fibroblast growth factor in protein-free culture of Shionogi carcinoma 115 cells

1990 • 15 citations

Production of Basic Fibroblast Growth Factor‐like Factor by Cultured Human Cholangiocellular Carcinoma Cells

1990 • 12 citations

Time dependent suppression of wound healing with the angiogenesis inhibitor agm 1470

1991 • 9 citations

Angiogenesis

1989 • 8 citations

Enhancement of anchorage‐independent growth of a human adrenal carcinoma cell line by endogenously produced basic fibroblast growth factor

1990 • 7 citations

Molecular Biology in 2001

1990 • 7 citations

Oncogenic Transformation by Basic Fibroblast Growth Factor

1989 • 2 citations