Tumor Angiogenesis and Polyamines: α-Difluoromethylornithine, an Irreversible Inhibitor of Ornithine Decarboxylase, Inhibits B16 Melanoma-induced Angiogenesis in Ovo and the Proliferation of Vascular Endothelial Cells in Vitro

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

The Fluorometric Measurement of Deoxyribonucleic Acid in Animal Tissues with Special Reference to the Central Nervous System

1958 • 1,786 citations

Polyamine metabolism and function

1982 • 1,649 citations

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

1988 • 1,533 citations

Polyamines in rapid growth and cancer

1978 • 1,354 citations

Catalytic irreversible inhibition of mammalian ornithine decarboxylase (E.C.4.1.1.17) by substrate and product analogs

1978 • 998 citations

Role of Polyamines in the Control of Cell Proliferation and Differentiation

1981 • 935 citations

Protamine is an inhibitor of angiogenesis

1982 • 582 citations

Anti-proliferative properties of DL-α-difluoromethyl ornithine in cultured cells. A consequence of the irreversible inhibition of ornithine decarboxylase

1978 • 398 citations

Tumor Angiogenesis: A Possible Control Point in Tumor Growth

1975 • 277 citations

Effect of alpha-difluoromethylornithine, an enzyme-activated irreversible inhibitor of ornithine decarboxylase, on L1210 leukemia in mice.

1978 • 121 citations

Polyamine and differentiation: induction of ornithine decarboxylase by parathyroid hormone is a good marker of differentiated chondrocytes.

1980 • 112 citations

Polyamines are necessary for the survival of human small-cell lung carcinoma in culture.

1981 • 111 citations

Phorbol esters induce angiogenesis in vitro from large‐vessel endothelial cells

1987 • 109 citations

Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by alpha-difluoromethylornithine.

1983 • 101 citations

Polyamine biosynthesis and skin tumor promotion: Inhibition of 12-0-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase α-difluoromethylornithine

1982 • 90 citations

Effects of alpha-difluoromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia in mice, EMT6 solid tumors in mice, and solid tumors induced by injection of hepatoma tissue culture cells in rats.

1981 • 62 citations

Antimetastatic activity of DL-alpha-difluoromethylornithine, an inhibitor of polyamine biosynthesis, in mice.

1987 • 57 citations

Tumor-promoting phorbol esters induce angiogenesis in vivo

1988 • 53 citations

Successful treatment with DL-alpha-difluoromethylornithine in established human small cell variant lung carcinoma implants in athymic mice.

1983 • 49 citations

Effects of alpha-difluoromethylornithine and 5-fluorouracil on the proliferation of a human colon adenocarcinoma cell line.

1983 • 40 citations

Effect of inhibition of polyamine biosynthesis by DL-alpha-difluoromethylornithine on the growth and melanogenesis of B16 melanoma in vitro and in vivo.

1985 • 39 citations

An essential role for polyamines in tumor metastases

1982 • 30 citations

Treatment of metastatic lewis lung carcinoma with dl-α-difluoromethylornithine

1983 • 27 citations

Effects of alpha-difluoromethylornithine on the growth of experimental Wilms' tumor and renal adenocarcinoma.

1983 • 26 citations

Effects of DL‐α‐difluoromethylornithine on the growth and metastasis of b16 melanoma in vivo

1987 • 21 citations

Cartilage-derived anti-tumor factor (CATF) inhibits the proliferation of endothelial cells in culture

1985 • 20 citations

A factor in conditioned medium of rabbit costal chondrocytes inhibits the proliferation of cultured endothelial cells and angiogenesis induced by B16 melanoma: its relation with cartilage-derived anti-tumor factor (CATF).

1987 • 11 citations

Cartilage-derived anti-tumor factor (CATF)

1988 • 8 citations

Enhanced inhibition of colony formation of human renal cell carcinoma in soft agar by the combination of alpha-difluoromethylornithine and recombinant gamma-interferon.

1986 • 7 citations