Transforming growth factor‐β1 stimulates macrophage urokinase expression and release of matrix‐bound basic fibroblast growth factor

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Basement membrane complexes with biological activity

1986 • 1,489 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

The plasminogen activator/plasmin system.

1991 • 1,196 citations

Expression cloning of the TGF-β type II receptor, a functional transmembrane serine/threonine kinase

1992 • 1,071 citations

Recent developments in the cell biology of basic fibroblast growth factor.

1989 • 1,049 citations

Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix.

1987 • 1,045 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Molecular architecture of basement membranes

1990 • 937 citations

Effects of the tumour promoter okadaic acid on intracellular protein phosphorylation and metabolism

1989 • 848 citations

Heparan sulphate bound growth factors: a mechanism for stromal cell mediated haemopoiesis

1988 • 845 citations

α-Macroglobulins: structure, shape, and mechanism of proteinase complex formation

1989 • 673 citations

Autocrine activities of basic fibroblast growth factor: regulation of endothelial cell movement, plasminogen activator synthesis, and DNA synthesis.

1988 • 647 citations

Release of basic fibroblast growth factor-heparan sulfate complexes from endothelial cells by plasminogen activator-mediated proteolytic activity.

1990 • 545 citations

Growth factors in wound healing. Single and synergistic effects on partial thickness porcine skin wounds.

1989 • 539 citations

The plasminogen system and cell surfaces: evidence for plasminogen and urokinase receptors on the same cell type.

1986 • 466 citations

Transforming growth factor-beta 1 modulates basic fibroblast growth factor-induced proteolytic and angiogenic properties of endothelial cells in vitro.

1990 • 466 citations

Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta.

1986 • 443 citations

Inhibition of Endothelial Regeneration by Type-Beta Transforming Growth Factor from Platelets

1986 • 439 citations

Latent transforming growth factor-beta in serum. A specific complex with alpha 2-macroglobulin.

1987 • 434 citations

Transforming growth factor beta (TGF-?) in inflammation: A cause and a cure

1992 • 417 citations

The opposing effects of basic fibroblast growth factor and transforming growth factor beta on the regulation of plasminogen activator activity in capillary endothelial cells.

1987 • 378 citations

Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta.

1989 • 346 citations

TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expression

1987 • 344 citations

Platelet-derived growth factor (BB homodimer), transforming growth factor-beta 1, and basic fibroblast growth factor in dermal wound healing. Neovessel and matrix formation and cessation of repair.

1992 • 336 citations

Binding of plasminogen to cultured human endothelial cells.

1986 • 311 citations

Extracellular matrix‐resident basic fibroblast growth factor: Implication for the control of angiogenesis

1991 • 268 citations

Differential regulation of extracellular matrix proteoglycan (PG) gene expression. Transforming growth factor-beta 1 up-regulates biglycan (PGI), and versican (large fibroblast PG) but down-regulates decorin (PGII) mRNA levels in human fibroblasts in culture

1991 • 261 citations

Regulation of Type 1 Plasminogen Activator Inhibitor Gene Expression in Cultured Bovine Aortic Endothelial Cells

1989 • 248 citations

Transforming growth factor-beta is a strong and fast acting positive regulator of the level of type-1 plasminogen activator inhibitor mRNA in WI-38 human lung fibroblasts.

1987 • 247 citations

Macrophage plasminogen activator: induction by concanavalin A and phorbol myristate acetate

1977 • 241 citations

Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex.

1989 • 225 citations

Macrophage fibrinolytic activity: Identification of two pathways of plasmin formation by intact cells and of a plasminogen activator inhibitor

1982 • 225 citations

Transforming growth factor beta 1, a potent chemoattractant for human neutrophils, bypasses classic signal-transduction pathways.

1991 • 219 citations

Heparanase activity expressed by platelets, neutrophils, and lymphoma cells releases active fibroblast growth factor from extracellular matrix.

1990 • 203 citations

Expression of the urokinase receptor in vascular endothelial cells is stimulated by basic fibroblast growth factor.

1991 • 178 citations

Binding of plasminogen to extracellular matrix.

1986 • 175 citations

Thrombin immobilized to extracellular matrix is a potent mitogen for vascular smooth muscle cells: nonenzymatic mode of action.

1990 • 167 citations

Complex formation of platelet thrombospondin with plasminogen. Modulation of activation by tissue activator.

1984 • 164 citations

Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells.

1987 • 158 citations

Transforming growth factor-beta stimulates wound healing and modulates extracellular matrix gene expression in pig skin. I. Excisional wound model.

1990 • 138 citations

Macrophage and foam cell release of matrix-bound growth factors. Role of plasminogen activation

1993 • 137 citations

Platelet-derived growth factor and transforming growth factor-beta regulate plasminogen activator inhibitor-1 synthesis in vascular smooth muscle cells

1991 • 133 citations

Plasminogen-activator inhibitor type 1 is a potent natural inhibitor of extracellular matrix degradation by fibrosarcoma and colon carcinoma cells.

1990 • 131 citations

Urokinase‐type plasminogen activator and its inhibitor secreted by cultured human monocyte‐macrophages

1985 • 130 citations

Regulation of the synthesis and activity of urokinase plasminogen activator in A549 human lung carcinoma cells by transforming growth factor-beta

1988 • 118 citations

Urokinase-receptor biosynthesis, mRNA level and gene transcription are increased by transforming growth factor beta 1 in human A549 lung carcinoma cells.

1991 • 117 citations

Transforming growth factor β alters plasminogen activator activity in human skin fibroblasts

1986 • 114 citations

Antagonistic and agonistic effects of transforming growth factor-beta and IL-1 in rheumatoid synovium.

1990 • 112 citations

Urokinase receptor mRNA level and gene transcription are strongly and rapidly increased by phorbol myristate acetate in human monocyte-like U937 cells.

1991 • 111 citations

Functional characteristics of receptor-bound urokinase on human monocytes: catalytic efficiency and susceptibility to inactivation by plasminogen activator inhibitors

1989 • 99 citations

Endothelial cell-mediated conversion of Glu-plasminogen to Lys-plasminogen. Further evidence for assembly of the fibrinolytic system on the endothelial cell surface.

1988 • 98 citations

Polypeptide Growth Factors in Bone Matrix

2007 • 81 citations

Modulation of monocyte type I transforming growth factor-beta receptors by inflammatory stimuli.

1991 • 72 citations

Involvement of both heparanase and plasminogen activator in lymphoma cell‐mediated degradation of heparan sulfate in the subendothelial extracellular matrix

1986 • 67 citations

Alpha 2-macroglobulin and serum preferentially counteract the mitoinhibitory effect of transforming growth factor-beta 2 in rat hepatocytes.

1990 • 64 citations

Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin

1990 • 61 citations

Plasminogen activator in synovial fluid from patients with rheumatoid arthritis.

1987 • 55 citations

Transforming growth factor beta stimulates urokinase-type plasminogen activator and DNA synthesis, but not prostaglandin E2 production, in human synovial fibroblasts.

1991 • 47 citations

Stimulation of macrophage urokinase expression by polyanions is protein kinase C-dependent and requires protein and RNA synthesis.

1991 • 42 citations

Binding of transforming growth factor-β1 to methylamine-modified α2-macroglobulin and to binary and ternary α2-macroglobulin-proteinase complexes

1992 • 37 citations

Reaction of α2-macroglobulin with plasmin increases binding of transforming growth factors-β1 and β2

1991 • 36 citations

Inhibition by Methylprednisolone Acetate Suggests an Indirect Mechanism for TGF-B Induced Angiogenesis

1992 • 32 citations

Heparin stimulation of plasminogen activator secretion by macrophage‐like cell line raw264.7: Role of the scavenger receptor

1989 • 28 citations

Increased proteolytic activity on the surface of monocytes from patients with rheumatoid arthritis

1991 • 16 citations

Activation of platelet heparitinase by tumor cell-derived factors

1991 • 13 citations

The effects of the protein kinase C inhibitors staurosporine and H7 on the IgE dependent mediator release from RBL 2H3 cells

1990 • 11 citations

Modulation of plasminogen activators and plasminogen activator inhibitors by TGF-β, IL-1α and EGF in fetal rat caivaria cells at different times of culture

1991 • 10 citations

A selective role for brain histamine in prolactin release induced by opiates

1990 • 5 citations