Thrombospondins: structure and regulation of expression

Progressive sequence alignment as a prerequisitetto correct phylogenetic trees

1987 • 1,899 citations

Molecular modeling of protein-glycosaminoglycan interactions.

1989 • 1,288 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Identification of a protein-binding site that mediates transcriptional response of the c-fos gene to serum factors

1986 • 883 citations

Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10.

1991 • 878 citations

The structure of human thrombospondin, an adhesive glycoprotein with multiple calcium-binding sites and homologies with several different proteins.

1986 • 575 citations

Extracellular proteins that modulate cell-matrix interactions. SPARC, tenascin, and thrombospondin

1991 • 560 citations

Cartilage matrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage.

1992 • 521 citations

Cell attachment to thrombospondin: the role of ARG-GLY-ASP, calcium, and integrin receptors.

1988 • 481 citations

Isolation and characterization of a high molecular weight glycoprotein from human blood platelets.

1978 • 428 citations

Molecular aspects of cellular regulation

1980 • 394 citations

F-spondin: A gene expressed at high levels in the floor plate encodes a secreted protein that promotes neural cell adhesion and neurite extension

1992 • 382 citations

Domains of laminin with growth-factor activity

1989 • 341 citations

The structural and functional properties of thrombospondin

1986 • 333 citations

A Thrombin-Sensitive Protein of Human Platelet Membranes

1971 • 333 citations

Identification of a phorbol ester-repressible v-src-inducible gene.

1989 • 322 citations

Proviral rearrangements and overexpression of a new cellular gene (nov) in myeloblastosis-associated virus type 1-induced nephroblastomas.

1992 • 311 citations

Synthesis and secretion of thrombospondin by cultured human endothelial cells.

1982 • 311 citations

Isolation and Properties of a Thrombin-sensitive Protein of Human Platelets

1972 • 306 citations

Structure and function of epidermal growth factor‐like regions in proteins

1988 • 305 citations

EGF‐like domains in extracellular matrix proteins: Localized signals for growth and differentiation?

1989 • 304 citations

Intron‐dependent evolution: Preferred types of exons and introns

1987 • 300 citations

Light microscopic immunolocation of thrombospondin in human tissues.

1985 • 265 citations

The properdin-like type I repeats of human thrombospondin contain a cell attachment site.

1991 • 238 citations

Vitronectin and thrombospondin promote retinal neurite outgrowth: Developmental regulation and role of integrins

1991 • 237 citations

Unique distribution of the extracellular matrix component thrombospondin in the developing mouse embryo.

1988 • 212 citations

Electron microscopy of native cartilage oligomeric matrix protein purified from the Swarm rat chondrosarcoma reveals a five-armed structure.

1992 • 209 citations

Human proα1(I) collagen gene structure reveals evolutionary conservation of a pattern of introns and exons

1984 • 208 citations

Thrombospondin: a modular adhesive glycoprotein of platelets and nucleated cells.

1987 • 205 citations

Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein.

1991 • 203 citations

Interactions of thrombospondin with extracellular matrix proteins: selective binding to type V collagen.

1984 • 202 citations

Physiology of Thrombospondin

1990 • 195 citations

Properdin, the terminal complement components, thrombospondin and the circumsporozoite protein of malaria parasites contain similar sequence motifs

1988 • 189 citations

Cyr61, product of a growth factor-inducible immediate early gene, is associated with the extracellular matrix and the cell surface.

1991 • 183 citations

Isolation and characterization of a heparin-binding domain from the amino terminus of platelet thrombospondin.

1984 • 181 citations

Heparin- and sulfatide-binding peptides from the type I repeats of human thrombospondin promote melanoma cell adhesion.

1992 • 163 citations

Molecular cloning of SC1: A putative brain extracellular matrix glycoprotein showing partial similarity to osteonectin/BM40/SPARC

1990 • 153 citations

Induction of thrombospondin messenger RNA levels occurs as an immediate primary response to platelet-derived growth factor.

1987 • 139 citations

Evidence for calcium-sensitive structure in platelet thrombospondin. Isolation and partial characterization of thrombospondin in the presence of calcium.

1982 • 132 citations

Identification of a Gene Family Regulated by Transforming Growth Factor-β

1991 • 122 citations

A second, expressed thrombospondin gene (Thbs2) exists in the mouse genome

1991 • 120 citations

Characterization of mouse thrombospondin 2 sequence and expression during cell growth and development.

1992 • 118 citations

Deposition and role of thrombospondin in the histogenesis of the cerebellar cortex.

1990 • 118 citations

Thrombospondin 3 (Thbs3), a new member of the thrombospondin gene family.

1992 • 115 citations

Thrombospondin and a 140 kd fragment promote adhesion and neurite outgrowth from embryonic central and peripheral neurons and from PC12 cells

1991 • 114 citations

Monoclonal antibodies that recognize calcium-dependent structures of human thrombospondin. Characterization and mapping of their epitopes.

1986 • 111 citations

Mapping of epitopes for monoclonal antibodies against human platelet thrombospondin with electron microscopy and high sensitivity amino acid sequencing.

1985 • 109 citations

Cell-Adhesive Motif in Region II of Malarial Circumsporozoite Protein

1990 • 107 citations

The hypervariable gene locus PUM, which codes for the tumour associated epithelial mucins, is located on chromosome 1, within the region 1g21–24

1987 • 106 citations

Physical characterization of platelet thrombospondin.

1981 • 104 citations

Thrombospondin deposition in rat carotid artery injury.

1990 • 100 citations

Cellular attachment to thrombospondin. Cooperative interactions between receptor systems

1991 • 99 citations

Cooperative binding of calcium to thrombospondin. The effect of calcium on the circular dichroism and limited tryptic digestion of thrombospondin.

1983 • 98 citations

Thrombospondin promotes process outgrowth in neurons from the peripheral and central nervous systems

1992 • 98 citations

Novel type of very high affinity calcium-binding sites in beta-hydroxyasparagine-containing epidermal growth factor-like domains in vitamin K-dependent protein S.

1990 • 92 citations

Biological activities of peptides and peptide analogues derived from common sequences present in thrombospondin, properdin, and malarial proteins.

1992 • 87 citations

Structure of thrombospondin.

1984 • 74 citations

Complete thrombospondin mRNA sequence includes potential regulatory sites in the 3' untranslated region.

1989 • 72 citations

Transcription of a quail gene expressed in embryonic retinal cells is shut off sharply at hatching.

1991 • 67 citations

Free thiols of platelet thrombospondin. Evidence for disulfide isomerization.

1990 • 67 citations

A second thrombospondin gene in the mouse is similar in organization to thrombospondin 1 but does not respond to serum.

1991 • 66 citations

Synthesis of truncated amino-terminal trimers of thrombospondin

1991 • 57 citations

Von Willebrand factor shares a distinctive cysteine-rich domain with thrombospondin and procollagen

1987 • 57 citations

Structure and chromosomal localization of the human thrombospondin gene

1990 • 54 citations

Characterization of the Promoter Region of the Human Thrombospondin Gene

1989 • 54 citations

Amino Acid Sequence of the Aminoterminal Segment of Dermatosparactic Calf‐Skin Procollagen Type I

1979 • 52 citations

Thrombospondin II: Partial cDNA sequence, chromosome location, and expression of a second member of the thrombospondin gene family in humans

1992 • 49 citations

Cloning and sequencing of chicken thrombospondin

1991 • 47 citations

Location and partial characterization of the heparin-binding fragment of platelet thrombospondin

1984 • 46 citations

Neutron and x-ray scattering studies on the human complement protein properdin provide an analysis of the thrombospondin repeat

1991 • 39 citations

Characterization of the murine thrombospondin gene

1991 • 39 citations

Mapping of the thrombospondin gene to human chromosome 15 and mouse chromosome 2 by in situ hybridization

1990 • 37 citations

Cell attachment activity of the carboxyl-terminal domain of human thrombospondin expressed in Escherichia coli.

1991 • 36 citations

Expression and analysis of COOH-terminal deletions of the human thrombospondin molecule.

1989 • 35 citations

Thrombospondin: phenomenology to function.

1989 • 33 citations

Feedback regulation of collagen gene expression: a Trojan horse approach.

1991 • 31 citations

Modulation of thrombospondin gene expression during osteoblast differentiation in MC3T3-E1 cells

1992 • 28 citations

Thrombospondin

1987 • 12 citations