Angiogenesis, neovascular proliferation and vascular pathophysiology as targets for cancer therapy

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

1955 • 2,174 citations

Induction of angiogenesis during the transition from hyperplasia to neoplasia

1989 • 1,912 citations

ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS

1971 • 1,643 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth

1990 • 1,308 citations

Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.

1986 • 1,079 citations

Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells.

1984 • 944 citations

Endothelial proliferation in tumours and normal tissues: Continuous labelling studies

1984 • 562 citations

Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses.

1987 • 491 citations

Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers.

1986 • 413 citations

Autoradiographic distribution of hematoporphyrin derivative in normal and tumor tissue of the mouse.

1981 • 330 citations

Active versus passive absorption kinetics as the basis for selective protection of normal tissues by S-2-(3-aminopropylamino)-ethylphosphorothioic acid.

1980 • 300 citations

The hypoxic tumor cell: A target for selective cancer chemotherapy

1980 • 291 citations

Differential Chemoprotection of Normal and Malignant Tissues<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

1969 • 266 citations

Endothelial-cell proliferation in experimental tumours

1982 • 236 citations

Leukocyte antigen CD34 is expressed by a subset of cultured endothelial cells and on endothelial abluminal microprocesses in the tumor stroma.

1990 • 197 citations

Microvascular Injury in Pathogenesis of Interferon-Induced Necrosis of Subcutaneous Tumors in Mice

1989 • 192 citations

Alterations in tumor microvasculature during hyperthermia.

1980 • 173 citations

The use of fluorescent probes to identify regions of transient perfusion in murine tumors

1989 • 173 citations

Blood Flow Failure as a Major Determinant in the Antitumor Action of Flavone Acetic Acid

1989 • 151 citations

A therapeutic benefit from combining normobaric carbogen or oxygen with nicotinamide in fractionated X-ray treatments

1991 • 148 citations

TUMOUR CELL PROLIFERATION IN RELATION TO THE VASCULATURE

1979 • 143 citations

Radioprotection of tumor and normal tissues by thiophosphate compounds

1973 • 136 citations

Activity of flavone acetic acid (NSC-347512) against solid tumors of mice

1986 • 124 citations

Radiosensitization by Nicotinamide in Vivo: A Greater Enhancement of Tumor Damage Compared to That of Normal Tissues

1987 • 106 citations

Cytotoxic Effects of the Hypoxic Cell Radiosensitizer Ro 7-0582 to Tumor Cells in Vivo

1977 • 100 citations

Vascular collapse after flavone acetic acid: A possible mechanism of its anti-tumour action

1989 • 98 citations

Phase II trials of flavone acetic acid in advanced malignant melanoma and colorectal carcinoma

1989 • 87 citations

The antitumor function of tumor necrosis factor (TNF) II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma.

1988 • 83 citations

Phase I and pharmacokinetic study of flavone acetic acid.

1987 • 81 citations

Flow cytometric evaluation of hypoxic cells in solid experimental tumours using fluorescence immunodetection

1991 • 73 citations

Vascular changes in a human malignant melanoma xenograft following single-dose irradiation.

1984 • 72 citations

Quantitative studies of microcirculatory function in malignant tissue: Influence of temperature on microvascular hemodynamics during the early growth of the BA 1112 rat SARCOMA

1979 • 69 citations

A monoclonal antibody reacting with endothelial cells of budding vessels in tumors and inflammatory tissues, and non‐reactive with normal adult tissues

1986 • 68 citations

Vascular Changes in a Human Malignant Melanoma Xenograft Following Single-Dose Irradiation

1984 • 67 citations

Vascular endothelial cell differentiation: organ-specificity and selective affinities as the basis for developing anti-cancer strategies

1991 • 65 citations

Comparison of the effects of flavone acetic acid, fostriecin, homoharringtonine and tumour necrosis factor α on Colon 38 tumours in mice

1989 • 64 citations

Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid)

1987 • 61 citations

Thermal Sensitivity of Endothelial Cells

1985 • 61 citations

In vivo targets of recombinant human tumour necrosis factor-α: blood flow, oxygen consumption and growth of isotransplanted rat tumours

1989 • 58 citations

Mechanism of cultured endothelial injury induced by lymphokine-activated killer cells.

1988 • 57 citations

Photofrin uptake by murine macrophages.

1991 • 56 citations

Anti-tumour activity of flavone acetic acid (NSC 347512) in mice – influence of immune status

1991 • 46 citations

A review of hypoxic cell radiosensitization

1991 • 45 citations

Angiogenic attack as a therapeutic strategy for cancer

1991 • 45 citations

Coagulation and cancer

1991 • 42 citations

Flavone acetic acid induces a coagulopathy in mice

1989 • 41 citations

Endotoxin-mediated necrosis and regression of established tumours in the mouse

1986 • 38 citations

Reduced thermal sensitivity of the vasculature in a slowly growing tumour

1989 • 35 citations

Cell yield and cell survival following chemotherapy of the B16 melanoma

1978 • 34 citations

The effects of melphalan and misonidazole on the vasculature of a murine sarcoma

1987 • 33 citations

Selective induction of endothelial cell tissue factor in the presence of a tumour‐derived mediator: A potential mechanism of flavone acetic acid action in tumour vasculature

1991 • 24 citations

Factors influencing the chemosensitization of melphalan by misonidazole

1985 • 20 citations

BW12C: effects on tumour hypoxia, tumour thermosensitivity and relative tumour and normal tissue perfusion in C3H mice

1991 • 17 citations

Vascular markers for murine tumours

1989 • 16 citations

Radioprotection in Vivo: Cellular Heterogeneity and Fractionation

1987 • 9 citations

Low-density Lipoprotein Uptake and the Sensitivity to Photodynamic Treatment of Cultured Endothelial Cells

1991 • 5 citations