Dominoes and Clocks: the Union of Two Views of the Cell Cycle

Checkpoints: Controls That Ensure the Order of Cell Cycle Events

1989 • 3,036 citations

G ₁ Events and Regulation of Cell Proliferation

1989 • 2,203 citations

Cyclin/PCNA is the auxiliary protein of DNA polymerase-δ

1987 • 1,766 citations

Cytoplasmic control of nuclear behavior during meiotic maturation of frog oocytes

1971 • 1,553 citations

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

1983 • 1,506 citations

Cyclin synthesis drives the early embryonic cell cycle

1989 • 1,223 citations

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

1987 • 1,153 citations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

1989 • 1,114 citations

A major developmental transition in early xenopus embryos: II. control of the onset of transcription

1982 • 1,065 citations

Negative regulation of mitosis by wee1+, a gene encoding a protein kinase homolog

1987 • 1,004 citations

cdc25+ functions as an inducer in the mitotic control of fission yeast

1986 • 973 citations

Purified maturation-promoting factor contains the product of a Xenopus homolog of the fission yeast cell cycle control gene cdc2+

1988 • 885 citations

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

1988 • 829 citations

Activation of cdc2 protein kinase during mitosis in human cells: Cell cycle-dependent phosphorylation and subunit rearrangement

1988 • 786 citations

Mammalian Cell Fusion : Studies on the Regulation of DNA Synthesis and Mitosis

1970 • 759 citations

Saccharomyces cerevisiae cell cycle

1974 • 747 citations

Gene required in G1 for commitment to cell cycle and in G2 for control of mitosis in fission yeast

1981 • 740 citations

Animal Cell Cycle

1978 • 723 citations

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

1989 • 666 citations

Purification of maturation-promoting factor, an intracellular regulator of early mitotic events.

1988 • 640 citations

The Molecular biology of the yeast saccharomyces, life cycle and inheritance

1981 • 636 citations

Formation in Vitro of Sperm Pronuclei and Mitotic Chromosomes Induced by Amphibian Ooplasmic Components

1983 • 630 citations

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

1988 • 617 citations

A role for the nuclear envelope in controlling DNA replication within the cell cycle

1988 • 605 citations

Cell cycle dynamics of an M-phase-specific cytoplasmic factor in Xenopus laevis oocytes and eggs.

1984 • 575 citations

Genetic control of cell division patterns in the Drosophila embryo

1989 • 567 citations

The WHI1+ gene of Saccharomyces cerevisiae tethers cell division to cell size and is a cyclin homolog.

1988 • 563 citations

Unequal division in Saccharomyces cerevisiae and its implications for the control of cell division.

1977 • 561 citations

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

1988 • 535 citations

The clam embryo protein cyclin A induces entry into M phase and the resumption of meiosis in Xenopus oocytes

1986 • 534 citations

The cell cycle control gene cdc2+ of fission yeast encodes a protein kinase potentially regulated by phosphorylation

1986 • 502 citations

The fission yeast dis2+ gene required for chromosome disjoining encodes one of two putative type 1 protein phosphatases

1989 • 486 citations

DAF1, a mutant gene affecting size control, pheromone arrest, and cell cycle kinetics of Saccharomyces cerevisiae.

1988 • 445 citations

Translation of cyclin mRNA is necessary for extracts of activated Xenopus eggs to enter mitosis

1989 • 438 citations

Control of cell size at division in fission yeast by a growth-modulated size control over nuclear division

1977 • 438 citations

A family of cyclin homologs that control the G1 phase in yeast.

1989 • 416 citations

Functionally homologous cell cycle control genes in budding and fission yeast

1982 • 410 citations

Expression and function of Drosophila cyclin a during embryonic cell cycle progression

1989 • 399 citations

The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localization

1989 • 392 citations

THE SELECTION OF S. CEREVISIAE MUTANTS DEFECTIVE IN THE START EVENT OF CELL DIVISION

1980 • 391 citations

Regulation of the cell cycle during early Xenopus development

1984 • 376 citations

Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells.

1985 • 370 citations

Purification of MPF from starfish: Identification as the H1 histone kinase p34cdc2 and a possible mechanism for its periodic activation

1989 • 366 citations

Regulated replication of DNA microinjected into eggs of Xenopus laevis

1980 • 362 citations

A cytoplasmic clock with the same period as the division cycle in Xenopus eggs.

1980 • 358 citations

Primary structure homology between the product of yeast cell division control gene CDC28 and vertebrate oncogenes

1984 • 354 citations

RAS proteins can induce meiosis in xenopus oocytes

1985 • 341 citations

The mitotic inducer nim1+ functions in a regulatory network of protein kinase homologs controlling the initiation of mitosis

1987 • 334 citations

Fission yeast p13 blocks mitotic activation and tyrosine dephosphorylation of the Xenopus cdc2 protein kinase

1989 • 327 citations

The bimG gene of Aspergillus nidulans, required for completion of anaphase, encodes a homolog of mammalian phosphoprotein phosphatase 1

1989 • 326 citations

Mitotic induction and maintenance by overexpression of a G2-specific gene that encodes a potential protein kinase

1988 • 324 citations

Activation at M-phase of a protein kinase encoded by a starfish homologue of the cell cycle control gene cdc2+

1988 • 314 citations

Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases

1984 • 313 citations

Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.

1987 • 309 citations

Cyclin is a component of the sea urchin egg M-phase specific histone H1 kinase.

1989 • 308 citations

Dephosphorylation and activation of Xenopusp34cdc2 protein kinase during the cell cycle

1989 • 300 citations

Effects of cycloheximide on a cytoplasmic factor initiating meiotic maturation in Xenopus oocytes

1975 • 294 citations

Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans.

1987 • 288 citations

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

1988 • 285 citations

Conservation of mitotic controls in fission and budding yeasts

1989 • 275 citations

Mitotic factors from mammalian cells induce germinal vesicle breakdown and chromosome condensation in amphibian oocytes.

1979 • 252 citations

Regulation of Oocyte Maturation

1980 • 250 citations

The role of cyclin B in meiosis I.

1989 • 241 citations

Spindle formation and chromatin condensation in cells blocked at interphase by mutation of a negative cell cycle control gene

1988 • 235 citations

Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.

1988 • 234 citations

A bifunctional gene product involved in two phases of the yeast cell cycle

1982 • 225 citations

The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function

1986 • 222 citations

Cloning and sequencing of the cyclin-related Cdc13 + gene and a cytological study of its role in fission yeast mitosis

1988 • 220 citations

Molecular cloning and characterization of the mRNA for cyclin from sea urchin eggs.

1987 • 220 citations

The cyclic behavior of a cytoplasmic factor controlling nuclear membrane breakdown.

1978 • 216 citations

Regulation of MPF activity in vitro

1988 • 209 citations

Regulated expression and phosphorylation of a possible mammalian cell-cycle control protein

1988 • 189 citations

Involvement of a type 1 protein phosphatase encoded by bws1+ in fission yeast mitotic control

1989 • 188 citations

Directing Cell Division During Development

1989 • 186 citations

Cyclin synthesis, modification and destruction during meiotic maturation of the starfish oocyte

1987 • 176 citations

Maturation-promoting factor induces nuclear envelope breakdown in cycloheximide-arrested embryos of Xenopus laevis.

1983 • 169 citations

Cell cycle control genes in fission yeast and mammalian cells

1988 • 168 citations

Cell division from a genetic perspective

1978 • 167 citations

Dual regulation of the yeast CDC28-p40 protein kinase complex: Cell cycle, pheromone, and nutrient limitation effects

1987 • 166 citations

Control of cell division in Saccharomyces cerevisiae mutants defective in adenylate cyclase and cAMP-dependent protein kinase

1983 • 165 citations

Sucl+ encodes a predicted 13-kilodalton protein that is essential for cell viability and is directly involved in the division cycle of Schizosaccharomyces pombe.

1987 • 158 citations

Studies on the appearance and nature of a maturation-inducing factor in the cytoplasm of amphibian oocytes exposed to progesterone

1974 • 157 citations

Regulation of mating in the cell cycle of Saccharomyces cerevisiae.

1977 • 156 citations

PHO85, a negative regulator of the PHO system, is a homolog of the protein kinase gene, CDC28, of Saccharomyces cerevisiae

1988 • 141 citations

Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA.

1976 • 134 citations

Periodic DNA synthesis in cell-free extracts of Xenopus eggs.

1987 • 127 citations

Nuclei act as independent and integrated units of replication in a Xenopus cell-free DNA replication system.

1987 • 119 citations

Phosphorylation changes associated with the early cell cycle in Xenopus eggs

1987 • 118 citations

The timing of synthesis of proteins required for mitosis in the cell cycle of the sea urchin embryo*1

1983 • 111 citations

Enhanced synthesis and stabilization of Mr 68,000 protein in transformed BALB/c-3T3 cells: candidate for restriction point control of cell growth.

1983 • 111 citations

Ca and Mg control of cytostatic factors from Rana pipiens oocytes which cause metaphase and cleavage arrest

1977 • 106 citations

Protein factor(s) from mitotic CHO cells induce meiotic maturation in Xenopus laevis oocytes

1980 • 95 citations

The control of DNA replication in a cell-free extract that recapitulates a basic cell cycle in vitro

1988 • 91 citations

A cytostatic factor in amphibian oocytes: Its extraction and partial characterization

1974 • 76 citations

G2-population cells in mouse kidney and duodenum and their behavior during the cell division cycle

1970 • 73 citations

Preliminary characterization of maturation-promoting factor from yeast Saccharomyces cerevisiae *

1987 • 52 citations

A requirement for protein phosphorylation in regulating the meiotic and mitotic cell cycles in echinoderms

1989 • 51 citations

Change in the rate of CO2 production in synchronous cultures of the fission yeast Schizosaccharomyces pombe: A periodic cell cycle event that persists after the DNA-division cycle has been blocked

1986 • 48 citations

Mating-defective ste mutations are suppressed by cell division cycle start mutations in Saccharomyces cerevisiae.

1982 • 34 citations

CYCLIC CHANGES OF THE CORTEX AND THE CYTOPLASM OF THE FERTILIZED AND THE ACTIVATED SEA URCHIN EGG*

1960 • 26 citations

Nucleoside diphosphokinase, an enzyme with step changes in activity during the cell cycle of the fission yeast Schizosaccharomyces pombe: I persistence of steps after a block to the DNA-division cycle

1986 • 25 citations

H1 histone kinases from nuclei of Physarum polycephalum

1983 • 25 citations

Cyclins in meiosis and mitosis

1987 • 24 citations

Effects of emetine on initiation of DNA synthesis in embryonic cells of sea urchin

1983 • 10 citations