Free radicals, lipoproteins and cardiovascular dysfunction

Free radicals in biology and medicine

1991 • 17,840 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Beyond Cholesterol

1989 • 6,533 citations

A Receptor-Mediated Pathway for Cholesterol Homeostasis

1986 • 5,638 citations

Oxygen-Derived Free Radicals in Postischemic Tissue Injury

1985 • 5,488 citations

The Pathogenesis of Atherosclerosis — An Update

1986 • 4,951 citations

Analysis of the accuracy and implications of simple methods for predicting the secondary structure of globular proteins

1978 • 4,566 citations

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

Examination of the secondary structure of proteins by deconvolved FTIR spectra

1986 • 2,865 citations

Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.

1981 • 2,777 citations

Malondialdehyde and thiobarbituric acid-reactivity as diagnostic indices of lipid peroxidation and peroxidative tissue injury

1990 • 2,639 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

Advanced Glycosylation End Products in Tissue and the Biochemical Basis of Diabetic Complications

1988 • 2,527 citations

Oxygen-Dependent Microbial Killing by Phagocytes

1978 • 2,519 citations

Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition

1979 • 2,458 citations

Lycopene as the most efficient biological carotenoid singlet oxygen quencher

1989 • 2,238 citations

β-Carotene: an Unusual Type of Lipid Antioxidant

1984 • 2,147 citations

The Pathogenesis of Atherosclerosis

1976 • 2,000 citations

Reactivity of HO2/O−2 Radicals in Aqueous Solution

1985 • 1,972 citations

Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man.

1989 • 1,914 citations

cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

1987 • 1,842 citations

A Platelet-Dependent Serum Factor That Stimulates the Proliferation of Arterial Smooth Muscle Cells In Vitro

1974 • 1,838 citations

Continuous Monitoring ofin VztroOxidation of Human Low Density Lipoprotein

1989 • 1,824 citations

Modification of low density lipoprotein by endothelial cells involves lipid peroxidation and degradation of low density lipoprotein phospholipids.

1984 • 1,631 citations

Generation of superoxide anion by the NADH dehydrogenase of bovine heart mitochondria

1980 • 1,609 citations

Free-radical mechanisms in tissue injury

1984 • 1,518 citations

The role of the monocyte in atherogenesis: I. Transition of blood-borne monocytes into foam cells in fatty lesions.

1981 • 1,325 citations

Biochemistry of Oxidative Stress

1986 • 1,307 citations

Antioxidant defenses and lipid peroxidation in human blood plasma.

1988 • 1,253 citations

Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease.

1990 • 1,190 citations

Superoxide Radical: An Endogenous Toxicant

1983 • 1,176 citations

Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis.

1987 • 1,152 citations

Minimally modified low density lipoprotein induces monocyte chemotactic protein 1 in human endothelial cells and smooth muscle cells.

1990 • 1,147 citations

Vitamin E: application of the principles of physical organic chemistry to the exploration of its structure and function

1986 • 1,103 citations

Type I macrophage scavenger receptor contains α-helical and collagen-like coiled coils

1990 • 1,039 citations

Enhanced macrophage degradation of low density lipoprotein previously incubated with cultured endothelial cells: recognition by receptors for acetylated low density lipoproteins.

1981 • 1,037 citations

Modulation of coronary vasomotor tone in humans. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis.

1991 • 1,010 citations

How to Characterize a Biological Antioxidant

1990 • 943 citations

Minimally modified low density lipoprotein stimulates monocyte endothelial interactions.

1990 • 930 citations

Canine myocardial reperfusion injury. Its reduction by the combined administration of superoxide dismutase and catalase.

1984 • 915 citations

Impairment of endothelium-dependent arterial relaxation by lysolecithin in modified low-density lipoproteins

1990 • 871 citations

Coronary Vasospasm as a Possible Cause of Myocardial Infarction

1978 • 845 citations

Endothelial and smooth muscle cells alter low density lipoprotein in vitro by free radical oxidation.

1984 • 826 citations

Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing

1988 • 787 citations

Induction of endothelial cell expression of granulocyte and macrophage colony-stimulating factors by modified low-density lipoproteins

1990 • 785 citations

Antioxidant activity of albumin-bound bilirubin.

1987 • 763 citations

Hyperlipidemia and Atherosclerosis

1976 • 746 citations

HÆMOSTATIC FUNCTION AND CARDIOVASCULAR DEATH: EARLY RESULTS OF A PROSPECTIVE STUDY

1980 • 704 citations

Demonstration of free radical generation in "stunned" myocardium of intact dogs with the use of the spin trap alpha-phenyl N-tert-butyl nitrone.

1988 • 691 citations

Endothelium-derived relaxing factor

1988 • 686 citations

Platelet Function in Hyperlipoproteinemia

1974 • 682 citations

Xanthine oxidase as a source of free radical damage in myocardial ischemia

1985 • 678 citations

Purification of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1976 • 668 citations

Glutathione Peroxidase: The Primary Agent for the Elimination of Hydrogen Peroxide in Erythrocytes^*

1963 • 667 citations

Reduction of experimental canine myocardial reperfusion injury by a monoclonal antibody (anti-Mo1, anti-CD11b) that inhibits leukocyte adhesion.

1988 • 650 citations

Albumin—An important extracellular antioxidant?

1988 • 643 citations

Iron promoters of the Fenton reaction and lipid peroxidation can be released from haemoglobin by peroxides

1986 • 634 citations

Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology.

1989 • 630 citations

Direct detection of free radicals in the reperfused rat heart using electron spin resonance spectroscopy.

1987 • 628 citations

Antisera and monoclonal antibodies specific for epitopes generated during oxidative modification of low density lipoprotein.

1990 • 627 citations

Oxidation of human low density lipoprotein results in derivatization of lysine residues of apolipoprotein B by lipid peroxide decomposition products.

1987 • 625 citations

Flavonoids inhibit the oxidative modification of low density lipoproteins by macrophages

1990 • 624 citations

Low density lipoprotein cytotoxicity induced by free radical peroxidation of lipid.

1983 • 623 citations

Complete protein sequence and identification of structural domains of human apolipoprotein B

1986 • 620 citations

A spectrophotometric assay for lipid peroxides in serum lipoproteins using a commercially available reagent.

1989 • 594 citations

Marked reduction of free radical generation and contractile dysfunction by antioxidant therapy begun at the time of reperfusion. Evidence that myocardial "stunning" is a manifestation of reperfusion injury.

1989 • 580 citations

Free radicals, lipids and protein degradation

1986 • 556 citations

Lipoproteins and Atherogenesis

1990 • 549 citations

Iron and copper promote modification of low density lipoprotein by human arterial smooth muscle cells in culture.

1984 • 547 citations

Atherosclerotic plaque caps are locally weakened when macrophages density is increased

1991 • 541 citations

Biochemical structural and functional properties of oxidized low-density lipoprotein

1990 • 536 citations

Monocytes and Neutrophils Oxidize Low Density Lipoprotein Making It Cytotoxic

1985 • 536 citations

Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5'-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta.

1987 • 534 citations

Vitamin E: Interactions with Free Radicals and Ascorbate

1985 • 527 citations

Chemical determination of free radical-induced damage to DNA

1991 • 523 citations

Diet, Lipoproteins, and the Progression of Coronary Atherosclerosis

1985 • 494 citations

The lipoprotein-associated coagulation inhibitor that inhibits the factor VII-tissue factor complex also inhibits factor Xa: insight into its possible mechanism of action

1988 • 482 citations

Distribution of oxidation specific lipid-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits.

1990 • 478 citations

Enzymic mechanisms of superoxide production

1991 • 475 citations

Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL. Correlation with changes in receptor-mediated catabolism.

1987 • 473 citations

Enhanced macrophage degradation of biologically modified low density lipoprotein.

1983 • 469 citations

Role of leukocytes in acute myocardial infarction in anesthetized dogs: relationship to myocardial salvage by anti-inflammatory drugs.

1984 • 468 citations

Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis.

1990 • 461 citations

Sequence, structure, receptor-binding domains and internal repeats of human apolipoprotein B-100

1986 • 423 citations

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1977 • 421 citations

Free radicals in biology and medicine

1985 • 416 citations

Oxygen radicals stimulate intracellular proteolysis and lipid peroxidation by independent mechanisms in erythrocytes.

1987 • 414 citations

Formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Is haemoglobin a biological Fenton reagent?

1988 • 408 citations

Modification of human serum low density lipoprotein by oxidation — Characterization and pathophysiological implications

1987 • 400 citations

Species, Tissue and Subcellular Distribution of Non Se-Dependent Glutathione Peroxidase Activity

1978 • 399 citations

Dietary induced atherogenesis in swine. Morphology of the intima in prelesion stages.

1979 • 393 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

Gene expression in macrophage-rich human atherosclerotic lesions. 15-lipoxygenase and acetyl low density lipoprotein receptor messenger RNA colocalize with oxidation specific lipid-protein adducts.

1991 • 386 citations

Prevention of Myocardial Damage in Acute Myocardial Ischemia by Early Treatment with Intravenous Streptokinase

1985 • 382 citations

Risk factors and atherosclerotic lesions. A review of autopsy studies.

1983 • 378 citations

Augmented responses to vasoconstrictor stimuli in hypercholesterolemic and atherosclerotic monkeys.

1984 • 375 citations

Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging.

1990 • 370 citations

Biosynthesis of N- and O-linked oligosaccharides of the low density lipoprotein receptor.

1983 • 369 citations

The Biosynthesis and Metabolism of Prostaglandins

1979 • 366 citations

Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium".

1986 • 360 citations

Intracellular mechanisms for the decomposition of a lipid peroxide. I. Decomposition of a lipid peroxide by metal ions, heme compounds, and nucleophiles

1969 • 353 citations

Visualization of the binding, endocytosis, and transcytosis of low-density lipoprotein in the arterial endothelium in situ.

1983 • 349 citations

Fragmentation of proteins by free radicals and its effect on their susceptibility to enzymic hydrolysis

1986 • 345 citations

Arginine restores cholinergic relaxation of hypercholesterolemic rabbit thoracic aorta.

1991 • 340 citations

Initiation of atherosclerotic lesions in cholesterol-fed rabbits. II. Selective retention of LDL vs. selective increases in LDL permeability in susceptible sites of arteries.

1989 • 339 citations

Free radicals in liver injury

1987 • 338 citations

Hyperoxia increases H2O2 release by lung mitochondria and microsomes

1982 • 336 citations

Oxidized low density lipoprotein induces differentiation and adhesion of human monocytes and the monocytic cell line U937.

1990 • 335 citations

Macrophage and smooth muscle cell proliferation in atherosclerotic lesions of WHHL and comparably hypercholesterolemic fat-fed rabbits.

1990 • 333 citations

Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Possible role of early coronary atherosclerosis.

1990 • 324 citations

Effect of Cholesterol on Production of Thromboxane B₂by Platelets in Vitro

1980 • 322 citations

Leukocytes and Ischemia-Induced Myocardial Injury

1986 • 321 citations

Altered Metabolism (In Vivo and In Vitro) of Plasma Lipoproteins after Selective Chemical Modification of Lysine Residues of the Apoproteins

1979 • 313 citations

Oxidized low density lipoproteins cause contraction and inhibit endothelium-dependent relaxation in the pig coronary artery.

1990 • 312 citations

α-tocopherol consumption during low-density-lipoprotein oxidation

1990 • 312 citations

Low-density lipoproteins inhibit endothelium-dependent relaxation in rabbit aorta

1987 • 310 citations

Free radicals and myocardial ischemia and reperfusion injury.

1987 • 307 citations

Role of prostaglandin endoperoxide PGG2 in inflammatory processes

1977 • 307 citations

Enzymatic modification of low density lipoprotein by purified lipoxygenase plus phospholipase A2 mimics cell-mediated oxidative modification

1988 • 301 citations

Physiologic levels of ascorbate inhibit the oxidative modification of low density lipoprotein

1990 • 297 citations

The role of calcium in the ischemic myocardium.

1981 • 287 citations

Ascorbate: The Most Effective Antioxidant in Human Blood Plasma

1990 • 286 citations

The production of free radicals during the autoxidation of cysteine and their effect on isolated rat hepatocytes

1982 • 283 citations

Cholesteryl ester synthesis in macrophages: stimulation by beta-very low density lipoproteins from cholesterol-fed animals of several species

1980 • 279 citations

Intracellular proteolytic systems may function as secondary antioxidant defenses: An hypothesis

1986 • 279 citations

L-arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits.

1990 • 278 citations

Cellular aspects of transcapillary exchange

1983 • 277 citations

The antioxidant hypothesis of cardiovascular disease: epidemiology and mechanisms

1990 • 276 citations

Superoxide initiates oxidation of low density lipoprotein by human monocytes.

1987 • 273 citations

Endotoxin pretreatment increases endogenous myocardial catalase activity and decreases ischemia-reperfusion injury of isolated rat hearts.

1989 • 267 citations

Serum fatty acids, apolipoproteins, selenium and vitamin antioxidants and the risk of death from coronary artery disease

1985 • 262 citations

Free Radicals and Their Involvement During Long-Term Myocardial Ischemia and Reperfusion

1990 • 259 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals from hydrogen peroxide in the presence of iron. Are lactoferrin and transferrin promoters of hydroxyl-radical generation?

1987 • 253 citations

Stimulation of arterial endothelial cell prostacyclin synthesis by high density lipoproteins.

1982 • 252 citations

Carotenoids : chemistry and biology

1989 • 250 citations

Direct evidence for a protein recognized by a monoclonal antibody against oxidatively modified LDL in atherosclerotic lesions from a Watanabe heritable hyperlipidemic rabbit.

1989 • 250 citations

Improvement of postischemic myocardial function and metabolism induced by administration of deferoxamine at the time of reflow: the role of iron in the pathogenesis of reperfusion injury.

1987 • 249 citations

Serum selenium, vitamin antioxidants, and cardiovascular mortality: a 9-year follow-up study in the Netherlands

1987 • 246 citations

Reduction of myocardial infarct size by neutrophil depletion: Effect of duration of occlusion

1986 • 238 citations

Preservation of the endogenous antioxidants in low density lipoprotein by ascorbate but not probucol during oxidative modification.

1991 • 228 citations

Book-Review - Contact with the Stars - the Search for Extraterrestrial Life

1982 • 226 citations

Membrane microviscosity and human platelet function

1976 • 225 citations

Bovine aortic endothelial cells display macrophage-like properties towards acetylated 125I-labelled low density lipoprotein

1980 • 212 citations

The participation of coenzyme Q in free radical production and antioxidation

1990 • 210 citations

Interactions of serum copper, selenium, and low density lipoprotein cholesterol in atherogenesis.

1991 • 210 citations

Vitamin E. An inhibitor of the platelet release reaction.

1976 • 209 citations

Effect of vitamin C and E supplementation on susceptibility of plasma lipoproteins to peroxidation induced by acute smoking

1990 • 205 citations

Modulation of Leukocyte-Mediated Myocardial Reperfusion Injury

1990 • 204 citations

Ultrastructural damage associated with reoxygenation of the anoxic myocardium

1975 • 202 citations

Myocardial ischemia and reperfusion: direct evidence for free radical generation by electron spin resonance spectroscopy.

1988 • 200 citations

Free Radicals and the Regulation of Mammalian Cell Proliferation

1989 • 195 citations

Cigarette smoking renders LDL susceptible to peroxidative modification and enhanced metabolism by macrophages

1989 • 191 citations

Effects of native and oxidized low density lipoproteins on formation and inactivation of endothelium-derived relaxing factor.

1991 • 190 citations

Lysophosphatidylcholine: Essential role in the inhibition of endothelium-dependent vasorelaxation by oxidized low density lipoprotein

1990 • 187 citations

Platelet activation by oxidatively modified low density lipoproteins

1989 • 183 citations

Native and oxidized low‐density lipoproteins have different inhibitory effects on endothelium‐derived relaxing factor in the rabbit aorta

1990 • 183 citations

Lysophosphatidylcholine concentrations and metabolism in aortic intima plus inner media: effect of nutritionally induced atherosclerosis

1969 • 181 citations

Superoxide dependent iron release from ferritin in inflammatory diseases

1988 • 179 citations

Lipid hydroperoxide involvement in copper-dependent and independent oxidation of low density lipoproteins.

1991 • 177 citations

Do human neutrophils make hydroxyl radical? Determination of free radicals generated by human neutrophils activated with a soluble or particulate stimulus using electron paramagnetic resonance spectrometry.

1986 • 171 citations

The oxidative modification of low-density lipoproteins by macrophages

1990 • 169 citations

The action of defined oxygen-centred free radicals on human low-density lipoprotein

1989 • 167 citations

Evidence that desferrioxamine cannot enter cells by passive diffusion

1991 • 164 citations

Prostacyclin and arterial wall biology.

1982 • 164 citations

St Cyres lecture. Endothelium in control.

1991 • 164 citations

Effect of hydrogen peroxide on prostaglandin production and cellular integrity in cultured porcine aortic endothelial cells.

1985 • 162 citations

The metabolic and molecular basis of acquired disease

1991 • 161 citations

Role of endothelial cells and their products in the modification of low-density lipoproteins

1986 • 159 citations

Non‐enzymatic glycosylation of human serum lipoproteins Elevated ϵ‐lysine glycosylated low density lipoprotein in diabetic patients

1981 • 153 citations

Lipid hydroperoxy and hydroxy derivatives in copper-catalyzed oxidation of low density lipoprotein.

1990 • 153 citations

Prevention of postischemic cardiac injury by the orally active iron chelator 1,2-dimethyl-3-hydroxy-4-pyridone (L1) and the antioxidant (+)-cyanidanol-3.

1989 • 152 citations

Oxidized low density lipoproteins potentiate vasoconstrictions to various agonists by direct interaction with vascular smooth muscle.

1990 • 152 citations

Free radical modification of low-density lipoprotein: Mechanisms and biological consequences

1987 • 150 citations

Oxidized low density lipoprotein suppresses the expression of tumor necrosis factor-alpha mRNA in stimulated murine peritoneal macrophages.

1990 • 150 citations

Modification of low density lipoprotein by lipoprotein lipase or hepatic lipase induces enhanced uptake and cholesterol accumulation in cells.

1988 • 148 citations

Diet, Lipoproteins and the Progression of Coronary Atherosclerosis

1986 • 148 citations

Glutathione peroxidase and the destruction of hydrogen peroxide in animal tissues

1960 • 145 citations

Platelet interaction with high and low density lipoproteins

1983 • 145 citations

Multiple receptors for modified low density lipoproteins in mouse peritoneal macrophages : different uptake mechanisms for acetylated and oxidized low density lipoproteins

1991 • 145 citations

Desferrioxamine (Desferal) and superoxide free radicals. Formation of an enzyme-damaging nitroxide

1987 • 138 citations

Vitamin E and other Lipophilic Antioxidants Protect LDL against Oxidation

1989 • 134 citations

MACROPHAGES AND ATHEROGENESIS

1987 • 134 citations

Hyperlipidaemia: Diagnosis and Management

1991 • 131 citations

Lipoproteins and atherogenesis. Current concepts

1990 • 130 citations

Superoxide dismutase reduces reperfusion arrhythmias but fails to salvage regional function or myocardium at risk in conscious dogs.

1989 • 129 citations

Inhibition of adriamycin‐promoted microsomal lipid peroxidation by β‐carotene, α‐tocopherol and retinol at high and low oxygen partial pressures

1988 • 128 citations

Immunoregulatory plasma lipoproteins. Role of apoprotein E and apoprotein B.

1980 • 126 citations

Protective effect of lipoproteins containing apoprotein A‐I on Cu²⁺ ‐ catalyzed oxidation of human low density lipoprotein

1989 • 126 citations

Lipoprotein aggregation as an essential condition of intracellular lipid accumulation caused by modified low density lipoproteins

1989 • 124 citations

Early treatment with deferoxamine limits myocardial ischemic/reperfusion injury

1989 • 124 citations

Uptake of canine beta-very low density lipoproteins by mouse peritoneal macrophages is mediated by a low density lipoprotein receptor.

1986 • 123 citations

Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins

1988 • 122 citations

The aggregation of isolated human platelets in the presence of lipoproteins and prostacyclin

1983 • 118 citations

Release and vascular activity of endothelium-derived relaxing factor in atherosclerotic rabbit aorta

1990 • 116 citations

Low density lipoprotein causes general cellular activation with increased phosphatidylinositol turnover and lipoprotein catabolism.

1988 • 116 citations

Binding of apoE-rich high density lipoprotein particles by saturable sites on human blood platelets inhibits agonist-induced platelet aggregation.

1989 • 114 citations

Enhanced in vivo platelet release reaction and malondialdehyde formation in patients with hyperlipidemia

1981 • 114 citations

Glutathione redox pathway and reperfusion injury. Effect of N-acetylcysteine on infarct size and ventricular function.

1988 • 113 citations

Plasma antioxidants and coronary heart disease: vitamins C and E, and selenium.

1990 • 112 citations

Oxidation of oxymyoglobin to metmyoglobin with hydrogen peroxide: involvement of ferryl intermediate

1987 • 112 citations

Structure of human low-density lipoprotein subfractions determined by X-ray small-angle scattering

1990 • 111 citations

The enzymatic oxidation of Desferal to a nitroxide free radical

1987 • 111 citations

Lipoproteins and the inhibitory effect of human endothelial cells on platelet function.

1978 • 110 citations

Iron-mediated oxidative stress in erythrocytes

1987 • 108 citations

In vivo lipid peroxidation: measurement via exhaled pentane and protection by vitamin E.

1981 • 106 citations

Can superoxide dismutase alter myocardial infarct size?

1989 • 105 citations

Studies on the metal-ion and lipoxygenase-catalysed breakdown of hydroperoxides using electron-spin-resonance spectroscopy

1987 • 103 citations

Is the autoxidation of catecholamines involved in ischemia-reperfusion injury?

1989 • 101 citations

Sulfhydryl chemistry and solubility properties of human plasma apolipoprotein B

1982 • 98 citations

The LDL receptor pathway delivers arachidonic acid for eicosanoid formation in cells stimulated by platelet-derived growth factor

1990 • 94 citations

Spin trapping evidence for the lack of significant hydroxyl radical production during the respiration burst of human phagocytes using a spin adduct resistant to superoxide-mediated destruction.

1990 • 93 citations

The modulation of ferryl myoglobin formation and its oxidative effects on low density lipoproteins by nitric oxide

1991 • 93 citations

Membrane structure and function

1990 • 92 citations

The Suppression of Iron Release from Activated Myoglobin by Physiological Electron Donors and by Desferrioxamine

1989 • 92 citations

Effect of probucol on the physical properties of low-density lipoproteins oxidized by copper

1989 • 90 citations

Correlation of platelet aggregation, plasma factor activity, and megathrombocytes in diabetic subjects with and without vascular disease

1977 • 90 citations

Leukocyte ascorbic acid and its relationship to coronary artery disease in man

1980 • 89 citations

Free radicals, cell damage and disease

1986 • 89 citations

The formation of free radicals by cardiac myocytes under oxidative stress and the effects of electron-donating drugs

1991 • 88 citations

Rapid activation of human platelets by low concentrations of low‐density lipoprotein via phosphatidylinositol cycle

1988 • 88 citations

Interaction of plasma lipoproteins with human platelets

1984 • 88 citations

Quantitative studies on the complexes formed between aortic mucopolysaccharides and serum lipoproteins

1967 • 87 citations

Vitamin C and cardiovascular risk factors

1991 • 87 citations

In Vitro Activation of Complement by Isolated Human Heart Subcellular Membranes

1979 • 85 citations

Effect of Alpha-Tocopherol Administration on Platelet Function in Man

1983 • 85 citations

Interaction of lactoperoxidase with hydrogen peroxideFormation of enzyme intermediates and generation of free radicals

1989 • 82 citations

Increased in vivo and in vitro platelet function in type II- and type IV-hyperlipoproteinemia

1979 • 82 citations

The structure of serum lipoproteins as analysed by X-ray small-angle scattering

1978 • 82 citations

Effect of early and advanced atherosclerosis on vascular responses to serotonin, thromboxane A2, and ADP.

1989 • 81 citations

Detection of new epitopes formed upon oxidation of low-density lipoprotein, lipoprotein (a) and very-low-density lipoprotein. Use of an antiserum against 4-hydroxynonenal-modified low-density lipoprotein

1990 • 80 citations

Protection from reperfusion injury in the isolated rat heart by postischaemic deferoxamine and oxypurinol administration

1987 • 79 citations

Myoglobinemia in the early phase of acute myocardial infarction

1983 • 78 citations

Effect of human plasma lipoproteins on prostacyclin production by cultured endothelial cells.

1985 • 75 citations

Influence of plasma lipoproteins on platelet aggregation in a normal male population.

1983 • 74 citations

Desferrioxamine as an Electron Donor. Inhibition of Membranal Lipid Peroxidation Initiated by H₂0₂–Activated Metmyoglobin and Other Peroxidizing Systems

1987 • 71 citations

Glutathione-dependent reduction of peroxides during ferryl- and met-myoglobin interconversion: A potential protective mechanism in muscle

1989 • 71 citations

The Structure of Human‐Plasma Low‐Density Lipoprotein B

1978 • 71 citations

t-butyl hydroperoxide-induced perturbations of human erythrocytes as a model for oxidant stress

1985 • 69 citations

Specific Macrophage Receptor Activity for Advanced Glycosylation End Products Inversely Correlates With Insulin Levels In Vivo

1988 • 68 citations

Hypothesis: lipoprotein(a) is a surrogate for ascorbate.

1990 • 68 citations

The anatomy and physiology of reverse cholesterol transport

1986 • 68 citations

Human apolipoprotein B: analysis of internal repeats and homology with other apolipoproteins.

1987 • 67 citations

Effects of the free radical scavenger DMTU and mannitol on the oxygen paradox in perfused rat hearts*

1987 • 66 citations

A method for the comparative assessment of antioxidants as peroxyl radical scavengers

1989 • 66 citations

Low Plasma Vitamins E and C Increased Risk of Angina in Scottish Men^a

1989 • 66 citations

Enhancement of Platelet Aggregation by Low-Density Lipoproteins From IDDM Patients

1988 • 66 citations

Platelets and foam cells in the evolution of atherosclerosis

1986 • 65 citations

Detection of ferryl myoglobin in the isolated ischemic rat heart

1990 • 64 citations

Differences in the metabolism of oxidatively modified low density lipoprotein and acetylated low density lipoprotein by human endothelial cells: inhibition of cholesterol esterification by oxidatively modified low density lipoprotein.

1989 • 64 citations

Sensitivity of tryptophan and related compounds to oxidation induced by lipid autoperoxidation. Application to human serum low- and high-density lipoproteins

1990 • 63 citations

Metabolism of lysolecithin in vivo: effects of hyperlipemia and atherosclerosis in squirrel monkeys

1970 • 60 citations

Evaluation of the secondary structure of apo B-100 in low-density lipoprotein (LDL) by infrared spectroscopy

1989 • 60 citations

Lethal Neonatal Deficiency of Carbamyl Phosphate Synthetase

1974 • 59 citations

Desferrioxamine as a lipid chain‐breaking antioxidant in sickle erythrocyte membranes

1990 • 58 citations

Erythrocytes decrease myocardial hydrogen peroxide levels and reperfusion injury

1989 • 57 citations

Protection by superoxide dismutase and catalase in the isolated rat heart reperfused after prolonged cardioplegia: a combined study of metabolic, functional, and morphometric ultrastructural variables

1987 • 54 citations

Oxidized low density lipoprotein stimulates prostacyclin production by adult human vascular endothelial cells.

1988 • 53 citations

Reaction of hematin with allylic fatty acid hydroperoxides: identification of products and implications for pathways of hydroperoxide-dependent epoxidation of 7,8-dihydroxy-7,8-dihydrobenzol[a]pyrene

1988 • 51 citations

Vascular responses to endothelin-1 in atherosclerotic primates.

1990 • 51 citations

Oxidized LDL increase free cholesterol and fail to stimulate cholesterol esterification in murine macrophages

1990 • 51 citations

Accumulation of cholesteryl esters in macrophages incubated with human lipoprotein-antibody autoimmune complex

1988 • 50 citations

Modification of low density lipoproteins by polymorphonuclear cell elastase leads to enhanced uptake by human monocyte-derived macrophages via the low density lipoprotein receptor pathway

1988 • 49 citations

Beta-very low density lipoprotein pretreatment of endothelial monolayers increases monocyte adhesion.

1989 • 49 citations

Investigation of human plasma low density lipoprotein by three‐dimensional flourescence spectroscopy

1986 • 49 citations

Dietary treatment of atherosclerosis abolishes hyperresponsiveness to serotonin: implications for vasospasm.

1987 • 47 citations

The Incidence of Acid-Fast Pigment (Ceroid) in Aortic Atherosclerosis

1952 • 46 citations

Correlations and apparent contradictions in assessment of oxidant stress status in vivo

1991 • 46 citations

Low level hyperlipidemia impairs endothelium-dependent relaxation of porcine coronary arteries by two mechanisms. Functional change in endothelium and impairment of endothelium-dependent relaxation by two mediators

1991 • 46 citations

Inhibition of antithrombin III by lipid peroxides

1985 • 45 citations

Lipoprotein‐binding proteins in the human platelet plasma membrane

1986 • 43 citations

Endothelium-dependent relaxation, cholesterol content and high energy metabolite balance in Watanabe hyperlipemic rabbit aorta

1989 • 42 citations

Inverse relationship between ESR spin trapping of oxyradicals and degree of functional recovery during myocardial reperfusion in isolated working rat heart

1990 • 41 citations

Plasma concentrations of lysolecithin and other phospholipids in the healthy population and in men suffering from atherosclerotic diseases

1975 • 41 citations

Changes in the secondary structure of apolipoprotein B-100 after Cu2+-catalysed oxidation of human low-density lipoproteins monitored by Fourier transform infrared spectroscopy

1987 • 40 citations

Generation of reactive oxygen metabolites by phagocytosing endothelial cells

1988 • 40 citations

Inhibition of platelet aggregation by lysolecithin

1971 • 39 citations

REVERSIBLE THERMAL CONFORMATION CHANGES IN HUMAN SERUM LOW-DENSITY LIPOPROTEIN

1969 • 39 citations

Studies on the Effects of Antioxidants and Inhibitors of Radical Generation on Free Radical Production in the Reperfused Rat Heart Using Electron Spin Resonance Spectroscopy

1990 • 36 citations

Pulse radiolysis of aqueous solutions of sodium azide: Reactions of azide radical with tryptophan and tyrosine

1982 • 36 citations

An immunochemical marker of low density lipoprotein oxidation.

1989 • 35 citations

Carotenoids in Medicine

1989 • 35 citations

Low‐density lipoproteins increase intracellular calcium in aequorin‐loaded platelets

1988 • 35 citations

The role of lipid transfer proteins in plasma lipoprotein metabolism

1987 • 35 citations

Relationship between prostacyclin and nitric oxide in the thrombotic process

1990 • 34 citations

Experimental Study of the Retinal Toxicity of Hemoglobinic Iron

1986 • 34 citations

The effects of plasma lipoproteins on platelet responsiveness and on platelet and vascular prostanoid synthesis

1989 • 33 citations

Role of intimal mucoid substances in the pathogenesis of atherosclerosis

1962 • 33 citations

Effects of PGI2 on platelet aggregation and adenylate cyclase activity in human type IIa hypercholesterolemia

1983 • 32 citations

Cause and course of acute myocardial infarction

1980 • 32 citations

Blood cells and ischemia-reperfusion injury.

1990 • 32 citations

Enhancement of platelet aggregation by low-density lipoproteins from IDDM patients

1988 • 31 citations

Scavenging of Hypochlorous Acid and the Myoglobin-Derived Oxidants By of Cardioprotective Agent Mercaptopropionylglycine

1990 • 31 citations

Cardioprotective effects of captopril in myocardial ischaemia, ischaemia/reperfusion and infarction

1990 • 29 citations

Specific macrophage receptor activity for advanced glycosylation end products inversely correlates with insulin levels in vivo

1988 • 29 citations

Regulation of autosensitisation to encephalitogenic myelin basic protein by macrophage-associated and soluble antigen

1977 • 29 citations

Myoglobin in the Very Early Phase of Acute Myocardial Infarction

1985 • 29 citations

Effect of blood on the activity and persistence of antigen induced inflammation in the rat air pouch.

1985 • 28 citations

Insolubilization of low density lipoprotein induces cholesterol accumulation in cultured subendothelial cells of human aorta

1989 • 28 citations

The effect of low-density lipoproteins on the synthesis of cyclic nucleotides induced by prostacyclin in isolated platelets

1984 • 27 citations

Recombinant human extracellular superoxide dismutase reduces concentration of oxygen free radicals in the reperfused rat heart

1990 • 27 citations

Hyperlipidaemia and atherosclerosis

1989 • 27 citations

The interactions of desferrioxamine and hydroxypyridone compounds with haemoglobin and erythrocytes

1989 • 26 citations

Oxidation and release of glutathione from myocardium during early reperfusion

1989 • 26 citations

Chylomicrons from patients with Type V hyperlipoproteinemia inhibit platelet function

1985 • 26 citations

FLUOROMETRIC STUDY OF TRYPTOPHAN PHOTOLYSIS

1979 • 26 citations

Detection of a Protein in Human Platelet Membranes which Binds Low-density Lipoproteins

1990 • 26 citations

Pharmacological approaches to the modulation of plasma cholesterol

1988 • 25 citations

Studies on oxidized low density lipoproteins. Controlled oxidation and a prostaglandin artifact.

1989 • 22 citations

Iron-Mediated Oxidative Stress and Erythrocytes

1990 • 22 citations

Free radicals, myocytes and reperfusion injury

1990 • 20 citations

Inhibitors of NADPH oxidase as guides to its mechanism

1991 • 20 citations

Reduction in reperfusion injury by blood-free reperfusion after experimental myocardial infarction

1990 • 20 citations

Aggregation of Gel-Filtered Guinea-Pig Platelets by Lipoproteins

1979 • 19 citations

SHORT TERM VITAMIN E SUPPLEMENTATION HAS NO EFFECT ON PLATELET FUNCTION, PLASMA PHOSPHOLIPASE A₂ AND LYSO‐PAF IN MALE VOLUNTEERS

1990 • 19 citations

Vasoconstriction: A novel activity for low density lipoprotein

1989 • 18 citations

Structural changes in oxidised low‐density lipoproteins and of the effect of the anti‐atherosclerotic drug probucol observed by synchrotron X‐ray and neutron solution scattering

1989 • 18 citations

Interaction between fibronectin, proteoglycans and lipoproteins

1990 • 18 citations

The production of ceroid by mouse peritoneal macrophages in vitro.

1984 • 17 citations

β-Migrating Very Low Density Lipoprotein Attenuates Endothelium-Dependent Relaxation in Rabbit Atherosclerotic Aortas

1989 • 17 citations

Inhibition of endothelium-dependent relaxation by oxidized low-density lipoproteins

1990 • 17 citations

Platelet function in familial hypercholesterolaemia in south africa and the effects of probucol

1982 • 17 citations

Linoleic acid and coronary heart disease.

1989 • 15 citations

Inorganic radicals of relevance to biological systems

1985 • 14 citations

Lipid and Lipoprotein Effects on Endothelial Eicosanoid Formation

1988 • 14 citations

Effect of lysophosphatidylcholine on atherosclerotic rabbit arteries

1989 • 14 citations

Platelet low-density lipoprotein receptors

1985 • 14 citations

Low-density lipoproteins stimulate internal free calcium and prostacyclin release in endothelial cells.

1990 • 12 citations

Circulating immune complexes, immunoglobulins, complement, antibodies to dietary antigens, cholesterol and lipoproteins levels in patients with occlusive coronary lesions

1984 • 12 citations

Interaction of tryptic peptides of apolipoprotein B-100 with dimyristoylphosphatidylcholine

1986 • 12 citations

The Increased Sensitivity of Platelets to Prostacyclin in Marathon Runners

1984 • 12 citations

Hypothesis: Lipoprotein(a) is a surrogate for ascorbate

1991 • 11 citations

Factors regulating the metabolism of low-density lipoprotein-proteoglycan complex in macrophages

1990 • 8 citations

Low density lipoprotein modulation of porcine coronary artery contractile response to histamine

1987 • 7 citations

Reduction of heme by lipid peroxides and its potential relevance to understanding control of cyclo-oxygenase activity

1981 • 7 citations

Adenine nucleotide depletion and contractile dysfunction in the "stunned" myocardium

1990 • 6 citations

Reperfusion-induced arrhythmias are not prevented by ibuprofen in isolated rat heart

1990 • 4 citations

Myocardial Reperfusion Injury

1990 • 3 citations

Isolation of a macrophage receptor for proteins modified by advanced glycosylation end products

1987 • 3 citations

Hormone-mediated increases in cytosolic free Ca2+ in isolated rat liver cells

1985 • 3 citations