Mitogens and Ion Fluxes

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Early Signals in the Mitogenic Response

1986 • 1,498 citations

T-cell mitogens cause early changes in cytoplasmic free Ca2+ and membrane potential in lymphocytes

1982 • 1,026 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts

1983 • 721 citations

Mechanisms of regulation of the Na+/H+ exchanger

1986 • 685 citations

Modifier role of internal H+ in activating the Na+–H+ exchanger in renal microvillus membrane vesicles

1982 • 681 citations

Sodium/proton antiport in brush-border-membrane vesicles isolated from rat small intestine and kidney

1976 • 665 citations

Changes of free calcium levels with stages of the cell division cycle

1985 • 591 citations

Intracellular pH and activation of sea urchin eggs after fertilisation

1976 • 561 citations

A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH.

1984 • 544 citations

Effects of Growth Factors on Intracellular pH Regulation

1986 • 498 citations

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.

1986 • 468 citations

A common sequence of calcium and pH signals in the mitogenic stimulation of eukaryotic cells

1985 • 456 citations

Ras -Transformed Cells: Altered Levels of Phosphatidylinositol-4,5-Bisphosphate and Catabolites

1986 • 450 citations

Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH

1984 • 447 citations

Enhancement of calcium uptake and phosphatidylinositol turnover by epidermal growth factor in A-431 cells

1981 • 426 citations

Growth factors immediately raise cytoplasmic free Ca2+ in human fibroblasts.

1984 • 394 citations

Blockade of the Na+/H+ antiport abolishes growth factor-induced DNA synthesis in fibroblasts. Structure-activity relationships in the amiloride series.

1984 • 305 citations

The epidermal growth factor-induced calcium signal in A431 cells.

1986 • 297 citations

Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization.

1982 • 282 citations

Stimulation of the T3-T cell receptor complex induces a membrane-potential-sensitive calcium influx

1985 • 282 citations

Diacylglycerol stimulates DNA synthesis and cell division in mouse 3T3 cells: role of Ca2+-sensitive phospholipid-dependent protein kinase.

1984 • 266 citations

Two growth factor signalling pathways in fibroblasts distinguished by pertussis toxin

1987 • 254 citations

Characterization of the activation of Na+/H+ exchange in lymphocytes by phorbol esters: change in cytoplasmic pH dependence of the antiport.

1985 • 254 citations

Cytoplasmic pH, a key determinant of growth factor‐induced DNA synthesis in quiescent fibroblasts

1985 • 247 citations

Rapid ionic events and the initiation of growth in serum-stimulated neuroblastoma cells

1981 • 242 citations

Growth factors activate the Na+/H+ antiporter in quiescent fibroblasts by increasing its affinity for intracellular H+.

1984 • 233 citations

Epidermal growth factor stimulates the production of phosphatidylinositol monophosphate and the breakdown of polyphosphoinositides in A431 cells.

1987 • 230 citations

Angiotensin II-stimulated Na+/H+ exchange in cultured vascular smooth muscle cells. Evidence for protein kinase C-dependent and -independent pathways.

1987 • 228 citations

Epidermal growth factor stimulates the rapid accumulation of inositol (1,4,5)-trisphosphate and a rise in cytosolic calcium mobilized from intracellular stores in A431 cells.

1987 • 202 citations

Phorbol esters induce differentiation in a pre-B-lymphocyte cell line by enhancing Na+/H+ exchange.

1984 • 185 citations

The mitogenic signaling pathway of fibroblast growth factor is not mediated through polyphosphoinositide hydrolysis and protein kinase C activation in hamster fibroblasts.

1986 • 178 citations

Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling.

1985 • 175 citations

Pertussis Toxin-Sensitive Pathway in the Stimulation of c- myc Expression and DNA Synthesis by Bombesin

1986 • 171 citations

Pertussis toxin inhibits thrombin-induced activation of phosphoinositide hydrolysis and Na+/H+ exchange in hamster fibroblasts.

1986 • 165 citations

Lack of association of epidermal growth factor-, insulin-, and serum-induced mitogenesis with stimulation of phosphoinositide degradation in BALB/c 3T3 fibroblasts.

1986 • 156 citations

Single-channel and whole-cell recordings of mitogen-regulated inward currents in human cloned helper T lymphocytes

1986 • 151 citations

Epidermal growth factor stimulates amiloride-sensitive 22Na+ uptake in A431 cells. Evidence for Na+/H+ exchange.

1983 • 142 citations

Mitogen induction of ion channels in murine T lymphocytes.

1987 • 118 citations

Extracellular Na+ and initiation of DNA synthesis: role of intracellular pH and K+.

1984 • 117 citations

Mitogens and Oncogenes Can Block the Induction of Specific Voltage-Gated Ion Channels

1987 • 114 citations

Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation.

1985 • 114 citations

Phorbol ester stimulation of Na influx and Na-K pump activity in swiss 3T3 cells

1981 • 106 citations

Microinjection of ras p21 Induces a Rapid Rise in Intracellular pH

1987 • 100 citations

Mitogens trigger a calcium-independent signal for proliferation in phorbol-ester-treated lymphocytes

1985 • 88 citations

Ionic Signalling by Growth Factor Receptors

1986 • 76 citations

Activation of Na+/H+ exchange in cultured fibroblasts: synergism and antagonism between phorbol ester, Ca2+ ionophore, and growth factors.

1985 • 71 citations

Serum triggers a sequence of rapid ionic conductance changes in quiescent neuroblastoma cells

1979 • 57 citations

Calcium regulates inositol 1,3,4,5-tetrakisphosphate production in lysed thymocytes and in intact cells stimulated with concanavalin A.

1987 • 52 citations

Intracellular univalent cations and the regulation of the BALB/c-3T3 cell cycle.

1981 • 39 citations