Activation of hepatocyte protein kinase C by redox-cycling quinones

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

The molecular heterogeneity of protein kinase C and its implications for cellular regulation

1988 • 4,243 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

[4] Isolation and use of liver cells

1978 • 1,230 citations

High-performance liquid chromatography analysis of nanomole levels of glutathione, glutathione disulfide, and related thiols and disulfides

1980 • 1,179 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

ROLE OF REVERSIBLE OXIDATION-REDUCTION OF ENZYME THIOLS-DISULFIDES IN METABOLIC REGULATION

1985 • 840 citations

The Role of Protein Kinase C in Transmembrane Signalling

1986 • 557 citations

Advances in enzyme regulation

1988 • 452 citations

Alterations in intracellular thiol homeostasis during the metabolism of menadione by isolated rat hepatocytes

1984 • 411 citations

Overview of enzyme systems involved in bioreduction of drugs and in redox cycling

1986 • 392 citations

Free radicals in liver injury

1987 • 338 citations

Phosphoinositides and receptor mechanisms

1987 • 320 citations

Redox cycling and sulphydryl arylation; Their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes

1988 • 296 citations

The Role of Oxygen Radicals as a Possible Mechanism of Tumor Promotion

1985 • 282 citations

[31] Calcium-activated, phospholipid-dependent protein kinase (protein kinase C) from rat brain

1983 • 281 citations

Formation and reduction of glutathione-protein mixed disulfides during oxidative stress

1987 • 267 citations

Specificity and mechanism of protein kinase C activation by sn-1,2-diacylglycerols.

1986 • 254 citations

Free radicals in biology and medicine

1985 • 249 citations

Possible involvement of protein kinase C and calcium ion in growth factor-induced expression of c-myc oncogene in Swiss 3T3 fibroblasts.

1986 • 241 citations

Host Biochemical Defense Mechanisms Against Prooxidants

1988 • 200 citations

Insulin increases membrane and cytosolic protein kinase C activity in BC3H-1 myocytes.

1987 • 171 citations

Quinone toxicity in hepatocytes without oxidative stress

1986 • 166 citations

Role of insulin receptor phosphorylation in the insulinomimetic effects of hydrogen peroxide.

1987 • 156 citations

Correlation between cytosolic Ca2+ concentration and cytotoxicity in hepatocytes exposed to oxidative stress

1988 • 139 citations

Protein kinase C in fibroblasts. Characteristics of its intracellular location during growth and after exposure to phorbol esters and other mitogens.

1987 • 127 citations

Hydrogen peroxide has a role in the aggregation of human platelets

1985 • 121 citations

Hydrogen peroxide stimulates tyrosine phosphorylation of the insulin receptor and its tyrosine kinase activity in intact cells

1988 • 120 citations

Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells

1988 • 119 citations

Two independent growth factor-generated signals regulate c-fos and c-myc mRNA levels in Swiss 3T3 cells.

1987 • 105 citations

Inhibition of protein synthesis initiation by oxidized glutathione: Activation of a protein kinase that phosphorylates the α subunit of eukaryotic initiation factor 2

1978 • 87 citations

Rapid Assay of Binding of Tumor-Promoting Phorbol Esters to Protein Kinase C1

1986 • 84 citations

Thiol/disulfide exchange between 3-hydroxy-3-methylglutaryl-CoA reductase and glutathione. A thermodynamically facile dithiol oxidation.

1988 • 77 citations

A New Principle of Regulation of Enzymic Activity

1981 • 67 citations

Susceptibility of protein kinase C to oxidative inactivation: Loss of both phosphotransferase activity and phorbol diester binding

1987 • 63 citations

Stimulation of tyrosine-specific protein phosphorylation in the rat liver plasma membrane by oxygen radicals

1986 • 57 citations

Phorbol esters induce both intracellular translocation and down-regulation of protein kinase C in MCF-7 cells

1986 • 56 citations

Hormones, glutathione status and protein S-thiolation

1987 • 52 citations

H2O2 activates CD11b/CD18-dependent cell adhesion

1988 • 45 citations

Tumor promoter chloroform is a potent protein kinase C activator

1987 • 37 citations

ACTIVATION OF RABBIT LIVER FRUCTOSE DIPHOSPHATASE BY COENZYME A AND ACYL CARRIER PROTEIN

1969 • 35 citations

Phorbol ester-induced alteration of differentiation and proliferation in human hematopoietic tumor cell lines: relationship to the presence and subcellular distribution of protein kinase C.

1985 • 33 citations

Enhancement by adriamycin of the effects of 12-O-tetradecanoylphorbol-13-acetate on mouse epidermal glutathione peroxidase activity, ornithine decarboxylase induction and skin tumor promotion

1985 • 15 citations

Involvement of sulfatide in activation of protein kinase C by tumor promoters

1986 • 15 citations