Amino acid regulation of gene expression

THE UBIQUITIN SYSTEM

1998 • 8,360 citations

Induction of autophagy and inhibition of tumorigenesis by beclin 1

1999 • 3,194 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 2,349 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

Molecular Biology of Mammalian Plasma Membrane Amino Acid Transporters

1998 • 820 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

Multiple upstream AUG codons mediate translational control of GCN4

1986 • 654 citations

Role of insulin-like growth factors in embryonic and postnatal growth

1993 • 644 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

The role of cellular hydration in the regulation of cell function

1996 • 571 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

CONTROL OF TRANSLATION INITIATION IN ANIMALS

1998 • 507 citations

Bidirectional modulation of insulin action by amino acids.

1998 • 491 citations

Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast

1987 • 476 citations

Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae

1988 • 449 citations

Apg16p is required for the function of the Apg12p–Apg5p conjugate in the yeast autophagy pathway

1999 • 418 citations

Regulation and Function of Insulin-Like Growth Factor-Binding Protein-1

1993 • 387 citations

A Signaling Pathway to Translational Control

1996 • 370 citations

Regulatory and molecular aspects of mammalian amino acid transport

1994 • 368 citations

Leucine Regulates Translation of Specific mRNAs in L6 Myoblasts through mTOR-mediated Changes in Availability of eIF4E and Phosphorylation of Ribosomal Protein S6

1999 • 356 citations

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1998 • 331 citations

Identification of novel stress-induced genes downstream of chop

1998 • 306 citations

Apg10p, a novel protein-conjugating enzyme essential for autophagy in yeast

1999 • 296 citations

Target of rapamycin (TOR): balancing the opposing forces of protein synthesis and degradation

1999 • 276 citations

MUSCLE PROTEIN TURNOVER AND THE WASTING DUE TO INJURY AND DISEASE

1985 • 258 citations

Molecular mechanisms for the control of translation by insulin

1997 • 257 citations

Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2α kinase

1999 • 254 citations

Free Amino Acid Pools and Their Role in Regulation

1970 • 246 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

Branched-chain Amino Acids Are Essential in the Regulation of PHAS-I and p70 S6 Kinase by Pancreatic β-Cells

1998 • 236 citations

Radioimmunoassay of a 26,000-Dalton Plasma Insulin-Like Growth Factor-Binding Protein: Control by Nutritional Variables*

1988 • 231 citations

Autophagic proteolysis: control and specificity.

1997 • 228 citations

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70^s6k

1997 • 228 citations

Amino Acid-dependent Control of p70s6k

1999 • 205 citations

Amino Acid Limitation Induces Expression of CHOP, a CCAAT/Enhancer Binding Protein-related Gene, at Both Transcriptional and Post-transcriptional Levels

1997 • 203 citations

Metabolic response to injury and sepsis: changes in protein metabolism

1997 • 201 citations

Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice.

1995 • 197 citations

Regulation of Translational Effectors by Amino Acid and Mammalian Target of Rapamycin Signaling Pathways

1999 • 197 citations

Regulation of translation initiation factors by signal transduction

1998 • 195 citations

Recent Advances in Mammalian Amino Acid Transport

1993 • 194 citations

Transcriptional control of metabolic regulation genes by carbohydrates

1994 • 191 citations

Interrelationship of Plasma Amino Acid Levels and Weight Gain in the Chick as Influenced by Suboptimal and Superoptimal Dietary Concentrations of Single Amino Acids

1965 • 189 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Enzymes of Arginine Metabolism in Mammalian Cell Culture

1964 • 179 citations

Targeted disruption of p70^s6kdefines its role in protein synthesis and rapamycin sensitivity

1998 • 178 citations

Influence of dietary deprivations on plasma concentration of free amino acids of man.

1968 • 174 citations

Different Tissue Distribution and Hormonal Regulation of Messenger RNAs Encoding Rat Insulin-Like Growth Factor-Binding Proteins-1 and -2

1990 • 165 citations

Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae.

1988 • 162 citations

Metabolic Regulation of Gene Transcription in Mammals

1995 • 160 citations

Nutritional regulation of hormones and growth factors that control mammalian growth

1994 • 159 citations

Amino acid effects on translational repressor 4E-BP1 are mediated primarily by<scp>l</scp>-leucine in isolated adipocytes

1998 • 150 citations

Insulin regulates the 35 kDa IGF binding protein in patients with diabetes mellitus

1988 • 150 citations

Metabolic Response to Injury and Sepsis: Changes in Protein Metabolism

1997 • 150 citations

Regulation of amino acid transport in chick embryo heart cells

1972 • 148 citations

Effect of Dietary Protein Deprivation on Insulin-Like Growth Factor (IGF)-I and -II, IGF Binding Protein-2, and Serum Albumin Gene Expression in Rat*

1990 • 148 citations

Effect of amino acid limitation on the expression of 19 genes in rat hepatoma cells

1994 • 140 citations

Effects of branched‐chain amino acids on protein turnover

1989 • 132 citations

The eIF-2α kinases: regulators of protein synthesis in starvation and stress

1994 • 130 citations

Amino acids stimulate phosphorylation of p70 ^S6k and organization of rat adipocytes into multicellular clusters

1998 • 130 citations

Liver-Specific Expression of Human Insulin-Like Growth Factor Binding Protein-1 in Transgenic Mice: Repercussions on Reproduction, Ante- and Perinatal Mortality and Postnatal Growth¹

1997 • 124 citations

Contribution of Amino Acids and Insulin to Protein Anabolism During Meal Absorption

1996 • 124 citations

Adaptive regulation of amino acid transport in cultured human fibroblasts. Sites and mechanism of action.

1981 • 120 citations

Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture.

1994 • 118 citations

Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity

1991 • 114 citations

Physical and Functional Association between GADD153 and CCAAT/Enhancer-binding Protein β during Cellular Stress

1996 • 113 citations

Regulation of Guanine Nucleotide Exchange through Phosphorylation of Eukaryotic Initiation Factor eIF2α

1998 • 111 citations

Cis- and trans-acting elements involved in amino acid regulation of asparagine synthetase gene expression.

1993 • 108 citations

STRATEGIES FOR ATTENUATING PROTEIN-CATABOLIC RESPONSES IN THE CRITICALLY ILL

1994 • 107 citations

Activation of the Human Asparagine Synthetase Gene by the Amino Acid Response and the Endoplasmic Reticulum Stress Response Pathways Occurs by Common Genomic Elements

2000 • 105 citations

Molecular mechanisms in the control of translation by hormones and growth factors

1994 • 101 citations

Induction of insulin-like growth factor binding protein-1 gene expression in liver of protein-restricted rats and in rat hepatoma cells limited for a single amino acid.

1993 • 99 citations

Amino acid‐regulated gene expression in eukaryotic cells

1994 • 98 citations

In Vitro Transcriptional Activation by a Metabolic Intermediate: Activation by Leu3 Depends on α-Isopropylmalate

1992 • 98 citations

Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice.

1996 • 96 citations

Amino acid levels across normal forearm muscle and splanchnic bed after a protein meal

1976 • 95 citations

Protein and amino acid metabolism after injury

1989 • 94 citations

Physiological concentration of amino acids regulates insulin-like-growth-factor-binding protein 1 expression

1998 • 93 citations

Regulation of asparagine synthetase gene expression by amino acid starvation.

1991 • 92 citations

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response

1999 • 87 citations

Amino Acid Imbalance

1965 • 86 citations

Postprandial stimulation of muscle protein synthesis is independent of changes in insulin

1997 • 86 citations

Differential Regulation of the Insulin-Like Growth Factors (IGF-I and -II) and IGF Binding Proteins During Malnutrition in the Neonatal Rat*

1991 • 86 citations

NUTRITION AND PROTEIN TURNOVER IN MAN

1981 • 85 citations

Isolation of human cDNAs for asparagine synthetase and expression in Jensen rat sarcoma cells.

1987 • 82 citations

Cloning and Characterization of a cDNA Encoding a Protein Synthesis Initiation Factor-2α (eIF-2α) Kinase fromDrosophila melanogaster

1997 • 76 citations

Growth Hormone and Nutrition

1992 • 73 citations

The IGF system in metabolism regulation.

1995 • 72 citations

Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism.

1998 • 72 citations

Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content

1994 • 71 citations

Activation of the Unfolded Protein Response Pathway Induces Human Asparagine Synthetase Gene Expression

1999 • 69 citations

Increased translatable messenger ribonucleic acid for argininosuccinate synthetase in canavanine-resistant human cells

1981 • 68 citations

Serum proteins and plasma free amino acids in severe malnutrition

1974 • 67 citations

Analysis of Constitutive and Noninducible Mutations of the PUT3 Transcriptional Activator

1991 • 65 citations

Relationship Between Plasma Amino Acids and Composition of the Ingested Protein

1961 • 64 citations

Evidence for Multiple Signaling Pathways in the Regulation of Gene Expression by Amino Acids in Human Cell Lines

2000 • 63 citations

Translational control during amino acid starvation

1994 • 62 citations

Growth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice

1995 • 61 citations

Translational regulation of protein synthesis in the liver and skeletal muscle of mice in response to refeeding

1995 • 60 citations

Impaired estrogen action in the uterus of insulin-like growth factor binding protein-1 transgenic mice.

1996 • 59 citations

Molecular mechanisms of the synergistic induction of ornithine decarboxylase by asparagine and glucagon in primary cultured hepatocytes.

1987 • 58 citations

Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia.

1999 • 56 citations

Amino Acid Balance and Imbalance. IX. Effect of Amino Acid Imbalance on Blood Amino Acid Pattern.

1962 • 54 citations

Fluxes and membrane transport of amino acids in rat liver under different protein diets

1990 • 54 citations

Glucose regulation of gene expression

1998 • 53 citations

Isolation of the Gene Encoding the Drosophila melanogaster Homolog of the Saccharomyces cerevisiae GCN2 eIF-2α Kinase

1998 • 53 citations

Deprivation of a Single Amino Acid Induces Protein SynthesisDependent Increases in c-jun, c-myc, and Ornithine Decarboxylase mRNAs in Chinese Hamster Ovary Cells

1990 • 51 citations

Glutamine regulates glutamine synthetase expression in skeletal muscle cells in culture

1990 • 51 citations

Effects of nutrient deprivation and differentiation on the expression of growth-arrest genes (gas and gadd) in F9 embryonal carcinoma cells

1998 • 49 citations

FASTING SERUM-AMINOACID PATTERNS IN KWASHIORKOR AND AFTER ADMINISTRATION OF DIFFERENT LEVELS OF PROTEIN

1970 • 48 citations

Asparaginyl-tRNA aminoacylation levels and asparagine synthetase expression in cultured Chinese hamster ovary cells.

1979 • 48 citations

Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25

1994 • 46 citations

Amino acid limitation regulates gene expression

1999 • 46 citations

Induction of ornithine decarboxylase activity by insulin and growth factors is mediated by amino acids.

1985 • 43 citations

Some Qualitative Amino Acid Needs of Adult Swine for Maintenance

1966 • 41 citations

Inhibition of collagenase and stromelysin gene expression by interferon-gamma in human dermal fibroblasts is mediated in part via induction of tryptophan degradation.

1995 • 39 citations

Liver-Specific Expression of Human Insulin-Like Growth Factor Binding Protein-1 in Transgenic Mice: Repercussions on Reproduction, Ante- and Perinatal Mortality and Postnatal Growth

1997 • 39 citations

Can We Define Indispensable Amino Acid Requirements and Assess Protein Quality in Adults?

1994 • 39 citations

THE INFLUENCE OF FASTING AND NITROGEN DEPRIVATION ON THE CONCENTRATION OF FREE AMINO ACIDS IN RAT PLASMA

1949 • 38 citations

Essential Amino Acids Regulate Fatty Acid Synthase Expression through an Uncharged Transfer RNA-dependent Mechanism

1995 • 38 citations

Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture

1994 • 37 citations

Regulation of gene expression by fatty acids

1998 • 37 citations

Deprivation of a single amino acid induces protein synthesis-dependent increases in c-jun, c-myc, and ornithine decarboxylase mRNAs in Chinese hamster ovary cells.

1990 • 37 citations

Metabolite regulation of argininosuccinate synthetase in cultured human cells.

1988 • 36 citations

Induction of insulin-like growth factor binding protein-1 gene expression in liver of protein-restricted rats and in rat hepatoma cells limited for a single amino acid

1993 • 35 citations

Glutamine Increases Argininosuccinate Synthetase mRNA Levels in Rat'Hepatocytes

1996 • 34 citations

Effect of Fasting and Level of Dietary Protein on Free Amino Acids in Pig Plasma2

1965 • 33 citations

Induction of High Affinity Glutamate Transport Activity by Amino Acid Deprivation in Renal Epithelial Cells Does Not Involve an Increase in the Amount of Transporter Protein

1996 • 33 citations

Mechanism of regulation of ornithine decarboxylase gene expression by asparagine in a variant mouse neuroblastoma cell line.

1992 • 31 citations

The role of amino acids in ApoB100 synthesis and catabolism in human HepG2 cells.

1993 • 29 citations

Analysis of constitutive and noninducible mutations of the PUT3 transcriptional activator.

1991 • 28 citations

A ‘swell’ way to regulate metabolism

1990 • 27 citations

Isolation of Human cDNAs for Asparagine Synthetase and Expression in Jensen Rat Sarcoma Cells

1987 • 26 citations

Calreticulin — a stress protein induced in the renal epithelial cell line NBL-1 by amino acid deprivation

1994 • 26 citations

Amino acid availability regulates p70 S6 kinase and multiple translation factors

1998 • 25 citations

Regulation of Asparagine Synthetase Gene Expression by Amino Acid Starvation

1991 • 24 citations

Human argininosuccinate synthetase minigenes are subject to arginine-mediated repression but not to trans induction.

1986 • 23 citations

Contribution of amino acids and insulin to protein anabolism during meal absorption

1996 • 23 citations

Specificity of Leucine Effect on Protein Degradation in Perfused Rat Heart

1994 • 23 citations

Control of Extracellular Matrix Degradation by Interferon-γ

1996 • 22 citations

The biochemistry and physiology of protein and amino acid metabolism, with reference to protein nutrition

1994 • 21 citations

PROTEIN NUTRITION IN CLINICAL PRACTICE

1981 • 19 citations

Impaired estrogen action in the uterus of insulin-like growth factor binding protein-1 transgenic mice

1996 • 19 citations

L-Tryptophan in supraphysiologic concentrations stimulates collagenase gene expression in human skin fibroblasts.

1994 • 19 citations

The Effect of Individual Amino Acids on ApoB100 and Lp(a) Secretion by HepG2 Cells

1996 • 19 citations

Adaptation of cultured human lymphoblasts to growth in citrulline

1974 • 18 citations

cis- and trans-Acting Elements Involved in Amino Acid Regulation of Asparagine Synthetase Gene Expression

1993 • 17 citations

Amino acids regulate kidney cell protein breakdown.

1991 • 15 citations

Histidine Availability Alters Glucagon Gene Expression in Murine αTC6 Cells

1998 • 14 citations

The Effects of Haem on Translational Control of Protein Synthesis in Cell‐Free Extracts from Fed and Lysine‐Deprived Ehrlich Ascites Tumour Cells

1981 • 13 citations

Recent Advances in Mammalian Amino Acid Transport

1993 • 10 citations

Regulation of Hepatic Protein Degradation

1997 • 9 citations

Amino acid limitation regulates CHOP expression through a specific pathway independent of the unfolded protein response

1999 • 9 citations

Induction of ornithine decarboxylase activity by insulin and growth factors is mediated by amino acids

1985 • 7 citations

Human Argininosuccinate Synthetase Minigenes Are Subject To Arginine-Mediated Repression but Not To trans Induction

1986 • 7 citations

Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia

1999 • 6 citations

Liver-specific Induction of Ribosomal Protein Gene Expression by Amino Acid Starvation in Rats

1993 • 5 citations

Enhanced mRNA Content in Response to Amino Acid Starvation for a 73-kDa Protein of the Inner Mitochondrial Membrane

1993 • 4 citations

Identification and partial characterization of a novel membrane glycoprotein induced by amino acid deprivation in renal epithelial cells

1997 • 4 citations

L-tryptophan induces expression of collagenase gene in human fibroblasts: demonstration of enhanced AP-1 binding and AP-1 binding site-driven promoter activity.

1995 • 4 citations

Molecular Cloning of a Bovine Renal G-Protein Coupled Receptor Gene (bRGR): Regulation of bRGR mRNA Levels by Amino Acid Availability

1997 • 2 citations