Essential Amino Acids Regulate Fatty Acid Synthase Expression through an Uncharged Transfer RNA-dependent Mechanism

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

FATTY ACID SYNTHESIS AND ITS REGULATION

1983 • 1,007 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

GCN4 protein, synthesize in vitro, binds HIS3 regulatory sequences: Implications for general control of amino acid biosynthetic genes in yeast

1985 • 496 citations

The 2.9 Å Crystal Structure of T. thermophilus Seryl-tRNA Synthetase Complexed with tRNA ^Ser

1994 • 452 citations

Mechanisms and regulation of biosynthesis of saturated fatty acids.

1976 • 340 citations

tRNA as a positive regulator of transcription antitermination in B. subtilis

1993 • 265 citations

Translational control of GCN4: an in vivo barometer of initiation-factor activity

1994 • 183 citations

Dietary Regulation of Gene Expression: Enzymes Involved in Carbohydrate and Lipid Metabolism

1987 • 178 citations

Nutritional Biochemistry and Metabolism: With Clinical Applications

1985 • 172 citations

Transfer RNA: From minihelix to genetic code

1995 • 171 citations

The Transfer RNA Identity Problem: a Search for Rules

1994 • 169 citations

Crystal Structures at 2.5 Angstrom Resolution of Seryl-tRNA Synthetase Complexed with Two Analogs of Seryl Adenylate

1994 • 163 citations

SINEs

1991 • 161 citations

Effects of nutrients and hormones on transcriptional and post‐transcriptional regulation of fatty acid synthase in rat liver

1990 • 158 citations

A Conspectus of Research on Amino Acid Requirements of Man

1971 • 139 citations

Suppression of Rat Hepatic Fatty Acid Synthase and S14 Gene Transcription by Dietary Polyunsaturated Fat

1990 • 132 citations

Studies of the sites of intracellular degradation of apolipoprotein B in Hep G2 cells.

1992 • 131 citations

Control of Initiation of Protein Synthesis in Human Cells

1973 • 129 citations

tRNA genes as transcriptional repressor elements.

1994 • 127 citations

Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases.

1992 • 127 citations

Proportion of the HeLa cell genome complementary to transfer RNA and 5 s RNA

1971 • 119 citations

Differential regulation of insulin-like growth factor I (IGF-I) and IGF binding protein-1 messenger ribonucleic acids by amino acid availability and growth hormone in rat hepatocyte primary culture.

1994 • 118 citations

Amino Acid Requirements of the Novikoff Hepatoma in vitro.

1959 • 116 citations

Reversible Inhibition by Histidinol of Protein Synthesis in Human Cells at the Activation of Histidine

1972 • 108 citations

Nutritional Biochemistry and Metabolism with Clinical Applications

1986 • 100 citations

Regulatory significance of transfer RNA charging levels I. Measurements of charging levels in livers of chow-fed rats, fasting rats, and rats fed balanced or imbalanced mixtures of amino acids

1969 • 99 citations

Modification of tRNA as a regulatory device

1993 • 95 citations

Regulation of asparagine synthetase gene expression by amino acid starvation.

1991 • 92 citations

Physiologic concentrations of glucose regulate fatty acid synthase activity in HepG2 cells by mediating fatty acid synthase mRNA stability.

1993 • 91 citations

Triiodothyronine stimulates transcription of the fatty acid synthase gene in chick embryo hepatocytes in culture. Insulin and insulin-like growth factor amplify that effect.

1990 • 90 citations

Regulation of expression of the fatty acid synthase gene in 3T3-L1 cells by differentiation and triiodothyronine.

1991 • 87 citations

Estrogens induce low-density lipoprotein receptor activity and decrease intracellular cholesterol in human hepatoma cell line Hep G2

1987 • 76 citations

Hydroxyprolinemia

1965 • 75 citations

Nutritional and Hormonal Regulation of mRNA Levels of Lipogenic Enzymes in Primary Cultures of Rat Hepatocytes1

1992 • 70 citations

Transcription and replication silencer element is present within conserved region of human Alu repeats interacting with nuclear protein

1990 • 66 citations

Regulation of formation of aminoacyl-ribonucleic acid synthetases in Escherichia coli

1967 • 63 citations

Intracellular condition of Escherichia coli transfer RNA.

1966 • 59 citations

Human fatty acid synthase mRNA: tissue distribution, genetic mapping, and kinetics of decay after glucose deprivation

1995 • 56 citations

Progestin Increases Gene Transcription and Messenger Ribonucleic Acid Stability of Fatty Acid Synthetase in Breast Cancer Cells

1989 • 45 citations

Cholesteryl ester storage disease: complex molecular effects of chronic lovastatin therapy.

1992 • 40 citations

A comparison of fasting serum amino acid profiles of young and elderly subjects.

1991 • 36 citations

Regulation of the glutamate transporter by amino acid deprivation and associated effects on the level of EAAC1 mRNA in the renal epithelial cell line NBL-I

1993 • 35 citations

The role of amino acids in ApoB100 synthesis and catabolism in human HepG2 cells.

1993 • 29 citations

Regulation of synthesis of hepatic fatty acid synthetase: polysomal translation in a cell-free system.

1975 • 26 citations

Induction of HL-60 differentiation by starvation for a single essential amino acid but not by protein synthesis inhibitors.

1987 • 20 citations

Point mutation associated with hereditary persistence of fetal hemoglobin decreases RNA polymerase III transcription upstream of the affected gamma-globin gene.

1986 • 16 citations

Effects of amino-acid composition of the medium and addition of fatty-acid derivatives on the induction of lipogenic enzymes in cultured hepatocytes

1987 • 7 citations