Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

Comparison of initiation of protein synthesis in procaryotes, eucaryotes, and organelles

1983 • 1,256 citations

Functional dissection of a eukaryotic transcriptional activator protein, GCN4 of Yeast

1986 • 946 citations

Deletion analysis of GAL4 defines two transcriptional activating segments

1987 • 898 citations

Multiple upstream AUG codons mediate translational control of GCN4

1986 • 654 citations

Separation of DNA Binding from the Transcription-Activating Function of a Eukaryotic Regulatory Protein

1986 • 626 citations

The Saccharomyces cerevisiae Cell Cycle

1981 • 539 citations

Naturally occurring poly(dA-dT) sequences are upstream promoter elements for constitutive transcription in yeast.

1985 • 526 citations

GCN4 protein, synthesize in vitro, binds HIS3 regulatory sequences: Implications for general control of amino acid biosynthetic genes in yeast

1985 • 496 citations

Promoters, activator proteins, and the mechanism of transcriptional initiation in yeast

1987 • 476 citations

Evidence for translational regulation of the activator of general amino acid control in yeast.

1984 • 472 citations

GCN4, a eukaryotic transcriptional activator protein, binds as a dimer to target DNA.

1987 • 395 citations

Selection of initiation sites by eucaryotic ribosomes: effect of inserting AUG triplets upstream from the coding sequence for preproinsulin

1984 • 390 citations

Sequence and structural features associated with translational initiator regions in yeast — a review

1987 • 381 citations

Saturation Mutagenesis of the Yeast his3 Regulatory Site: Requirements for Transcriptional Induction and for Binding by GCN4 Activator Protein

1986 • 352 citations

Each of three "TATA elements" specifies a subset of the transcription initiation sites at the CYC-1 promoter of Saccharomyces cerevisiae.

1985 • 342 citations

Repressor structure and the mechanism of positive control

1983 • 324 citations

GCN4 protein, a positive transcription factor in yeast, binds general control promoters at all 5' TGACTC 3' sequences.

1986 • 320 citations

A short nucleotide sequence required for regulation of HIS4 by the general control system of yeast

1983 • 288 citations

Positive regulation in the general amino acid control of Saccharomyces cerevisiae.

1983 • 279 citations

Homology between the DNA-binding domain of the GCN4 regulatory protein of yeast and the carboxyl-terminal region of a protein coded for by the oncogene jun.

1987 • 279 citations

Insertion of the eukaryotic transposable element Ty1 creates a 5-base pair duplication

1980 • 266 citations

The relationship between the "TATA" sequence and transcription initiation sites at the HIS4 gene of Saccharomyces cerevisiae.

1985 • 265 citations

Regulation of Amino Acid and Nucleotide Biosynthesis in Yeast

1982 • 260 citations

The DNA-binding domains of the jun oncoprotein and the yeast GCN4 transcriptional activator protein are functionally homologous

1987 • 260 citations

The leader peptide of yeast gene CPA1 is essential for the translational repression of its expression

1987 • 259 citations

5' untranslated sequences are required for the translational control of a yeast regulatory gene.

1984 • 257 citations

Integration of amino acid biosynthesis into the cell cycle of Saccharomyces cerevisiae

1975 • 252 citations

Multiple Global Regulators Control HIS4 transcription in Yeast

1987 • 246 citations

Yeast gene TRP5: structure, function, regulation.

1982 • 245 citations

A hierarchy of trans-acting factors modulates translation of an activator of amino acid biosynthetic genes in Saccharomyces cerevisiae.

1985 • 244 citations

Guanosine 5'-diphosphate 3'-diphosphate (ppGpp): positive effector for histidine operon transcription and general signal for amino-acid deficiency.

1975 • 240 citations

Initiation of translation at internal AUG codons in mammalian cells

1984 • 231 citations

Repeated DNA sequences upstream from HIS1 also occur at several other co-regulated genes in Saccharomyces cerevisiae.

1983 • 231 citations

ATTENUATION IN AMINO ACID BIOSYNTHETIC OPERONS

1982 • 218 citations

Termination-reinitiation occurs in the translation of mammalian cell mRNAs.

1986 • 213 citations

Nucleotide sequence of yeast LEU2 shows 5′-noncoding region has sequences cognate to leucine

1982 • 208 citations

Tryptophan biosynthesis in Saccharomyces cerevisiae: control of the flux through the pathway

1978 • 189 citations

Positive regulatory interactions of the HIS4 gene of Saccharomyces cerevisiae.

1984 • 166 citations

Regulatory sites for his3 gene expression in yeast

1982 • 165 citations

Yeast LEU2. Repression of mRNA levels by leucine and primary structure of the gene product.

1984 • 152 citations

Regulation of Tryptophan Biosynthesis in Saccharomyces cerevisiae : Mode of Action of 5-Methyl-Tryptophan and 5-Methyl-Tryptophan-Sensitive Mutants

1974 • 149 citations

A synthetic HIS4 regulatory element confers general amino acid control on the cytochrome c gene (CYC1) of yeast.

1985 • 144 citations

Nucleotide sequence of the yeastILV2gene which encodes acetolactate synthase

1985 • 144 citations

The Regulation of Arginine Biosynthesis in Saccharomyces cerevisiae. The Specificity of argR- Mutations and the General Control of Amino-Acid Biosynthesis

1975 • 141 citations

Regulation of glutamine-repressible gene products by the GLN3 function in Saccharomyces cerevisiae.

1984 • 139 citations

A cis-dominant regulatory mutation linked to the argB-argC gene cluster in Saccharomyces cerevisiae

1980 • 138 citations

Genetic properties and chromatin structure of the yeast gal regulatory element: an enhancer-like sequence.

1984 • 137 citations

Control of cell division in Saccharomyces cerevisiae by methionyl-tRNA.

1976 • 134 citations

Nucleotide sequence of Saccharomyces cerevisiae genes TRP2 and TRP3 encoding bifunctional anthranilate synthase: indole-3-glycerol phosphate synthase.

1984 • 127 citations

Regulation of Compartmentation of Amino Acid Pools in Saccharomyces cerevisiae and Its Effects on Metabolic Control

1980 • 123 citations

Biological role of the general control of amino acid biosynthesis in Saccharomyces cerevisiae.

1981 • 119 citations

The General Control of Amino Acid Biosynthetic Genes in the Yeast Saccharomyces Cerevisia

1986 • 112 citations

Saccharomyces cerevisiae ribosomes recognize non-AUG initiation codons.

1984 • 110 citations

The nucleotide sequence of the yeast ARG4 gene

1984 • 109 citations

Translation of insulin-related polypeptides from messenger RNAs with tandemly reiterated copies of the ribosome binding site

1983 • 105 citations

Cross-Pathway Regulation: Histidine-Mediated Control of Histidine, Tryptophan, and Arginine Biosynthetic Enzymes in Neurospora crassa

1974 • 105 citations

Identification of AAS genes and their regulatory role in general control of amino acid biosynthesis in yeast.

1983 • 101 citations

Multiple GCD genes required for repression of GCN4, a transcriptional activator of amino acid biosynthetic genes in Saccharomyces cerevisiae.

1986 • 100 citations

Cross-Pathway Regulation: Tryptophan-Mediated Control of Histidine and Arginine Biosynthetic Enzymes in Neurospora crassa

1974 • 100 citations

Affecting gene expression by altering the length and sequence of the 5' leader.

1984 • 95 citations

DNA sequences of two yeast promoter-up mutants

1983 • 92 citations

Participation of transcriptional and post-transcriptional regulatory mechanisms in the control of arginine metabolism in yeast

1983 • 90 citations

A segment of GCN4 mRNA containing the upstream AUG codons confers translational control upon a heterologous yeast transcript.

1987 • 89 citations

Structure of yeast LEU4. The 5' flanking region contains features that predict two modes of control and two productive translation starts.

1986 • 89 citations

Temporal analysis of general control of amino acid biosynthesis in Saccharomyces cerevisiae: role of positive regulatory genes in initiation and maintenance of mRNA derepression.

1984 • 85 citations

Initiation of meiosis in cell cycle initiation mutants of Saccharomyces cerevisiae

1978 • 84 citations

Effects of Guanosine Tetraphosphate, Guanosine Pentaphosphate, and β-γ Methylenyl-Guanosine Pentaphosphate on Gene Expression of Escherichia coli In Vitro

1974 • 84 citations

Leucine biosynthesis in yeast

1983 • 83 citations

Mutations in the spoT gene of Salmonella typhimurium: effects on his operon expression

1985 • 79 citations

Eukaryotic ribosomes can recognize preproinsulin initiation codons irrespective of their position relative to the 5′ end of mRNA

1982 • 76 citations

Role of an upstream regulatory element in leucine repression of the Saccharomyces cerevisiae leu2 gene

1984 • 75 citations

α-Isopropylmalate Synthase from Yeast: Purification, Kinetic Studies, and Effect of Ligands on Stability

1972 • 75 citations

Yeast LEU1. Repression of mRNA levels by leucine and relationship of 5'-noncoding region to that of LEU2.

1984 • 74 citations

TheILVSgene ofSaccharomyces cerevisiaeis highly expressed

1986 • 72 citations

Multiple cis-acting elements modulate the translational efficiency of GCN4 mRNA in yeast.

1986 • 70 citations

Nucleotide sequence of yeast gene CPA1 encoding the small subunit of arginine‐pathway carbamoyl‐phosphate synthetase

1985 • 70 citations

Regulation of HIS4-lacZ Fusions in Saccharomyces cerevisiae

1982 • 69 citations

Structure of yeast regulatory geneLEU3and evidence thatLEU3itself is under general amino acid control

1987 • 67 citations

Effects of Ty Insertions on HIS4 Transcription in Saccharomyces cerevisiae

1984 • 65 citations

Biosynthesis of Branched-Chain Amino Acids in Yeast: Regulation of Leucine Biosynthesis in Prototrophic and Leucine Auxotrophic Strains

1968 • 65 citations

Methionine-Mediated Repression in Saccharomyces cerevisiae: a Pleiotropic Regulatory System Involving Methionyl Transfer Ribonucleic Acid and the Product of Gene eth2

1971 • 63 citations

Structure of the yeast HIS5 gene responsive to general control of amino acid biosynthesis

1987 • 62 citations

Regulation of the carbamoylphosphate synthetase belonging to the arginine biosynthetic pathway of Saccharomyces cerevisiae

1972 • 61 citations

Analysis of temperature-sensitive mutant ts 187 of Saccharomyces cerevisiae altered in a component required for the initiation of protein synthesis.

1982 • 60 citations

Promoter domain mediates guanosine tetraphosphate activation of the histidine operon.

1986 • 60 citations

Mutants affecting amino acid cross-pathway control inNeurospora crassa

1982 • 58 citations

Mutations Altering Initiation of Translation of Yeast Iso-1-cytochrome c ; Contrasts between the Eukaryotic and Prokaryotic Initiation Process

1982 • 54 citations

Role of Transfer Ribonucleic Acids in the Regulation of Several Biosyntheses in Saccharomyces cerevisiae

1976 • 54 citations

Structure and expression of two aminoacyl-tRNA synthetase genes from Saccharomyces cerevisiae.

1983 • 53 citations

Promoter- and attenuator-related metabolic regulation of the Salmonella typhimurium histidine operon

1978 • 52 citations

Cross-pathway Regulation of Ornithine Carbamoyltransferase Synthesis in Aspergillus nidulans

1980 • 52 citations

Absence of involvement of glutamine synthetase and of NAD-linked glutamate dehydrogenase in the nitrogen catabolite repression of arginase and other enzymes in Saccharomyces cerevisiae

1974 • 52 citations

General amino acid control and specific arginine repression in Saccharomyces cerevisiae: physical study of the bifunctional regulatory region of the ARG3 gene.

1985 • 48 citations

Thermolability of the stringent factor in rel mutants of Escherichia coli

1973 • 48 citations

Cloning of the ARO3 gene of Saccharomyces cerevisiae and its regulation

1986 • 47 citations

Concerted repression of the synthesis of the arginine biosynthetic enzymes by aminoacids: A comparison between the regulatory mechanisms controlling aminoacid biosyntheses in bacteria and in yeast

1979 • 47 citations

Identification and characterization of four new GCD genes in Saccharomyces cerevisiae

1986 • 45 citations

Three Regulatory Systems Control Production of Glutamine Synthetase in Saccharomyces cerevisiae

1984 • 45 citations

TheTRP4gene ofSaccharomyces cerevisiae: isolation and structural analysis

1986 • 43 citations

Cellular Regulation of Guanosine Tetraphosphate and Guanosine Pentaphosphate

1974 • 42 citations

Evidence that alpha-isopropylmalate synthase of Saccharomyces cerevisiae is under the "general" control of amino acid biosynthesis

1982 • 41 citations

Interactions Between Positive and Negative Regulators of GCN4 Controlling Gene Expression and Entry Into the Yeast Cell Cycle

1987 • 41 citations

Control-mechanisms acting at the transcriptional and post-transcriptional levels are involved in the synthesis of the arginine pathway carbamoylphosphate synthase of yeast.

1983 • 40 citations

GENETICS OF ARGININE BIOSYNTHESIS IN NEUROSPORA CRASSA

1979 • 40 citations

Constitutive and Coordinately Regulated Transcription of Yeast Genes: Promoter Elements, Positive and Negative Regulatory Sites, and DNA Binding Proteins

1985 • 39 citations

Free tryptophan pool and tryptophan biosynthetic enzymes in Saccharomyces cerevisiae

1976 • 38 citations

Two related regulatory sequences are required for maximal induction of Saccharomyces cerevisiae his3 transcription.

1987 • 37 citations

Structure and function of the TRP3 gene of Saccharomyces cerevisiae: Analysis of transcription, promoter sequence, and sequence coding for a glutamine amidotransferase

1984 • 36 citations

Nucleotide sequence of the gene for threonine deaminase (ILV1) of Saccharomyces cerevisiae

1984 • 35 citations

Mutation affecting the specific regulatory control of lysine biosynthetic enzymes in Saccharomyces cerevisiae

1985 • 32 citations

Regulation of activity and synthesis of N-acetylglutamate synthase from Saccharomyces cerevisiae

1979 • 31 citations

Cloning of the arg-12 gene of Neurospora crassa and regulation of its transcript via cross-pathway amino acid control

1986 • 27 citations

Cloning, Disruption and Chromosomal Mapping of Yeast LEU3, a Putative Regulatory Gene

1987 • 27 citations

Dual regulation of the synthesis of the arginine pathway carbamoylphosphate synthase of Saccharomyces cerevisiae by specific and general controls of amino acid biosynthesis

1979 • 26 citations

Influence of the General Control of Amino Acid Biosynthesis on Cell Growth and Cell Viability in Saccharomyces cerevisiae

1983 • 25 citations

Changes in gene expression elicited by amino acid limitation in Neurospora crassa strains having normal or mutant cross-pathway amino acid control

1985 • 21 citations

New Positive and Negative Regulators for General Control of Amino Acid Biosynthesis in Saccharomyces cerevisiae

1986 • 18 citations

Expression of an artificial yeast TRP-gene cluster in yeast and Escherichia coli

1984 • 15 citations

Deletion mapping the yeast TRP5 control region.

1985 • 12 citations

Roles of the TGACT repeat sequence in the yeast TRP5 promoter.

1987 • 11 citations

A rapid method for determining tRNA charging levelsin vivo;analysis of yeast mutants defective in the general control of amino acid biosynthesis

1986 • 10 citations

Cross-pathway Control of Ornithine Carbamoyltransferase Synthesis in Neurospora crassa

1982 • 8 citations

Negative regulatory gene for general control of amino acid biosynthesis in Saccharomyces cerevisiae.

1986 • 7 citations