Branched-chain Amino Acids Are Essential in the Regulation of PHAS-I and p70 S6 Kinase by Pancreatic β-Cells

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

4E-BP1, a repressor of mRNA translation, is phosphorylated and inactivated by the Akt(PKB) signaling pathway

1998 • 872 citations

Leucine. A possible regulator of protein turnover in muscle.

1975 • 746 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

1996 • 713 citations

Stimulation of insulin secretion by amino acids.

1966 • 707 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

Continuous, clonal, insulin- and somatostatin-secreting cell lines established from a transplantable rat islet cell tumor.

1980 • 496 citations

Bidirectional modulation of insulin action by amino acids.

1998 • 491 citations

Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway

1998 • 487 citations

Insulin Signal Transduction and the IRS Proteins

1996 • 323 citations

Influence of amino acid availability on protein turnover in perfused skeletal muscle

1978 • 277 citations

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70^s6k

1997 • 228 citations

Pancreatic Beta-cell growth and diabetes mellitus

1992 • 206 citations

PHAS/4E-BPs as regulators of mRNA translation and cell proliferation

1997 • 199 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Targeted disruption of p70^s6kdefines its role in protein synthesis and rapamycin sensitivity

1998 • 178 citations

Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.

1994 • 165 citations

The Mammalian Target of Rapamycin Phosphorylates Sites Having a (Ser/Thr)-Pro Motif and Is Activated by Antibodies to a Region near Its COOH Terminus

1997 • 165 citations

Interleukin-1 beta-induced nitric oxide synthase expression by rat pancreatic beta-cells: evidence for the involvement of nuclear factor kappa B in the signaling mechanism.

1995 • 161 citations

Thrombin Stimulates Phosphorylation of Insulin-like Growth Factor-1 Receptor, Insulin Receptor Substrate-1, and Phospholipase C-γ1 in Rat Aortic Smooth Muscle Cells

1995 • 143 citations

Effects of branched‐chain amino acids on protein turnover

1989 • 132 citations

[16] A subcellular fractionation approach for studying insulin release mechanisms and calcium metabolism in islets of langerhans

1983 • 129 citations

Requirement of Protein Kinase Cζ for Stimulation of Protein Synthesis by Insulin

1997 • 127 citations

Effects of glucose and other modifiers of insulin release on the oxidative metabolism of amino acids in micro-dissected pancreatic islets

1971 • 113 citations

Insulin Mediates Glucose-stimulated Phosphorylation of PHAS-I by Pancreatic Beta Cells

1998 • 106 citations

Overexpression and Characterization of the Human Mitochondrial and Cytosolic Branched-chain Aminotransferases

1998 • 105 citations

Cooling inhibits exocytosis in single mouse pancreatic B‐cells by suppression of granule mobilization.

1996 • 102 citations

Insulin, Glucagon, and Somatostatin Receptors on Cultured Cells and Clones from Rat Islet Cell Tumor

1982 • 82 citations

Creation and characterization of a mitochondrial DNA-depleted pancreatic beta-cell line: impaired insulin secretion induced by glucose, leucine, and sulfonylureas.

1998 • 82 citations

Tyrosine kinase involvement in IL-1 beta-induced expression of iNOS by beta-cells purified from islets of Langerhans

1994 • 71 citations

Synergistic Effect of Alanine and Glycine on Bovine Embryos Cultured in a Chemically Defined Medium and Amino Acid Uptake by in Vitro-Produced Bovine Morulae and Blastocysts

1996 • 70 citations

Target of rapamycin proteins and their kinase activities are required for meiosis

1997 • 63 citations

Glucose-stimulated DNA Replication of the Pancreatic Islets During the Development of the Rat Fetus: Effects of Nutrients, Growth Hormone, and Triiodothyronine

1985 • 59 citations

Uptake of Alanine, Arginine, and Leucine by Mammalian Pancreatic β-Cells

1971 • 57 citations

STIMULATION OF INSULIN SECRETION IN VITRO BY ESSENTIAL AMINOACIDS

1969 • 38 citations

Neutral amino acid transport in isolated rat pancreatic islets.

1983 • 33 citations

Effect of low temperatures on glucose-induced insulin secretion and ionic fluxes in rat pancreatic islets

1987 • 22 citations

Intracellular signalling pathways regulating initiation factor elF4E phosphorylation during the activation of cell growth

1997 • 21 citations

Insulin-like growth factor-I-induced DNA synthesis in insulin-secreting cell line RINm5F is associated with phosphorylation of the insulin-like growth factor-I receptor and the insulin receptor substrate-2

1998 • 16 citations