Amino Acid-dependent Control of p70s6k

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

Amino Acid Sufficiency and mTOR Regulate p70 S6 Kinase and eIF-4E BP1 through a Common Effector Mechanism

1998 • 1,319 citations

Tor, a Phosphatidylinositol Kinase Homologue, Controls Autophagy in Yeast

1998 • 1,271 citations

RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1

1998 • 1,136 citations

Role of amino acid transport and countertransport in nutrition and metabolism.

1990 • 1,101 citations

Phosphatidylinositol 3-Kinase Activation Is Required for Insulin Stimulation of pp70 S6 Kinase, DNA Synthesis, and Glucose Transporter Translocation

1994 • 1,020 citations

Phosphorylation of the Translational Repressor PHAS-I by the Mammalian Target of Rapamycin

1997 • 953 citations

Rapamycin suppresses 5'TOP mRNA translation through inhibition of p70s6k

1997 • 930 citations

Phosphorylation and Activation of p70 ^s6k by PDK1

1998 • 835 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

TOR controls translation initiation and early G1 progression in yeast.

1996 • 728 citations

PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase

1994 • 728 citations

Control of p70 S6 kinase by kinase activity of FRAP in vivo

1995 • 717 citations

Inhibitors of Ribosome Functions

1971 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Phosphorylation of Ribosomal Protein S6 Is Inhibitory for Autophagy in Isolated Rat Hepatocytes

1995 • 654 citations

IMMUNOPHARMACOLOGY OF RAPAMYCIN

1996 • 651 citations

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

1998 • 579 citations

Regulation of eIF-4E BP1 Phosphorylation by mTOR

1997 • 511 citations

Synthesis of Guanosine Tetra- and Pentaphosphate Requires the Presence of a Codon-Specific, Uncharged Transfer Ribonucleic Acid in the Acceptor Site of Ribosomes

1973 • 466 citations

The Histidyl-tRNA Synthetase-Related Sequence in the eIF-2α Protein Kinase GCN2 Interacts with tRNA and Is Required for Activation in Response to Starvation for Different Amino Acids

1995 • 455 citations

Mechanisms of gene regulation in the general control of amino acid biosynthesis in Saccharomyces cerevisiae

1988 • 449 citations

A Signaling Pathway to Translational Control

1996 • 370 citations

A specific chromosomal abnormality in rhabdomyosarcoma

1987 • 326 citations

Juxtaposition of domains homologous to protein kinases and histidyl-tRNA synthetases in GCN2 protein suggests a mechanism for coupling GCN4 expression to amino acid availability.

1989 • 278 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

The Insulin-Induced Signalling Pathway Leading to S6 and Initiation Factor 4E Binding Protein 1 Phosphorylation Bifurcates at a Rapamycin-Sensitive Point Immediately Upstream of p70^s6k

1997 • 228 citations

ATTENUATION IN AMINO ACID BIOSYNTHETIC OPERONS

1982 • 218 citations

Phosphatidylinositol 3-kinase signals activation of p70 S6 kinase in situ through site-specific p70 phosphorylation.

1995 • 208 citations

Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase.

1990 • 194 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Targeted disruption of p70^s6kdefines its role in protein synthesis and rapamycin sensitivity

1998 • 178 citations

elF-2 kinases: regulators of general and gene-specific translation initiation

1994 • 140 citations

Amino acids stimulate phosphorylation of p70 ^S6k and organization of rat adipocytes into multicellular clusters

1998 • 130 citations

EGF induces biphasic S6 kinase activation: Late phase is protein kinase C-dependent and contributes to mitogenicity

1989 • 122 citations

A single gene encodes two isoforms of the p70 S6 kinase: activation upon mitogenic stimulation.

1992 • 119 citations

Reversible Inhibition by Histidinol of Protein Synthesis in Human Cells at the Activation of Histidine

1972 • 108 citations

Amino acid‐regulated gene expression in eukaryotic cells

1994 • 98 citations

Failure of rapamycin to block proliferation once resting cells have entered the cell cycle despite inactivation of p70 S6 kinase

1993 • 82 citations

Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum.

1993 • 79 citations

Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells

1992 • 64 citations

Evidence for structural gene alterations affecting aminoacyl-tRNA synthetases in CHO cell mutants and revertants

1978 • 32 citations

Biosynthesis of mammalian transfer RNA. Evidence for regulation by deacylated transfer RNA

1976 • 16 citations

A hamster temperature‐sensitive G1 mutant, tsBN250 has a single point mutation in histidyl‐tRNA synthetase that inhibits an accumulation of cyclin D1

1996 • 16 citations

Vesnarinone inhibits nucleoside and nucleobase transport

1995 • 12 citations

A single point mutation of hamster aminoacyl‐tRNA synthetase causes apoptosis by deprivation of cognate amino acid residue

1996 • 10 citations

Overexpression of wild type p70 S6 kinase interferes with cytokinesis

1997 • 9 citations