Initiation of Protein Synthesis in Eukaryotic Cells

The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14

1993 • 12,238 citations

Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans

1993 • 4,021 citations

The scanning model for translation: an update.

1989 • 3,525 citations

Internal initiation of translation of eukaryotic mRNA directed by a sequence derived from poliovirus RNA

1988 • 1,884 citations

Structural features in eukaryotic mRNAs that modulate the initiation of translation.

1991 • 1,849 citations

An analysis of vertebrate mRNA sequences: intimations of translational control.

1991 • 1,655 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

The cap and poly(A) tail function synergistically to regulate mRNA translational efficiency.

1991 • 795 citations

Initiation of Protein Synthesis by the Eukaryotic Translational Apparatus on Circular RNAs

1995 • 690 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 • 662 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

1990 • 632 citations

Ornithine decarboxylase activity is critical for cell transformation

1992 • 630 citations

Circumstances and mechanisms of inhibition of translation by secondary structure in eucaryotic mRNAs.

1989 • 618 citations

Do the poly(A) tail and 3′ untranslated region control mRNA translation?

1990 • 618 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

Mechanism and regulation of eukaryotic protein synthesis

1992 • 591 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

The poly(A) binding protein is required for poly(A) shortening and 60S ribosomal subunit-dependent translation initiation

1989 • 561 citations

Internal initiation of translation mediated by the 5′ leader of a cellular mRNA

1991 • 554 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

1995 • 541 citations

The intracellular localization of messenger RNAs

1995 • 534 citations

Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.

1987 • 494 citations

La autoantigen enhances and corrects aberrant translation of poliovirus RNA in reticulocyte lysate

1993 • 485 citations

Regulation of Translation in Eukaryotic Systems

1992 • 467 citations

Translational control

1991 • 464 citations

The Histidyl-tRNA Synthetase-Related Sequence in the eIF-2α Protein Kinase GCN2 Interacts with tRNA and Is Required for Activation in Response to Starvation for Different Amino Acids

1995 • 455 citations

Translational regulation of oskar mRNA by Bruno, an ovarian RNA-binding protein, is essential

1995 • 451 citations

CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation

1994 • 451 citations

A developmentally regulated activity that unwinds RNA duplexes

1987 • 439 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

Staufen protein associates with the 3′UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner

1994 • 435 citations

Binding of pumilio to maternal hunchback mRNA is required for posterior patterning in drosophila embryos

1995 • 419 citations

mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E.

1992 • 414 citations

Poly(A) elongation during Xenopus oocyte maturation is required for translational recruitment and is mediated by a short sequence element.

1989 • 412 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

Translational regulation in development

1995 • 394 citations

Cytoplasmic regulation of mRNA function: The importance of the 3′ untranslated region

1993 • 391 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

1994 • 384 citations

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

1993 • 383 citations

Sequence and structural features associated with translational initiator regions in yeast — a review

1987 • 381 citations

The novel mechanism of initiation of picornavirus RNA translation

1990 • 368 citations

Initiation of protein synthesis in mammalian cells

1986 • 359 citations

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

1994 • 358 citations

mRNA poly(A) tail, a 3' enhancer of translational initiation.

1990 • 353 citations

Alternative Translation of Human Fibroblast Growth Factor 2 mRNA Occurs by Internal Entry of Ribosomes

1995 • 332 citations

Poly(A) addition during maturation of frog oocytes: distinct nuclear and cytoplasmic activities and regulation by the sequence UUUUUAU.

1989 • 332 citations

The 3'-untranslated regions of c-mos and cyclin mRNAs stimulate translation by regulating cytoplasmic polyadenylation.

1994 • 330 citations

Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220

1987 • 329 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex

1988 • 319 citations

RNA on the move: the mRNA localization pathway [published erratum appears in J Cell Biol 1993 Dec;123(6 Pt 1):1625]

1993 • 315 citations

Translational regulation of nanos by RNA localization

1994 • 307 citations

Protein Phosphorylation Controls Translation Rates

1989 • 303 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Regulation of protein synthesis by heme-regulated eIF-2α kinase

1995 • 297 citations

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1995 • 288 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.

1995 • 283 citations

Mutations at a Zn(II) finger motif in the yeast elF-2β gene alter ribosomal start-site selection during the scanning process

1988 • 283 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase

1995 • 277 citations

Cap-dependent and cap-independent translation by internal initiation of mRNAs in cell extracts prepared from Saccharomyces cerevisiae.

1994 • 274 citations

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

1994 • 273 citations

Elevated Levels of Cyclin D1 Protein in Response to Increased Expression of Eukaryotic Initiation Factor 4E

1993 • 270 citations

Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus.

1993 • 268 citations

Eukaryotic Translation Initiation Factor 4E Regulates Expression of Cyclin D1 at Transcriptional and Post-transcriptional Levels

1995 • 268 citations

Translation of 15-lipoxygenase mRNA is inhibited by a protein that binds to a repeated sequence in the 3′ untranslated region.

1994 • 267 citations

Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity.

1994 • 262 citations

Increased expression of eukaryotic translation initiation factors eIF-4E and eIF-2 alpha in response to growth induction by c-myc.

1993 • 246 citations

Translational control by cytoplasmic polyadenylation of c-mos mRNA is necessary for oocyte maturation in the mouse.

1994 • 243 citations

Diversity of cytoplasmic functions for the 3′ untranslated region of eukaryotic transcripts

1995 • 241 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

Transient translational silencing by reversible mRNA deadenylation

1992 • 239 citations

Coordinate Initiation of Drosophila Development by Regulated Polyadenylation of Maternal Messenger RNAs

1994 • 236 citations

Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation

1995 • 232 citations

Translational control of maternal glp-1 mRNA establishes an asymmetry in the C. elegans embryo

1994 • 231 citations

The effect of capping and polyadenylation on the stability, movement and translation of synthetic messenger RNAs inXenopusoocytes

1985 • 231 citations

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

1995 • 226 citations

PKR: a new name and new roles

1995 • 223 citations

Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras

1994 • 217 citations

Homeotic gene Antennapedia mRNA contains 5'-noncoding sequences that confer translational initiation by internal ribosome binding.

1992 • 215 citations

Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209

1995 • 210 citations

Translation In Eukaryotes

1991 • 209 citations

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.

1995 • 209 citations

Initiation codons within 5′-leaders of mRNAs as regulators of translation

1994 • 207 citations

The Mechanisms of mRNA Degradation in Eukaryotes

1999 • 204 citations

Sequence analysis of cytoplasmic mRNA-binding proteins of Xenopus oocytes identifies a family of RNA-binding proteins.

1992 • 204 citations

Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.

1994 • 202 citations

Translational Regulation of Gene Expression 2

1993 • 202 citations

Immunological detection of the messenger RNA cap-binding protein.

1985 • 201 citations

Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

1989 • 201 citations

A role for transcription and FRGY2 in masking maternal mRNA within Xenopus oocytes

1994 • 198 citations

A fraction of the mRNA 5' cap-binding protein, eukaryotic initiation factor 4E, localizes to the nucleus.

1992 • 198 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

Interaction between mRNA, ribosomes and the cytoskeleton

1991 • 196 citations

Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma

1994 • 191 citations

Translational regulation of tra-2 by its 3′ untranslated region controls sexual identity in C. elegans

1993 • 191 citations

Posttranscriptional Regulation of Gene Expression in Plants

1993 • 190 citations

Pestivirus translation initiation occurs by internal ribosome entry

1995 • 189 citations

Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E.

1993 • 186 citations

The proto‐oncogene/translation factor eIF4E: A survey of its expression in breast carcinomas

1995 • 180 citations

Purification of two picornaviral 2A proteinases: Interaction with eIF-4.gamma. and influence on the in vitro translation

1993 • 180 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Efficiency of reinitiation of translation on human immunodeficiency virus type 1 mRNAs is determined by the length of the upstream open reading frame and by intercistronic distance

1995 • 178 citations

Identification of an RNA binding site for human thymidylate synthase.

1993 • 178 citations

A maternal tail of poly(a): The long and the short of it

1992 • 177 citations

Regulation of the interferon-induced PKR: can viruses cope?

1995 • 176 citations

GCN20, a novel ATP binding cassette protein, and GCN1 reside in a complex that mediates activation of the eIF-2 alpha kinase GCN2 in amino acid-starved cells.

1995 • 175 citations

The Major Protein of Messenger Ribonucleoprotein Particles in Somatic Cells Is a Member of the Y-box Binding Transcription Factor Family

1995 • 175 citations

mRNA translation: influence of the 5′ and 3′ untranslated regions

1994 • 173 citations

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.

1992 • 172 citations

Tales of poly(A): a review

1990 • 171 citations

Influenza virus NS1 protein enhances the rate of translation initiation of viral mRNAs

1995 • 169 citations

Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E

1991 • 168 citations

Translational control by cytoplasmic polyadenylation during Xenopus oocyte maturation: characterization of cis and trans elements and regulation by cyclin/MPF.

1990 • 165 citations

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.

1995 • 165 citations

The cytoskeleton and mRNA localization

1992 • 157 citations

Translational control by poly(A) elongation during Xenopus development: differential repression and enhancement by a novel cytoplasmic polyadenylation element.

1992 • 156 citations

Changes in the polysome content of developing Xenopus laevis embryos

1974 • 154 citations

Deadenylation of maternal mRNAs during Xenopus oocyte maturation does not require specific cis-sequences: a default mechanism for translational control.

1990 • 152 citations

Expression of Antisense RNA against Initiation Factor eIF-4E mRNA in HeLa Cells Results in Lengthened Cell Division Times, Diminished Translation Rates, and Reduced Levels of Both eIF-4E and the p220 Component of eIF-4F

1991 • 151 citations

Cytoplasmic mRNA-protein interactions in eukaryotic gene expression

1995 • 150 citations

Serine 209, Not Serine 53, Is the Major Site of Phosphorylation in Initiation Factor eIF-4E in Serum-treated Chinese Hamster Ovary Cells

1995 • 149 citations

Internal translation initiation on poliovirus RNA: further characterization of La function in poliovirus translation in vitro

1994 • 147 citations

Relationship of p220 cleavage during picornavirus infection to 2A proteinase sequencing

1988 • 146 citations

Gene‐specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2

1993 • 146 citations

Ras mediates translation initiation factor 4E-induced malignant transformation.

1992 • 146 citations

Maturation-specific polyadenylation and translational control: diversity of cytoplasmic polyadenylation elements, influence of poly(A) tail size, and formation of stable polyadenylation complexes.

1990 • 144 citations

Maturation-specific polyadenylation: in vitro activation by p34cdc2 and phosphorylation of a 58-kD CPE-binding protein.

1991 • 144 citations

La autoantigen alleviates translational repression by the 5' leader sequence of the human immunodeficiency virus type 1 mRNA

1994 • 143 citations

Translational control during heat shock

1994 • 142 citations

An internal ribosomal entry mechanism promotes translation of murine leukemia virus gag polyprotein precursors

1995 • 140 citations

elF-2 kinases: regulators of general and gene-specific translation initiation

1994 • 140 citations

Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma

1992 • 139 citations

Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation

1995 • 139 citations

Masking mRNA from translation in somatic cells.

1993 • 138 citations

A Consideration of Alternative Models for the Initiation of Translation in Eukaryotes

1992 • 137 citations

Inhibition of translational initiation in the yeast Saccharomyces cerevisiae as a function of the stability and position of hairpin structures in the mRNA leader.

1993 • 136 citations

Proteins Binding to 5′ Untranslated Region Sites: a General Mechanism for Translational Regulation of mRNAs in Human and Yeast Cells

1994 • 136 citations

Translational regulation by mRNA/protein interactions in eukaryotic cells: Ferritin and beyond

1993 • 134 citations

The involvement of a spliceosome component in internal initiation of human rhinovirus RNA translation

1993 • 134 citations

Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis

1995 • 134 citations

Cap recap: The involvement of eIF-4F in regulating gene expression

1992 • 134 citations

Translational enhancement of the poliovirus 5' noncoding region mediated by virus-encoded polypeptide 2A.

1992 • 134 citations

Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.

1990 • 133 citations

Cell biology of viruses that assemble along the biosynthetic pathway

1992 • 132 citations

A Saccharomyces cerevisiae homologue of mammalian translation initiation factor 4B contributes to RNA helicase activity.

1993 • 129 citations

The cellular polypeptide p57 (pyrimidine tract-binding protein) binds to multiple sites in the poliovirus 5' nontranslated region

1994 • 129 citations

Translation factors as effectors of cell growth and tumorigenesis

1993 • 128 citations

Poly(A) removal during oocyte maturation: a default reaction selectively prevented by specific sequences in the 3' UTR of certain maternal mRNAs.

1990 • 128 citations

Iron-responsive element-binding protein. Phosphorylation by protein kinase C.

1993 • 128 citations

Translation of encephalomyocarditis virus RNA: parameters influencing the selection of the internal initiation site.

1994 • 126 citations

Activation of the Double-stranded RNA-regulated Protein Kinase by Depletion of Endoplasmic Reticular Calcium Stores

1995 • 126 citations

Effects of long 5' leader sequences on initiation by eukaryotic ribosomes in vitro.

1991 • 126 citations

Does Mitogen-Activated-Protein Kinase have a Role in Insulin Action?. The Cases for and Against

1995 • 125 citations

Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.

1990 • 125 citations

Nuclear polyadenylation factors recognize cytoplasmic polyadenylation elements.

1994 • 125 citations

Determinants of translational fidelity and efficiency in vertebrate mRNAs

1994 • 124 citations

Structure of the β subunit of translational initiation factor elF-2

1988 • 122 citations

The 58-kilodalton inhibitor of the interferon-induced double-stranded RNA-activated protein kinase is a tetratricopeptide repeat protein with oncogenic properties.

1994 • 122 citations

Ceramide As a Modulator of Endocytosis

1995 • 121 citations

Regulation of translation and cell growth by eIF-4E

1994 • 121 citations

Selective recruitment of masked maternal mRNA from messenger ribonucleoprotein particles containing FRGY2 (mRNP4).

1993 • 121 citations

Simultaneous cytoplasmic redistribution of ribosomal protein L32 mRNA and phosphorylation of eukaryotic initiation factor 4E after mitogenic stimulation of Swiss 3T3 cells.

1990 • 120 citations

Discrete sequence elements control posterior pole accumulation and translational repression of maternal cyclin B RNA in Drosophila.

1993 • 118 citations

Elongation factor-1 alpha mRNA is selectively translated following mitogenic stimulation.

1994 • 117 citations

Cell-specific translational regulation of S-adenosylmethionine decarboxylase mRNA. Dependence on translation and coding capacity of the cis-acting upstream open reading frame.

1993 • 117 citations

Regulation of protein synthesis by mRNA structure

1994 • 117 citations

Structural Requirements for Double-Stranded RNA Binding, Dimerization, and Activation of the Human eIF-2α Kinase DAI in Saccharomyces cerevisiae

1995 • 116 citations

Effect of sequence context at stop codons on efficiency of reinitiation in GCN4 translational control

1994 • 115 citations

Proteolysis of the p220 component of the cap-binding protein complex is not sufficient for complete inhibition of host cell protein synthesis after poliovirus infection

1987 • 114 citations

A Mammalian Translation Initiation Factor Can Substitute for Its Yeast Homologue in Vivo

1989 • 114 citations

Autoregulation of poly(A)-binding protein synthesisin vitro

1995 • 113 citations

Alternative Translation Initiation of the Moloney Murine Leukemia Virus mRNA Controlled by Internal Ribosome Entry Involving the p57/PTB Splicing Factor

1995 • 113 citations

Dual initiation sites of protein synthesis on foot-and-mouth disease virus RNA are selected following internal entry and scanning of ribosomes in vivo.

1992 • 110 citations

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E.

1990 • 110 citations

Regulation of translation by specific protein/mRNA interactions

1994 • 110 citations

The adenovirus tripartite leader may eliminate the requirement for cap-binding protein complex during translation initiation

1988 • 109 citations

The Translation Initiation Factor eIF-4B Contains an RNA-Binding Region That Is Distinct and Independent from its Ribonucleoprotein Consensus Sequence

1994 • 108 citations

Does Mitogen‐Activated‐Protein Kinase have a Role in Insulin Action?

1995 • 107 citations

Requirements for intercistronic distance and level of eukaryotic initiation factor 2 activity in reinitiation on GCN4 mRNA vary with the downstream cistron.

1994 • 105 citations

The War Against the Interferon-induced dsRNA-Activated Protein Kinase: Can Viruses Win?

1992 • 105 citations

Proteins binding to 5' untranslated region sites: a general mechanism for translational regulation of mRNAs in human and yeast cells.

1994 • 104 citations

Truncated protein phosphatase GLC7 restores translational activation of GCN4 expression in yeast mutants defective for the eIF-2 alpha kinase GCN2.

1992 • 104 citations

Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region.

1985 • 104 citations

A new yeast translation initiation factor suppresses a mutation in the eIF-4A RNA helicase.

1993 • 103 citations

The Saccharomyces cerevisiae translation initiation factor Tif3 and its mammalian homologue, eIF-4B, have RNA annealing activity.

1995 • 102 citations

Purified yeast translational initiation factor eIF-3 is an RNA-binding protein complex that contains the PRT1 protein.

1994 • 102 citations

Poly(A) binds to initiation factors and increases cap-dependent translation in vitro.

1994 • 101 citations

Molecular mechanisms in the control of translation by hormones and growth factors

1994 • 101 citations

The guanine nucleotide-exchange factor, eIF-2B

1994 • 101 citations

The immediate downstream codon strongly influences the efficiency of utilization of eukaryotic translation initiation codons.

1994 • 101 citations

Two Functionally Distinct RNA-Binding Motifs in the Regulatory Domain of the Protein Kinase DAI

1995 • 99 citations

Internal initiation of translation of picornavirus RNAs

1994 • 98 citations

Analysis of 40 S and 80 S complexes with mRNA as measured by sucrose density gradients and primer extension inhibition.

1992 • 96 citations

Poly (A) polymerases in the nucleus and cytoplasm of frog oocytes: dynamic changes during oocyte maturation and early development.

1995 • 95 citations

Modification of eukaryotic initiation factor 4F during infection by influenza virus

1993 • 94 citations

Further analysis of cytoplasmic polyadenylation in Xenopus embryos and identification of embryonic cytoplasmic polyadenylation element-binding proteins.

1994 • 94 citations

Translation and the cytoskeleton: a mechanism for targeted protein synthesis

1994 • 93 citations

Proteolytic cleavage of initiation factor elF-4γ in the reticulocyte lysate inhibits translation of capped mRNAs but enhances that of uncapped mRNAs

1995 • 91 citations

Eukaryotic initiation factor (eIF)-4F. Implications for a role in internal initiation of translation

1991 • 91 citations

Features in the 5′ non-coding sequences of rabbit α and β-globin mRNAs that affect translational efficiency

1994 • 91 citations

Intron-less RNA injected into the nucleus of Xenopus oocytes accesses a regulated translation control pathway

1994 • 90 citations

Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.

1993 • 90 citations

Translation by the adenovirus tripartite leader: elements which determine independence from cap-binding protein complex

1990 • 88 citations

mRNP4, a major mRNA-binding protein from Xenopus oocytes is identical to transcription factor FRG Y2.

1992 • 88 citations

Positions +5 and +6 can be major determinants of the efficiency of non-AUG initiation codons for protein synthesis.

1994 • 88 citations

Evidence that GCD6 and GCD7, Translational Regulators of GCN4, Are Subunits of the Guanine Nucleotide Exchange Factor for eIF-2 in Saccharomyces cerevisiae

1993 • 88 citations

Phosphorylatlon of a 60 kDa polypeptide fromXenopusoocytes blocks messenger RNA translation

1987 • 87 citations

Heat shock impairs the interaction of cap-binding protein complex with 5' mRNA cap.

1991 • 87 citations

Isolation and sequence of the cDNAs encoding the subunits of the isozyme form of wheat protein synthesis initiation factor 4F

1992 • 87 citations

Mobilization of specific maternal RNA species into polysomes after fertilization in Xenopus laevis.

1985 • 86 citations

Polyribosome targeting to microtubules: enrichment of specific mRNAs in a reconstituted microtubule preparation from sea urchin embryos.

1994 • 85 citations

Selective Translation and Degradation of Heat-Shock Messenger RNAs in Drosophila

1990 • 85 citations

GCD11, a Negative Regulator of GCN4 Expression, Encodes the γ Subunit of eIF-2 in Saccharomyces cerevisiae

1993 • 84 citations

The poly(A)‐binding protein facilitates in vitro translation of poly(A)‐rich mRNA

1988 • 84 citations

Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation.

1991 • 83 citations

Interleukin 3 stimulates protein synthesis by regulating double-stranded RNA-dependent protein kinase.

1994 • 83 citations

Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin

1995 • 82 citations

Translational Repressor Activity Is Equivalent and Is Quantitatively Predicted by in Vitro RNA Binding for Two Iron-responsive Element-binding Proteins, IRP1 and IRP2

1995 • 82 citations

The role of the dsRNA-activated kinase, PKR, in signal transduction

1995 • 82 citations

Cowpea mosaic virus middle component RNA contains a sequence that allows internal binding of ribosomes and that requires eukaryotic initiation factor 4F for optimal translation

1991 • 82 citations

Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR

1995 • 81 citations

Translational control by influenza virus. Selective translation is mediated by sequences within the viral mRNA 5'-untranslated region.

1993 • 81 citations

Initiation factor eIF-4E of Saccharomyces cerevisiae. Distribution within the cell, binding to mRNA, and consequences of its overproduction.

1994 • 80 citations

Functional analysis of the two alternative translation initiation sites of foot-and-mouth disease virus

1995 • 80 citations

Molecular Mechanisms Responsible for Malignant Transformation by Regulatory and Catalytic Domain Variants of the Interferon-induced Enzyme RNA-dependent Protein Kinase

1995 • 79 citations

Cap-Dependent and Cap-Independent Translation: Operational Distinctions and Mechanistic Interpretations

1995 • 79 citations

Mitogenesis and protein synthesis: A role for ribosomal protein S6 phosphorylation?

1994 • 78 citations

The iron-responsive element binding protein: a target for synaptic actions of nitric oxide.

1994 • 78 citations

Participation of initiation factors in the recruitment of mRNA to ribosomes

1994 • 75 citations

cis-acting translational effects of the 5' noncoding region of c-myc mRNA.

1988 • 75 citations

Poly(A) and translation: development control

1993 • 75 citations

Preferential translation of heat shock mRNAs in HeLa cells deficient in protein synthesis initiation factors eIF-4E and eIF-4 gamma.

1992 • 74 citations

Erythroid expression of the heme-regulated eIF-2 alpha kinase.

1994 • 73 citations

GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.

1995 • 73 citations

Two structural domains of initiation factor eIF-4B are involved in binding to RNA.

1994 • 73 citations

Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression.

1994 • 72 citations

Independent Signaling of grp78 Gene Transcription and Phosphorylation of Eukaryotic Initiation Factor 2α by the Stressed Endoplasmic Reticulum

1995 • 72 citations

Interactions of the heme-regulated eIF-2 alpha kinase with heat shock proteins in rabbit reticulocyte lysates.

1992 • 71 citations

Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation

1993 • 71 citations

Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1992 • 70 citations

An element of the transforming growth factor-beta 1 5'-untranslated region represses translation and specifically binds a cytosolic factor.

1993 • 70 citations

Lack of direct correlation between p220 cleavage and the shut-off of host translation after poliovirus infection

1992 • 70 citations

Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit.

1994 • 70 citations

Maternal mRNA from clam oocytes can be specifically unmasked in vitro by antisense RNA complementary to the 3'-untranslated region.

1990 • 70 citations

Eukaryotic initiation factors eIF-2 and eIF-3: interactions, structure and localization in ribosomal initiation complexes

1991 • 69 citations

Altered mRNA cap recognition activity of initiation factor 4E in the yeast cell cyde division mutant cdc33

1989 • 69 citations

Multiple Sequence Elements and a Maternal mRNA Product Control cdk2 RNA Polyadenylation and Translation during Early Xenopus Development

1994 • 68 citations

Mutations in GCD11, the structural gene for eIF-2 gamma in yeast, alter translational regulation of GCN4 and the selection of the start site for protein synthesis.

1995 • 68 citations

The effect of poliovirus proteinase 2Apro expression on cellular metabolism. Inhibition of DNA replication, RNA polymerase II transcription, and translation

1991 • 67 citations

Eukaryotic initiation factors-4E and -4F stimulate 5' cap-dependent as well as internal initiation of protein synthesis.

1992 • 66 citations

Translational regulation: versatile mechanisms for metabolic and developmental control

1995 • 66 citations

The cap-binding protein complex in uninfected and poliovirus-infected HeLa cells.

1987 • 66 citations

Capped mRNAs with Reduced Secondary Structure Can Function in Extracts from Poliovirus-Infected Cells

1982 • 66 citations

Sequences mediating the translation of mouse S16 ribosomal protein mRNA during myoblast differentiation and in vitro and possible control points for the in vitro translation.

1991 • 66 citations

Enhanced translational efficiency of a novel transforming growth factor beta 3 mRNA in human breast cancer cells.

1994 • 66 citations

Translational control of ornithine aminotransferase. Modulation by initiation factor eIF-4E.

1991 • 66 citations

Site-directed mutagenesis of the tryptophan residues in yeast eukaryotic initiation factor 4E. Effects on cap binding activity.

1988 • 66 citations

A late adenovirus factor induces eIF-4E dephosphorylation and inhibition of cell protein synthesis

1994 • 65 citations

Cloning and Characterization of a Xenopus Poly(A) Polymerase

1995 • 65 citations

Regulation of translation initiation factor gene expression during human T cell activation.

1992 • 64 citations

Induction of Mesoderm in Xenopus laevis Embryos by Translation Initiation Factor 4E

1994 • 64 citations

Isolation of a Protein Complex Containing Translation Initiation Factor Prt1 from Saccharomyces cerevisiae

1995 • 64 citations

The role of the cytoskeleton in eukaryotic protein synthesis A minireview

1983 • 64 citations

Proteins that interact with PKR

1994 • 63 citations

Internal initiation of translation

1993 • 63 citations

Translational control during amino acid starvation

1994 • 62 citations

Elevated levels of eukaryotic translation initiation factor eIF-4E, mRNA in a broad spectrum of transformed cell lines

1995 • 62 citations

Cell-specific translational regulation of S-adenosylmethionine decarboxylase mRNA. Influence of the structure of the 5' transcript leader on regulation by the upstream open reading frame.

1994 • 62 citations

Hormone-induced meiotic maturation in Xenopus oocytes occurs independently of p70s6k activation and is associated with enhanced initiation factor (eIF)-4F phosphorylation and complex formation

1995 • 62 citations

Cloning and characterization of a Xenopus poly(A) polymerase

1995 • 62 citations

Regulation of the interferon-inducible eIF-2α protein kinase by small RNAs

1994 • 61 citations

Use of monoclonal antibodies to study the structure and function of eukaryotic protein synthesis initiation factor eIF‐2B

1994 • 60 citations

The La antigen inhibits the activation of the interferoninducible protein kinase PKR by sequestering and unwinding double-stranded RNA

1994 • 59 citations

Relationship of eukaryotic initiation factor 3 to poliovirus-induced p220 cleavage activity

1992 • 58 citations

Inactivation of mRNA cap-binding protein complex in Drosophila melanogaster embryos under heat shock

1991 • 58 citations

Characterization of the in Vivo Phosphorylation Sites of the mRNA·Cap-binding Complex Proteins Eukaryotic Initiation Factor-4E and p20 in Saccharomyces cerevisiae

1995 • 57 citations

Translational Control: Awakening dormant mRNAs

1995 • 54 citations

Overexpression of initiation factor eIF-4E does not relieve the translational repression of ribosomal protein mRNAs in quiescent cells.

1995 • 53 citations

Regulation of eIF-2 .alpha.-Subunit Phosphorylation in Reticulocyte Lysate

1994 • 53 citations

Synthesis of heat-shock proteins in HeLa cells: Inhibition by virus infection

1984 • 52 citations

Measures and countermeasures in the modulation of initiation factor activities by viruses.

1990 • 51 citations

Signal transduction mechanisms in the regulation of protein synthesis

1994 • 50 citations

Translational control of cytokine expression by 3′ UA-rich sequences

1994 • 50 citations

Effect of mutations downstream of the internal ribosome entry site on initiation of poliovirus protein synthesis

1994 • 50 citations

Efficient translation of poly(A)-deficient mRNAs in Saccharomyces cerevisiae.

1994 • 49 citations

Interactions of the eIF-4F subunits in the yeast Saccharomyces cerevisiae.

1992 • 49 citations

The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence.

1994 • 49 citations

Stem-Loop Structure Synergy in Binding Cellular Proteins to the 5′| Noncoding Region of Poliovirus RNA

1995 • 49 citations

Helicases and RNA unwinding in translation

1993 • 48 citations

Translational Potentiation of Messenger RNA with Secondary Structure in Xenopus

1991 • 48 citations

Photoaffinity labeling of the rabbit reticulocyte guanine nucleotide exchange factor and eukaryotic initiation factor 2 with 8-azidopurine nucleotides

1989 • 48 citations

Evidence that GCD6 and GCD7, translational regulators of GCN4, are subunits of the guanine nucleotide exchange factor for eIF-2 in Saccharomyces cerevisiae.

1993 • 48 citations

The Translational Repression Mediated by the Platelet-derived Growth Factor 2/c-sis mRNA Leader Is Relieved during Megakaryocytic Differentiation

1995 • 47 citations

Multiple sequence elements and a maternal mRNA product control cdk2 RNA polyadenylation and translation during early Xenopus development.

1994 • 47 citations

Basepairing with 18S ribosomal RNA in internal initiation of translation

1994 • 46 citations

Regulation of translation initiation and modulation of cellular physiology

1993 • 46 citations

In vitro synthesis of human protein synthesis initiation factor 4 gamma and its localization on 43 and 48 S initiation complexes.

1994 • 45 citations

Defective RNA replication by poliovirus mutants deficient in 2A protease cleavage activity

1995 • 45 citations

Characterization of Yeast Translation Initiation Factor 1A and Cloning of Its Essential Gene

1995 • 45 citations

Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E by Insulin-stimulated Protamine Kinase

1995 • 45 citations

Translation initiation factor-dependent extracts from Saccharomyces cerevisiae

1990 • 43 citations

Eukaryotic protein synthesis: An in vitro analysis

1994 • 43 citations

Mechanism of action of a cellular inhibitor of the dsRNA-dependent protein kinase from 3T3-F442A cells.

1992 • 42 citations

Gene regulation: translational initiation by internal ribosome binding

1993 • 42 citations

Regulation of eukaryotic protein synthesis by protein kinases that phosphorylate initiation factor eIF-2

1994 • 41 citations

Encephalomyocarditis virus internal ribosomal entry site RNA-protein interactions

1994 • 41 citations

Effect of cytoarchitecture on the transport and localization of protein synthetic machinery

1993 • 41 citations

Host cell proteins binding to domain IV of the 5' noncoding region of poliovirus RNA

1995 • 40 citations

Translational regulation of the heat shock response

1994 • 39 citations

Mutational Analysis of the Prt1 Protein Subunit of Yeast Translation Initiation Factor 3

1995 • 39 citations

The ATP requirement for initiation of eukaryotic translation varies according to the mRNA species

1991 • 39 citations

Purification and Characterization of Bacterially Expressed Mammalian Translation Initiation Factor 5 (eIF-5): Demonstration That eIF-5 Forms a Specific Complex with eIF-2

1994 • 38 citations

Protein Synthesis Initiation Factor eIF-1A Is a Moderately Abundant RNA-binding Protein

1995 • 38 citations

Secondary Structure Analysis of Adenovirus Tripartite Leader

1989 • 38 citations

Reversal of the double‐stranded‐RNA‐induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR

1993 • 38 citations

The effect of reducing reagents on binding of thymidylate synthase protein to thymidylate synthase messenger RNA.

1994 • 38 citations

Heat Shock Effects on Phosphorylation of Protein Synthesis Initiation Factor Proteins eIF-4E and eIF-2.alpha. in Drosophila

1995 • 37 citations

GCD11, a negative regulator of GCN4 expression, encodes the gamma subunit of eIF-2 in Saccharomyces cerevisiae.

1993 • 37 citations

Purification and characterization of eukaryotic polypeptide chain initiation factor 4F from Drosophila melanogaster embryos.

1994 • 36 citations

Determination of the amino acid sequence of rabbit, human, and wheat germ protein synthesis factor eIF-4C by cloning and chemical sequencing.

1994 • 36 citations

5′ untranslated leader sequences of eukaryotic mRNAs encoding heat shock induced proteins

1995 • 36 citations

Identification of RNA-binding proteins specific to Xenopus Eg maternal mRNAs: association with the portion of Eg2 mRNA that promotes deadenylation in embryos

1992 • 36 citations

Eukaryotic translation initiation factor 5 from Saccharomyces cerevisiae. Cloning, characterization, and expression of the gene encoding the 45,346-Da protein

1993 • 36 citations

Protein phosphorylation in cell growth regulation

1996 • 36 citations

Cap-Independent Translation of Heat Shock Messenger RNAs

1995 • 35 citations

Role of the 5′-untranslated region of mRNA in the synthesis of S-adenosylmethionine decarboxylase and its regulation by spermine

1994 • 34 citations

Regulation of heme-regulated eIF-2α kinase and its expression in erythroid cells

1994 • 34 citations

An element of the transforming growth factor-beta 1 5'-untranslated region represses translation and specifically binds a cytosolic factor

1993 • 33 citations

Mechanisms of translational control in liver and skeletal muscle

1994 • 32 citations

Evidence for similar structural organization of the multienzyme aminoacyl-tRNA synthetase complex in vivo and in vitro

1994 • 31 citations

Molecular cloning and expression of cDNA for mammalian translation initiation factor 5.

1993 • 30 citations

A small yeast RNA selectively inhibits internal initiation of translation programmed by poliovirus RNA: specific interaction with cellular proteins that bind to the viral 5'-untranslated region

1994 • 30 citations

Translation initiation factor eIF-4E from Drosophila: cDNA sequence and expression of the gene

1995 • 28 citations

Casein kinase II is implicated in the regulation of heme-controlled translational inhibitor of reticulocyte lysates.

1994 • 27 citations

The amino acid sequence of eukaryotic translation initiation factor 1 and its similarity to yeast initiation factor SUI1

1995 • 27 citations

Dependence of the adenovirus tripartite leader on the p220 submit of eukaryotic initiation factor 4F during in vitro translation

1992 • 26 citations

Maturation hormone induced an increase in the translational activity of starfish oocytes coincident with the phosphorylation of the mRNA cap binding protein, eIF‐4E, and the activation of several kinases

1993 • 24 citations

Interaction of initiation factors with the cap structure of chimaeric mRNA containing the 5′‐untranslated regions of Semliki Forest virus RNA is related to translational efficiency

1992 • 24 citations

Changes in rates of protein synthesis and eukaryotic initiation factor-4 inhibitory activity in cell-free translation systems of sea urchin eggs and early cleavage stage embryos.

1992 • 21 citations

Regulated polyadenylation of clam maternal mRNAs in vitro

1993 • 21 citations

Isolation and immunochemical characterization of eukaryotic translation initiation factor 5 from Saccharomyces cerevisiae.

1993 • 21 citations

Molecular biology of translation in yeast

1992 • 21 citations

Characterization of mammalian translation initiation factor 5 (eIF-5). Demonstration that eIF-5 is a phosphoprotein and is present in cells as a single molecular form of apparent M(r) 58,000.

1993 • 21 citations

Control of protein synthesis by hemin. Purification of a rabbit reticulocyte hsp 70 and characterization of its regulation of the activation of the hemin-controlled eIF-2(alpha) kinase.

1994 • 21 citations

Translational Regulation: Y the message is masked?

1994 • 21 citations

The yeast Saccharomyces cerevisiae system: A powerful tool to study the mechanism of protein synthesis initiation in eukaryotes

1994 • 20 citations

Translation initiation on the insulin-like growth factor II leader 1 is developmentally regulated

1994 • 19 citations

Proteins binding to the leader of the 6.0 kb mRNA of human insulin-like growth factor 2 influence translation

1995 • 18 citations

RNA/protein interactions in the 5'-untranslated leader of HSP70 mRNA in Drosophila lysates. Lack of evidence for specific protein binding.

1994 • 16 citations

Control of Translation of Masked mRNAs in Clam Oocytes

1990 • 16 citations

Guanine nucleotide exchange factor for eukaryotic initiation factor-2. Cloning of cDNA for the δ-subunit of rabbit translation initiation factor-2B

1994 • 15 citations

Translational Regulation in Reticulocytes

1993 • 14 citations

Developmental regulation of translation by the 5' noncoding region of murine c-myc mRNA in Xenopus laevis.

1988 • 13 citations

The RNA-binding properties of protein synthesis initiation factor eIF-2

1994 • 12 citations

Cloning and expression of cDNAs for the β subunit of eukaryotic initiation factor-2B, the guanine nucleotide exchange factor for eukaryotic initiation factor-2

1995 • 11 citations

Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B.

1995 • 10 citations

mRNAs containing the unstructured 5' leader sequence of alfalfa mosaic virus RNA 4 translate inefficiently in lysates from poliovirus-infected HeLa cells

1995 • 10 citations

Isolation and characterization of the Drosophila melanogaster gene encoding translation-initiation factor eIF-2β

1994 • 8 citations