Molecular mechanisms in the control of translation by hormones and growth factors

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Chemistry and Biology of the Immunophilins and Their Immunosuppressive Ligands

1991 • 1,479 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Nuclear localization and regulation of erk- and rsk-encoded protein kinases.

1992 • 1,107 citations

The MAP kinase cascade is essential for diverse signal transduction pathways

1993 • 1,091 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Inactivation of glycogen synthase kinase-3β by phosphorylation: new kinase connections in insulin and growth-factor signalling

1993 • 877 citations

Intermediate states in the movement of transfer RNA in the ribosome

1989 • 736 citations

NEURONAL Ca²⁺/CALMODULIN-DEPENDENT PROTEIN KINASES

1992 • 713 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

1990 • 632 citations

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes

1988 • 617 citations

Rapamycin selectively inhibits interleukin-2 activation of p70 S6 kinase

1992 • 601 citations

EUKARYOTIC PROTEIN SYNTHESIS

1985 • 538 citations

Three-Dimensional Structure of an Oncogene Protein: Catalytic Domain of Human c-H- ras P21

1988 • 532 citations

The molecular mechanism by which insulin stimulates glycogen synthesis in mammalian skeletal muscle

1990 • 529 citations

Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.

1987 • 494 citations

Phosphorylation of elongation factor 2 by EF-2 kinase affects rate of translation

1988 • 447 citations

Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6

1991 • 442 citations

Extracellular signals and reversible protein phosphorylation: What to Mek of it all

1993 • 426 citations

mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E.

1992 • 414 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

p70s6k function is essential for G1 progression

1993 • 348 citations

Identification of the major Mr 100,000 substrate for calmodulin-dependent protein kinase III in mammalian cells as elongation factor-2.

1987 • 339 citations

The catalytic mechanism of guanine nucleotide exchange factor action and competitive inhibition by phosphorylated eukaryotic initiation factor 2.

1988 • 325 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Glycogen Synthase from Rabbit Skeletal Muscle; Effect of Insulin on the State of phosphorylation of the Seven Phosphoserine Residues in vivo

1983 • 292 citations

The influence of basic residues on the substrate specificity of protein kinase C.

1987 • 287 citations

The molecular and cellular basis of affinity maturation in the antibody response

1992 • 278 citations

Functional properties of phosphorylated elongation factor 2

1990 • 274 citations

Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation

1988 • 266 citations

Structure, expression, and regulation of protein kinases involved in the phosphorylation of ribosomal protein S6.

1991 • 265 citations

pp54 microtubule-associated protein 2 kinase. A novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine.

1990 • 256 citations

Cap recognition and the entry of mRNA into the protein synthesis initiation cycle

1988 • 256 citations

An array of insulin-activated, proline-directed serine/threonine protein kinases phosphorylate the p70 S6 kinase.

1992 • 242 citations

Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis.

1987 • 220 citations

RNA-stimulated ATPase activity of eukaryotic initiation factors.

1984 • 211 citations

MAP2 kinase and 70K S6 kinase lie on distinct signalling pathways

1991 • 208 citations

Mechanism and regulation of eukaryotic protein synthesis.

1992 • 199 citations

Calcium-Dependent Regulation of Protein Synthesis in Intact Mammalian Cells

1990 • 198 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini.

1991 • 182 citations

Regulation of elongation factor‐2 by multisite phosphorylation

1993 • 181 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Effect of diabetes on the rates of synthesis and degradation of ribosomes in rat muscle and liver in vivo.

1986 • 169 citations

Insulin induction of ornithine decarboxylase. Importance of mRNA secondary structure and phosphorylation of eucaryotic initiation factors eIF-4B and eIF-4E

1991 • 168 citations

Leader length and secondary structure modulate mRNA function under conditions of stress.

1988 • 161 citations

Translational dynamics

1990 • 159 citations

Substrate recognition determinants of the mitogen-activated 70K S6 kinase from rat liver.

1992 • 158 citations

Mechanism of elongation factor 2 (EF‐2) inactivation upon phosphorylation Phosphorylated EF‐2 is unable to catalyze translocation

1989 • 157 citations

Regulation of initiation factors during translational repression caused by serum depletion. Covalent modification.

1985 • 153 citations

Ca²⁺/calmodulin‐dependent phosphorylation of elongation factor 2

1987 • 150 citations

The role of mRNA competition in regulating translation. I. Demonstration of competition in vivo.

1981 • 146 citations

Amino acid sequence of the human protein synthesis initiation factor eIF-4 gamma

1992 • 139 citations

A common denominator linking glycogen metabolism, nuclear oncogenes and development

1991 • 138 citations

Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.

1990 • 133 citations

The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.

1993 • 130 citations

Rapid activation of calmodulin-dependent protein kinase III in mitogen-stimulated human fibroblasts. Correlation with intracellular Ca2+ transients.

1987 • 129 citations

Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA-activated inhibitor

1987 • 129 citations

Action of growth factors in the cell cycle

1979 • 125 citations

Phosphorylation of eukaryotic initiation factor (eIF) 2 alpha and inhibition of eIF-2B in GH3 pituitary cells by perturbants of early protein processing that induce GRP78.

1992 • 122 citations

EGF induces biphasic S6 kinase activation: Late phase is protein kinase C-dependent and contributes to mitogenicity

1989 • 122 citations

Phorbol esters stimulate phosphorylation of eukaryotic initiation factors 3, 4B, and 4F

1989 • 121 citations

Simultaneous cytoplasmic redistribution of ribosomal protein L32 mRNA and phosphorylation of eukaryotic initiation factor 4E after mitogenic stimulation of Swiss 3T3 cells.

1990 • 120 citations

The Role of Guanosine Triphosphate in Translocation Reaction Catalyzed by Elongation Factor G

1974 • 119 citations

Translational control of mRNA expression during the early mitogenic response in Swiss mouse 3T3 cells: identification of specific proteins.

1986 • 119 citations

Involvement of an initiation factor and protein phosphorylation in translational control of GCN4 mRNA

1990 • 117 citations

Purification and characterisation of the insulin‐stimulated protein kinase from rabbit skeletal muscle; close similarity to S6 kinase II

1991 • 117 citations

Identification of the phosphorylation sites in elongation factor‐2 from rabbit reticulocytes

1991 • 116 citations

Comparative analysis of phosphorylation of translational initiation and elongation factors by seven protein kinases

1989 • 110 citations

Rapamycin: FK506's fraternal twin or distant cousin?

1991 • 107 citations

Physiological stresses inhibit guanine‐nucleotide‐exchange factor in Ehrlich cells

1988 • 104 citations

Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis.

1991 • 100 citations

Dissociation of pp70 ribosomal protein S6 kinase from insulin-stimulated glucose transport in 3T3-L1 adipocytes.

1993 • 98 citations

Translational control of gene expression in a normal fibroblast. Characterization of a subclass of mRNAs with unusual kinetic properties

1986 • 98 citations

Phosphorylation of eukaryotic translation initiation factor 4E is increased in Src-transformed cell lines.

1991 • 95 citations

Phosphorylation site of eukaryotic initiation factor 4E.

1987 • 95 citations

The tumour promoter okadaic acid inhibits reticulocyte-lysate protein synthesis by increasing the net phosphorylation of elongation factor 2

1989 • 94 citations

Nerve growth factor-induced increase in the cell-free phosphorylation of a nuclear protein in PC12 cells.

1985 • 92 citations

Regulation of protein synthesis at the elongation stage New insights into the control of gene expression in eukaryotes

1991 • 91 citations

Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.

1993 • 90 citations

FK506 and rapamycin: novel pharmacological probes of the immune response

1991 • 89 citations

Phosphorylation of elongation factor 1 (EF-1) and valyl-tRNA synthetase by protein kinase C and stimulation of EF-1 activity

1991 • 88 citations

Heat shock impairs the interaction of cap-binding protein complex with 5' mRNA cap.

1991 • 87 citations

Purification and characterization of calmodulin-dependent protein kinase III from rabbit reticulocytes and rat pancreas

1993 • 87 citations

Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation.

1992 • 86 citations

Phosphorylation of eIF-4F by protein kinase C or multipotential S6 kinase stimulates protein synthesis at initiation.

1991 • 83 citations

Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E.

1992 • 81 citations

Cyclic AMP-dependent protein kinase phosphorylates rabbit reticulocyte elongation factor-2 kinase and induces calcium-independent activity

1993 • 81 citations

Identification of 40 S ribosomal protein S6 phosphorylation sites in Swiss mouse 3T3 fibroblasts stimulated with serum.

1993 • 79 citations

Phosphorylation of valyl-tRNA synthetase and elongation factor 1 in response to phorbol esters is associated with stimulation of both activities

1991 • 71 citations

Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors

1992 • 70 citations

Nerve growth factor treatment or cAMP elevation reduces Ca2+/calmodulin-dependent protein kinase III activity in PC12 cells.

1987 • 70 citations

Purification, phosphorylation and control of the guanine‐nucleotide‐exchange factor from rabbit reticulocyte lysates

1992 • 69 citations

Purification and phosphorylation of elongation factor‐2 kinase from rabbit reticulocytes

1993 • 68 citations

Insulin-stimulated Protein Tyrosine Phosphorylation in Intact Cells Evaluated by Giant Two-dimensional Gel Electrophoresis

1989 • 66 citations

Association of initiation factor eIF-4E in a cap binding protein complex (eIF-4F) is critical for and enhances phosphorylation by protein kinase C.

1990 • 63 citations

Regulation of initiation factors during translational repression caused by serum depletion. Abundance, synthesis, and turnover rates.

1985 • 63 citations

Mechanism of the inhibition of protein synthesis by vasopressin in rat liver.

1990 • 62 citations

Epidermal growth factor or okadaic acid stimulates phosphorylation of eukaryotic initiation factor 4F.

1991 • 61 citations

Effect of diabetes on guanine nucleotide exchange factor activity in skeletal muscle and heart

1988 • 59 citations

Isolation and properties of the trypsin-derived ADP-ribosyl peptide from diphtheria toxin-modified yeast elongation factor 2.

1978 • 58 citations

Isolation of a cDNA clone encoding S-adenosylmethionine decarboxylase. Expression of the gene in mitogen-activated lymphocytes.

1986 • 57 citations

Thrombin and Histamine Stimulate the Phosphorylation of Elongation Factor 2 in Human Umbilical Vein Endothelial Cells

1989 • 57 citations

Pattern of protein phosphorylation in aortic endothelial cells. Modulation by adenine nucleotides and bradykinin.

1988 • 57 citations

Nerve growth factor-induced decrease in the cell-free phosphorylation of a soluble protein in PC12 cells.

1983 • 56 citations

Increased rate of phosphorylation-dephosphorylation of the translational initiation factor eIF-4E correlates with the induction of protein and glycoprotein biosynthesis in activated B lymphocytes.

1990 • 55 citations

Presence in many mammalian tissues of an identical major cytosolic substrate (M_r 100000) for calmodulin‐dependent protein kinase

1983 • 54 citations

Identification and early activation of a Xenopus laevis p70s6k following progesterone-induced meiotic maturation.

1992 • 53 citations

Insulin rapidly induces the biosynthesis of elongation factor 2

1989 • 49 citations

Characterization of insulin-stimulated protein serine/threonine kinases in CHO cells expressing human insulin receptors with point and deletion mutations

1992 • 49 citations

A brain-specific Ca2+/calmodulin-dependent protein kinase (CaM kinase-Gr) is regulated by autophosphorylation. Relevance to neuronal Ca2+ signaling

1991 • 46 citations

Initiation factor protein modifications and inhibition of protein synthesis.

1987 • 46 citations

Regulation of protein synthesis in isolated hepatocytes by calcium-mobilizing hormones.

1986 • 44 citations

Inhibition or down-regulation of protein kinase C attenuates late phase p70s6k activation induced by epidermal growth factor but not by platelet-derived growth factor or insulin.

1992 • 44 citations

Regulation of eukaryotic translation initiation factor expression during T-cell activation

1993 • 40 citations

Serum growth factors cause rapid stimulation of protein synthesis and dephosphorylation of eIF-2 in serum deprived Ehrlich cells

1989 • 39 citations

Insulin stimulation of growth in diabetic rats. Synthesis and degradation of ribosomes and total tissue protein in skeletal muscle and heart.

1986 • 38 citations

Insulin promoted decrease in the phosphorylation of protein synthesis initiation factor eIF-2

1984 • 37 citations

Regulation of Nerve Growth Factor Action on Nsp100 Phosphorylation in PC12h Cells by Calcium

1986 • 37 citations

Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor.

1991 • 35 citations

Effect of starvation and diabetes on the activity of the eukaryotic initiation factor eIF-2 in rat skeletal muscle

1990 • 35 citations

Platelet‐derived growth factor stimulates phosphorylation of the 25 kDa mRNA cap binding protein (eIF‐4E) in human lung fibroblasts

1991 • 34 citations

Structure and phosphorylation of eukaryotic initiation factor 2. Casein kinase 2 and protein kinase C phosphorylate distinct but adjacent sites in the β-subunit

1988 • 34 citations

Phosphorylation of elongation factor 2 during Ca2+-mediated secretion from rat parotid acini

1992 • 29 citations

On the mechanism of the glucagon-induced inhibition of hepatic protein synthesis

1979 • 29 citations

Casein kinase I phosphorylates the 25-kDa mRNA cap-binding protein

1991 • 29 citations

Regulation of protein synthesis in intact rat liver by calcium mobilizing agents

1988 • 28 citations

Primary structure of rat liver elongation factor 2 deduced from the cDNA sequence

1989 • 26 citations

Protamine kinase phosphorylates eukaryotic protein synthesis initiation factor 4E

1992 • 26 citations

Saccharomyces cerevisiaeelongation factor 2 is phosphorylated by an endorenous kinase

1991 • 25 citations

Regulation of Eukaryotic Initiation Factor-2B Activity by Polyamines and Amino Acid Starvation in Rabbit Reticulocyte Lysate

1989 • 23 citations

Regulation of polypeptide-chain initiation in rat skeletal muscle Starvation does not alter the activity or phosphorylation state of initiation factor eIF-2

1988 • 22 citations

Study of phosphorylation of translation elongation factor 2 (EF‐2) from wheat germ

1993 • 22 citations

Inhibition of microsomal calcium sequestration causes an impairment of initiation of protein synthesis in perfused rat liver

1991 • 18 citations

Effect of vasopressin on the regulation of protein synthesis initiation in liver cells

1988 • 17 citations

Interrelation between gluconeogenesis and hepatic protein sysnthesis

1986 • 17 citations

Regulation of initiation of protein synthesis by insulin in skeletal muscle

1991 • 17 citations

Modification of the reactivity of three amino-acid residues in elongation factor 2 during its binding to ribosomes and translocation

1990 • 15 citations

Identification of a protein kinase activity in rabbit reticulocytes that phosphorylates the mRNA cap binding protein

1988 • 15 citations

Casein kinase-2 phosphorylates serine-2 in the β-subunit of initiation factor-2

1989 • 14 citations

Phosphorylation of the p220 subunit of eIF-4F by cAMP dependent protein kinase and protein kinase C in vitro

1988 • 11 citations

Action of phenylephrine on protein synthesis in liver cells

1987 • 10 citations

Phosphorylation of elongation factor‐2 from the lepidopteran insect, spodoptera frugiperda

1993 • 8 citations

Ribosomes terminated in vitro are in a tight association with non‐phosphorylated elongation factor 2 (eEF‐2) and GDP

1993 • 6 citations

Amiloride analogs induce the phosphorylation of elongation factor-2 in vascular endothelial cells.

1990 • 6 citations