Adaptation of the ubiquitin-proteasome proteolytic pathway in cancer cachexia.

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

Mechanisms of Muscle Wasting — The Role of the Ubiquitin–Proteasome Pathway

1996 • 1,149 citations

Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-κB activation in response to tumor necrosis factor α

1998 • 486 citations

Importance of the ATP-Ubiquitin-Proteasome Pathway in the Degradation of Soluble and Myofibrillar Proteins in Rabbit Muscle Extracts

1996 • 429 citations

Muscle wasting in insulinopenic rats results from activation of the ATP-dependent, ubiquitin-proteasome proteolytic pathway by a mechanism including gene transcription.

1996 • 347 citations

Role of calpain in skeletal-muscle protein degradation

1998 • 333 citations

Inhibitors of the proteasome reduce the accelerated proteolysis in atrophying rat skeletal muscles.

1997 • 315 citations

Role of different proteolytic systems in the degradation of muscle proteins during denervation atrophy.

1990 • 294 citations

Sepsis is associated with increased mRNAs of the ubiquitin-proteasome proteolytic pathway in human skeletal muscle.

1997 • 264 citations

Activation of the ATP-ubiquitin-proteasome pathway in skeletal muscle of cachectic rats bearing a hepatoma

1995 • 263 citations

Sepsis stimulates nonlysosomal, energy-dependent proteolysis and increases ubiquitin mRNA levels in rat skeletal muscle.

1994 • 256 citations

Energy-ubiquitin-dependent muscle proteolysis during sepsis in rats is regulated by glucocorticoids.

1996 • 249 citations

Increase in ubiquitin-protein conjugates concomitant with the increase in proteolysis in rat skeletal muscle during starvation and atrophy denervation

1995 • 228 citations

Increased mRNA levels for components of the lysosomal, Ca2+-activated, and ATP-ubiquitin-dependent proteolytic pathways in skeletal muscle from head trauma patients.

1996 • 222 citations

Simultaneous binding of PA28 and PA700 activators to 20 S proteasomes

1998 • 219 citations

Increased ATP-ubiquitin-dependent proteolysis in skeletal muscles of tumor-bearing rats.

1994 • 210 citations

TNF Can Directly Induce the Expression of Ubiquitin-Dependent Proteolytic System in Rat Soleus Muscles

1997 • 184 citations

Skeletal muscle metabolism in patients with malignant tumor

1976 • 183 citations

Rates of ubiquitin conjugation increase when muscles atrophy, largely through activation of the N-end rule pathway

1998 • 155 citations

Developmental Changes of the 26 S Proteasome in Abdominal Intersegmental Muscles of Manduca sexta during Programmed Cell Death

1995 • 152 citations

Skeletal muscle myocytes undergo protein loss and reactive oxygen‐mediated NF‐κB activation in response to tumor necrosis factorα

1998 • 142 citations

Mechanism of muscle protein degradation induced by a cancer cachectic factor

1998 • 141 citations

Muscle protein waste in tumor-bearing rats is effectively antagonized by a beta 2-adrenergic agonist (clenbuterol). Role of the ATP-ubiquitin-dependent proteolytic pathway.

1995 • 141 citations

Ubiquitin gene expression is increased in skeletal muscle of tumour‐bearing rats

1994 • 135 citations

Early development of protein metabolic perturbations in the liver and skeletal muscle of tumour-bearing rats. A model system for cancer cachexia

1987 • 134 citations

Increased protein degradation and decreased protein synthesis in skeletal muscle during cancer cachexia

1993 • 131 citations

Different cytokines modulate ubiquitin gene expression in rat skeletal muscle

1998 • 111 citations

Muscle wasting associated with cancer cachexia is linked to an important activation of the atp‐dependent ubiquitin‐mediated proteolysis

1995 • 104 citations

Effects of systemic inhibition of prostaglandin production on protein metabolism in tumor-bearing rats

1989 • 86 citations

Sepsis-induced increase in muscle proteolysis is blocked by specific proteasome inhibitors

1998 • 84 citations

Ubiquitin Gene Expression in Skeletal Muscle Is Increased by Tumor Necrosis Factor-α

1994 • 83 citations

Manipulation of the ubiquitin-proteasome pathway in cachexia: pentoxifylline suppresses the activation of 20S and 26S proteasomes in muscles from tumor-bearing rats.

1999 • 78 citations

Ubiquitin and proteasome gene expression is increased in skeletal muscle of slim AIDS patients.

1998 • 66 citations

Anti-TNF Treatment Reverts Increased Muscle Ubiquitin Gene Expression in Tumour-Bearing Rats

1996 • 64 citations

Prevention of adenocarcinoma colon 26-induced cachexia by interleukin 10 gene transfer.

1997 • 60 citations

Cancer cachexia

1991 • 57 citations

Amino Acid Metabolism in Human Cancer Cachexia

1990 • 53 citations

Complex mechanisms for c-fos and c-jun degradation.

1997 • 50 citations

Contribution of elevated protein turnover and anorexia to cachexia in patients with hepatocellular carcinoma.

1990 • 34 citations

Expression of subunits of the 19S complex and of the PA28 activator in rat skeletal muscle.

1997 • 32 citations

Muscle hypercatabolism during cancer cachexia is not reversed by the glucocorticoid receptor antagonist RU38486

1996 • 31 citations