Identification and isolation of hematopoietic stem cells

Multilineage Potential of Adult Human Mesenchymal Stem Cells

1999 • 20,447 citations

Stem cells, cancer, and cancer stem cells

2001 • 9,488 citations

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells¹

2010 • 4,125 citations

Osteoblastic cells regulate the haematopoietic stem cell niche

2003 • 3,370 citations

Isolation and functional properties of murine hematopoietic stem cells that are replicating in vivo.

1996 • 2,901 citations

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype

2001 • 2,274 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

1996 • 2,160 citations

Conditions controlling the proliferation of haemopoietic stem cells in vitro

1977 • 2,157 citations

A role for Wnt signalling in self-renewal of haematopoietic stem cells

2003 • 2,131 citations

Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells

2001 • 1,999 citations

Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells

2003 • 1,851 citations

Dystrophin expression in the mdx mouse restored by stem cell transplantation

1999 • 1,817 citations

AC133, a Novel Marker for Human Hematopoietic Stem and Progenitor Cells

1997 • 1,755 citations

A Stem Cell Molecular Signature

2002 • 1,553 citations

The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus

1999 • 1,549 citations

Little Evidence for Developmental Plasticity of Adult Hematopoietic Stem Cells

2002 • 1,504 citations

Bmi-1 determines the proliferative capacity of normal and leukaemic stem cells

2003 • 1,435 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

2000 • 1,326 citations

Control of Neuronal Precursor Proliferation in the Cerebellum by Sonic Hedgehog

1999 • 1,313 citations

Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation

2003 • 1,303 citations

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

Dye efflux studies suggest that hematopoietic stem cells expressing low or undetectable levels of CD34 antigen exist in multiple species

1997 • 1,116 citations

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

1994 • 1,109 citations

Expression and activity of P-glycoprotein, a multidrug efflux pump, in human hematopoietic stem cells

1991 • 962 citations

A Novel Five-Transmembrane Hematopoietic Stem Cell Antigen: Isolation, Characterization, and Molecular Cloning

1997 • 935 citations

Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice

1997 • 879 citations

Sequential generations of hematopoietic colonies derived from single nonlineage-committed CD34+CD38- progenitor cells

1991 • 869 citations

Endoglin is a component of the transforming growth factor-beta receptor system in human endothelial cells.

1992 • 837 citations

Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: Implications for gene therapy

1996 • 795 citations

Flk-2 is a marker in hematopoietic stem cell differentiation: A simple method to isolate long-term stem cells

2001 • 769 citations

The T Cell Leukemia Oncoprotein SCL/tal-1 Is Essential for Development of All Hematopoietic Lineages

1996 • 746 citations

HOXB4-Induced Expansion of Adult Hematopoietic Stem Cells Ex Vivo

2002 • 707 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Upregulation of Flt3 Expression within the Bone Marrow Lin−Sca1+c-kit+ Stem Cell Compartment Is Accompanied by Loss of Self-Renewal Capacity

2001 • 691 citations

Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

2001 • 675 citations

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

2000 • 641 citations

A newly discovered class of human hematopoietic cells with SCID-repopulating activity

1998 • 640 citations

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment

2002 • 638 citations

Isolation of primitive human hematopoietic progenitors on the basis of aldehyde dehydrogenase activity

1999 • 534 citations

Identification, cloning, and regulation of a novel endothelial cell protein C/activated protein C receptor

1994 • 508 citations

Bcrp1gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cellsin vivo

2002 • 506 citations

Expansion in vitro of transplantable human cord blood stem cells demonstrated using a quantitative assay of their lympho-myeloid repopulating activity in nonobese diabetic– scid/scid mice

1997 • 495 citations

KDR Receptor: A Key Marker Defining Hematopoietic Stem Cells

1999 • 491 citations

Primitive Human Hematopoietic Cells Are Enriched in Cord Blood Compared With Adult Bone Marrow or Mobilized Peripheral Blood as Measured by the Quantitative In Vivo SCID-Repopulating Cell Assay

1997 • 488 citations

Notch1 but Not Notch2 Is Essential for Generating Hematopoietic Stem Cells from Endothelial Cells

2003 • 465 citations

The Developmental Biology of Brain Tumors

2001 • 462 citations

Precursors of colony-forming cells in humans can be distinguished from colony-forming cells by expression of the CD33 and CD34 antigens and light scatter properties.

1989 • 453 citations

Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells.

1990 • 450 citations

The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells

2000 • 432 citations

Quantitative Analysis Reveals Expansion of Human Hematopoietic Repopulating Cells After Short-term Ex Vivo Culture

1997 • 424 citations

Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP

2000 • 424 citations

Notch1 activation increases hematopoietic stem cell self-renewal in vivo and favors lymphoid over myeloid lineage outcome

2002 • 414 citations

Reversible Expression of CD34 by Murine Hematopoietic Stem Cells

1999 • 408 citations

Self-renewal of primitive human hematopoietic cells (long-term-culture-initiating cells) in vitro and their expansion in defined medium.

1996 • 393 citations

Telomerase Activity in Hematopoietic Cells Is Associated with Self-Renewal Potential

1996 • 385 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene

2003 • 378 citations

Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis

2002 • 375 citations

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

1992 • 368 citations

Sonic hedgehogRegulates Proliferation and Inhibits Differentiation of CNS Precursor Cells

1999 • 360 citations

A Role for the Wnt Gene Family in Hematopoiesis: Expansion of Multilineage Progenitor Cells

1997 • 355 citations

Stem cell repopulation efficiency but not pool size is governed by p27kip1

2000 • 352 citations

Peripheral blood stem cell versus bone marrow allotransplantation: does the source of hematopoietic stem cells matter?

2001 • 347 citations

Human bone marrow CD34- cells engraft in vivo and undergo multilineage expression that includes giving rise to CD34+ cells.

1998 • 346 citations

The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

1997 • 343 citations

The Role of Apoptosis in the Regulation of Hematopoietic Stem Cells

2000 • 334 citations

Role of Members of the Wnt Gene Family in Human Hematopoiesis

1998 • 333 citations

Isolation of murine pluripotent hemopoietic stem cells.

1984 • 333 citations

Resting and activated subsets of mouse multipotent hematopoietic stem cells.

1990 • 333 citations

Isolation and characterization of human CD34−Lin− and CD34+Lin− hematopoietic stem cells using cell surface markers AC133 and CD7

2000 • 323 citations

Assessment of aldehyde dehydrogenase in viable cells

1995 • 322 citations

Side population cells from diverse adult tissues are capable of in vitro hematopoietic differentiation

2002 • 320 citations

Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation

2003 • 316 citations

Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation

1998 • 299 citations

Rapid myeloerythroid repopulation after intrafemoral transplantation of NOD-SCID mice reveals a new class of human stem cells

2003 • 279 citations

Expansionin vitroof adult murine hematopoietic stem cells with transplantable lympho-myeloid reconstituting ability

1997 • 276 citations

Use of limiting-dilution type long-term marrow cultures in frequency analysis of marrow-repopulating and spleen colony-forming hematopoietic stem cells in the mouse

1991 • 267 citations

Functional differences between transplantable human hematopoietic stem cells from fetal liver, cord blood, and adult marrow

1999 • 266 citations

Identification of the hemangioblast in postnatal life

2002 • 266 citations

Expansion of human cord blood CD34+CD38−cells in ex vivo culture during retroviral transduction without a corresponding increase in SCID repopulating cell (SRC) frequency: dissociation of SRC phenotype and function

2000 • 262 citations

Selective expression of CD45 isoforms on functional subpopulations of CD34+ hemopoietic cells from human bone marrow.

1990 • 259 citations

Growth Disturbance in Fetal Liver Hematopoiesis of Mll-Mutant Mice

1998 • 245 citations

Enhanced detection, maintenance, and differentiation of primitive human hematopoietic cells in cultures containing murine fibroblasts engineered to produce human steel factor, interleukin-3, and granulocyte colony-stimulating factor

1996 • 234 citations

Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow.

1992 • 231 citations

Distinct roles for CREB-binding protein and p300 in hematopoietic stem cell self-renewal

2002 • 228 citations

Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow

1992 • 224 citations

Regulated expression on human macrophages of endoglin, an Arg‐Gly‐Asp‐containing surface antigen

1992 • 222 citations

Nestin-positive progenitor cells derived from adult human pancreatic islets of Langerhans contain side population (SP) cells defined by expression of the ABCG2 (BCRP1) ATP-binding cassette transporter

2002 • 218 citations

Wnt-5A augments repopulating capacity and primitive hematopoietic development of human blood stem cellsinvivo

2003 • 216 citations

SCID-repopulating cell activity of human cord blood-derived CD34- cells assured by intra-bone marrow injection

2003 • 214 citations

Assay of human stem cells by repopulation of NOD/SCID mice

1997 • 195 citations

A highly sensitive strategy for SCID-repopulating cell assay by direct injection of primitive human hematopoietic cells into NOD/SCID mice bone marrow

2003 • 193 citations

Telomere Shortening Accompanies Increased Cell Cycle Activity during Serial Transplantation of Hematopoietic Stem Cells

2001 • 193 citations

Biology and Plasticity of CD133⁺ Hematopoietic Stem Cells

2003 • 190 citations

Hematopoietic stem cell and progenitor defects in Sca-1/Ly-6A–null mice

2002 • 186 citations

Polycomb Group Gene rae28 Is Required for Sustaining Activity of Hematopoietic Stem Cells

2002 • 184 citations

Flow cytometric assessment of human T-cell differentiation in thymus and bone marrow

1992 • 183 citations

Antigenic analysis of hematopoiesis. V. Characterization of My-10 antigen expression by normal lymphohematopoietic progenitor cells.

1986 • 181 citations

Distribution of surface-membrane molecules on bone marrow and cord blood CD34+ hematopoietic cells.

1992 • 177 citations

Mouse strain variability in the expression of the hematopoietic stem cell antigen Ly-6A/E by bone marrow cells

1993 • 175 citations

The Hox cofactor and proto-oncogene Pbx1 is required for maintenance of definitive hematopoiesis in the fetal liver

2001 • 171 citations

Ex Vivo Generation of CD34+ Cells From CD34− Hematopoietic Cells

1999 • 169 citations

Identification of endoglin as a functional marker that defines long-term repopulating hematopoietic stem cells

2002 • 165 citations

Differential long-term and multilineage engraftment potential from subfractions of human CD34⁺cord blood cells transplanted into NOD/SCID mice

2002 • 165 citations

Effects ofHOX homeobox genes in blood cell differentiation

1997 • 164 citations

In Vitro Generation of Long-Term Repopulating Hematopoietic Stem Cells by Fibroblast Growth Factor-1

2003 • 161 citations

CD34+ human marrow cells that express low levels of Kit protein are enriched for long-term marrow-engrafting cells

1996 • 160 citations

Highly purified CD34-positive cells reconstitute hematopoiesis.

1996 • 159 citations

Marrow- and spleen-seeding efficiencies of all murine hematopoietic stem cell subsets are decreased by preincubation with hematopoietic growth factors

1995 • 148 citations

CD34+ marrow cells, devoid of T and B lymphocytes, reconstitute stable lymphopoiesis and myelopoiesis in lethally irradiated allogeneic baboons

1992 • 144 citations

Hematopoietic stem cells engraft in mice with absolute efficiency

2003 • 144 citations

Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential

1994 • 139 citations

Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer

2001 • 131 citations

Cytokine treatment or accessory cells are required to initiate engraftment of purified primitive human hematopoietic cells transplanted at limiting doses into NOD/SCID mice

1999 • 129 citations

Transplantable hematopoietic stem cells in human fetal liver have a CD34+ side population (SP)phenotype

2001 • 128 citations

Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen

2003 • 125 citations

Reduced Proliferative Capacity of Hematopoietic Stem Cells Deficient inHoxb3andHoxb4

2003 • 119 citations

Separation of functionally distinct subpopulations of primitive human hematopoietic cells using rhodamine-123.

1991 • 103 citations

Regulation of Hematopoietic Stem Cell Self-Renewal

2003 • 101 citations

Reversible expression of CD34 by adult human bone marrow long-term engrafting hematopoietic stem cells

2003 • 97 citations

Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines

1993 • 96 citations

Mobilized peripheral blood SSC^loALDH^br cells have the phenotypic and functional properties of primitive haematopoietic cells and their number correlates with engraftment following autologous transplantation

2003 • 94 citations

Equal distribution of competitive long-term repopulating stem cells in the CD34+ and CD34- fractions of Thy-1lowLin-/lowSca-1+ bone marrow cells.

1998 • 93 citations

Phenotypic analysis of murine long-term hemopoietic reconstituting cells quantitated competitively in vivo and comparison with more advanced colony-forming progeny.

1995 • 90 citations

RAPID ISOLATION OF HUMAN CD34 HEMATOPOIETIC STEM CELLS—PURGING OF HUMAN TUMOR CELLS

1992 • 90 citations

Transplantation of hematopoietic stem cells in utero

1997 • 90 citations

4-Hydroperoxycyclophosphamide inhibits proliferation by human granulocytemacrophage colony-forming cells (GM-CFC) but spares more primitive progenitor cells

1985 • 88 citations

Changing phenotypes of hematopoietic stem cells

2002 • 88 citations

Transplantation of Human Umbilical Cord Blood Cells in Macrophage-Depleted SCID Mice: Evidence for Accessory Cell Involvement in Expansion of Immature CD34+CD38−Cells

1998 • 81 citations

Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines

1993 • 77 citations

Role for aldehyde dehydrogenase in survival of progenitors for murine blast cell colonies after treatment with 4-hydroperoxycyclophosphamide in vitro.

1988 • 70 citations

Candidate hematopoietic stem cells from fetal tissues, umbilical cord blood vs. adult bone marrow and mobilized peripheral blood.

1998 • 67 citations

Liver and marrow of adult mdr-1a/1b−/− mice show normal generation, function, and multi-tissue trafficking of primitive hematopoietic cells

2002 • 65 citations

Kinetics of engraftment of CD34− and CD34+ cells from mobilized blood differs from that of CD34− and CD34+ cells from bone marrow

2000 • 65 citations

Rapid Differentiation of a Rare Subset of Adult Human Lin−CD34−CD38− Cells Stimulated by Multiple Growth Factors In Vitro

1999 • 61 citations

High marrow seeding efficiency of human lymphomyeloid repopulating cells in irradiated NOD/SCID mice

2000 • 55 citations

CDCP1 Is a Novel Marker for Hematopoietic Stem Cells

2003 • 54 citations

Hematopoietic stem cells: Inferences from in vivo assays

1997 • 51 citations

Purification of Hematopoietic Stem Cells for Further Biological Study

1999 • 50 citations

CD34+/CD105+ cells are enriched in primitive circulating progenitors residing in the G0 phase of the cell cycle and contain all bone marrow and cord blood CD34+/CD38^low/− precursors

2000 • 47 citations

The marrow homing efficiency of murine hematopoietic stem cells remains constant during ontogeny

2003 • 46 citations

Clinical Applications of CD34 ⁺ Peripheral Blood Progenitor Cells (PBPC)

2000 • 45 citations

Hematopoietic Stem Cell Protocols

2002 • 44 citations

Distal elements are critical for human CD34 expression in vivo

2002 • 41 citations

Extensive generation of human cord blood CD34+ stem cells from Lin−CD34− cells in a long-term in vitro system

2000 • 38 citations

Differential Expression of Receptors for Hemopoietic Growth Factors on Subsets of CD34⁺Hemopoietic Cells

1996 • 33 citations

Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients

1996 • 30 citations

Interleukin-1 and Tumor Necrosis Factor Alpha Induce Class 1 Aldehyde Dehydrogenase mRNA and Protein in Bone Marrow Cells

1995 • 27 citations

Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients

1996 • 25 citations

Quantitation of Murine and Human Hematopoietic Stem Cells by Limiting-Dilution Analysis in Competitively Repopulated Hosts

2003 • 23 citations

The Cobblestone-Area-Forming Cell Assay

2003 • 22 citations

Transplantation of stem cells enriched by immunoadsorption.

1992 • 20 citations

Acquired and inherited basal cell carcinomas and the patched gene.

1999 • 20 citations

Peripheral Blood Stem Cell Transplantation

1997 • 15 citations

Flow Cytometry and Immunoselection of Human Stem Cells

2003 • 9 citations

Ex vivo manipulation of hematopoietic stem and progenitor cells

2009 • 6 citations

A simple and rapid method for removal of specific cell populations from whole blood

1996 • 6 citations

Selection of Murine Lymphoid and Hematopoietic Cells Using Polystyrene Tissue Culture Devices Containing Covalently Immobilized Antibody

1996 • 3 citations

50-FOLD Enrichment of CD34+ cells directly from cord blood in a single density separation

2000 • 1 citations