The anti-apoptosis function of Bcl-2 can be genetically separated from its inhibitory effect on cell cycle entry

Apoptosis: A Basic Biological Phenomenon with Wideranging Implications in Tissue Kinetics

1972 • 15,349 citations

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

A rapid and simple method for measuring thymocyte apoptosis by propidium iodide staining and flow cytometry

1991 • 4,682 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1β-converting enzyme

1993 • 2,484 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

Cloning of the Chromosome Breakpoint of Neoplastic B Cells with the t(14;18) Chromosome Translocation

1984 • 1,761 citations

pEF-BOS, a powerful mammalian expression vector

1990 • 1,641 citations

X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death

1996 • 1,456 citations

Structure of Bcl-x _L -Bak Peptide Complex: Recognition Between Regulators of Apoptosis

1997 • 1,429 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Life, death, and the pursuit of apoptosis.

1996 • 1,333 citations

BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and heterodimerization with Bax

1994 • 1,303 citations

A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification

1988 • 934 citations

Deregulated Bcl-2 gene expression selectively prolongs survival of growth factor-deprived hemopoietic cell lines.

1990 • 926 citations

BID: a novel BH3 domain-only death agonist.

1996 • 921 citations

Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2

1990 • 910 citations

Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14;18)

1991 • 876 citations

Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B.

1993 • 875 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

Cooperative interaction between c-myc and bcl-2 proto-oncogenes

1992 • 766 citations

Inactivation of Bcl-2 by phosphorylation.

1995 • 744 citations

Induction of apoptosis by the Bcl-2 homologue Bak

1995 • 738 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

A License to Kill

1996 • 649 citations

Regulators of cell death

1995 • 647 citations

Interaction of CED-4 with CED-3 and CED-9: A Molecular Framework for Cell Death

1997 • 635 citations

Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation.

1990 • 622 citations

Modulation of apoptosis by the widely distributed Bcl-2 homologue Bak

1995 • 514 citations

Cloning of a bcl-2 homologue by interaction with adenovirus E1B 19K

1995 • 501 citations

A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions.

1995 • 491 citations

Immediate early up-regulation of bax expression by p53 but not TGF beta 1: a paradigm for distinct apoptotic pathways.

1994 • 482 citations

Adenovirus E1B 19 kDa and Bcl-2 proteins interact with a common set of cellular proteins

1994 • 467 citations

[17]Gene splicing by overlap extension

1993 • 463 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Bik, a novel death-inducing protein shares a distinct sequence motif with Bcl-2 family proteins and interacts with viral and cellular survival-promoting proteins.

1995 • 431 citations

Structure-Function Analysis of Bcl-2 Protein

1995 • 419 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

Regulation of Lymphocyte Survival by the BCL-2 Gene Family

1995 • 380 citations

Programmed cell death in Caenorhabditis elegans

1994 • 379 citations

ICE-like proteases in apoptosis

1995 • 353 citations

Interaction and Regulation of Subcellular Localization of CED-4 by CED-9

1997 • 345 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

The Caenorhabditis elegans cell-death protein CED-3 is a cysteine protease with substrate specificities similar to those of the human CPP32 protease.

1996 • 331 citations

bcl-w, a novel member of the bcl-2 family, promotes cell survival.

1996 • 309 citations

Interaction between the C. elegans cell-death regulators CED-9 and CED-4

1997 • 304 citations

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

1996 • 284 citations

Bcl-2 associates with the ras-related protein R-rasp23

1993 • 259 citations

Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death

1997 • 248 citations

The protein product of the oncogene bcl-2 is a component of the nuclear envelope, the endoplasmic reticulum, and the outer mitochondrial membrane.

1994 • 233 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells

1994 • 225 citations

Complexes of polyoma virus medium T antigen and cellular proteins.

1985 • 223 citations

Diminished Cell Proliferation Associated with the Death-protective Activity of Bcl-2

1996 • 202 citations

Induction of Apoptosis by Human Nbk/Bik, a BH3-Containing Protein That Interacts with E1B 19K

1996 • 201 citations

Modulation of p53-Mediated Transcriptional Repression and Apoptosis by the Adenovirus E1B 19K Protein

1995 • 191 citations

The protein bcl-2 alpha does not require membrane attachment, but two conserved domains to suppress apoptosis.

1994 • 186 citations

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

1996 • 170 citations

Bcl-2 has a cell cycle inhibitory function separable from its enhancement of cell survival.

1996 • 167 citations

E mu-bcl-2 transgene facilitates spontaneous transformation of early pre-B and immunoglobulin-secreting cells but not T cells.

1993 • 162 citations

The p53-Binding Protein 53BP2 Also Interacts with Bcl2 and Impedes Cell Cycle Progression at G₂/M

1996 • 159 citations

Apoptosis suppressing protein bcl‐2 is expressed in well‐differentiated breast carcinomas with favourable prognosis

1995 • 156 citations

R-Ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 suppressible mechanism.

1995 • 142 citations

Phosphorylation of Bcl-2 Protein and Association with p21Ras in Ras-induced Apoptosis

1996 • 132 citations

Morphologic transformation of follicular lymphoma is associated with somatic mutation of the translocated Bcl-2 gene

1996 • 130 citations

Functional Dissection of the Human Bcl2 Protein: Sequence Requirements for Inhibition of Apoptosis

1996 • 126 citations

R-Ras induces malignant, but not morphologic, transformation of NIH3T3 cells.

1994 • 112 citations

A Peptide Sequence from Bax That Converts Bcl-2 into an Activator of Apoptosis

1996 • 111 citations

Frequent incidence of somatic mutations in translocated BCL2 oncogenes of non-Hodgkin's lymphomas

1992 • 98 citations

Peripheral T-cell lymphoma in lckpr-bcl-2 transgenic mice

1995 • 92 citations

Expression of a bcl-2 transgene reduces proliferation and slows turnover of developing B lymphocytes in vivo.

1997 • 82 citations

Oncogenic activation of human R-ras by point mutations analogous to those of prototype H-ras oncogenes.

1994 • 78 citations

Growth factor starvation of bcl-2 overexpressing murine bone marrow cells induced refractoriness to IL-3 stimulation of proliferation.

1994 • 67 citations

Deletion of a nonconserved region of Bcl-2 confers a novel gain of function: suppression of apoptosis with concomitant cell proliferation.

1996 • 65 citations

Unmasking of a proliferation-restraining activity of the anti-apoptosis protein EBV BHRF1.

1996 • 56 citations

Evidence for α-Helical Conformation of an Essential N-terminal Region in the Human Bcl2 Protein

1996 • 50 citations

bcl-2 transgene expression promotes survival and reduces proliferation of CD3-CD4-CD8- T cell progenitors

1997 • 49 citations

Abrogation of p53-induced G1 arrest by the HPV 16 E7 protein does not inhibit p53-induced apoptosis.

1996 • 21 citations

Chapter 29 Simultaneous Fluorescent Labeling of DNA, RNA, and Protein

1990 • 15 citations