Identification of properties that can distinguish primitive populations of stromal-cell-responsive lympho-myeloid cells from cells that are stromal-cell-responsive but lymphoid-restricted and cells that have lympho-myeloid potential but are also capable of competitively repopulating myeloablated recipients

A Direct Measurement of the Radiation Sensitivity of Normal Mouse Bone Marrow Cells

1961 • 3,579 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers.

1990 • 697 citations

Long-term culture of B lymphocytes and their precursors from murine bone marrow.

1982 • 612 citations

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

1995 • 606 citations

Characterization and regulation of RB6-8C5 antigen expression on murine bone marrow cells.

1991 • 512 citations

The evaluation of limiting dilution assays

1982 • 458 citations

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

1990 • 456 citations

Ligand for FLT3/FLK2 receptor tyrosine kinase regulates growth of haematopoietic stem cells and is encoded by variant RNAs

1994 • 453 citations

CYTOLOGICAL EVIDENCE FOR A RELATIONSHIP BETWEEN NORMAL HEMATOPOIETIC COLONY-FORMING CELLS AND CELLS OF THE LYMPHOID SYSTEM

1968 • 441 citations

Sensitivity of corticosteroid-dependent insulin-resistant lipogenesis in marrow preadipocytes of obese-diabetic (db/db) mice

1978 • 231 citations

Clonal proliferation of murine lymphohemopoietic progenitors in culture.

1992 • 163 citations

Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.

1992 • 144 citations

Steel factor influences the distribution and activity of murine hematopoietic stem cells in vivo.

1993 • 137 citations

Characterization and purification of a primitive hematopoietic cell type in adult mouse marrow capable of lymphomyeloid differentiation in long-term marrow "switch" cultures

1995 • 131 citations

Clonal Hematopoiesis Demonstrated by X-Linked DNA Polymorphisms after Allogeneic Bone Marrow Transplantation

1989 • 121 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 121 citations

Purification of pluripotent hemopoietic stem cells: past and present.

1990 • 102 citations

Studies of W mutant mice provide evidence for alternate mechanisms capable of activating hematopoietic stem cells.

1996 • 92 citations

Pre-B cell generation potentiated by soluble factors from a bone marrow stromal cell line.

1988 • 74 citations

In vitro differentiation of B lymphocytes from primitive hemopoietic precursors present in long-term bone marrow cultures.

1986 • 73 citations

Maintenance of high levels of pluripotent hematopoietic stem cells in vitro: effect of stromal cells and c-kit

1993 • 70 citations

Stromal cell independent growth of bipotent B cell – macrophage precursors from murine fetal liver

1994 • 67 citations

Marrow repopulating cells, but not CFU-S, establish long-term in vitro hemopoiesis on a marrow-derived stromal layer.

1990 • 58 citations

Loss of long-term repopulating ability in long-term bone marrow culture.

1993 • 45 citations

In vitro development of B lymphocytes from long-term cultured precursor cells.

1986 • 42 citations

Differential and synergistic effects of human granulocyte-macrophage colony-stimulating factor and human granulocyte colony-stimulating factor on hematopoiesis in human long-term marrow cultures

1991 • 42 citations

Differential regulation of primitive human hematopoietic cells in long- term cultures maintained on genetically engineered murine stromal cells

1991 • 35 citations

Long-term cultured B lymphocytes and their precursors reconstitute the B-lymphocyte lineage in vivo.

1984 • 32 citations

Lymphohematopoietic progenitors of normal mice

1995 • 26 citations

Phenotypic and functional characterization of competitive long-term repopulating hematopoietic stem cells enriched from 5-fluorouracil- treated murine marrow

1993 • 17 citations

Biologic significance of constitutive and subliminal growth factor production by bone marrow stroma

1992 • 17 citations

Introduction of interleukin-3 gene into stromal cells from the bone marrow alters hemopoietic differentiation but does not modify stem cell renewal

1988 • 12 citations

Characterization of murine bone marrow and spleen-derived stromal cells: analysis of leukocyte marker and growth factor mRNA transcript levels

1989 • 12 citations

Reconstitution of immune-deficient mice with cells from long-term bone marrow cultures.

1984 • 11 citations

T- and B-lymphocyte differentiation potentials of spleen colony-forming cells

1993 • 10 citations

Alternative mechanisms with and without steel factor support primitive human hematopoiesis

1993 • 8 citations

Expansion in vitro of retrovirally marked totipotent hematopoietic stem cells

1990 • 8 citations

Use of scid mice to identify and quantitate lymphoid-restricted stem cells in long-term bone marrow cultures

1989 • 8 citations

Characterization of a primitive erythropoietic progenitor found in mouse marrow before and after several weeks in culture

1979 • 6 citations

Mock Retroviral Infection Alters the Developmental Potential of Murine Bone Marrow Stem Cells

1989 • 5 citations