The Role of Apoptosis in the Regulation of Hematopoietic Stem Cells

Death Receptors: Signaling and Modulation

1998 • 5,873 citations

The Bcl-2 Protein Family: Arbiters of Cell Survival

1998 • 5,359 citations

Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells

1988 • 3,194 citations

BCL-2 FAMILY: Regulators of Cell Death

1998 • 1,687 citations

Cell Death in Development

1999 • 1,567 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes

1991 • 1,223 citations

Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18

1985 • 1,188 citations

Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.

1986 • 1,118 citations

The long-term repopulating subset of hematopoietic stem cells is deterministic and isolatable by phenotype

1994 • 1,109 citations

bcl-2 transgene inhibits T cell death and perturbs thymic self-censorship

1991 • 1,090 citations

The aging of hematopoietic stem cells

1996 • 850 citations

In vivo proliferation and cell cycle kinetics of long-term self-renewing hematopoietic stem cells

1999 • 832 citations

Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis.

1995 • 791 citations

The purification and characterization of fetal liver hematopoietic stem cells.

1995 • 607 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Quiescence, cycling, and turnover in the primitive hematopoietic stem cell compartment.

1997 • 431 citations

The cell death inhibitor Bcl-2 and its homologues influence control of cell cycle entry.

1996 • 384 citations

Suppression of apoptosis allows differentiation and development of a multipotent hemopoietic cell line in the absence of added growth factors

1993 • 380 citations

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

1998 • 328 citations

Cyclophosphamide/granulocyte colony-stimulating factor induces hematopoietic stem cells to proliferate prior to mobilization

1997 • 316 citations

Systemic Overexpression of BCL-2 in the Hematopoietic System Protects Transgenic Mice From the Consequences of Lethal Irradiation

1998 • 299 citations

Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice

1997 • 292 citations

bcl-2 inhibits apoptosis of neutrophils but not their engulfment by macrophages.

1994 • 288 citations

Regulation of cell division cycle progression by bcl-2 expression: a potential mechanism for inhibition of programmed cell death.

1996 • 284 citations

Phenotypic and Functional Changes Induced at the Clonal Level in Hematopoietic Stem Cells After 5-Fluorouracil Treatment

1997 • 280 citations

bcl-2 transgene expression can protect neurons against developmental and induced cell death.

1995 • 261 citations

Bcl-2 Rescues T Lymphopoiesis, but Not B or NK Cell Development, in Common γ Chain–Deficient Mice

1997 • 220 citations

Hematopoietic activity of a stromal cell transmembrane protein containing epidermal growth factor-like repeat motifs

1997 • 199 citations

Self-renewal, differentiation or death: regulation and manipulation of hematopoietic stem cell fate

1999 • 195 citations

Mice Defective in Two Apoptosis Pathways in the Myeloid Lineage Develop Acute Myeloblastic Leukemia

1998 • 173 citations

Bax alpha perturbs T cell development and affects cell cycle entry of T cells.

1996 • 170 citations

Bcl-2 prevents death of factor-deprived cells but fails to prevent apoptosis in targets of cell mediated killing

1992 • 165 citations

Bcl-2 prevents apoptosis induced by perforin and granzyme B, but not that mediated by whole cytotoxic lymphocytes.

1997 • 161 citations

Insights from Bcl-2 and Myc: malignancy involves abrogation of apoptosis as well as sustained proliferation.

1999 • 153 citations

Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells

1998 • 150 citations

Differentiation of hematopoietic stem cells in irradiated mouse thymic lobes. Kinetics and phenotype of progeny.

1990 • 148 citations

Intrinsic and Extrinsic Control of Hemopoietic Stem Cell Numbers: Mapping of a Stem Cell Gene

1997 • 142 citations

bcl-2 transgenic Lpr mice show profound enhancement of lymphadenopathy.

1995 • 53 citations

Hematopoietic reserve provided by spleen colony-forming units (CFU-S).

1995 • 15 citations

Estimation of Extent of Cell Death in Different Stages of Normal Murine Hematopoiesis

1998 • 15 citations

8 Apoptosis, haemopoiesis and leukaemogenesis

1997 • 13 citations

Purification of murine hemopoietic stem cells and committed progenitors by fluorescence activated cell sorting using wheat germ agglutinin and monoclonal antibodies.

1988 • 12 citations