Amplification of Sca-1+ Lin-WGA+ cells in serum-free cultures containing steel factor, interleukin-6, and erythropoietin with maintenance of cells with long-term in vivo reconstituting potential

Purification and Characterization of Mouse Hematopoietic Stem Cells

1988 • 2,856 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies. I. Data analysis.

1981 • 1,281 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Evidence that hematopoietic stem cells express mouse c-kit but do not depend on steel factor for their generation.

1992 • 650 citations

Quantitative assay for totipotent reconstituting hematopoietic stem cells by a competitive repopulation strategy.

1990 • 456 citations

Dead cell discrimination with 7‐amino‐actinomcin D in combination with dual color immunofluorescence in single laser flow cytometry

1992 • 443 citations

Separation of pluripotent haematopoietic stem cells from spleen colony-forming cells

1990 • 414 citations

Limiting dilution assays for the determination of immunocompetent cell frequencies.

1981 • 386 citations

Clonal analysis of hematopoietic stem-cell differentiation in vivo.

1991 • 379 citations

Searching for hematopoietic stem cells: evidence that Thy-1.1lo Lin- Sca-1+ cells are the only stem cells in C57BL/Ka-Thy-1.1 bone marrow.

1992 • 368 citations

Isolation of murine pluripotent hemopoietic stem cells.

1984 • 333 citations

Resting and activated subsets of mouse multipotent hematopoietic stem cells.

1990 • 333 citations

Regulation of very primitive, multipotent, hemopoietic cells by hemopoietin-1

1986 • 283 citations

Analysis in serum-free culture of the targets of recombinant human hemopoietic growth factors: interleukin 3 and granulocyte/macrophage-colony-stimulating factor are specific for early developmental stages.

1988 • 239 citations

Long-term erythropoiesis from constant numbers of CD34+ cells in serum-free cultures initiated with highly purified progenitor cells from human bone marrow.

1992 • 231 citations

Separation of CFU-S from primitive cells responsible for reconstitution of the bone marrow hemopoietic stem cell compartment following irradiation: evidence for a pre-CFU-S cell.

1989 • 209 citations

Enhancement of murine hematopoiesis by synergistic interactions between steel factor (ligand for c-kit), interleukin-11, and other early acting factors in culture

1992 • 167 citations

The effect of recombinant mast cell growth factor on purified murine hematopoietic stem cells.

1991 • 157 citations

Interleukin-6 interacts with interleukin-4 and other hematopoietic growth factors to selectively enhance the growth of megakaryocytic, erythroid, myeloid, and multipotential progenitor cells

1989 • 156 citations

The Efficient Design of Transplantable Tumour Assays

1963 • 147 citations

Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells.

1991 • 146 citations

Proliferation of totipotent hematopoietic stem cells in vitro with retention of long-term competitive in vivo reconstituting ability.

1992 • 144 citations

Survival and retrovirus infection of murine hematopoietic stem cells in vitro: effects of 5-FU and method of infection.

1991 • 137 citations

A simplified method for enrichment of mouse hematopoietic stem cells.

1990 • 128 citations

Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture

1991 • 117 citations

Interactions among colony-stimulating factors, IL-1 beta, IL-6, and kit-ligand in the regulation of primitive murine hematopoietic cells.

1992 • 104 citations

Isolation in a single step of a highly enriched murine hematopoietic stem cell population with competitive long-term repopulating ability

1989 • 100 citations

Alternative mechanisms with and without steel factor support primitive human hematopoiesis

1993 • 90 citations

The in vitro response of phenotypically defined mouse stem cells and myeloerythroid progenitors to single or multiple growth factors.

1991 • 86 citations

Proliferative state of human pluripotent hemopoietic progenitors (CFU- GEMM) in normal individuals and under regenerative conditions after bone marrow transplantation

1979 • 75 citations

Two monoclonal antibodies identify thymic-repopulating cells in mouse bone marrow.

1989 • 74 citations

Synergism between erythropoietin and interleukin-3 in the induction of hematopoietic stem cell proliferation and erythroid burst colony formation

1988 • 74 citations

Wheat germ agglutinin affinity of murine hemopoietic stem cell subpopulations is an inverse function of their long-term repopulating ability in vitro and in vivo.

1993 • 71 citations

In vitro proliferation of primitive hemopoietic stem cells supported by stromal cells: evidence for the presence of a mechanism(s) other than that involving c-kit receptor and its ligand.

1992 • 69 citations

Enrichment of murine haemopoietic stem cells: diverging roads

1989 • 66 citations

Effects of rrSCF on multiple cytokine responsive HPP-CFC generated from SCA+Lin- murine hematopoietic progenitors.

1991 • 64 citations

Marrow repopulating cells, but not CFU-S, establish long-term in vitro hemopoiesis on a marrow-derived stromal layer.

1990 • 58 citations

Normal cycling patterns of hematopoietic stem cell subpopulations: an assay using long-term in vivo BrdU infusion

1985 • 44 citations

Long-term hemopoietic repopulation by Thy-1lo, Lin-, Ly6A/E+ cells.

1992 • 37 citations

[Humoral regulation of stem cell proliferation].

1991 • 22 citations

Synergistic effect of IL-3 and IL-6 on highly enriched murine hemopoietic progenitors.

1992 • 21 citations

Characterization of murine hematopoietic progenitor subsets involved in interleukin-3-induced interleukin-6 production

1991 • 20 citations