Molecular Mechanisms of Interferon Resistance Mediated by Viral-Directed Inhibition of PKR, the Interferon-Induced Protein Kinase

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Expression monitoring by hybridization to high-density oligonucleotide arrays

1996 • 2,796 citations

Functional Role of Type I and Type II Interferons in Antiviral Defense

1994 • 2,437 citations

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Accessing Genetic Information with High-Density DNA Arrays

1996 • 1,511 citations

Heat shock proteins.

1990 • 1,365 citations

The Interferon System

1979 • 1,035 citations

Mutations in the Nonstructural Protein 5a Gene and Response to Interferon in Patients with Chronic Hepatitis C Virus 1b Infection

1996 • 1,016 citations

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

1990 • 1,003 citations

The complete DNA sequence of vaccinia virus

1990 • 847 citations

Evidence That Hepatitis C Virus Resistance to Interferon Is Mediated through Repression of the PKR Protein Kinase by the Nonstructural 5A Protein

1997 • 824 citations

Phosphorylation of initiation factor 2α by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

1992 • 768 citations

The γ ₁ 34.5 protein of herpes simplex virus 1 complexes with protein phosphatase 1α to dephosphorylate the α subunit of the eukaryotic translation initiation factor 2 and preclude the shutoff of protein synthesis by double-stranded RNA-activated protein kinase

1997 • 734 citations

Transmission of Hepatitis C by Intrahepatic Inoculation with Transcribed RNA

1997 • 718 citations

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase.

1995 • 640 citations

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.

1995 • 638 citations

The interferon system. A bird's eye view of its biochemistry.

1992 • 633 citations

Tetratrico peptide repeat interactions: to TPR or not to TPR?

1995 • 624 citations

Antiviral actions of interferon interferon-regulated cellular proteins and their surprisingly selective antiviral activities

1991 • 600 citations

The Double-Stranded RNA-Dependent Protein Kinase PKR: Structure and Function

1997 • 600 citations

Heat shock proteins: molecular chaperones of protein biogenesis

1993 • 598 citations

Double-stranded RNA-dependent protein kinase activates transcription factor NF-kappa B by phosphorylating I kappa B.

1994 • 569 citations

A conserved double-stranded RNA-binding domain.

1992 • 540 citations

Expression cloning of 2-5A-dependent RNAase: A uniquely regulated mediator of interferon action

1993 • 509 citations

Epidemiology of Hepatitis C in the West

1995 • 506 citations

The involvement of NF-κB in β-interferon gene regulation reveals its role as widely inducible mediator of signal transduction

1989 • 494 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

Interactions between double-stranded RNA regulators and the protein kinase DAI.

1992 • 475 citations

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

1992 • 469 citations

The TPR snap helix: a novel protein repeat motif from mitosis to transcription

1991 • 452 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.

1992 • 396 citations

Adenovirus VAI RNA is required for efficient translation of viral mRNAs at late times after infection

1982 • 395 citations

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis

1997 • 394 citations

The Phosphorylation State of Eucaryotic Initiation Factor 2 Alters Translational Efficiency of Specific mRNAs

1989 • 393 citations

Binding of the Influenza Virus NS1 Protein to Double-Stranded RNA Inhibits the Activation of the Protein Kinase That Phosphorylates the eIF-2 Translation Initiation Factor

1995 • 391 citations

Characterization of a Human TAR RNA-Binding Protein That Activates the HIV-1 LTR

1991 • 391 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

The eIF-2 alpha protein kinases, regulators of translation in eukaryotes from yeasts to humans.

1993 • 383 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappa B

1997 • 353 citations

Interferon-Induced Proteins and the Antiviral State

1990 • 353 citations

1 Progress and Perspectives on the Biology of Heat Shock Proteins and Molecular Chaperones

1994 • 342 citations

Interferon-α But Not AZT Suppresses HIV Expression in Chronically Infected Cell Lines

1989 • 339 citations

Interferon-Induced Antiviral Actions and Their Regulation

1993 • 338 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

The Interferon-induced Double-Stranded RNA-Activated Protein Kinase Induces Apoptosis

1994 • 322 citations

Involvement of the IRF-1 Transcription Factor in Antiviral Responses to Interferons

1994 • 306 citations

Early events in Epstein-Barr virus infection of human B lymphocytes

1991 • 297 citations

Regulation of protein synthesis by heme-regulated eIF-2α kinase

1995 • 297 citations

The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms

1993 • 265 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

The influenza virus NS1 protein is a poly(A)-binding protein that inhibits nuclear export of mRNAs containing poly(A)

1994 • 243 citations

Two RNA-binding motifs in the double-stranded RNA-activated protein kinase, DAI.

1992 • 243 citations

Sequence and regulation of a gene encoding a human 89-kilodalton heat shock protein.

1989 • 241 citations

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1991 • 233 citations

The nature of the polypeptide encoded by each of the 10 double-stranded RNA segments of reovirus type 3

1978 • 233 citations

Eukaryotic DnaJ homologs and the specificity of Hsp70 activity

1993 • 228 citations

Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast.

1993 • 227 citations

2 The Pathway and Mechanism of Eukaryotic Protein Synthesis

1996 • 225 citations

PKR: a new name and new roles

1995 • 223 citations

Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR

1997 • 223 citations

Studies on the intracellular synthesis of reovirus-specified proteins

1970 • 217 citations

Blockage of NF-κB Signaling by Selective Ablation of an mRNA target by 2-5A Antisense Chimeras

1994 • 217 citations

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.

1994 • 215 citations

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system.

1991 • 207 citations

The vaccinia virus K3L gene product potentiates translation by inhibiting double-stranded-RNA-activated protein kinase and phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 207 citations

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

1988 • 204 citations

Cloning of the cDNA of the heme-regulated eukaryotic initiation factor 2 alpha (eIF-2 alpha) kinase of rabbit reticulocytes: homology to yeast GCN2 protein kinase and human double-stranded-RNA-dependent eIF-2 alpha kinase.

1991 • 200 citations

Expression and Replication of the Influenza Virus Genome

1989 • 198 citations

A template for the protein kinase family

1993 • 196 citations

Activation of double-stranded RNA-dependent kinase (dsl) by the TAR region of HIV-1 mRNA: A novel translational control mechanism

1989 • 196 citations

Reversal of the interferon-sensitive phenotype of a vaccinia virus lacking E3L by expression of the reovirus S4 gene

1995 • 193 citations

Double-stranded RNA in Vaccinia Virus Infected Cells

1969 • 191 citations

Binding of influenza A virus NS1 protein to dsRNA in vitro

1992 • 190 citations

Therapy of Hepatitis C

1995 • 189 citations

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

1989 • 184 citations

Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase

1993 • 183 citations

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

1987 • 181 citations

Regulation of the interferon-induced PKR: can viruses cope?

1995 • 176 citations

Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase.

1992 • 176 citations

Comparative analysis of the regulation of the interferoninducible protein kinase PKR by Epstein - Barr virus RNAs EBER-1 and EBER-2 and adenovirus VA, RNA

1993 • 175 citations

Reovirus-coded polypeptides in infected cells: Isolation of two native monomeric polypeptides with affinity for single-stranded and double-stranded RNA, respectively

1976 • 175 citations

An essential role for the interferon-inducible, double-stranded RNA-activated protein kinase PKR in the tumor necrosis factor-induced apoptosis in U937 cells.

1996 • 171 citations

Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo.

1995 • 165 citations

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

1990 • 164 citations

The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs.

1989 • 163 citations

Binding of Epstein-Barr virus small RNA EBER-1 to the double-stranded RNA-activated protein kinase DAI

1991 • 162 citations

The 58,000-Dalton Cellular Inhibitor of the Interferon-Induced Double-Stranded RNA-Activated Protein Kinase (PKR) Is a member of the Tetratricopeptide Repeat Family of Proteins

1994 • 162 citations

Mechanism of Interferon Action

1996 • 161 citations

Inhibition of influenza viral mRNA synthesis in cells expressing the interferon-induced Mx gene product

1985 • 159 citations

A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function.

1996 • 158 citations

Regulation of a protein synthesis initiation factor by adenovirus virus-associated RNAI

1985 • 157 citations

Identification of a Conserved Motif That Is Necessary for Binding of the Vaccinia Virus E3L Gene Products to Double-Stranded RNA

1993 • 157 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

HIV-1 Tat Directly Interacts with the Interferon-Induced, Double-Stranded RNA-Dependent Kinase, PKR

1995 • 149 citations

Mechanisms for the Inhibition of HIV Replication by Interferons-α, -β, and -γ, in Primary Human Macrophages

1993 • 148 citations

The interferon-inducible double-stranded RNA-activated protein kinase self-associates in vitro and in vivo.

1995 • 147 citations

The Tat Protein of Human Immunodeficiency Virus Type 1 Is a Substrate and Inhibitor of the Interferon-induced, Virally Activated Protein Kinase, PKR

1997 • 146 citations

The binding of double-stranded RNA and adenovirus VAI RNA to the interferon-induced protein kinase

1989 • 143 citations

HIV-1 TAR RNA Has an Intrinsic Ability to Activate Interferon-Inducible Enzymes

1994 • 142 citations

Regulation of the Protein Kinase PKR by the Vaccinia Virus Pseudosubstrate Inhibitor K3L Is Dependent on Residues Conserved between the K3L Protein and the PKR Substrate eIF2α

1997 • 139 citations

Mutants of the RNA-Dependent Protein Kinase (PKR) Lacking Double-Stranded RNA Binding Domain I Can Act as Transdominant Inhibitors and Induce Malignant Transformation

1995 • 139 citations

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins.

1994 • 136 citations

Suppression of the phenotype of gamma(1)34.5- herpes simplex virus 1: failure of activated RNA-dependent protein kinase to shut off protein synthesis is associated with a deletion in the domain of the alpha47 gene

1997 • 136 citations

Calcium Depletion from the Endoplasmic Reticulum Activates the Double-stranded RNA-dependent Protein Kinase (PKR) to Inhibit Protein Synthesis

1995 • 134 citations

Tat-responsive region RNA of human immunodeficiency virus 1 can prevent activation of the double-stranded-RNA-activated protein kinase.

1990 • 131 citations

The eIF-2α kinases: regulators of protein synthesis in starvation and stress

1994 • 130 citations

Characterization of the Solution Complex between the Interferon-induced, Double-stranded RNA-activated Protein Kinase and HIV-I Trans-activating Region RNA

1997 • 128 citations

Relatedness of an RNA-Binding Motif in Human Immunodeficiency Virus Type 1 TAR RNA-Binding Protein TRBP to Human P1/dsI Kinase and Drosophila Staufen

1993 • 126 citations

Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded rna-dependent protein kinase

1991 • 125 citations

Distinct binding sites for zinc and double-stranded RNA in the reovirus outer capsid protein sigma 3.

1988 • 124 citations

The Apoptosis Pathway Triggered by the Interferon-Induced Protein Kinase PKR Requires the Third Basic Domain, Initiates Upstream of Bcl-2, and Involves ICE-like Proteases1

1997 • 124 citations

Interferons in the Persistence, Pathogenesis, and Treatment of HIV Infection

1992 • 123 citations

Reovirus inhibition of cellular RNA and protein synthesis: Role of the S4 gene

1982 • 121 citations

Identification of the double-stranded RNA-binding domain of the human interferon-inducible protein kinase.

1992 • 121 citations

Translational control by adenovirus: lack of virus-associated RNAI during adenovirus infection results in phosphorylation of initiation factor eIF-2 and inhibition of protein synthesis.

1985 • 117 citations

Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA

1988 • 116 citations

Structural Requirements for Double-Stranded RNA Binding, Dimerization, and Activation of the Human eIF-2α Kinase DAI in Saccharomyces cerevisiae

1995 • 116 citations

Mechanism of interferon action: cDNA structure, expression, and regulation of the interferon-induced, RNA-dependent P1/eIF-2α protein kinase from human cells

1992 • 116 citations

Control of the ppp(A2′p)_nA System in HeLa Cells

1982 • 115 citations

Mechanism of interferon action: structure of the mouse PKR gene encoding the interferon-inducible RNA-dependent protein kinase.

1994 • 114 citations

Characterization of a specific kinase inhibitory factor produced by vaccinia virus which inhibits the interferon-induced protein kinase

1984 • 114 citations

Two small RNAs encoded by Epstein-Barr virus can functionally substitute for the virus-associated RNAs in the lytic growth of adenovirus 5.

1983 • 113 citations

The integrity of the stem structure of human immunodeficiency virus type 1 Tat-responsive sequence of RNA is required for interaction with the interferon-induced 68,000-Mr protein kinase

1991 • 111 citations

Double-Stranded RNA-Dependent Protein Kinase (PKR) Is Regulated by Reovirus Structural Proteins

1997 • 111 citations

Distinct Patterns of IFN Sensitivity Observed in Cells Infected with Vaccinia K3L- and E3L- Mutant Viruses

1995 • 110 citations

Autophosphorylation Sites Participate in the Activation of the Double-Stranded-RNA-Activated Protein Kinase PKR

1996 • 110 citations

IRF-1 induced cell growth inhibition and interferon induction requires the activity of the protein kinase PKR.

1995 • 109 citations

Influenza virus regulates protein synthesis during infection by repressing autophosphorylation and activity of the cellular 68,000-Mr protein kinase

1988 • 108 citations

Host-range restriction of vaccinia virus E3L-specific deletion mutants

1996 • 106 citations

The molecular chaperone hsp40 regulates the activity of P58 ^IPK , the cellular inhibitor of PKR

1997 • 103 citations

Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase.

1992 • 101 citations

In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.

1996 • 100 citations

Interaction of the Interferon-Induced PKR Protein Kinase with Inhibitory Proteins P58^IPK and Vaccinia Virus K3L Is Mediated by Unique Domains: Implications for Kinase Regulation

1996 • 96 citations

Fascination with 2-5A-Dependent RNase: A Unique Enzyme That Functions in Interferon Action*

1994 • 94 citations

Cytosolic double-stranded RNA-dependent protein kinase is likely a dimer of partially phosphorylated Mr = 66,000 subunits.

1992 • 93 citations

Interaction of adenovirus VA RNAI with the protein kinase DAI: Nonequivalence of binding and function

1990 • 93 citations

Translational regulation by the interferon-induced double-stranded-RNA-activated 68-kDa protein kinase.

1993 • 90 citations

Immunology of HIV infection

1997 • 88 citations

Translational stimulation by reovirus polypeptide sigma 3: substitution for VAI RNA and inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 88 citations

Specific Mutations Near the Amino Terminus of Double-stranded RNA-dependent Protein Kinase (PKR) Differentially Affect Its Double-stranded RNA Binding and Dimerization Properties

1996 • 87 citations

Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA

1993 • 87 citations

Translational control by the Epstein‐Barr virus small RNA EBER‐1

1990 • 84 citations

Regulation of Interferon-Induced Protein Kinase PKR: Modulation of P58^IPK Inhibitory Function by a Novel Protein, P52^rIPK

1998 • 83 citations

The role of the dsRNA-activated kinase, PKR, in signal transduction

1995 • 82 citations

The P58 Cellular Inhibitor Complexes with the Interferon-induced, Double-stranded RNA-dependent Protein Kinase, PKR, to Regulate Its Autophosphorylation and Activity

1996 • 82 citations

Specific inhibition of viral protein synthesis in HIV-infected cells in response to interferon treatment.

1994 • 81 citations

Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA.

1992 • 81 citations

Platelet-derived Growth Factor Signal Transduction through the Interferon-inducible Kinase PKR

1995 • 81 citations

Reovirus polypeptide sigma 3 and N-terminal myristoylation of polypeptide mu 1 are required for site-specific cleavage to mu 1C in transfected cells

1992 • 80 citations

Ribosome Targeting of PKR Is Mediated by Two Double-stranded RNA-binding Domains and Facilitates in Vivo Phosphorylation of Eukaryotic Initiation Factor-2

1997 • 80 citations

Construction and analysis of additional adenovirus substitution mutants confirm the complementation of VAI RNA function by two small RNAs encoded by Epstein-Barr virus

1985 • 79 citations

Mechanism of interferon action. Purification and substrate specificities of the double-stranded RNA-dependent protein kinase from untreated and interferon-treated mouse fibroblasts.

1985 • 78 citations

Diversity of coding strategies in influenza viruses

1991 • 75 citations

The Antiviral Potentials of Mx Proteins

1991 • 75 citations

Preferential Translation of Reovirus mRNA by a σ3-Dependent Mechanism

1997 • 73 citations

A human homologue of theEscherichia coliDnaJ heatshock protein

1991 • 72 citations

Relatedness of an RNA-binding motif in human immunodeficiency virus type 1 TAR RNA-binding protein TRBP to human P1/dsI kinase and Drosophila staufen.

1993 • 70 citations

Therapy of acute and chronic viral hepatitis.

1994 • 68 citations

Organization of the double-stranded rna-activated protein kinase dai and virus-associated va rnai in adenovirus-2-infected hela cells

1993 • 67 citations

TIK, a novel serine/threonine kinase, is recognized by antibodies directed against phosphotyrosine

1991 • 67 citations

Viral evasion of cellular defense mechanisms: regulation of the protein kinase DAI by RNA effectors

1993 • 66 citations

Mechanism of interferon action: characterization of the intermolecular autophosphorylation of PKR, the interferon-inducible, RNA-dependent protein kinase

1995 • 64 citations

Vaccinia specific kinase inhibitory factor prevents translational inhibition by double-stranded RNA in rabbit reticulocyte lysate

1989 • 63 citations

Proteolytic cleavage of the reovirus sigma 3 protein results in enhanced double-stranded RNA-binding activity: identification of a repeated basic amino acid motif within the C-terminal binding region

1992 • 63 citations

Site-Directed Mutagenic Analysis of Reovirus σ3 Protein Binding to dsRNA

1994 • 61 citations

Regulation of the interferon-inducible eIF-2α protein kinase by small RNAs

1994 • 61 citations

Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.

1991 • 61 citations

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

1991 • 59 citations

Stimulation of chloramphenicol acetyltransferase mRNA translation by reovirus capsid polypeptide sigma 3 in cotransfected COS cells

1989 • 58 citations

Epstein-Barr virus-encoded small RNAs (EBERs) do not modulate interferon effects in infected lymphocytes

1992 • 57 citations

Paradoxical interactions between human delta hepatitis agent RNA and the cellular protein kinase PKR

1996 • 56 citations

The Kinase Insert Domain of Interferon-induced Protein Kinase PKR Is Required for Activity but Not for Interaction with the Pseudosubstrate K3L

1996 • 51 citations

The Protein Kinase Family

1987 • 50 citations

Games viruses play: a strategic initiative against the interferon-induced dsRNA activated 68,000 Mr protein kinase

1993 • 50 citations

PKR: Proposed Nomenclature for the RNA-Dependent Protein Kinase Induced by Interferon

1993 • 50 citations

The small RNAs of Epstein-Barr virus

1993 • 49 citations

Interferon Treatment Inhibits Virus Replication in HIV-1- and SIV-Infected CD4+ T-Cell Lines by Distinct Mechanisms: Evidence for Decreased Stability and Aberrant Processing of HIV-1 Proteins

1995 • 47 citations

Multiple Effects of Interferon on HIV-1 Replication

1991 • 46 citations

Characterization of two murine (2′‐5′)(A)_n‐dependent endonucleases of different molecular mass

1989 • 46 citations

Physical and Functional Characterization of the Double-Stranded RNA Binding Protein Encoded by the Vaccinia Virus E3 Gene

1996 • 45 citations

Differentiation of the Shutoff of Protein Synthesis by Virion Host Shutoff and Mutant γ134.5 Genes of Herpes Simplex Virus 1

1997 • 45 citations

The Interferon-inducible Protein Kinase PKR Modulates the Transcriptional Activation of Immunoglobulin κ Gene

1995 • 44 citations

Mutational analysis of the vaccinia virus E3 protein defines amino acid residues involved in E3 binding to double-stranded RNA

1996 • 44 citations

Activation of the double‐stranded RNA‐dependent eIF‐2α kinase by cellular RNA from 3T3‐F442A cells

1991 • 41 citations

Molecular Biology: The Interferon System: A Review with Emphasis on the Role of PKR in Growth Control

1995 • 41 citations

Regulation of the Double-stranded RNA-Dependent Protein Kinase PKR by RNAs Encoded by a Repeated Sequence in the Epstein-Barr Virus Genome

1996 • 41 citations

Translational effects and sequence comparisons of the three serotypes of the reovirus S4 gene

1992 • 40 citations

Mechanism of interferon action: RNA-binding activity of full-length and R-domain forms ofthe RNA-dependent protein kinase PKR — Determination of K values for VAI and TAR RNAs

1995 • 40 citations

Secondary and tertiary structure in the central domain of adenovirus type 2 VA RNA I.

1996 • 40 citations

Expression of cellular genes in CD4 positive lymphoid cells infected by the human immunodeficiency virus, HIV-1: Evidence for a host protein synthesis shut-off induced by cellular mRNA degradation

1990 • 38 citations

CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

1992 • 37 citations

Cloning, expression, and cellular localization of the oncogenic 58-kDa inhibitor of the RNA-activated human and mouse protein kinase

1996 • 37 citations

Protein kinases that phosphorylate eIF-2 and eIF-2B, and their role in eukaryotic cell translational control.

1996 • 36 citations

Control of Translation in Adenovirus-Infected Cells

1990 • 35 citations

The Lang strain of reovirus serotype 1 and the Dearing strain of reovirus serotype 3 differ in their sensitivities to beta interferon

1991 • 34 citations

Current State of Interferon Therapy for Chronic Hepatitis C

1994 • 34 citations

Anti-HIV-1 Activity of Recombinant and Hybrid Species of Interferon-α

1992 • 33 citations

The viral protein sigma 3 participates in translation of late viral mRNA in reovirus-infected L cells

1987 • 30 citations

Regulated, stable expression and nuclear presence of reovirus double-stranded RNA-binding protein sigma3 in HeLa cells

1996 • 30 citations

Leading article

1994 • 24 citations

20 Adenovirus and Vaccinia Virus Translational Control

1996 • 23 citations

Simian Virus 40 Large-T Bypasses the Translational Block Imposed by the Phosphorylation of eIF-2α

1996 • 22 citations

Cloning and characterization of a human protein phosphatase 1-encoding cDNA

1993 • 21 citations

Cellular Inhibitors of the Interferon-Induced, dsRNA-Activated Protein Kinase

1994 • 21 citations

Protein synthesis in different cell lines infected with orthoreovirus serotype 3: inhibition of host-cell protein synthesis correlates with accelerated viral multiplication and cell killing

1993 • 21 citations

A novel translational regulation function for the simian virus 40 large-T antigen gene

1995 • 21 citations

The mouse antiphosphotyrosine immunoreactive kinase, TIK, is indistinguishable from the double-stranded RNAdependent, interferon-induced protein kinase, PKR

1993 • 20 citations

Immunology of HIV Infection, I: Biology of the Interferons

1990 • 19 citations

Characterization and mapping of the double-stranded regions involved in activation of PKR within a cellular RNA from 3T3-F442A cells

1997 • 18 citations

Regulation of Viral and Cellular RNA Turnover in Cells Infected by Eukaryotic Viruses including HIV-1

1990 • 17 citations

21 Translational Control in Cells Infected with Influenza Virus and Reovirus

1996 • 17 citations

Expression of the cloned S4 gene of reovirus serotype 3 in transformed eucaryotic cells: enrichment of the viral protein in the crude initiation factor fraction

1986 • 13 citations

High level of transgene expression in cell cultures and in the mouse by replication-incompetent adenoviruses harboring modified VAI genes

1997 • 10 citations