Immunology of HIV Infection, I: Biology of the Interferons

INTERFERONS AND THEIR ACTIONS

1987 • 1,838 citations

Identification of two distinct regulatory regions adjacent to the human β-interferon gene

1983 • 1,076 citations

Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells

1984 • 729 citations

Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control.

1988 • 583 citations

Two interferon mRNAs in human fibroblasts: in vitro translation and Escherichia coli cloning studies.

1980 • 341 citations

Interferon-α But Not AZT Suppresses HIV Expression in Chronically Infected Cell Lines

1989 • 339 citations

Acid-Labile Human Leukocyte Interferon in Homosexual Men with Kaposi's Sarcoma and Lymphadenopathy

1982 • 327 citations

Induction of IL-6 (B cell stimulatory factor-2/IFN-beta 2) production by HIV.

1989 • 314 citations

Synergistic inhibition of human immunodeficiency virus in vitro by azidothymidine and recombinant alpha A interferon

1987 • 237 citations

Regulation of Cytokine Gene Expression

1988 • 234 citations

Biological response modifiers: the new immunotherapy.

1989 • 202 citations

Coordinate regulation of immune and inflammatory responses by T cell‐derived lymphokines

1988 • 197 citations

Different pathways mediate virus inducibility of the human IFN-α1 and IFN-β genes

1990 • 158 citations

Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product

1990 • 155 citations

Human chromosomes 6 and 21 are required for sensitivity to human interferon gamma.

1987 • 146 citations

Activation of interferon-regulated, dsRNA-dependent enzymes by human immunodeficiency virus-1 leader RNA

1989 • 135 citations

In vitro and in vivo activation of human mononuclear phagocytes by interferon-gamma. Studies with normal and AIDS monocytes.

1987 • 124 citations

Human lymphoblastoid interferon treatment of Kaposi's sarcoma in the acquired immune deficiency syndrome. Clinical response and prognostic parameters

1985 • 111 citations

Decreased expression of human class II antigens on monocytes from patients with acquired immune deficiency syndrome. Increased expression with interferon-gamma.

1984 • 106 citations

Interferon Production in Patients Infected with HIV-1

1989 • 100 citations

The role of interferons in the control of HIV replication in macrophages

1990 • 93 citations

A primitive immune system

1989 • 93 citations

Antiviral state against influenza virus neutralized by microinjection of antibodies to interferon-induced Mx proteins.

1988 • 86 citations

Modulation of Nuclear Matrix-associated 2′,5′-Oligoadenylate Metabolism and Ribonuclease L Activity in H9 Cells by Human Immunodeficiency Virus

1989 • 82 citations

Marked Disparity in Incidence of Bacterial Infections in Patients with the Acquired Immunodeficiency Syndrome Receiving Interleukin-2 or Interferon-γ

1988 • 74 citations

Improvement of platelet counts in steroid-unresponsive idiopathic immune thrombocytopenic purpura after short-course therapy with recombinant alpha 2b interferon [see comments]

1989 • 73 citations

Effect of Interferon on Murine Leukaemia Virus Infection. IV. Formation of Non-infectious Virus in Chronically Infected Cells

1979 • 67 citations

Downregulation of interferon alpha but not gamma receptor expression in vivo in the acquired immunodeficiency syndrome.

1988 • 40 citations

A phase I trial of recombinant human interferon-γ in patients with Kaposi's sarcoma and the acquired immunodeficiency syndrome (AIDS)

1989 • 37 citations

The interferon-induced Mx-homologous protein in people with symptomatic HIV-1 infection

1990 • 36 citations

Microinjected interferon does not promote an antiviral response in Hela cells

1983 • 27 citations

Human interferons: structure and function.

1987 • 27 citations

PolyI.polyC12U-mediated inhibition of loss of alloantigen responsiveness viral replication in human CD4+ T cell clones exposed to human immunodeficiency virus in vitro.

1987 • 17 citations

Distinct domains of recombinant human IFN-gamma responsible for anti-viral effector function.

1988 • 17 citations