In vitro activation of the interferon-induced, double-stranded RNA-dependent protein kinase PKR by RNA from the 3' untranslated regions of human alpha-tropomyosin.

Biochemistry of Interferons and Their Actions

1982 • 868 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

Interactions between double-stranded RNA regulators and the protein kinase DAI.

1992 • 475 citations

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

1992 • 469 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

Interferon-mediated protein kinase and low-molecular-weight inhibitor of protein synthesis

1976 • 435 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

Interferon, double-stranded RNA, and protein phosphorylation.

1976 • 328 citations

Human p68 kinase exhibits growth suppression in yeast and homology to the translational regulator GCN2.

1992 • 325 citations

Autophosphorylation of the protein kinase dependent on double-stranded RNA.

1987 • 301 citations

Structural requirements of double-stranded RNA for the activation of 2‘,5‘-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells.

1979 • 263 citations

The characteristics of inhibition of protein synthesis by double-stranded ribonucleic acid in reticulocyte lysates

1975 • 254 citations

Genetic complementation reveals a novel regulatory role for 3? untranslated regions in growth and differentiation

1993 • 245 citations

Specific phosphorylation in vitro of a protein associated with ribosomes of interferon‐treated mouse L cells

1976 • 238 citations

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1991 • 233 citations

Interferon action: two distinct pathways for inhibition of protein synthesis by double-stranded RNA.

1978 • 216 citations

Inhibitory activity for the interferon-induced protein kinase is associated with the reovirus serotype 1 sigma 3 protein.

1988 • 204 citations

Tumor suppression by RNA from the 3′ untranslated region of α-tropomyosin

1993 • 201 citations

Purification and activation of the double-stranded RNA-dependent eIF-2 kinase DAI.

1989 • 197 citations

Isolation of two interferon-induced translational inhibitors: a protein kinase and an oligo-isoadenylate synthetase.

1978 • 194 citations

The cellular 68,000-Mr protein kinase is highly autophosphorylated and activated yet significantly degraded during poliovirus infection: implications for translational regulation

1989 • 184 citations

Recombinant vaccinia virus K3L gene product prevents activation of double-stranded RNA-dependent, initiation factor 2 alpha-specific protein kinase

1993 • 183 citations

Adenovirus VAI RNA complexes with the 68 000 Mr protein kinase to regulate its autophosphorylation and activity.

1987 • 181 citations

Expression of transduced tropomyosin 1 cDNA suppresses neoplastic growth of cells transformed by the ras oncogene.

1993 • 175 citations

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

1990 • 164 citations

Interactions between Double-Stranded RNA Regulators and the Protein Kinase DAI

1992 • 151 citations

Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells.

1985 • 138 citations

Suppression of tropomyosin synthesis, a common biochemical feature of oncogenesis by structurally diverse retroviral oncogenes.

1985 • 138 citations

Characterization of a vaccinia virus-encoded double-stranded RNA-binding protein that may be involved in inhibition of the double-stranded rna-dependent protein kinase

1991 • 125 citations

Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA

1988 • 116 citations

Mechanism of interferon action. Increased phosphorylation of protein synthesis initiation factor eIF-2 alpha in interferon-treated, reovirus-infected mouse L929 fibroblasts in vitro and in vivo.

1984 • 112 citations

Characterization and regulation of the 58,000-dalton cellular inhibitor of the interferon-induced, dsRNA-activated protein kinase.

1992 • 101 citations

Products of the porcine group C rotavirus NSP3 gene bind specifically to double-stranded RNA and inhibit activation of the interferon-induced protein kinase PKR

1994 • 96 citations

Interaction of adenovirus VA RNAI with the protein kinase DAI: Nonequivalence of binding and function

1990 • 93 citations

Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA

1993 • 87 citations

Intermolecular duplexes formed from polyadenylylated vaccinia virus RNA

1979 • 86 citations

Inhibition of protein synthesis in reovirus-infected HeLa cells with elevated levels of interferon-induced protein kinase activity.

1982 • 76 citations

Tat-responsive region RNA of human immunodeficiency virus type 1 stimulates protein synthesis in vivo and in vitro: relationship between structure and function.

1992 • 67 citations

Purification and Activation of the Double-Stranded RNA-Dependent eIF-2 Kinase DAI

1989 • 64 citations

Binding of the adenovirus VAI RNA to the interferon-induced 68-kDa protein kinase correlates with function.

1991 • 61 citations

Mechanism of interferon action. Characterization of sites of phosphorylation in the interferon-induced phosphoprotein P1 from mouse fibroblasts: evidence for two forms of P1.

1982 • 59 citations

Role of the amino-terminal residues of the interferon-induced protein kinase in its activation by double-stranded RNA and heparin

1994 • 51 citations

Activation of 2',5'-oligo(A) polymerase and protein kinase of interferon-treated HeLa cells by 2'-O-methylated poly (inosinic acid) . poly(cytidylic acid), Correlations with interferon-inducing activity.

1980 • 47 citations

Mechanism of action of a cellular inhibitor of the dsRNA-dependent protein kinase from 3T3-F442A cells.

1992 • 42 citations

Activation of the double‐stranded RNA‐dependent eIF‐2α kinase by cellular RNA from 3T3‐F442A cells

1991 • 41 citations

Reversal of the double‐stranded‐RNA‐induced inhibition of protein synthesis by a catalytically inactive mutant of the protein kinase PKR

1993 • 38 citations

Role of the apical stem in maintaining the structure and function of adenovirus virus-associated RNA

1992 • 29 citations

Activation of the Interferon-lnducible Enzymes, 2′, 5′-Oligoadenylate Synthetase and PKR by Human T-Cell Leukemia Virus Type I Rex-Response Element

1995 • 23 citations