A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function.

Mapping of Herpes Simplex Virus-1 Neurovirulence to γ ₁ 34.5, a Gene Nonessential for Growth in Culture

1990 • 705 citations

Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

1992 • 543 citations

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth.

1994 • 484 citations

The E3L gene of vaccinia virus encodes an inhibitor of the interferon-induced, double-stranded RNA-dependent protein kinase.

1992 • 469 citations

Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase.

1993 • 436 citations

The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.

1992 • 396 citations

Adenovirus virus-associated RNA and translation control

1991 • 387 citations

Adenovirus VAI RNA antagonizes the antiviral action of interferon by preventing activation of the interferon-induced eIF-2α kinase

1986 • 358 citations

Abrogation of translation initiation factor eIF-2 phosphorylation causes malignant transformation of NIH 3T3 cells.

1995 • 288 citations

MAMMALIAN GENES INDUCED BY RADIATION; Activation of Genes Associated with Growth Control

1992 • 284 citations

Association of a M(r) 90,000 phosphoprotein with protein kinase PKR in cells exhibiting enhanced phosphorylation of translation initiation factor eIF-2 alpha and premature shutoff of protein synthesis after infection with gamma 134.5- mutants of herpes simplex virus 1.

1995 • 283 citations

The E3L and K3L vaccinia virus gene products stimulate translation through inhibition of the double-stranded RNA-dependent protein kinase by different mechanisms

1993 • 265 citations

A mechanism for the control of protein synthesis by adenovirus VA RNAI

1986 • 256 citations

Herpes simplex virus type 1 deletion variants 1714 and 1716 pinpoint neurovirulence-related sequences in Glasgow strain 17+ between immediate early gene 1 and the 'a' sequence

1991 • 256 citations

Vaccinia virus-encoded elF-2α homolog abrogates the antiviral effect of interferon

1991 • 233 citations

TAR RNA-binding protein is an inhibitor of the interferon-induced protein kinase PKR.

1994 • 215 citations

Herpes simplex virus 1 gamma(1)34.5 gene function, which blocks the host response to infection, maps in the homologous domain of the genes expressed during growth arrest and DNA damage.

1994 • 201 citations

Tumor-suppressor genes: news about the interferon connection.

1993 • 199 citations

Regulation of the interferon-induced PKR: can viruses cope?

1995 • 176 citations

Comparative analysis of the regulation of the interferoninducible protein kinase PKR by Epstein - Barr virus RNAs EBER-1 and EBER-2 and adenovirus VA, RNA

1993 • 175 citations

Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells.

1990 • 164 citations

Generation of an inverting herpes simplex virus 1 mutant lacking the L-S junction a sequences, an origin of DNA synthesis, and several genes including those specifying glycoprotein E and the alpha 47 gene

1986 • 159 citations

Molecular controls of apoptosis: differentiation/growth arrest primary response genes, proto-oncogenes, and tumor suppressor genes as positive & negative modulators.

1994 • 153 citations

ICP34.5 mutants of herpes simplex virus type 1 strain 17syn+ are attenuated for neurovirulence in mice and for replication in confluent primary mouse embryo cell cultures

1994 • 152 citations

HIV-1 TAR RNA Has an Intrinsic Ability to Activate Interferon-Inducible Enzymes

1994 • 142 citations

The carboxyl terminus of the murine MyD116 gene substitutes for the corresponding domain of the gamma(1)34.5 gene of herpes simplex virus to preclude the premature shutoff of total protein synthesis in infected human cells

1996 • 141 citations

The herpes simplex virus 1 RNA binding protein US11 is a virion component and associates with ribosomal 60S subunits

1992 • 130 citations

The gadd and MyD Genes Define a Novel Set of Mammalian Genes Encoding Acidic Proteins That Synergistically Suppress Cell Growth

1994 • 119 citations

Characterization of the double-stranded RNA implicated in the inhibition of protein synthesis in cells infected with a mutant adenovirus defective for VA RNA

1988 • 116 citations

Two small RNAs encoded by Epstein-Barr virus can functionally substitute for the virus-associated RNAs in the lytic growth of adenovirus 5.

1983 • 113 citations

Mechanism of interferon action activation of the human P1/eIF-2α protein kinase by individual reovirus s-class mRNAs: s1 mRNA is a potent activator relative to s4 mRNA

1989 • 92 citations

Translational stimulation by reovirus polypeptide sigma 3: substitution for VAI RNA and inhibition of phosphorylation of the alpha subunit of eukaryotic initiation factor 2

1992 • 88 citations

Degradation of the interferon-induced 68,000-M(r) protein kinase by poliovirus requires RNA

1993 • 87 citations

Modification of protein synthesis initiation factors and the shut-off of host protein synthesis in adenovirus-infected cells

1989 • 80 citations

The Product of Gene US11 of Herpes Simplex Virus Type 1 Is Expressed as a True Late Gene

1986 • 76 citations

Detection of activated double-stranded RNA-dependent protein kinase in 3T3-F442A cells.

1988 • 74 citations

Tat-responsive region RNA of human immunodeficiency virus type 1 stimulates protein synthesis in vivo and in vitro: relationship between structure and function.

1992 • 67 citations

The herpes simplex virus Us11 open reading frame encodes a sequence-specific RNA-binding protein

1990 • 59 citations

Conversion of a Fraction of the Unique Sequence to Part of the Inverted Repeats in the S Component of the Herpes Simplex Virus Type 1 Genome

1986 • 58 citations

The US 9, 10, 11, and 12 Genes of Herpes Simplex Virus Type 1 Are of No Importance for Its Neurovirulence and Latency in Mice

1993 • 49 citations

Herpes simplex virus 1 RNA-binding protein US11 negatively regulates the accumulation of a truncated viral mRNA

1991 • 48 citations

Three Mutants of Herpes Simplex Virus Type 2: One Lacking the Genes US10, US11 and US12 and Two in which RS Has Been Extended by 6 kb to 0{middle dot}91 Map Units with Loss of US Sequences between 0{middle dot}94 and the US/TRS Junction

1987 • 36 citations

Identification of an African swine fever virus gene with similarity to a myeloid differentiation primary response gene and a neurovirulence-associated gene of herpes simplex virus

1992 • 35 citations