RUNX proteins in transcription factor networks that regulate T-cell lineage choice

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

2006 • 4,815 citations

Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation

1997 • 4,191 citations

Targeted Disruption of Results in a Complete Lack of Bone Formation owing to Maturational Arrest of Osteoblasts

1997 • 4,168 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Cbfa1, a Candidate Gene for Cleidocranial Dysplasia Syndrome, Is Essential for Osteoblast Differentiation and Bone Development

1997 • 2,784 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

2008 • 1,759 citations

Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

2008 • 1,088 citations

Causal Relationship between the Loss of RUNX3 Expression and Gastric Cancer

2002 • 1,019 citations

Differential Requirements for Runx Proteins in CD4 Repression and Epigenetic Silencing during T Lymphocyte Development

2002 • 712 citations

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

2007 • 661 citations

The CBFβ Subunit Is Essential for CBFα2 (AML1) Function In Vivo

1996 • 630 citations

AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis

2004 • 584 citations

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells

2006 • 514 citations

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

2008 • 474 citations

Lineage fate and intense debate: myths, models and mechanisms of CD4- versus CD8-lineage choice

2008 • 440 citations

The Runx3 transcription factor regulates development and survival of TrkC dorsal root ganglia neurons

2002 • 424 citations

Foxp3 Inhibits RORγt-mediated IL-17A mRNA Transcription through Direct Interaction with RORγt*

2008 • 418 citations

A lineage-specific transcriptional silencer regulates CD4 gene expression during T lymphocyte development

1994 • 418 citations

Absence of fetal liver hematopoiesis in mice deficient in transcriptional coactivator core binding factor beta.

1996 • 382 citations

Runx3 and Runx1 are required for CD8 T cell development during thymopoiesis

2003 • 380 citations

The zinc finger transcription factor Th-POK regulates CD4 versus CD8 T-cell lineage commitment

2005 • 379 citations

Runx3 controls the axonal projection of proprioceptive dorsal root ganglion neurons

2002 • 301 citations

Critical Roles for Transcription Factor GATA-3 in Thymocyte Development

2003 • 299 citations

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

2007 • 263 citations

Genetic Evidence Supporting Selection of the Vα14i NKT Cell Lineage from Double-Positive Thymocyte Precursors

2005 • 262 citations

The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection

2005 • 256 citations

Coreceptor Reversal in the Thymus

2000 • 253 citations

The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells

2008 • 251 citations

THE REGULATION OF CD4 AND CD8 CORECEPTOR GENE EXPRESSION DURING T CELL DEVELOPMENT

1999 • 245 citations

The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate

2000 • 244 citations

GATA-3 Expression Is Controlled by TCR Signals and Regulates CD4/CD8 Differentiation

2003 • 241 citations

Repression of interleukin-4 in T helper type 1 cells by Runx/Cbfβ binding to the Il4 silencer

2007 • 233 citations

Evidence for a stochastic mechanism in the differentiation of mature subsets of T lymphocytes

1993 • 228 citations

Repression of the Transcription Factor Th-POK by Runx Complexes in Cytotoxic T Cell Development

2008 • 222 citations

Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage

1991 • 209 citations

Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells

2008 • 203 citations

RUNX Genes in Development and Cancer: Regulation of Viral Gene Expression and the Discovery of RUNX Family Genes

2007 • 201 citations

Development of all CD4 T lineages requires nuclear factor TOX

2008 • 199 citations

ThPOK acts late in specification of the helper T cell lineage and suppresses Runx-mediated commitment to the cytotoxic T cell lineage

2008 • 195 citations

Hematopoiesis in the fetal liver is impaired by targeted mutagenesis of a gene encoding a non-DNA binding subunit of the transcription factor, polyomavirus enhancer binding protein 2/core binding factor

1997 • 190 citations

TOX: an HMG box protein implicated in the regulation of thymocyte selection

2002 • 176 citations

Epigenetic silencing of CD4 in T cells committed to the cytotoxic lineage

2001 • 172 citations

Dual Functions of Runx Proteins for Reactivating CD8 and Silencing CD4 at the Commitment Process into CD8 Thymocytes

2005 • 160 citations

A transcriptional silencer controls the developmental expression of the CD4 gene.

1994 • 156 citations

Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate

2008 • 153 citations

CD4-CD8 Lineage Commitment Is Regulated by a Silencer Element at the ThPOK Transcription-Factor Locus

2008 • 133 citations

Recognition of DNA by Cys ₂ ,His ₂ Zinc Fingers

1991 • 124 citations

Deletion of a conserved Il4 silencer impairs T helper type 1–mediated immunity

2004 • 114 citations

An Enhancer That Directs Lineage-Specific Expression of CD8 in Positively Selected Thymocytes and Mature T Cells

1997 • 113 citations

Runx3 Regulates Integrin αE/CD103 and CD4 Expression during Development of CD4−/CD8+ T Cells

2005 • 112 citations

Multiple Developmental Stage–Specific Enhancers Regulate CD8 Expression in Developing Thymocytes and in Thymus-Independent T Cells

1998 • 107 citations

Chromatin and CD4, CD8A and CD8B gene expression during thymic differentiation

2002 • 106 citations

Regulation of Lineage Commitment Distinct from Positive Selection

1999 • 98 citations

CD4⧸CD8 Coreceptors in Thymocyte Development, Selection, and Lineage Commitment: Analysis of the CD4⧸CD8 Lineage Decision

2004 • 95 citations

The Transcription Factor Zbtb7b Promotes CD4 Expression by Antagonizing Runx-Mediated Activation of the CD4 Silencer

2007 • 85 citations

Overexpression of the Runx3 Transcription Factor Increases the Proportion of Mature Thymocytes of the CD8 Single-Positive Lineage

2005 • 81 citations

HD mice: A novel mouse mutant with a specific defect in the generation of CD4⁺T cells

1998 • 75 citations

Core binding factor and its role in normal hematopoietic development

2001 • 69 citations

Deletion of the CD4 silencer element supports a stochastic mechanism of thymocyte lineage commitment

2001 • 67 citations

c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3

2007 • 67 citations

Hierarchical Interactions of Control Elements Determine CD8α Gene Expression in Subsets of Thymocytes and Peripheral T Cells

1998 • 66 citations

Epigenetic gene silencing by Runx proteins

2004 • 63 citations

The role of BTB domain-containing zinc finger proteins in T cell development and function

2006 • 55 citations

The CD4⧸CD8 Lineage Choice: New Insights into Epigenetic Regulation during T Cell Development

2004 • 41 citations