CCR6 Marks Regulatory T Cells as a Colon-Tropic, IL-10–Producing Phenotype

Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease

2001 • 5,526 citations

A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease

2001 • 4,997 citations

Unravelling the pathogenesis of inflammatory bowel disease

2007 • 4,054 citations

Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease

2008 • 2,577 citations

Phenotypic and functional features of human Th17 cells

2007 • 1,832 citations

Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid

2007 • 1,816 citations

Surface phenotype and antigenic specificity of human interleukin 17–producing T helper memory cells

2007 • 1,773 citations

Specific Microbiota Direct the Differentiation of IL-17-Producing T-Helper Cells in the Mucosa of the Small Intestine

2008 • 1,653 citations

Increased expression of interleukin 17 in inflammatory bowel disease

2002 • 1,638 citations

An Essential Role for Interleukin 10 in the Function of Regulatory T Cells That Inhibit Intestinal Inflammation

1999 • 1,607 citations

TGF-β and IL-6 drive the production of IL-17 and IL-10 by T cells and restrain TH-17 cell–mediated pathology

2007 • 1,448 citations

Selective Recruitment of Immature and Mature Dendritic Cells by Distinct Chemokines Expressed in Different Anatomic Sites

1998 • 1,448 citations

Regulatory T Cell-Derived Interleukin-10 Limits Inflammation at Environmental Interfaces

2008 • 1,438 citations

A human natural killer cell subset provides an innate source of IL-22 for mucosal immunity

2008 • 1,188 citations

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

2009 • 1,171 citations

Inhibition of Thl responses prevents inflammatory bowel disease in scid mice reconstituted with CD45RBhi CD4+ T cells

1994 • 1,129 citations

C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE

2009 • 1,120 citations

ATP drives lamina propria TH17 cell differentiation

2008 • 1,035 citations

Unique Chemotactic Response Profile and Specific Expression of Chemokine Receptors Ccr4 and Ccr8 by Cd4+Cd25+ Regulatory T Cells

2001 • 888 citations

Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model

2007 • 870 citations

Interleukin-17-Producing γδ T Cells Selectively Expand in Response to Pathogen Products and Environmental Signals

2009 • 799 citations

Visualizing regulatory T cell control of autoimmune responses in nonobese diabetic mice

2005 • 783 citations

A protective function for interleukin 17A in T cell–mediated intestinal inflammation

2009 • 729 citations

Effector T cells control lung inflammation during acute influenza virus infection by producing IL-10

2009 • 588 citations

Localization of Distinct Peyer's Patch Dendritic Cell Subsets and Their Recruitment by Chemokines Macrophage Inflammatory Protein (Mip)-3α, Mip-3β, and Secondary Lymphoid Organ Chemokine

2000 • 578 citations

Regulatory T cells expressing interleukin 10 develop from Foxp3+ and Foxp3− precursor cells in the absence of interleukin 10

2007 • 576 citations

CCR6 Regulates the Migration of Inflammatory and Regulatory T Cells

2008 • 492 citations

Regulatory Lymphocytes and Intestinal Inflammation

2009 • 489 citations

CCR6 Mediates Dendritic Cell Localization, Lymphocyte Homeostasis, and Immune Responses in Mucosal Tissue

2000 • 485 citations

Characterization of Foxp3+CD4+CD25+ and IL-10-Secreting CD4+CD25+ T Cells during Cure of Colitis

2006 • 448 citations

Identification of CCR6, the Specific Receptor for a Novel Lymphocyte-directed CC Chemokine LARC

1997 • 413 citations

CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3 alpha.

1999 • 404 citations

Altering the distribution of Foxp3+ regulatory T cells results in tissue-specific inflammatory disease

2007 • 388 citations

Regulatory T Cells Sequentially Migrate from Inflamed Tissues to Draining Lymph Nodes to Suppress the Alloimmune Response

2009 • 382 citations

Human T Cells That Are Able to Produce IL-17 Express the Chemokine Receptor CCR6

2008 • 349 citations

CC-Chemokine Receptor 6 Is Expressed on Diverse Memory Subsets of T Cells and Determines Responsiveness to Macrophage Inflammatory Protein 3α

1999 • 345 citations

Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis

2002 • 324 citations

Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens

2006 • 317 citations

CCR6 expression defines regulatory effector/memory-like cells within the CD25+CD4+ T-cell subset

2004 • 314 citations

CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cells

2007 • 311 citations

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

2009 • 305 citations

The Majority of Human Peripheral Blood CD4+CD25highFoxp3+ Regulatory T Cells Bear Functional Skin-Homing Receptors

2006 • 278 citations

A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility

2010 • 258 citations

The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut

2009 • 245 citations

CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence

2006 • 224 citations

CCR6 is required for IL-23–induced psoriasis-like inflammation in mice

2009 • 220 citations

CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses

2001 • 218 citations

A Central Role for Induced Regulatory T Cells in Tolerance Induction in Experimental Colitis

2009 • 217 citations

Autoantigen-Specific TGFβ-Induced Foxp3+ Regulatory T Cells Prevent Autoimmunity by Inhibiting Dendritic Cells from Activating Autoreactive T Cells

2007 • 204 citations

Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin's Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells

2008 • 189 citations

Redirection of Regulatory T Cells With Predetermined Specificity for the Treatment of Experimental Colitis in Mice

2008 • 160 citations

TGF-β1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors

2000 • 159 citations

ATP drives lamina propria TH17 cell differentiation

2009 • 152 citations

Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease

2006 • 152 citations

Colonic epithelial cells are a major site of macrophage inflammatory protein 3alpha (MIP-3alpha) production in normal colon and inflammatory bowel disease

2002 • 148 citations

Distinctive role of CCR7 in migration and functional activity of naive‐ and effector/memory‐like Treg subsets

2007 • 147 citations

CCR4-dependent regulatory T cell function in inflammatory bowel disease

2007 • 128 citations

Role of Peyer's patches in the induction of Helicobacter pylori -induced gastritis

2007 • 128 citations

Inhibition of CCR6 Function Reduces the Severity of Experimental Autoimmune Encephalomyelitis via Effects on the Priming Phase of the Immune Response

2009 • 125 citations

A distinct subset of chemokines dominates the mucosal chemokine response in inflammatory bowel disease

2004 • 122 citations

CC Chemokine Receptor 9 Expression Defines a Subset of Peripheral Blood Lymphocytes with Mucosal T Cell Phenotype and Th1 or T-Regulatory 1 Cytokine Profile

2003 • 112 citations

Contrasting roles for all-trans retinoic acid in TGF-β–mediated induction of Foxp3 and Il10 genes in developing regulatory T cells

2009 • 106 citations

Characterization of chemokines and chemokine receptors in two murine models of inflammatory bowel disease: IL-10/ mice and Rag-2/ mice reconstituted with CD4+CD45RBhigh T cells

2001 • 104 citations

STRL22 Is a Receptor for the CC Chemokine MIP-3α

1997 • 97 citations

CC Chemokine Receptor 6 Expression by B Lymphocytes Is Essential for the Development of Isolated Lymphoid Follicles

2007 • 91 citations

CCR6 has a non‐redundant role in the development of inflammatory bowel disease

2003 • 88 citations

CCR6 regulates CD4+ T-cell–mediated acute graft-versus-host disease responses

2005 • 87 citations

CCR6 is expressed on an IL-10–producing, autoreactive memory T cell population with context-dependent regulatory function

2010 • 67 citations

MIP-3α neutralizing monoclonal antibody protects against TNBS-induced colonic injury and inflammation in mice

2007 • 63 citations

CCR6-dependent recruitment of blood phagocytes is necessary for rapid CD4 T cell responses to local bacterial infection

2007 • 47 citations

Pivotal roles of interleukin-6 in transmural inflammation in murine T cell transfer colitis

2004 • 35 citations