CD28 Facilitates the Generation of Foxp3− Cytokine Responsive Regulatory T Cell Precursors

Regulatory T Cells and Immune Tolerance

2008 • 4,778 citations

CD28/B7 SYSTEM OF T CELL COSTIMULATION

1996 • 2,726 citations

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

2005 • 2,256 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Differential T Cell Costimulatory Requirements in CD28-Deficient Mice

1993 • 1,271 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Foxp3-dependent programme of regulatory T-cell differentiation

2007 • 1,106 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Origin of regulatory T cells with known specificity for antigen

2002 • 854 citations

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells

2007 • 775 citations

The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells

2008 • 710 citations

Cutting Edge: CD28 Controls Peripheral Homeostasis of CD4+CD25+ Regulatory T Cells

2003 • 674 citations

A Two-Step Process for Thymic Regulatory T Cell Development

2008 • 615 citations

Foxp3 Transcription-Factor-Dependent and -Independent Regulation of the Regulatory T Cell Transcriptional Signature

2007 • 599 citations

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

2005 • 591 citations

An intersection between the self-reactive regulatory and nonregulatory T cell receptor repertoires

2006 • 523 citations

Regulatory T cell development in the absence of functional Foxp3

2007 • 467 citations

Linked T Cell Receptor and Cytokine Signaling Govern the Development of the Regulatory T Cell Repertoire

2008 • 405 citations

Intraclonal competition limits the fate determination of regulatory T cells in the thymus

2009 • 248 citations

CD28 is an inducible T cell surface antigen that transduces a proliferative signal in CD3+ mature thymocytes.

1990 • 173 citations

Thymic development and peripheral homeostasis of regulatory T cells

2007 • 160 citations

TCR-dependent differentiation of thymic Foxp3+ cells is limited to small clonal sizes

2009 • 137 citations

CD28 expression is not essential for positive and negative selection of thymocytes or peripheral T cell tolerance.

1996 • 105 citations

Regulatory T cell differentiation of thymocytes does not require a dedicated antigen-presenting cell but is under T cell-intrinsic developmental control

2009 • 98 citations

Induction of autoimmune disease in CTLA-4^−/−mice depends on a specific CD28 motif that is required forin vivocostimulation

2007 • 85 citations

TCR-based lineage tracing: no evidence for conversion of conventional into regulatory T cells in response to a natural self-antigen in pancreatic islets

2007 • 81 citations

Role of B7 in T Cell Tolerance

2004 • 79 citations

Targeted Knock-In Mice Expressing Mutations of CD28 Reveal an Essential Pathway for Costimulation

2009 • 79 citations

A dose-dependent requirement for the proline motif of CD28 in cellular and humoral immunity revealed by a targeted knockin mutant

2006 • 61 citations

CD28 Signaling in T Regulatory Precursors Requires p56lck and Rafts Integrity to Stabilize the Foxp3 Message

2009 • 26 citations