Hematopoietic cytokines, transcription factors and lineage commitment

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Multi-Organ, Multi-Lineage Engraftment by a Single Bone Marrow-Derived Stem Cell

2001 • 2,653 citations

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

Purified hematopoietic stem cells can differentiate into hepatocytes in vivo

2000 • 2,366 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Long-Term Lymphohematopoietic Reconstitution by a Single CD34-Low/Negative Hematopoietic Stem Cell

1996 • 2,160 citations

AML1, the Target of Multiple Chromosomal Translocations in Human Leukemia, Is Essential for Normal Fetal Liver Hematopoiesis

1996 • 1,885 citations

Turning Blood into Brain: Cells Bearing Neuronal Antigens Generated in Vivo from Bone Marrow

2000 • 1,859 citations

From Marrow to Brain: Expression of Neuronal Phenotypes in Adult Mice

2000 • 1,709 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Definitive Hematopoiesis Is Autonomously Initiated by the AGM Region

1996 • 1,548 citations

Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3

1998 • 1,518 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Turning Brain into Blood: A Hematopoietic Fate Adopted by Adult Neural Stem Cells in Vivo

1999 • 1,437 citations

A common precursor for hematopoietic and endothelial cells

1998 • 1,433 citations

An early haematopoietic defect in mice lacking the transcription factor GATA-2

1994 • 1,412 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Regulation of Cell Fate Decision of Undifferentiated Spermatogonia by GDNF

2000 • 1,333 citations

Hematopoietic Stem Cell Quiescence Maintained by p21 ^cip1/waf1

2000 • 1,326 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

The ikaros gene is required for the development of all lymphoid lineages

1994 • 976 citations

Hematopoietic potential of stem cells isolated from murine skeletal muscle

1999 • 960 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Absence of granulocyte colony-stimulating factor signaling and neutrophil development in CCAAT enhancer binding protein α-deficient mice

1997 • 929 citations

Dominant-negative mutations of CEBPA, encoding CCAAT/enhancer binding protein-α (C/EBPα), in acute myeloid leukemia

2001 • 900 citations

Stem Cell Factor and Hematopoiesis

1997 • 850 citations

Role of T-bet in Commitment of T _H 1 Cells Before IL-12-Dependent Selection

2001 • 813 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

Multilineage gene expression precedes commitment in the hemopoietic system.

1997 • 757 citations

Expression and function of c-kit in hemopoietic progenitor cells.

1991 • 756 citations

FOG, a Multitype Zinc Finger Protein, Acts as a Cofactor for Transcription Factor GATA-1 in Erythroid and Megakaryocytic Differentiation

1997 • 723 citations

Regulation of B Lymphocyte and Macrophage Development by Graded Expression of PU.1

2000 • 712 citations

Regulation of activity of the transcription factor GATA-1 by acetylation

1998 • 686 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Sonic hedgehog induces the proliferation of primitive human hematopoietic cells via BMP regulation

2001 • 675 citations

Immunodeficiency and Chronic Myelogenous Leukemia-like Syndrome in Mice with a Targeted Mutation of the ICSBP Gene

1996 • 650 citations

Pluripotent, cytokine-dependent, hematopoietic stem cells are immortalized by constitutive Notch1 signaling

2000 • 641 citations

Selective Defects in the Development of the Fetal and Adult Lymphoid System in Mice with an Ikaros Null Mutation

1996 • 619 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

Dendritic cell lineage, plasticity and cross-regulation

2001 • 613 citations

Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo.

1995 • 606 citations

Absence of yolk sac hematopoiesis from mice with a targeted disruption of the scl gene.

1995 • 582 citations

KDR Receptor: A Key Marker Defining Hematopoietic Stem Cells

1999 • 491 citations

CCAAT/Enhancer Binding Protein α Is a Regulatory Switch Sufficient for Induction of Granulocytic Development from Bipotential Myeloid Progenitors

1998 • 483 citations

Spi-1 is a putative oncogene in virally induced murine erythroleukaemias

1988 • 470 citations

Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

1999 • 457 citations

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

1999 • 444 citations

The Notch Ligand Jagged-1 Represents a Novel Growth Factor of Human Hematopoietic Stem Cells

2000 • 432 citations

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

1998 • 425 citations

The Genetic Program of Hematopoietic Stem Cells

2000 • 422 citations

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1997 • 411 citations

Essential role of STAT3 for embryonic stem cell pluripotency

1999 • 404 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

1999 • 386 citations

Bone Morphogenetic Proteins Regulate the Developmental Program of Human Hematopoietic Stem Cells

1999 • 383 citations

Cell-fate conversion of lymphoid-committed progenitors by instructive actions of cytokines

2000 • 382 citations

Somatic support cells restrict germline stem cell self-renewal and promote differentiation

2000 • 381 citations

CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

1998 • 357 citations

Stem cell repopulation efficiency but not pool size is governed by p27kip1

2000 • 352 citations

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

2000 • 351 citations

Coordinate Regulation of B Cell Differentiation by the Transcription Factors EBF and E2A

1999 • 334 citations

Functional analysis and in vivo footprinting implicate the erythroid transcription factor GATA-1 as a positive regulator of its own promoter.

1991 • 333 citations

GATA-1 interacts with the myeloid PU.1 transcription factor and represses PU.1-dependent transcription

2000 • 333 citations

JunB suppresses cell proliferation by transcriptional activation of p16INK4a expression

2000 • 311 citations

Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes

1999 • 308 citations

ICSBP Directs Bipotential Myeloid Progenitor Cells to Differentiate into Mature Macrophages

2000 • 302 citations

The T cell leukemia LIM protein Lmo2 is necessary for adult mouse hematopoiesis

1998 • 302 citations

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

1998 • 296 citations

Developmental potential of the earliest precursor cells from the adult mouse thymus.

1991 • 294 citations

MafB is an inducer of monocytic differentiation

2000 • 269 citations

Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12

1998 • 268 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

A transitional stage in the commitment of mesoderm to hematopoiesis requiring the transcription factor SCL/tal-1

2000 • 247 citations

Chronic Myeloid Leukemia with Increased Granulocyte Progenitors in Mice Lacking JunB Expression in the Myeloid Lineage

2001 • 237 citations

Use of Altered Specificity Mutants to Probe a Specific Protein–Protein Interaction in Differentiation

1999 • 232 citations

Defects in Hemopoietic Stem Cell Activity in Ikaros Mutant Mice

1999 • 230 citations

Distinct Origins of Adult and Embryonic Blood in Xenopus

2000 • 230 citations

HOXB4 overexpression mediates very rapid stem cell regeneration and competitive hematopoietic repopulation

2001 • 228 citations

The Earliest Stages of B Cell Development Require a Chemokine Stromal Cell-Derived Factor/Pre-B Cell Growth-Stimulating Factor

2001 • 218 citations

Lack of Interferon Consensus Sequence Binding Protein (ICSBP) Transcripts in Human Myeloid Leukemias

1998 • 207 citations

The role of BMP-4 and GATA-2 in the induction and differentiation of hematopoietic mesoderm in Xenopus laevis

1996 • 195 citations

Early Thymocyte Development Is Regulated by Modulation of E2a Protein Activity

2001 • 190 citations

Assembly requirements of PU.1–Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers

1999 • 190 citations

Loops, Lineage, and Leukemia

1998 • 189 citations

Bipotential B-macrophage progenitors are present in adult bone marrow

2001 • 185 citations

Notch1 Regulates Maturation of CD4+ and CD8+ Thymocytes by Modulating TCR Signal Strength

2001 • 182 citations

Hematopoietic stem cells and lymphoid progenitors express different Ikaros isoforms, and Ikaros is localized to heterochromatin in immature lymphocytes

1998 • 175 citations

Specification of hematopoietic and vascular development by the bHLH transcription factor SCL without direct DNA binding

1999 • 169 citations

Enhanced In Vivo Regenerative Potential of HOXB4-Transduced Hematopoietic Stem Cells With Regulation of Their Pool Size

1999 • 161 citations

Pre–T Cell Receptor (Tcr) and Tcr-Controlled Checkpoints in T Cell Differentiation Are Set by Ikaros

1999 • 157 citations

Down-regulation of TDT transcription in CD4⁺CD8⁺thymocytes by Ikaros proteins in direct competition with an Ets activator

2001 • 151 citations

Expression of Interferon Consensus Sequence Binding Protein (ICSBP) Is Downregulated in Bcr-Abl-Induced Murine Chronic Myelogenous Leukemia-Like Disease, and Forced Coexpression of ICSBP Inhibits Bcr-Abl-Induced Myeloproliferative Disorder

2000 • 150 citations

Binding of Ikaros to the lambda5 promoter silences transcription through a mechanism that does not require heterochromatin formation

2001 • 148 citations

TGF-β1 maintains hematopoietic immaturity by a reversible negative control of cell cycle and induces CD34 antigen up-modulation

2000 • 148 citations

Cell Cycle Arrest and Apoptosis Induced by Notch1 in B Cells

2000 • 146 citations

Rescue of the embryonic lethal hematopoietic defect reveals a critical role for GATA-2 in urogenital development

1998 • 145 citations

Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen

1996 • 141 citations

Notch signaling in T cell development

2000 • 141 citations

Tumor necrosis factor (TNF)–mediated activation of the p55 TNF receptor negatively regulates maintenance of cycling reconstituting human hematopoietic stem cells

2001 • 139 citations

Neutrophils Deficient in PU.1 Do Not Terminally Differentiate or Become Functionally Competent

1998 • 139 citations

Commitment to the B Lymphoid Lineage Occurs before DH-JH Recombination

1999 • 135 citations

Further studies on the differentiation of a cell line of myeloid leukemia

1970 • 135 citations

Evidence for Circulating Bone Marrow-Derived Endothelial Cells

1998 • 129 citations

p21 is a transcriptional target of HOXA10 in differentiating myelomonocytic cells

2000 • 128 citations

Key functional role and lineage-specific expression of selected HOXB genes in purified hematopoietic progenitor differentiation

1994 • 128 citations

Notch signalling via RBP-J promotes myeloid differentiation

2000 • 122 citations

Overexpression of HOXB4 enhances the hematopoietic potential of embryonic stem cells differentiated in vitro

1996 • 121 citations

Polarized expression of bone morphogenetic protein-4 in the human aorta-gonad-mesonephros region

2000 • 120 citations

Acetylation of GATA-3 affects T-cell survival and homing to secondary lymphoid organs

2000 • 119 citations

Antagonism between C/EBPβ and FOG in eosinophil lineage commitment of multipotent hematopoietic progenitors

2000 • 117 citations

Molecular genetics of acute promyelocytic leukemia

1999 • 116 citations

Functional Replacement of the Mouse E2A Gene with a Human HEB cDNA

1998 • 112 citations

Early growth response gene 1 stimulates development of hematopoietic progenitor cells along the macrophage lineage at the expense of the granulocyte and erythroid lineages

2001 • 108 citations

Lmo2 and GATA-3 associated expression in intraembryonic hemogenic sites

2000 • 108 citations

Overexpression of GATA-2 inhibits erythroid and promotes megakaryocyte differentiation

2000 • 106 citations

WNT signaling modulates the diversification of hematopoietic cells

2000 • 102 citations

Pluripotent hematopoietic stem cell development during embryogenesis

2001 • 102 citations

mSin3A Regulates Murine Erythroleukemia Cell Differentiation through Association with the TAL1 (or SCL) Transcription Factor

2000 • 101 citations

Lineage commitment in lymphopoiesis

2000 • 98 citations

Inhibition of the Transforming Growth Factor β1 Signaling Pathway by the AML1/ETO Leukemia-associated Fusion Protein

2000 • 93 citations

A Role for G-CSF Receptor Signaling in the Regulation of Hematopoietic Cell Function but Not Lineage Commitment or Differentiation

1999 • 91 citations

Identification of a Fetal Hematopoietic Precursor with B Cell, T Cell, and Macrophage Potential

1998 • 91 citations

A GATA-2/estrogen receptor chimera functions as a ligand-dependent negative regulator of self-renewal

1999 • 90 citations

Essential Role for the P55 Tumor Necrosis Factor Receptor in Regulating Hematopoiesis at a Stem Cell Level

1999 • 89 citations

Transforming growth factor beta 1 is an inducer of erythroid differentiation.

1994 • 88 citations

Characterization of HOX Gene Expression During Myelopoiesis: Role of HOX A5 in Lineage Commitment and Maturation

1999 • 88 citations

P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL

2000 • 87 citations

Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentiation

1991 • 87 citations

A Novel Mechanism of Cooperation between c-Kit and Erythropoietin Receptor

2001 • 85 citations

Stepwise specification of lymphocyte developmental lineages

2000 • 81 citations

Transforming Growth Factor-β1 (TGF-β1) Induces Thrombopoietin From Bone Marrow Stromal Cells, Which Stimulates the Expression of TGF-β Receptor on Megakaryocytes and, in Turn, Renders Them Susceptible to Suppression by TGF-β Itself With High Specificity

1999 • 80 citations

Enhanced Megakaryocyte and Erythroid Development From Normal Human CD34+ Cells: Consequence of Enforced Expression of SCL

1998 • 79 citations

Cellular proliferation and transformation induced by HOXB4 and HOXB3 proteins involves cooperation with PBX1

1998 • 77 citations

Acute promyelocytic leukemia: Cellular and molecular basis of differentiation and apoptosis

1997 • 77 citations

Human peripheral blood eosinophils express stem cell factor

2001 • 73 citations

Transforming Growth Factor-β1 (TGF-β1) Induces Thrombopoietin From Bone Marrow Stromal Cells, Which Stimulates the Expression of TGF-β Receptor on Megakaryocytes and, in Turn, Renders Them Susceptible to Suppression by TGF-β Itself With High Specificity

1999 • 71 citations

Biological Characteristics of the Leukemia-Associated Transcriptional Factor AML1 Disclosed by Hematopoietic Rescue of AML1-Deficient Embryonic Stem Cells by Using a Knock-in Strategy

2000 • 68 citations

Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver

2000 • 68 citations

Lymphoid precursors

2000 • 67 citations

Potentiation of GATA-2 Activity through Interactions with the Promyelocytic Leukemia Protein (PML) and the t(15;17)-Generated PML-Retinoic Acid Receptor α Oncoprotein

2000 • 64 citations

Transforming Growth Factor-β1 Induces Apoptosis Independently of p53 and Selectively Reduces Expression of Bcl-2 in Multipotent Hematopoietic Cells

2000 • 64 citations

Modulation of bcl-2 and p27 in human primitive proliferating hematopoietic progenitors by autocrine TGF-β1 is a cell cycle–independent effect and influences their hematopoietic potential

2000 • 63 citations

BSAP Can Repress Enhancer Activity by Targeting PU.1 Function

2000 • 63 citations

Untitled

1999 • 57 citations

c-myc Intron Element-binding Proteins Are Required for 1,25-Dihydroxyvitamin D3 Regulation of c-myc during HL-60 Cell Differentiation and the Involvement of HOXB4

1999 • 56 citations

Biologic significance of GATA-1 activities in Ras-mediated megakaryocytic differentiation of hematopoietic cell lines

2000 • 53 citations

Hematopoietic stem cells express Tie-2 receptor in the murine fetal liver

2000 • 52 citations

p21cip1 mRNA is controlled by endogenous transforming growth factor-?1 in quiescent human hematopoietic stem/progenitor cells

2000 • 52 citations

A Potential Role for Protein Kinase C-ε in Regulating Megakaryocytic Lineage Commitment

2001 • 52 citations

Hematopoietic Expression of Hoxb4 Is Regulated in Normal and Leukemic Stem Cells through Transcriptional Activation of the Hoxb4 Promoter by Upstream Stimulating Factor (Usf)-1 and Usf-2

2000 • 51 citations

Monoallelic Expression of Pax5: A Paradigm for the Haploinsufficiency of Mammalian Pax Genes?

1999 • 50 citations

The retroviral transduction of HOXC4 into human CD34+ cells induces an in vitro expansion of clonogenic and early progenitors

2000 • 49 citations

FMIP, a novel Fms-interacting protein, affects granulocyte/macrophage differentiation

1999 • 49 citations

CD40-ligand stimulates myelopoiesis by regulating flt3-ligand and thrombopoietin production in bone marrow stromal cells

2000 • 49 citations

Human Granulocyte Colony-Stimulating Factor (G-CSF) Stimulates the In Vitro and In Vivo Development But Not Commitment of Primitive Multipotential Progenitors From Transgenic Mice Expressing the Human G-CSF Receptor

1998 • 43 citations

Compound heterozygosity for two different amino-acid substitution mutations in the thrombopoietin receptor ( c-mpl gene) in congenital amegakaryocytic thrombocytopenia (CAMT)

2000 • 43 citations

Interleukin (IL)-7 Induces Rapid Activation of Pyk2, Which Is Bound to Janus Kinase 1 and IL-7Rα

2000 • 41 citations

Decreased expression of transcription factor GATA‐2 in haematopoietic stem cells in patients with aplastic anaemia

2001 • 41 citations

BSAP/Pax5A Expression Blocks Survival and Expansion of Early Myeloid Cells Implicating Its Involvement in Maintaining Commitment to the B-Lymphocyte Lineage

1999 • 40 citations

Notch Signaling Suppresses IgH Gene Expression in Chicken B Cells: Implication in Spatially Restricted Expression of Serrate2/Notch1 in the Bursa of Fabricius

2001 • 39 citations

Regulated Expression and Functional Role of the Transcription Factor CHOP (GADD153) in Erythroid Growth and Differentiation

1999 • 39 citations

Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Receptor Subunits in a Multipotential Hematopoietic Progenitor Cell Line Leads to Differential Effects on Development

1999 • 36 citations

mNotch1 signaling reduces proliferation of myeloid progenitor cells by altering cell-cycle kinetics

2000 • 35 citations

Untitled

2002 • 35 citations

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

2000 • 34 citations

Hemopoietic lineage commitment decisions: in vivo evidence from a transgenic mouse model harboring μLCR-βpro-LacZ as a transgene

2000 • 27 citations

A functional role of mitogen-activated protein kinases, Erk1 and Erk2, in the differentiation of a human leukemia cell line, UT-7/GM: A possible key factor for cell fate determination toward erythroid and megakaryocytic lineages

2001 • 27 citations

The C-Terminal Domain of B-Myb Acts As a Positive Regulator of Transcription and Modulates Its Biological Functions

1998 • 21 citations

Spi-1 transgenic mice develop a clonal erythroleukemia which does not depend on p53 mutation

1998 • 20 citations

Growth-inhibitory effects of transforming growth factor-β1 on myeloid leukemia cell lines

1998 • 18 citations

Receptor for macrophage colony-stimulating factor transduces a signal decreasing erythroid potential in the multipotent hematopoietic EML cell line

2000 • 17 citations

Myeloid Development Is Selectively Disrupted in PU.1 Null Mice

1998 • 15 citations

Interleukin-3 supports expansion of long-term multilineage repopulating activity after multiple stem cell divisions in vitro

2000 • 10 citations

Hematopoietic Stem Cell Maintenance and Differentiation Are Supported by Embryonic Aorta-Gonad-Mesonephros Region–Derived Endothelium

1998 • 9 citations

Ontogenic emergence of the hematon, a morphogenetic stromal unit that supports multipotential hematopoietic progenitors in mouse bone marrow

2000 • 8 citations

Murine hematopoietic stem cell characterization and its regulation in BM transplantation

2000 • 8 citations

Identification and characterization of a bipotent (erythroid and megakaryocytic) cell precursor from the spleen of phenylhydrazine-treated mice

2000 • 7 citations

Activation of Granulocyte-Macrophage Colony-Stimulating Factor and Interleukin-3 Receptor Subunits in a Multipotential Hematopoietic Progenitor Cell Line Leads to Differential Effects on Development

1999 • 6 citations

Dante's Interpretive Journey

1999 • 5 citations

Evidence that ceramide mediates the ability of tumor necrosis factor to modulate primitive human hematopoietic cell fates

2000 • 3 citations

The Presence of Novel Amino Acids in the Cytoplasmic Domain of Stem Cell Factor Results in Hematopoietic Defects inSteel17H Mice

1999 • 1 citations

The Distal Cytoplasmic Domain of the Erythropoietin Receptor Induces Granulocytic Differentiation in 32D Cells

1998 • 1 citations