BSAP Can Repress Enhancer Activity by Targeting PU.1 Function

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.

1982 • 8,069 citations

Recombinant Genomes Which Express Chloramphenicol Acetyltransferase in Mammalian Cells

1982 • 3,106 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

The macrophage and B cell-specific transcription factor PU.1 is related to the ets oncogene

1990 • 993 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

Pax-5 encodes the transcription factor BSAP and is expressed in B lymphocytes, the developing CNS, and adult testis.

1992 • 536 citations

Spi-1 is a putative oncogene in virally induced murine erythroleukaemias

1988 • 470 citations

Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

1999 • 457 citations

Negative cross-talk between hematopoietic regulators: GATA proteins repress PU.1

1999 • 444 citations

PU.1 induces myeloid lineage commitment in multipotent hematopoietic progenitors

1998 • 425 citations

DNA sequence recognition by Pax proteins: bipartite structure of the paired domain and its binding site.

1993 • 391 citations

PU.1 recruits a second nuclear factor to a site important for immunoglobulin kappa 3' enhancer activity.

1992 • 362 citations

Isolation of a candidate repressor/activator, NF-E1 (YY-1, delta), that binds to the immunoglobulin kappa 3' enhancer and the immunoglobulin heavy-chain mu E1 site.

1991 • 357 citations

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1998 • 331 citations

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

1992 • 325 citations

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1998 • 314 citations

PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors

1998 • 296 citations

Effect of PU.1 phosphorylation on interaction with NF-EM5 and transcriptional activation

1993 • 278 citations

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter.

1996 • 244 citations

The immunoglobulin kappa locus contains a second, stronger B-cell-specific enhancer which is located downstream of the constant region.

1989 • 213 citations

PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation

1995 • 200 citations

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

1996 • 189 citations

Spi-1/PU.1 Transgenic Mice Develop Multistep Erythroleukemias

1996 • 187 citations

c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor

1999 • 175 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

The transcription factor PU.1 is involved in macrophage proliferation.

1996 • 156 citations

NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation.

1993 • 151 citations

Inhibition of hematopoiesis by competitive binding of transcription factor PU.1.

1994 • 151 citations

A novel lineage-specific nuclear factor regulates mb-1 gene transcription at the early stages of B cell differentiation.

1991 • 146 citations

C-terminal activating and inhibitory domains determine the transactivation potential of BSAP (Pax-5), Pax-2 and Pax-8.

1996 • 145 citations

The putative oncogene Spi-1: murine chromosomal localization and transcriptional activation in murine acute erythroleukemias.

1989 • 140 citations

The B cell-specific transcription factor BSAP regulates B cell proliferation.

1994 • 140 citations

Characterization of Functional Domains within the Multifunctional Transcription Factor, YY1

1995 • 139 citations

An Interleukin-2 Signal Relieves BSAP (Pax5)-Mediated Repression of the Immunoglobulin J Chain Gene

1996 • 125 citations

Functional characterization of the developmentally controlled immunoglobulin kappa 3' enhancer: regulation by Id, a repressor of helix-loop-helix transcription factors.

1991 • 123 citations

The Sfpi-1 proviral integration site of Friend erythroleukemia encodes the ets-related transcription factor Pu.1

1991 • 121 citations

Physical and functional interactions between the transcription factor PU.1 and the coactivator CBP

1999 • 111 citations

Redox Potential Controls the Structure and DNA Binding Activity of the Paired Domain

1998 • 107 citations

PU.1 Recruits a Second Nuclear Factor to a Site Important for Immunoglobulin κ 3' Enhancer Activity

1992 • 107 citations

The murine Ig 3' alpha enhancer is a target site with repressor function for the B cell lineage-specific transcription factor BSAP (NF-HB, S alpha-BP).

1994 • 101 citations

Regulation of 3' IgH enhancers by a common set of factors, including kappa B-binding proteins.

1996 • 97 citations

Pax5 (BSAP) regulates the murine immunoglobulin 3' alpha enhancer by suppressing binding of NF-alpha P, a protein that controls heavy chain transcription.

1995 • 97 citations

Activation of Transcription by PU.1 Requires both Acidic and Glutamine Domains

1996 • 93 citations

The Ets-related transcription factor PU.1 immortalizes erythroblasts.

1993 • 92 citations

PU.1 can participate in an active enhancer complex without its transcriptional activation domain

1997 • 87 citations

In Vivo Occupancy of the κ Light Chain Enhancers in Primary Pro- and Pre-B Cells: A Model for κ Locus Activation

1997 • 86 citations

The Promoter of the CD19 Gene Is a Target for the B-Cell-Specific Transcription Factor BSAP

1992 • 79 citations

A Two-Step Mechanism for Recruitment of Pip by PU.1

1998 • 77 citations

Heterogeneously initiated transcription from the pre-B- and B-cell-specific mb-1 promoter: analysis of the requirement for upstream factor-binding sites and initiation site sequences.

1991 • 77 citations

Loss- and gain-of-function mutations reveal an important role of BSAP (Pax-5) at the start and end of B cell differentiation

1998 • 73 citations

Distinct Factors Regulate the Murine RAG-2 Promoter in B- and T-Cell Lines

1999 • 71 citations

The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human epsilon germline promoter.

1997 • 69 citations

Specific recognition of the blk promoter by the B-lymphoid transcription factor B-cell-specific activator protein.

1994 • 68 citations

BLyF, a Novel Cell-Type- and Stage-Specific Regulator of the B-Lymphocyte Gene mb-1

1992 • 67 citations

Essential Functions of Pax-5 (BSAP) in pro-B Cell Development

1997 • 67 citations

PU.1, a Shared Transcriptional Regulator of Lymphoid and Myeloid Cell Fates

1999 • 65 citations

The transcription factor BSAP (NF-HB) is essential for immunoglobulin germ-line epsilon transcription.

1994 • 64 citations

The partial homeodomain of the transcription factor Pax-5 (BSAP) is an interaction motif for the retinoblastoma and TATA-binding proteins.

1999 • 64 citations

A Developmentally Modulated Chromatin Structure at the Mouse Immunoglobulin κ 3′ Enhancer

1996 • 62 citations

The Highly Conserved β-Hairpin of the Paired DNA-Binding Domain Is Required for Assembly of Pax-Ets Ternary Complexes

1999 • 61 citations

AML1 (CBFα2) Cooperates with B Cell-specific Activating Protein (BSAP/PAX5) in Activation of the B Cell-specific BLK Gene Promoter

1999 • 60 citations

The 3′ enhancer region determines the B/T specificity and pro-B/pre-B specificity of immunoglobulin Vκ-Jκ joining

1995 • 59 citations

The transcription factor B cell-specific activator protein (BSAP) enhances both IL-4- and CD40-mediated activation of the human epsilon germline promoter.

1997 • 57 citations

Commitment to the Monocytic Lineage Occurs in the Absence of the Transcription Factor PU.1

1999 • 54 citations

Dependence of BSAP Repressor and Activator Functions on BSAP Concentration

1998 • 54 citations

Normal Myeloid Development Requires Both the Glutamine-Rich Transactivation Domain and the PEST Region of Transcription Factor PU.1 but Not the Potent Acidic Transactivation Domain

1998 • 48 citations

Characterization of the Human Immunoglobulin Kappa Gene 3' Enhancer: Functional Importance of Three Motifs That Demonstrate B-Cell-Specific In Vivo Footprints

1992 • 41 citations

The Ets-Related Transcription Factor PU.1 Immortalizes Erythroblasts

1993 • 41 citations

Functional Characterization of the Developmentally Controlled Immunoglobulin Kappa 3′ Enhancer: Regulation by Id, a Repressor of Helix-Loop-Helix Transcription Factors

1991 • 40 citations

Activating Transcription Factor 1 and Cyclic AMP Response Element Modulator Can Modulate the Activity of the Immunoglobulin κ 3′ Enhancer

1995 • 37 citations

The Transcription Factor NF-κB/p50 Interacts with the blkGene during B Cell Activation

1998 • 31 citations

Regulation of Mouse CD72 Gene Expression During B Lymphocyte Development

1998 • 26 citations

NF-HB (BSAP) is a Repressor of the Murine Immunoglobulin Heavy-Chain 3'α Enhancer at Early Stages of B-Cell Differentiation

1993 • 24 citations

Role of the Transcription Factor BSAP (Pax-5) in B-Cell Development

1998 • 19 citations

Heterogeneously Initiated Transcription from the Pre-B- and B-Cell-Specific mb-1 Promoter: Analysis of the Requirement for Upstream Factor-Binding Sites and Initiation Site Sequences

1991 • 17 citations

Activation of the immunoglobulin χ3′ enhancer in pre-B cells correlates with the suppression of a nuclear factor binding to a sequence flanking the active core

1994 • 16 citations

The PU.1 binding site is a cis-element that regulates pro-B/pre-B specificity of Vkappa-Jkappa joining.

1997 • 15 citations

Identification of an Sp1-like Element within the Immunoglobulin κ 3‘ Enhancer Necessary for Maximal Enhancer Activity

1996 • 13 citations

Regulation of Human Epsilon Germline Transcription: Role of B-Cell-Specific Activator Protein

1997 • 6 citations