Human peripheral blood eosinophils express stem cell factor

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Stem Cell Factor and Hematopoiesis

1997 • 850 citations

Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.

1993 • 835 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

Establishment of an immature mast cell line from a patient with mast cell leukemia

1988 • 749 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Quantitation of histamine, tryptase, and chymase in dispersed human T and TC mast cells.

1987 • 504 citations

Eosinophils express interleukin 5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics.

1992 • 364 citations

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

1992 • 320 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

Interleukin 5 synthesis by eosinophils: association with granules and immunoglobulin-dependent secretion.

1994 • 295 citations

The c-kit receptor ligand functions as a mast cell chemoattractant

1992 • 281 citations

c-kit ligand: a unique potentiator of mediator release by human lung mast cells.

1992 • 275 citations

Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form

1995 • 268 citations

The c-kit receptor ligand functions as a mast cell chemoattractant

1992 • 217 citations

Expression of Cd28 and Cd86 by Human Eosinophils and Role in the Secretion of Type 1 Cytokines (Interleukin 2 and Interferon γ)

1999 • 209 citations

Stem cell factor induces mast cell adhesion to fibronectin.

1994 • 205 citations

Nerve growth factor is preformed in and activates human peripheral blood eosinophils

1998 • 199 citations

Human eosinophils can express the cytokines tumor necrosis factor-alpha and macrophage inflammatory protein-1 alpha.

1993 • 188 citations

Chymase cleavage of stem cell factor yields a bioactive, soluble product

1997 • 181 citations

Constitutive production of IL-4 and IL-10 and stimulated production of IL-8 by normal peripheral blood eosinophils.

1996 • 163 citations

Release of granule proteins by eosinophils from allergic and nonallergic patients with eosinophilia on immunoglobulin-dependent activation

1991 • 163 citations

Human eosinophils synthesize and secrete interleukin-6, in vitro

1992 • 152 citations

Constitutive expression of steel factor gene by human stromal cells

1993 • 148 citations

Rapid Mobilization of Intracellularly Stored RANTES in Response to Interferon-γ in Human Eosinophils

1999 • 134 citations

The protooncogene c-kit and c-kit ligand in human disease☆☆☆★

1997 • 128 citations

Human umbilical vein endothelial cells display high-affinity c-kit receptors and produce a soluble form of the c-kit receptor

1994 • 126 citations

Human mast cells express stem cell factor

1998 • 120 citations

Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms.

1992 • 116 citations

Novel Role of Transmembrane SCF for Mast Cell Activation and Eotaxin Production in Mast Cell-Fibroblast Interactions

1998 • 114 citations

Mast cells enhance eosinophil survival in vitro: role of TNF-alpha and granulocyte-macrophage colony-stimulating factor.

1998 • 113 citations

Stem Cell Factor Is Localized in, Released from, and Cleaved by Human Mast Cells

1999 • 107 citations

Human Peripheral Blood Eosinophils Express a Functional c-kit Receptor for Stem Cell Factor that Stimulates Very Late Antigen 4 (VLA-4)–mediated Cell Adhesion to Fibronectin and Vascular Cell Adhesion Molecule 1 (VCAM-1)

1997 • 101 citations

Association of granulocyte-macrophage colony-stimulating factor with the crystalloid granules of human eosinophils

1995 • 86 citations

Identification of interleukin-2 in human peripheral blood eosinophils.

1996 • 85 citations

The role of stem cell factor (c-kit ligand) and inflammatory cytokines in pulmonary mast cell activation

1996 • 64 citations

Human Dermal Endothelial Cells Express Membrane-Associated Mast Cell Growth Factor

1995 • 54 citations

Release of Stem Cell Factor from a Human Keratinocyte Line, HaCaT, Is Increased in Differentiating versus Proliferating Cells

1996 • 51 citations

Human Mast Cells Produce and Differentially Express Both Soluble and Membrane‐Bound Stem Cell Factor

1999 • 49 citations

Role of pertussis toxin-sensitive G proteins in stimulus-dependent human eosinophil degranulation.

1991 • 46 citations

A role for stem cell factor and c-kit in the murine intestinal tract secretory response to cholera toxin.

1995 • 46 citations

Post-translational processing of membrane-associated recombinant human stem cell factor expressed in Chinese hamster ovary cells

1992 • 38 citations

Stem cell factor-induced downregulation of c-kit in human lung mast cells and HMC-1 mast cells.

1996 • 38 citations

The effect of recombinant stem cell factor on human skin and lung mast cells and basophil leukocytes

1997 • 26 citations

Human Eosinophils Release the Lymphocyte and Eosinophil Active Cytokines, RANTES and Lymphocyte Chemoattractant Factor

1995 • 24 citations

Novel Autocrine and Paracrine Loops of the Stem Cell Factor/Chymase Network

1999 • 21 citations

Eosinophils Activate Mast Cells to Release Histamine

1999 • 21 citations

Human Foreskin Mast Cell Viability and Functional Activity Is Maintained ex Vivo by Coculture with Fibroblasts

1995 • 16 citations