The Presence of Novel Amino Acids in the Cytoplasmic Domain of Stem Cell Factor Results in Hematopoietic Defects inSteel17H Mice

Signal transduction by receptors with tyrosine kinase activity

1990 • 5,528 citations

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

1995 • 2,106 citations

The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase

1995 • 2,024 citations

Dimerization of cell surface receptors in signal transduction

1995 • 1,631 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The proto-oncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus

1988 • 1,390 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

The hematopoietic growth factor KL is encoded by the SI locus and is the ligand of the c-kit receptor, the gene product of the W locus

1990 • 1,208 citations

Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture

1992 • 1,205 citations

Hereditary Anemias of the Mouse: A Review for Geneticists

1979 • 1,141 citations

Identification of a ligand for the c-kit proto-oncogene

1990 • 970 citations

Long-term proliferation of mouse primordial germ cells in culture

1992 • 873 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Primary structure and functional expression of rat and human stem cell factor DNAs

1990 • 779 citations

Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the SId mutant

1991 • 740 citations

Mast cell growth factor maps near the steel locus on mouse chromosome 10 and is deleted in a number of steel alleles

1990 • 632 citations

Insulin stimulates the kinase activity of RAC-PK, a pleckstrin homology domain containing ser/thr kinase.

1995 • 358 citations

Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2.

1992 • 320 citations

Support of human hematopoiesis in long-term bone marrow cultures by murine stromal cells selectively expressing the membrane-bound and secreted forms of the human homolog of the steel gene product, stem cell factor.

1992 • 306 citations

Steel-Dickie mutation encodes a c-kit ligand lacking transmembrane and cytoplasmic domains.

1991 • 300 citations

Membrane-bound Steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form

1995 • 268 citations

Hygromycin B phosphotransferase as a selectable marker for DNA transfer experiments with higher eucaryotic cells.

1984 • 258 citations

Cleavage of the membrane precursor for transforming growth factor alpha is a regulated process.

1991 • 209 citations

Intrathymically expressed c-kit ligand (stem cell factor) is a major factor driving expansion of very immature thymocytes in vivo

1995 • 201 citations

Phenotypic and functional characterization of c-kit expression during intrathymic T cell development.

1992 • 194 citations

Chymase cleavage of stem cell factor yields a bioactive, soluble product

1997 • 181 citations

Developmental abnormalities in Steel17H mice result from a splicing defect in the steel factor cytoplasmic tail.

1992 • 134 citations

Functional consequences of glycine mutations in the predicted cytoplasmic loops of P-glycoprotein.

1994 • 127 citations

The cytoplasmic carboxy-terminal amino acid specifies cleavage of membrane TGFα into soluble growth factor

1992 • 126 citations

Necessity of extracellular domain of W (c-kit) receptors for attachment of murine cultured mast cells to fibroblasts

1992 • 115 citations

Analysis of progressive deletions of the transmembrane and cytoplasmic domains of influenza hemagglutinin.

1986 • 108 citations

Signaling Through the Interaction of Membrane-Restricted Stem Cell Factor and c-kit Receptor Tyrosine Kinase: Genetic Evidence for a Differential Role in Erythropoiesis

1998 • 90 citations

Identification and mutation of primary and secondary proteolytic cleavage sites in murine stem cell factor cDNA yields biologically active, cell-associated protein.

1994 • 89 citations

Juxtacrine cell signaling molecules

1993 • 89 citations

Consequences of exclusive expression in vivo of kit-ligand lacking the major proteolytic cleavage site

1998 • 87 citations

The Majority of Stem Cell Factor Exists as Monomer under Physiological Conditions

1997 • 76 citations

The carboxyl-terminal valine residues of proTGF alpha are required for its efficient maturation and intracellular routing.

1997 • 76 citations

Mutants of the membrane-binding region of Semliki Forest virus E2 protein. I. Cell surface transport and fusogenic activity.

1986 • 54 citations

Secretion of alpha-1-proteinase inhibitor requires an almost full length molecule.

1992 • 50 citations

Transmembrane kit ligand cleavage does not require a signal in the cytoplasmic domain and occurs at a site dependent on spacing from the membrane.

1994 • 44 citations

Mutants of the membrane-binding region of Semliki Forest virus E2 protein. II. Topology and membrane binding.

1986 • 44 citations

Nucleotide sequences of the rabbit α-smooth-muscle and β-non-muscle actin mRNAs

1992 • 36 citations

Role of Dimerization of the Membrane-associated Growth Factor Kit Ligand in Juxtacrine Signaling: The Sl17H Mutation Affects Dimerization and Stability—Phenotypes in Hematopoiesis

1998 • 32 citations

Multiple Pathways for Steel Regulation Suggested by Genomic and Sequence Analysis of the Murine Steel Gene

1996 • 25 citations

Overexpression of Human Stem Cell Factor Impairs Melanocyte, Mast Cell, and Thymocyte Development: A Role for Receptor Tyrosine Kinase-Mediated Mitogen Activated Protein Kinase Activation in Cell Differentiation

1997 • 16 citations

Wn mutation of c-kit receptor affects its post-translational processing and extracellular expression.

1994 • 13 citations