Cell Cycle Arrest and Apoptosis Induced by Notch1 in B Cells

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

1991 • 1,693 citations

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

1998 • 1,600 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Signalling downstream of activated mammalian Notch

1995 • 1,375 citations

Notch Signaling

1995 • 1,282 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Avian hairy Gene Expression Identifies a Molecular Clock Linked to Vertebrate Segmentation and Somitogenesis

1997 • 954 citations

Notch1 is required for the coordinate segmentation of somites

1995 • 860 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Complete block of early B cell differentiation and altered patterning of the posterior midbrain in mice lacking Pax5/BSAP

1994 • 807 citations

E2A proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements

1994 • 766 citations

Embryonic Lethality and Vascular Defects in Mice Lacking the Notch Ligand Jagged1

1999 • 756 citations

Notch1 is essential for postimplantation development in mice.

1994 • 731 citations

Nuclear Access and Action of Notch In Vivo

1998 • 730 citations

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

1996 • 717 citations

A hyperconversion mechanism generates the chicken light chain preimmune repertoire

1987 • 693 citations

The suppressor of hairless protein participates in notch receptor signaling

1994 • 547 citations

A role for Bruton's tyrosine kinase in B cell antigen receptor-mediated activation of phospholipase C-gamma 2.

1996 • 494 citations

An Activated Form of Notch Influences the Choice between CD4 and CD8 T Cell Lineages

1996 • 488 citations

Somatic hyperconversion diversifies the single VH gene of the chicken with a high incidence in the D region

1989 • 467 citations

Intrinsic activity of the lin-12 and Notch intracellular domains in vivo

1993 • 466 citations

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor

1993 • 424 citations

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei.

1993 • 421 citations

Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice

1998 • 409 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos

1993 • 366 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Coordinate Regulation of B Cell Differentiation by the Transcription Factors EBF and E2A

1999 • 334 citations

The Notch Ligand, Jagged-1, Influences the Development of Primitive Hematopoietic Precursor Cells

1998 • 328 citations

Deltex acts as a positive regulator of Notch signaling through interactions with the Notch ankyrin repeats

1995 • 324 citations

The bHLH GeneHes1as a Repressor of the Neuronal Commitment of CNS Stem Cells

2000 • 311 citations

Notch signaling imposes two distinct blocks in the differentiation of C2C12 myoblasts

1999 • 304 citations

Inducible Site-Directed Recombination in Mouse Embryonic Stem Cells

1996 • 286 citations

The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1

1998 • 282 citations

EBF and E47 Collaborate to Induce Expression of the Endogenous Immunoglobulin Surrogate Light Chain Genes

1997 • 282 citations

Mutation in ankyrin repeats of the mouse Notch2 gene induces early embryonic lethality

1999 • 277 citations

NF-κB2 Is a Putative Target Gene of Activated Notch-1 via RBP-Jκ

1998 • 272 citations

Suppressor of Hairless, the Drosophila homolog of the mouse recombination signal-binding protein gene, controls sensory organ cell fates

1992 • 264 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

NUMB Localizes in the Basal Cortex of Mitotic Avian Neuroepithelial Cells and Modulates Neuronal Differentiation by Binding to NOTCH-1

1999 • 256 citations

lag-1, a gene required for lin-12 and glp-1 signaling in Caenorhabditis elegans, is homologous to human CBF1 and Drosophila Su(H)

1996 • 232 citations

Light chain gene conversion continues at high rate in an ALV-induced cell line.

1990 • 226 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

Ligand-induced cleavage and regulation of nuclear entry of Notch in Drosophila melanogaster embryos

1998 • 217 citations

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1999 • 208 citations

The shortest path from the surface to the nucleus: RBP‐Jκ/Su(H) transcription factor

1996 • 207 citations

Roles of the ankyrin repeats and C-terminal region of the mouse Notch1 intracellular region

1998 • 203 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

Human deltex is a conserved regulator of Notch signalling

1998 • 189 citations

A human homologue of the Drosophila developmental gene, Notch, is expressed in CD34+ hematopoietic precursors

1994 • 176 citations

HIRA, a mammalian homologue of Saccharomyces cerevisiae transcriptional co-repressors, interacts with Pax3

1998 • 165 citations

A protein binding to the Jk recombination sequence of immunoglobulin genes contains a sequence related to the integrase motif

1989 • 157 citations

Modulated expression of notch1 during thymocyte development

1996 • 147 citations

The B cell-specific transcription factor BSAP regulates B cell proliferation.

1994 • 140 citations

Apoptosis is associated with the extensive B cell death in the sheep ileal Peyer's patch and the chicken bursa of Fabricius: A possible role in B cell selection

1991 • 139 citations

Notch signalling via RBP-J promotes myeloid differentiation

2000 • 122 citations

The Drosophila homolog of the immunoglobulin recombination signal-binding protein regulates peripheral nervous system development

1992 • 116 citations

E47 activates the Ig-heavy chain and TdT loci in non-B cells.

1996 • 108 citations

Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase

1996 • 107 citations

Avian B cell precursors: Surface immunoglobulin expression is an early, possibly bursa‐independent event

1986 • 99 citations

Emigration of B cells from chicken bursa of Fabricius

1989 • 95 citations

Deregulated PAX-5 Transcription From a TranslocatedIgH Promoter in Marginal Zone Lymphoma

1998 • 93 citations

Rearrangement of chicken immunoglobulin genes is not an ongoing process in the embryonic bursa of Fabricius.

1986 • 87 citations

Induction of the antigen receptor expression on Blymphocytes results in rapid competence for signaling of SLP-65 and Syk

1998 • 83 citations

Essential Functions of Pax-5 (BSAP) in pro-B Cell Development

1997 • 67 citations

Restoration of surface IgM-mediated apoptosis in an anti-IgM-resistant variant of WEHI-231 lymphoma cells by HS1, a protein-tyrosine kinase substrate.

1995 • 64 citations

Immunoglobulin‐bearing stem cells for clones of B (bursa‐derived) lymphocytes

1985 • 57 citations

Immunomodulation of peripheral T cells in chickens infected with Marek's disease virus: involvement in immunosuppression

1995 • 56 citations

Ontogenic restriction of colonization of the bursa of Fabricius

1983 • 54 citations

Avian B Cell Development

1997 • 47 citations

Expression of the PAX5/BSAP transcription factor in haematological tumour cells and further molecular characterization of the t(9;14)(p13;q32) translocation in B‐cell non‐Hodgkin's lymphoma

1998 • 34 citations

Lyn-mediated down-regulation of B cell antigen receptor signaling: inhibition of protein kinase C activation by Lyn in a kinase-independent fashion.

1998 • 21 citations

B cells in the bursa of Fabricius express a novel C-type lectin gene.

1997 • 20 citations

Cutting Edge: Lyn-Mediated Down-Regulation of B Cell Antigen Receptor Signaling: Inhibition of Protein Kinase C Activation by Lyn in a Kinase-Independent Fashion

1998 • 20 citations

Deleted Work

1955 • 0 citations