Interleukin (IL)-7 Induces Rapid Activation of Pyk2, Which Is Bound to Janus Kinase 1 and IL-7Rα

Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice

1995 • 1,810 citations

JAKS AND STATS: Biological Implications

1998 • 1,788 citations

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

1994 • 1,572 citations

Lymphopenia in interleukin (IL)-7 gene-deleted mice identifies IL-7 as a nonredundant cytokine.

1995 • 1,447 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

Stat5a and Stat5b Proteins Have Essential and Nonessential, or Redundant, Roles in Cytokine Responses

1998 • 1,316 citations

Interleukin-2 Receptor γ Chain: a Functional Component of the Interleukin-7 Receptor

1993 • 1,128 citations

Defective lymphoid development in mice lacking expression of the common cytokine receptor γ chain

1995 • 1,024 citations

A role for Pyk2 and Src in linking G-protein-coupled receptors with MAP kinase activation

1996 • 971 citations

Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain.

1995 • 881 citations

Disruption of the Jak1 Gene Demonstrates Obligatory and Nonredundant Roles of the Jaks in Cytokine-Induced Biologic Responses

1998 • 827 citations

Mitogen-activated protein kinase cascades and regulation of gene expression

1996 • 759 citations

Defective Lymphoid Development in Mice Lacking Jak3

1995 • 650 citations

Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily

1990 • 614 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Defects in B Lymphocyte Maturation and T Lymphocyte Activation in Mice Lacking Jak3

1995 • 551 citations

Bcl-2 Can Rescue T Lymphocyte Development in Interleukin-7 Receptor–Deficient Mice but Not in Mutant rag-1 −/− Mice

1997 • 503 citations

Developmental defects of lymphoid cells in Jak3 kinase-deficient mice

1995 • 493 citations

Ras-dependent Mitogen-activated Protein Kinase Activation by G Protein-coupled Receptors

1997 • 454 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

Signal Transduction Due to HIV-1 Envelope Interactions with Chemokine Receptors CXCR4 or CCR5

1997 • 394 citations

Cloning and Characterization of Cell Adhesion Kinase β, a Novel Protein-tyrosine Kinase of the Focal Adhesion Kinase Subfamily

1995 • 385 citations

Identification and Characterization of a Novel Related Adhesion Focal Tyrosine Kinase (RAFTK) from Megakaryocytes and Brain

1995 • 365 citations

Functional Participation of the IL-2 Receptor γ Chain in IL-7 Receptor Complexes

1994 • 342 citations

An SH3 Domain-Containing GTPase-Activating Protein for Rho and Cdc42 Associates with Focal Adhesion Kinase

1996 • 337 citations

Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor

1998 • 331 citations

Activation of Pyk2 by Stress Signals and Coupling with JNK Signaling Pathway

1996 • 310 citations

Activation of a Novel Calcium-dependent Protein-tyrosine Kinase

1996 • 256 citations

Rho family members: Activators of MAP kinase cascades

1995 • 253 citations

Interleukin-7: physiological roles and mechanisms of action

1999 • 243 citations

Adaptor Proteins Grb2 and Crk Couple Pyk2 with Activation of Specific Mitogen-activated Protein Kinase Cascades

1999 • 207 citations

The Trophic Action of IL-7 on Pro-T Cells: Inhibition of Apoptosis of Pro-T1, -T2, and -T3 Cells Correlates with Bcl-2 and Bax Levels and Is Independent of Fas and p53 Pathways

1998 • 186 citations

Identification of a New Pyk2 Target Protein with Arf-GAP Activity

1999 • 171 citations

Characterization of RAFTK, a novel focal adhesion kinase, and its integrin-dependent phosphorylation and activation in megakaryocytes

1996 • 167 citations

The N-termini of FAK and JAKs contain divergent band 4.1 domains

1999 • 166 citations

Tyrosine Phosphorylation of Pyk2 Is Selectively Regulated by Fyn During TCR Signaling

1997 • 165 citations

Angiotensin II Stimulates Calcium-Dependent Activation of c-Jun N-Terminal Kinase

1995 • 149 citations

Identification of a Novel Family of Targets of PYK2 Related to Drosophila Retinal Degeneration B (rdgB) Protein

1999 • 139 citations

Activation of p38 Mitogen-activated Protein Kinase by PYK2/Related Adhesion Focal Tyrosine Kinase-dependent Mechanism

1999 • 133 citations

Protein tyrosine kinase Pyk2 mediates the Jak-dependent activation of MAPK and Stat1 in IFN-γ, but not IFN-α, signaling

1999 • 131 citations

Interleukin 7 Receptor Control of T Cell Receptor γ Gene Rearrangement: Role of Receptor-associated Chains and Locus Accessibility

1998 • 131 citations

Interleukin‐7 can induce the activation of Jak 1, Jak 3 and STAT 5 proteins in murine T cells

1995 • 127 citations

RAFTK, a Novel Member of the Focal Adhesion Kinase Family, Is Phosphorylated and Associates with Signaling Molecules upon Activation of Mature T Lymphocytes

1997 • 107 citations

Activation of protein tyrosine kinase PYK2 by the m1 muscarinic acetylcholine receptor

1998 • 104 citations

Growth Factor Activity of Endothelin-1 in Primary Astrocytes Mediated by Adhesion-Dependent and -Independent Pathways

1997 • 98 citations

Janus Kinases and Focal Adhesion Kinases Play in the 4.1 Band: A Superfamily of Band 4.1 Domains Important for Cell Structure and Signal Transduction

1998 • 95 citations

Interleukin 7 receptor functions by recruiting the tyrosine kinase p59fyn through a segment of its cytoplasmic tail.

1992 • 92 citations

Networking Rho Family GTPases in Lymphocytes

1998 • 82 citations

Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway

1998 • 75 citations

Cytokine signaling through the novel tyrosine kinase RAFTK in Kaposi's sarcoma cells.

1997 • 72 citations

Activation of src family kinases in human pre-B cells by IL-7.

1994 • 71 citations

A critical role of Lyn and Fyn for B cell responses to CD38 ligation and interleukin 5

1997 • 71 citations

JAK3 Janus kinase is involved in interleukin 7 signal pathway

1994 • 67 citations

Involvement of p59fynT in interleukin-5 receptor signaling.

1995 • 65 citations

Interaction of two proline-rich sequences of cell adhesion kinase β with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf

1998 • 65 citations

but Not JAK1 Activation of JAK3Is Critical to Interleukin-4 (IL4) Stimulated Proliferation and Requires a Membrane-proximal Region of IL4 Receptor α

1995 • 61 citations

Characterization of Signal Transduction Pathways in Human Bone Marrow Endothelial Cells

1997 • 55 citations

Activation of phosphatidylinositol-3 kinase by ligation of the interleukin-7 receptor is dependent on protein tyrosine kinase activity

1994 • 46 citations

Protein Kinase C and Protein Kinase A Inhibit Calcium-dependent but not Stress-dependent c-Jun N-terminal Kinase Activation in Rat Liver Epithelial Cells

1997 • 45 citations

Dispensability of Jak1 tyrosine kinase for interleukin‐2‐induced cell growth signaling in a human T cell line

1996 • 45 citations

Interleukin-4 Receptor Signalling Mechanisms and Their Biological Significance

1998 • 43 citations

IL-2-lnduced Cellular Events

1998 • 42 citations

Signal Transduction in Human Hematopoietic Cells by Vascular Endothelial Growth Factor Related Protein, a Novel Ligand for the FLT4 Receptor

1997 • 33 citations

Severe combined immune deficiencies due to defects of the common ? chain-JAK3 signaling pathway

1998 • 23 citations