Stepwise specification of lymphocyte developmental lineages

A clonogenic common myeloid progenitor that gives rise to all myeloid lineages

2000 • 2,528 citations

Identification of Clonogenic Common Lymphoid Progenitors in Mouse Bone Marrow

1997 • 2,205 citations

Requirement of Transcription Factor PU.1 in the Development of Multiple Hematopoietic Lineages

1994 • 1,506 citations

Deficient T Cell Fate Specification in Mice with an Induced Inactivation of Notch1

1999 • 1,392 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

Targeted disruption of the PU.1 gene results in multiple hematopoietic abnormalities.

1996 • 1,115 citations

Notch1 Expression in Early Lymphopoiesis Influences B versus T Lineage Determination

1999 • 956 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

Multilineage gene expression precedes commitment in the hemopoietic system.

1997 • 757 citations

Transcription Factors, Normal Myeloid Development, and Leukemia

1997 • 729 citations

Transcription Factors, Normal Myeloid Development, and Leukemia

1997 • 637 citations

Transcription factor GATA-3 is required for development of the T-cell lineage

1996 • 614 citations

An HMG-box-containing T-cell factor required for thymocyte differentiation

1995 • 518 citations

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1997 • 411 citations

E2A Deficiency Leads to Abnormalities in αβ T-Cell Development and to Rapid Development of T-Cell Lymphomas

1997 • 400 citations

Notch Activity Influences the αβ versus γδ T Cell Lineage Decision

1997 • 399 citations

Long-term in vivo reconstitution of T-cell development by Pax5-deficient B-cell progenitors

1999 • 386 citations

The Ets-1 Transcription Factor Is Required for the Development of Natural Killer Cells in Mice

1998 • 351 citations

Correlating Notch Signaling with Thymocyte Maturation

1998 • 350 citations

Redundant Regulation of T Cell Differentiation and TCRα Gene Expression by the Transcription Factors LEF-1 and TCF-1

1998 • 337 citations

Coordinate Regulation of B Cell Differentiation by the Transcription Factors EBF and E2A

1999 • 334 citations

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1998 • 314 citations

Transcription factor GATA-1 permits survival and maturation of erythroid precursors by preventing apoptosis.

1995 • 306 citations

The Human Homolog of Rat Jagged1Expressed by Marrow Stroma Inhibits Differentiation of 32D Cells through Interaction with Notch1

1998 • 282 citations

Inhibition of T Cell and Promotion of Natural Killer Cell Development by the Dominant Negative Helix Loop Helix Factor Id3

1997 • 279 citations

Induction of Early B Cell Factor (EBF) and Multiple B Lineage Genes by the Basic Helix-Loop-Helix Transcription Factor E12

1998 • 268 citations

Notch Inhibition of E47 Supports the Existence of a Novel Signaling Pathway

1998 • 261 citations

Precise developmental regulation of Ets family transcription factors during specification and commitment to the T cell lineage

1999 • 259 citations

Cutting Edge: Protective Effects of Notch-1 on TCR-Induced Apoptosis

1999 • 223 citations

The bHLH gene Hes1 is essential for expansion of early T cell precursors

1999 • 208 citations

Expression of the transcription factor GATA-3 is required for the development of the earliest T cell progenitors and correlates with stages of cellular proliferation in the thymus

1999 • 201 citations

CD34+CD38dim cells in the human thymus can differentiate into T, natural killer, and dendritic cells but are distinct from pluripotent stem cells

1996 • 200 citations

Expression pattern of Notch1, 2 and 3 and Jagged1 and 2 in lymphoid and stromal thymus components: distinct ligand–receptor interactions in intrathymic T cell development

1999 • 197 citations

A Role for Pref-1 and HES-1 in Thymocyte Development

2000 • 196 citations

Early stages in the development of human T, natural killer and thymic dendritic cells

1998 • 192 citations

PU.1 is required for myeloid-derived but not lymphoid-derived dendritic cells

2000 • 190 citations

Loops, Lineage, and Leukemia

1998 • 189 citations

Single Adult Human CD34+/Lin−/CD38− Progenitors Give Rise to Natural Killer Cells, B-Lineage Cells, Dendritic Cells, and Myeloid Cells

1999 • 180 citations

Kinetics of T cell receptor β, γ, and δ rearrangements during adult thymic development: T cell receptor rearrangements are present in CD44⁺CD25⁺Pro-T thymocytes

1998 • 169 citations

Commitment of Common T/Natural Killer (Nk) Progenitors to Unipotent T and Nk Progenitors in the Murine Fetal Thymus Revealed by a Single Progenitor Assay

1999 • 169 citations

Transcription Factor PU.1 Is Necessary for Development of Thymic and Myeloid Progenitor-Derived Dendritic Cells

2000 • 163 citations

Role of PU.1 in Hematopoiesis

1998 • 159 citations

Expression of pT mRNA in a Committed Dendritic Cell Precursor in the Human Thymus

1999 • 153 citations

c-Myb is essential for early T cell development

1999 • 153 citations

Stromal Expression of Jagged 1 Promotes Colony Formation by Fetal Hematopoietic Progenitor Cells

1998 • 150 citations

The lineage commitment of haemopoietic progenitor cells

1997 • 148 citations

Identification of a Novel Developmental Stage Marking Lineage Commitment of Progenitor Thymocytes

1997 • 146 citations

Direct evidence for the commitment of hematopoietic stem cells to T, B and myeloid lineages in murine fetal liver

1997 • 144 citations

Molecular and Cellular Events in Early Thymocyte Development 11Received for publication October 14, 1997

1998 • 137 citations

Commitment to the B Lymphoid Lineage Occurs before DH-JH Recombination

1999 • 135 citations

A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.

1999 • 133 citations

Massive Apoptosis of Thymocytes in T-Cell-Deficient Id1 Transgenic Mice

1999 • 133 citations

Functional Assessment of Precursors from Murine Bone Marrow Suggests a Sequence of Early B Lineage Differentiation Events

2000 • 130 citations

Positive and Negative Regulation of V(D)J Recombination by the E2A Proteins

1999 • 126 citations

The linkage between T‐cell and dendritic cell development in the mouse thymus

1998 • 118 citations

REGULATION OF T CELL FATE BY NOTCH

1999 • 105 citations

T Cell Development in PU.1-Deficient Mice

1999 • 102 citations

A Novel Role for HEB Downstream or Parallel to the Pre-TCR Signaling Pathway During αβ Thymopoiesis

1999 • 101 citations

CD19+ pro-B cells can give rise to dendritic cells in vitro.

1998 • 100 citations

The role of E-proteins in B- and T-lymphocyte development

1998 • 97 citations

Disruption of αβ but not of γδ T cell development by overexpression of the helix–loop–helix protein Id3 in committed T cell progenitors

1999 • 96 citations

Clonal Characterization of a Bipotent T Cell and NK Cell Progenitor in the Mouse Fetal Thymus

2000 • 92 citations

Identification of a Fetal Hematopoietic Precursor with B Cell, T Cell, and Macrophage Potential

1998 • 91 citations

Presence of progenitors restricted to T, B, or myeloid lineage, but absence of multipotent stem cells, in the murine fetal thymus.

1998 • 84 citations

Developmental dissociation of thymic dendritic cell and thymocyte lineages revealed in growth factor receptor mutant mice

1999 • 82 citations

Cutting Edge: CD19+ Pro-B Cells Can Give Rise to Dendritic Cells In Vitro

1998 • 81 citations

Transcriptional regulation of B-cell differentiation

1998 • 80 citations

Cutting Edge: Presence of Progenitors Restricted to T, B, or Myeloid Lineage, but Absence of Multipotent Stem Cells, in the Murine Fetal Thymus

1998 • 71 citations

BSAP Can Repress Enhancer Activity by Targeting PU.1 Function

2000 • 63 citations

Unexpectedly late expression of intracellular CD3ϵ and TCR γδ proteins during adult thymus development

1999 • 56 citations

Dependence of BSAP Repressor and Activator Functions on BSAP Concentration

1998 • 54 citations

GATA-1 Dominantly Activates a Program of Erythroid Gene Expression in Factor-Dependent Myeloid FDCW2 Cells

1998 • 49 citations

Molecular Biology of B-Cell and T-Cell Development

1998 • 49 citations

Transcriptional regulation of lymphocyte lineage commitment

1999 • 48 citations

In Vitro Intrathymic Differentiation Kinetics of Human Fetal Liver CD34+CD38− Progenitors Reveals a Phenotypically Defined Dendritic/T-NK Precursor Split

1999 • 43 citations

Acquisition of CD24 expression by Lin−CD43+B220lowckithi cells coincides with commitment to the B cell lineage

1998 • 42 citations

Identification of CD19–B220+c-Kit+Flt3/Flk-2+cells as early B lymphoid precursors before pre-B-I cells in juvenile mouse bone marrow

2000 • 42 citations

BSAP/Pax5A Expression Blocks Survival and Expansion of Early Myeloid Cells Implicating Its Involvement in Maintaining Commitment to the B-Lymphocyte Lineage

1999 • 40 citations

Development of Natural Killer Cells, B Lymphocytes, Macrophages, and Mast Cells From Single Hematopoietic Progenitors in Culture of Murine Fetal Liver Cells

1997 • 37 citations

CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells

1996 • 36 citations

Cross-lineage expression of Ig-β (B29) in thymocytes: Positive and negative gene regulation to establish T cell identity

1998 • 33 citations

A linkage between dendritic cell and T-cell development in the mouse thymus: the capacity of sequential T-cell precursors to form dendritic cells in culture

1998 • 31 citations

A Mouse Carrying Genetic Defect in the Choice Between T and B Lymphocytes

1998 • 30 citations

Threshold of pre-T-cell-receptor surface expression is associated with αβ T-cell lineage commitment

1999 • 27 citations

In vitro tracking of IL-7 responsiveness and gene expression during commitment of bipotent B-cell/macrophage progenitors

1996 • 26 citations

Precocious expression of T cell functional response genes in vivo in primitive thymocytes before T lineage commitment

1998 • 26 citations

T cell receptor Vβ8.2 gene germ‐line transcription: An early event of lymphocyte differentiation

1994 • 19 citations

T-cell development:

1999 • 11 citations

Gene Regulation in T-Cell Lineage Commitment

1998 • 7 citations