Major changes in complex I activity in mitochondria from aged rats may not be detected by direct assay of NADH:coenzyme Q reductase

MITOCHONDRIAL DNA MUTATIONS AS AN IMPORTANT CONTRIBUTOR TO AGEING AND DEGENERATIVE DISEASES

1989 • 1,179 citations

Mitochondrial role in cell aging

1980 • 919 citations

GENETICS OF MITOCHONDRIAL BIOGENESIS

1986 • 420 citations

Mitochondrial respiratory chain inhibitors induce apoptosis

1994 • 403 citations

The Kinetics of the Redox Reactions of Ubiquinone Related to the Electron‐Transport Activity in the Respiratory Chain

1973 • 338 citations

Analyses of mitochondrial respiratory chain function and mitochondrial DNA deletion in human skeletal muscle: Effect of ageing

1992 • 329 citations

Liver mitochondrial respiratory functions decline with age

1989 • 322 citations

Cytochrome c oxidase deficient fibres in the limb muscle and diaphragm of man without muscular disease: An age-related alteration

1990 • 276 citations

Cytochrome-c-oxidase deficient cardiomyocytes in the human heart--an age-related phenomenon. A histochemical ultracytochemical study.

1989 • 275 citations

Ubiquinol: an endogenous antioxidant in aerobic organisms

1993 • 270 citations

Ageing-associated 5 kb deletion in human liver mitochondrial DNA

1991 • 247 citations

Accumulation of deletions in human mitochondrial DNA during normal aging: analysis by quantitative PCR

1992 • 237 citations

Ubiquinone biosynthesis by the microsomal fraction from rat liver

1987 • 210 citations

The participation of coenzyme Q in free radical production and antioxidation

1990 • 210 citations

Assay conditions for the mitochondrial NADH:coenzyme Q oxidoreductase

1993 • 207 citations

Studies of sequence heterogeneity of mitochondrial DNA from rat and mouse tissues: Evidence for an increased frequency of deletions/additions with aging

1988 • 189 citations

Molecular proportion of the fixed cytochrome components of the respiratory chain of Keilin-Hartree particles and beef heart mitochondria

1966 • 181 citations

Bioenergetics in aging

1983 • 180 citations

Electron transfer properties of NADH: Ubiquinone reductase in the ND1/3460 and the ND4/11778 mutations of the Leber hereditary optic neuroretinopathy (LHON)

1991 • 165 citations

The point mutation of mitochondrial DNA characteristic for MERRF disease is found also in healthy people of different ages

1993 • 142 citations

Functional alterations of the mitochondrially encoded ND4 subunit associated with Leber's hereditary optic neuropathy

1994 • 126 citations

Tissue coenzyme Q (ubiquinone) and protein concentrations over the life span of the laboratory rat

1985 • 117 citations

Progressive loss of cytochrome c oxidase in the human extraocular muscles in ageing — a cytochemical-immunohistochemical study

1992 • 111 citations

Quantitative analysis of age-associated accumulation of mitochondrial DNA with deletion in human hearts

1991 • 110 citations

Saturation kinetics of coenzyme Q in NADH and succinate oxidation in beef heart mitochondria

1992 • 102 citations

Changes in skeletal muscle, heart and liver mitochondrial electron transport activities in rats and dogs of various ages.

1993 • 99 citations

[14] Stabilization of mitochondrial functions with digitonin

1979 • 98 citations

Complex I and Complex III of Mitochondria Have Common Inhibitors Acting as Ubiquinone Antagonists

1993 • 96 citations

A two-step hypothesis on the mechanisms of in vitro cell aging: Cell differentiation followed by intrinsic mitochondrial mutagenesis

1984 • 95 citations

The kinetics of quinone pools in electron transport

1985 • 85 citations

Is ubiquinone diffusion rate-limiting for electron transfer?

1986 • 57 citations

Mitochondrial activities of rat heart during ageing

1994 • 41 citations

Protective effect of exogenous coenzyme Q against damage by adriamycin in perfused rat liver.

1994 • 39 citations

Lack of age-dependent changes in rat heart mitochondria

1987 • 39 citations

Redox changes in coenzyme Q in the millisecond time range: An approach using rapid quenching and high-performance liquid chromatography

1985 • 32 citations

The influence of storage temperature on the transition, activation enthalpy, and activity of enzymes associated with inner mitochondrial membranes

1988 • 6 citations