The role of ascorbate in antioxidant protection of biomembranes: Interaction with vitamin E and coenzyme Q

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Cellular defenses against damage from reactive oxygen species

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Direct observation of a free radical interaction between vitamin E and vitamin C

1979 • 1,460 citations

Oxidative Stress: Oxidants and Antioxidants.

1992 • 1,193 citations

The relative contributions of vitamin E, urate, ascorbate and proteins to the total peroxyl radical-trapping antioxidant activity of human blood plasma

1987 • 889 citations

Antioxidant Functions of Vitamins

1992 • 810 citations

Supplemental ascorbate in the supportive treatment of cancer: Prolongation of survival times in terminal human cancer.

1976 • 686 citations

Antioxidants in relation to lipid peroxidation

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Diabetes mellitus and free radicals

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The antioxidant role of vitamin C

1986 • 660 citations

Quantitative measurement of the total, peroxyl radical‐trapping antioxidant capability of human blood plasma by controlled peroxidation

1985 • 637 citations

Ubiquinol-10 is an effective lipid-soluble antioxidant at physiological concentrations.

1990 • 621 citations

Vitamin E as the Biological Lipid Antioxidant

1962 • 581 citations

Inhibition of oxidation of methyl linoleate in solution by vitamin E and vitamin C.

1984 • 580 citations

Dietary Carotenes, Vitamin C, and Vitamin E as Protective Antioxidants in Human Cancers

1992 • 532 citations

RETRACTED: Effect of vitamin and trace-element supplementation on immune responses and infection in elderly subjects

1992 • 529 citations

Vitamin E: Interactions with Free Radicals and Ascorbate

1985 • 527 citations

Biology of free radical scavengers: an evaluation of ascorbate

1993 • 482 citations

Oxygen Radicals, Hydrogen Peroxide, and Oxygen Toxicity

1976 • 430 citations

Current status of antioxidant therapy

1993 • 429 citations

Antioxidant and co-antioxidant activity of vitamin C. The effect of vitamin C, either alone or in the presence of vitamin E or a water-soluble vitamin E analogue, upon the peroxidation of aqueous multilamellar phospholipid liposomes

1985 • 428 citations

Vitamin E, Ascorbate, Glutathione, Glutathicne Disulfide, and Enzymes of Glutathione Metabolism in Cultures of Chick Astrocytes and Neurons: Evidence that Astrocytes Play an Important Role in Antioxidative Processes in the Brain

1994 • 413 citations

The protection by ascorbate and glutathione against microsomal lipid peroxidation is dependent on vitamin E

1988 • 397 citations

Partners in defense, vitamin E and vitamin C

1993 • 385 citations

On the antioxidant effects of ascorbic acid and glutathione

1992 • 382 citations

Free-radical chain oxidation of rat red blood cells by molecular oxygen and its inhibition by α-tocopherol

1987 • 366 citations

Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to inhibition of collagen synthesis in scurvy

1991 • 363 citations

Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption

1991 • 351 citations

The Data Support a Role for Antioxidants in Reducing Cancer Risk

2009 • 330 citations

Physiology of oxygen radicals

1986 • 330 citations

Ascorbic acid protects lipids in human plasma and low-density lipoprotein against oxidative damage

1991 • 317 citations

Vitamin C: its chemistry and biochemistry

1992 • 316 citations

Increased risk of cardiovascular disease at suboptimal plasma concentrations of essential antioxidants: an epidemiological update with special attention to carotene and vitamin C

1993 • 314 citations

Dietary inhibitors of mutagenesis and carcinogenesis

1988 • 314 citations

The role of high-density lipoprotein and lipid-soluble antioxidant vitamins in inhibiting low-density lipoprotein oxidation

1993 • 304 citations

REGENERATION OF VITAMIN E FROM α-CHROMANOXYL RADICAL BY GLUTATHIONE AND VITAMIN C

1982 • 283 citations

Vitamin C supplementation reduces the incidence of postrace symptoms of upper-respiratory-tract infection in ultramarathon runners

1993 • 280 citations

Will antioxidant nutrients slow aging processes?

1968 • 279 citations

Ubiquinol: an endogenous antioxidant in aerobic organisms

1993 • 270 citations

Ascorbic acid and carnitine biosynthesis

1991 • 265 citations

Oxy-radicals in molecular biology and pathology

1989 • 262 citations

An analysis of the role of coenzyme Q in free radical generation and as an antioxidant

1992 • 245 citations

Prospects for the prevention of free radical disease, regarding cancer and cardiovascular disease

1993 • 245 citations

Ascorbic acid as a scavenger of singlet oxygen

1979 • 243 citations

Kinetics and mechanism for the oxidation of ascorbic acid/ascorbate by HO2/O2- (hydroperoxyl/superoxide) radicals. A pulse radiolysis and stopped-flow photolysis study

1983 • 231 citations

Plasma Antioxidant Vitamins and Subsequent Cancer Mortality in the 12-Year Follow-up of the Prospective Basel Study

1991 • 225 citations

Relationship between dietary vitamin C intake and pulmonary function in the First National Health and Nutrition Examination Survey (NHANES I)

1994 • 222 citations

Vitamin C and Cardiovascular Disease: A Review

1992 • 218 citations

Oxidation of Lipids. VIII. Synergistic Inhibition of Oxidation of Phosphatidylcholine Liposome in Aqueous Dispersion by Vitamin E and Vitamin C

1985 • 218 citations

The participation of coenzyme Q in free radical production and antioxidation

1990 • 210 citations

Vitamin E recycling in human erythrocyte membranes

1993 • 204 citations

Chemistry of Ascorbic Acid Radicals

1982 • 202 citations

Effect of combined supplementation with alpha-tocopherol, ascorbate, and beta carotene on low-density lipoprotein oxidation.

1993 • 199 citations

Autoxidation of micelles and model membranes. Quantitative kinetic measurements can be made by using either water-soluble or lipid-soluble initiators with water-soluble or lipid-soluble chain-breaking antioxidants

1984 • 197 citations

Antioxidant status and indexes of oxidative stress during consecutive days of exercise

1993 • 186 citations

Free radicals and the heart.

1991 • 184 citations

Lipid-Soluble Antioxidants: Biochemistry and Clinical Applications

1992 • 184 citations

Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis

1991 • 179 citations

Biochemical aspects of free radicals

1990 • 178 citations

The role of oxidative stress in disease progression in individuals infected by the human immunodeficiency virus

1992 • 166 citations

Superoxide ion as active intermediate in the autoxidation of ascorbate by molecular oxygen. Effect of superoxide dismutase.

1983 • 158 citations

Kinetics and mechanism for the oxidation of ascorbic acid/ascorbate by HO_2/O_2-radicals. A pulse radiolysis and stopped-flow photolysis study.

1983 • 150 citations

Immunocompetence and oxidant defense during ascorbate depletion of healthy men

1991 • 144 citations

Effect of antioxidant vitamin supplementation on muscle function after eccentric exercise

1993 • 142 citations

The Role of Ascorbic Acid in Mesenchymal Differentiation

2009 • 140 citations

Suppression of human immunodeficiency virus replication by ascorbate in chronically and acutely infected cells.

1990 • 137 citations

Iron containing superoxide dismutases from luminous bacteria

1974 • 133 citations

Ascorbic acid requirements for smokers: analysis of a population survey

1991 • 130 citations

Use of ascorbic acid to inhibit nitrosation: kinetic and mass transfer considerations for an in vitro system

1988 • 130 citations

Vitamins C and E donate single hydrogen atoms in vivo

1991 • 128 citations

Stopped-flow kinetic study of vitamin E regeneration reaction with biological hydroquinones (reduced forms of ubiquinone, vitamin K, and tocopherolquinone) in solution.

1992 • 125 citations

Inhibition of lipid peroxidation by ubiquinol in submitochondrial particles in the absence of vitamin E

1991 • 125 citations

Stopped-flow kinetic study of the regeneration reaction of tocopheroxyl radical by reduced ubiquinone-10 in solution

1990 • 118 citations

Cataract: relationship between nutrition and oxidation.

1993 • 117 citations

Can vitamin E protect humans against the pathological effects of ozone in smog?

1991 • 116 citations

Antioxidants

1993 • 110 citations

Lipid Peroxidation and Lipid Antioxidants in Normal and Tumor Cells

1984 • 110 citations

The mode of action of lipid-soluble antioxidants in biological membranes: relationship between the effects of ubiquinol and vitamin E as inhibitors of lipid peroxidation in submitochondrial particles.

1992 • 109 citations

Ascorbic acid and adriamycin toxicity

1991 • 108 citations

Vitamin C as an Antioxidant

2015 • 107 citations

Dietary vitamin C decreases endogenous protein oxidative damage, malondialdehyde, and lipid peroxidation and maintains fatty acid unsaturation in the guinea pig liver

1994 • 106 citations

The role of ascorbic acid in senile cataract.

1985 • 105 citations

A multivitamin infusion prevents lipid peroxidation and improves transplantation performance

1993 • 105 citations

Oxidation of Lipids. V. Oxidation of Methyl Linoleate in Aqueous Dispersion

1984 • 104 citations

The Mode of Action of Lipid-Soluble Antioxidants in Biological Membranes. Relationship between the Effects of Ubiquinol and Vitamin E as Inhibitors of Lipid Peroxidation in Submitochondrial Particles

1992 • 94 citations

Ascorbic Acid: Biologic Functions and Relation to Cancer

1991 • 94 citations

Vitamin C depletion and pressure sores in elderly patients with femoral neck fracture.

1992 • 91 citations

Effect of superoxide dismutase on the autoxidation of various hydroquinones—A possible role of superoxide dismutase as a superoxide: Semiquinone oxidoreductase

1988 • 87 citations

Ischemia/Reperfusion-Induced Injury of Forebrain Mitochondria and Protection by Ascorbate

1993 • 87 citations

Inhibition of lead chromate clastogenesis by ascorbate: relationship to particle dissolution and uptake

1993 • 85 citations

The Healing Factor: "Vitamin C" Against Disease

1972 • 83 citations

Simultaneous induction of SOD, glutathione reductase, GSH, and ascorbate in liver and kidney correlates with survival during aging

1993 • 83 citations

Antioxidant Properties of Ascorbic Acid in Foods

1982 • 83 citations

The Politics of Therapeutic Evaluation: The Vitamin C and Cancer Controversy

1988 • 82 citations

Ascorbic acid and the eye

1991 • 82 citations

Highlights in Ubiquinone research

1991 • 78 citations

Inverse correlation between essential antioxidants in plasma and subsequent risk to develop cancer, ischemic heart disease and stroke respectively: 12-year follow-up of the Prospective Basel Study

1992 • 76 citations

Estimating Ascorbic Acid Requirements for Cigarette Smokers

1993 • 75 citations

PROOXIDANT and ANTIOXIDANT EFFECTS OF ASCORBATE ON PHOTOSENSITIZED PEROXIDATION OF LIPIDS IN ERYTHROCYTE MEMBRANES

1985 • 73 citations

Reduction of adriamycin toxicity by ascorbate in mice and guinea pigs.

1982 • 73 citations

Additional Antilipoperoxidant Activities of Alpha-Tocopherol and Ascorbic Acid on Membrane-Like Systems Are Potentiated by Rutin

1991 • 71 citations

Low density lipoprotein oxidizability by copper correlates to its initial ubiquinol‐10 and polyunsaturated fatty acid content

1994 • 70 citations

Free-radical scavenging activities, interactions and recycling of antioxidants

1993 • 67 citations

Comparative study of the anti-HIV activities of ascorbate and thiol-containing reducing agents in chronically HIV-infected cells

1991 • 67 citations

Ascorbate protects guinea pig tissues against lipid peroxidation

1994 • 66 citations

Free radical chain oxidation and hemolysis of erythrocytes by molecular oxygen and their inhibition by vitamin E.

1986 • 64 citations

Potential role of beta-carotene in the prevention of cardiovascular disease.

1991 • 64 citations

Ascorbic acid metabolism in protection against free radicals: A radiation model

1990 • 63 citations

Radical Exchange Reactions between Vitamin E, Vitamin C and Phospholipids in Autoxidizing Polyunsaturated Lipids

1994 • 63 citations

Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. II. Synergism with combined chemotherapy action.

1993 • 62 citations

Vitamin C and cancer: medicine or politics?

1992 • 60 citations

Role of Nutrients in Delaying Cataracts^a

1992 • 59 citations

Synergistic Action of Vitamin E and Vitamin C in Vivo Using a New Mutant of Wistar-Strain Rats, ODS, Unable to Synthesize Vitamin C.

1991 • 59 citations

Oxygen-induced retinopathy in the rat. Vitamins C and E as potential therapies.

1992 • 57 citations

Dehydroascorbic Acid

1982 • 56 citations

Vitamin C Status and Cancer

1992 • 56 citations

Mechanism of inhibition of estrogen-induced renal carcinogenesis in male Syrian hamsters by vitamin C

1989 • 55 citations

Physiological Potential of Ascorbate, �-Carotene and a-Tocopherol Individually and in Combination in the Prevention of Tissue Damage, Carcinogenesis and Immune Dysfunction Mediated by Phagocyte-Derived Reactive Oxidants

2015 • 55 citations

Vitamin C in Health and Disease

1982 • 55 citations

Ascorbic Acid and the Immune Response

1981 • 54 citations

The Antioxidant and Nutritional Effects of Tocopherols, Ascorbic Acid and β-Carotene in Relation to Processing of Edible Oils

1989 • 54 citations

SHORT COMMUNICATION: Effect of ascorbate and 5-aminosalicylic acid on light-induced 8-hydroxydeoxyguanosine formation in V79 Chinese hamster cells

1993 • 53 citations

Marginal Vitamin C Deficiency, Lipid Metabolism, and Atherogenesis

1978 • 52 citations

Antioxidants: A biological defense mechanism for the prevention of atherosclerosis

1993 • 52 citations

The oxidation of ascorbic acid and hydroquinone by perhydroxyl radicals. A flash photolysis study

1979 • 52 citations

Serum levels of ascorbic acid (vitamin C) in patients with Parkinson's disease

1993 • 51 citations

Vitamin C and Cancer: Medicine or Politics?

1991 • 49 citations

Mutation and the environment-Part B

1990 • 47 citations

The effects of L- and D-ascorbic acid administration on retinal tissue levels and light damage in rats

1992 • 47 citations

Protection by vitamin E, selenium, trolox C, ascorbic acid palmitate, acetylcysteine, coenzyme Q, beta-carotene, canthaxanthin, and (+)-catechin against oxidative damage to liver slices measured by oxidized heme proteins

1994 • 46 citations

Protective effect of a new anti-oxidant on the rat brain exposed to ischemia-reperfusion injury: Inhibition of free radical formation and lipid peroxidation

1991 • 46 citations

Ascorbic acid stimulation of collagen biosynthesis independent of hydroxylation

1991 • 45 citations

Inhibition by coenzyme Q of ethanol- and carbon tetrachloride-stimulated lipid peroxidation in vivo and catalyzed by microsomal and mitochondrial systems

1988 • 44 citations

Micronutrients and Their Influence on Mutagenicity and Malignant Transformationa

1993 • 44 citations

Vitamin C in health and disease

1982 • 43 citations

Vitamin Intake and Health: A Scientific Review

1991 • 41 citations

Inhibitory Effects of Antioxidants on N‐Bis(2‐hydroxypropyl)nitrosamine‐induced Lung Carcinogenesis in Rats

1990 • 41 citations

The cause and correction of low blood vitamin C concentrations in the elderly

1985 • 40 citations

Ascorbic acid in cholesterol metabolism and in detoxification of xenobiotic substances: problem of optimum vitamin C intake.

1989 • 40 citations

Oxy-radicals in molecular biology and pathology

1988 • 39 citations

Vitamins as Radioprotectors In Vivo. I. Protection by Vitamin C against Internal Radionuclides in Mouse Testes: Implications to the Mechanism of Damage Caused by the Auger Effect

1994 • 38 citations

Cellular Antioxidant Status and Human Immunodeficiency Virus Replication

2009 • 38 citations

Inhibition of human leukocyte 3-hydroxy-3-methylglutaryl coenzyme A reductase activity by ascorbic acid. An effect mediated by the free radical monodehydroascorbate.

1986 • 37 citations

Ascorbic acid reduces the endotoxin‐induced lung injury in awake sheep

1994 • 37 citations

Electron Spin Resonance Studies of Free Radicals in Gamma-Irradiated Golden Hamster Embryo Cells: Radical Formation at 77 and 295 K, and Radioprotective Effects of Vitamin C at 295 K

1993 • 37 citations

Intermittent high-dose vitamin C therapy in patients with HTLV-I associated myelopathy.

1993 • 37 citations

ASCORBIC ACID AND PLASMA LIPIDS

1994 • 36 citations

A protective role for ascorbic acid during inflammatory episodes in the eye

1986 • 35 citations

Effect of L-ascorbic acid tretreatment on cadmium toxicity in the male Fischer (F344/NCr) rat

1993 • 34 citations

Modulation of cyclophosphamide mutagenicity by vitamin C in the in vivo rodent micronucleus assay

1992 • 32 citations

Vitamins and cancer prevention

1987 • 31 citations

The relative essentiality of the antioxidative function of Coenzyme Q—the interactive role of DT-diaphorase

1994 • 29 citations

Total radical-trapping antioxidant potential (TRAP) of plasma: effects of supplementation of young healthy volunteers with large doses of alpha-tocopherol and ascorbic acid.

1993 • 29 citations

The Effect of Vitamin C Nutriture on Complement Component C1q Concentrations in Guinea Pig Plasma

1987 • 29 citations

Pathobiology of Cardiovascular Injury

1985 • 28 citations

THE SYNTHESIS OF HIGHLY STABLEo- ANDp-QUINONE METHIDES

1977 • 26 citations

Effect of vitamin C supplementation on gastric mucosal DNA damage

1994 • 26 citations

Polymorphism in metoclopramide hydrochloride and metoclopramide

1985 • 26 citations

Vitamins and Immunity

1992 • 24 citations

A cross-sectional study of vitamin C intake and blood pressure in the elderly.

1992 • 24 citations

Relationship of Vitamin C Status to Cholesterol and Blood Pressure^a

1992 • 23 citations

Vitamin C, cancer and aging

1993 • 22 citations

Vitamin Intake and Health: A Scientific Review

1990 • 22 citations

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1991 • 20 citations

The roles of ascorbic acid and other antioxidants in the erythrocyte in reducing membrane nitroxide radicals

1994 • 20 citations

Studies in gastric carcinogenesis. V. The effects of ascorbic acid on N-nitroso compound formation in human gastric juice in vivo and in vitro

1991 • 19 citations

Inhibition of chrysarobin skin tumor promotion in SENCAR mice by antioxidants

1993 • 18 citations

Vitamin/Mineral Supplementation, the Aging Immune Response, and Risk of Infection

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Relevance of Endogenous Ascorbate and Tocopherol for Brain Cell Vitality Indicated by Photon Emission

1994 • 17 citations

Vitamin supplements: current controversies.

1994 • 16 citations

The Influence of Ascorbic Acid on the Free-Radical Metabolism of Xenobiotics: the Example of Diaziquone

1988 • 15 citations

[Free radicals, oxidative stress and antioxidant vitamins].

1993 • 15 citations

Synergism by sodium L-ascorbate but inhibition by L-ascorbic acid for sodium saccharin promotion of rat two-stage bladder carcinogenesis.

1990 • 15 citations

Antimetabolic activity of l-ascorbic acid in human and animal tumors

1989 • 15 citations

Kinetics of the reaction between ascorbate and free radical from vitamin E as studied by ESR steady-state method

1993 • 14 citations

Coenzyme Q and Myocardial Function in Aging and Exercise

1985 • 14 citations

Antioxidant Nutrition and Cataract in Women: A Prospective Study

2009 • 13 citations

Complement component C1q activity and ascorbic acid nutriture in guinea pigs

1991 • 12 citations

Ascorbic acid deficiency and the flavin-containing monooxygenase

1986 • 12 citations

The Regulatory Effect of Ascorbate on the Carmnitine Synthesis in Primary Cultured Guinea Pig Hepatocytes.

1991 • 12 citations

Chemoprevention of lung cancer

1995 • 12 citations

Antioxidant therapy in the aging process

1992 • 12 citations

Inhibition of mitomycin C‐induced sister chromatid exchanges by Vitamin C in vivo

1992 • 11 citations

Vitamins and Related Dietary Antioxidants

1991 • 10 citations

Ascorbic Acid Deficiency Reduces the Level of mRNA for Cytochrome P-450 on the Induction by Polychlorinated Biphenyls.

1993 • 9 citations

Are the recommended allowances for dietary antioxidants adequate?

1987 • 9 citations

Experimental conditions determine effects of ascorbic acid on reperfusion injury: comparison of tissue damage with hemodynamic parameters in rat isolated hearts.

1992 • 8 citations

Antioxidant Intake in the U.S

1993 • 8 citations

Assessment of l-ascorbic acid requirement for prolonged survival in ODS rats and their susceptibility to urinary bladder carcinogenesis by N-butyl-N-(4-hydroxybutyl)nitrosamine

1988 • 8 citations

A review of the use of antioxidant supplements in the treatment of human oral leukoplakia

1993 • 8 citations

Epidemiological Correlations between Poor Plasma Levels of Essential Antioxidants and the Risk of Coronary Heart Disease and Cancer

1992 • 7 citations

Protective action of ascorbic acid against mutagenicity of aminopyrine plus nitrite.

1985 • 5 citations

Myocardial salvage by trolox and ascorbic acid, but not ascorbic acid alone, in anesthetized dogs and rabbits

1992 • 5 citations

The effects of various levels of ascorbic acid on the response of the ODS rat to trimethyltin.

1993 • 5 citations

Effect of ascorbic acid on humoral and other factors of immunity in coal‐tar exposed workers

1986 • 4 citations

Vitamin C: Biologic functions and relation to cancer

1991 • 4 citations

Vitamin undernutrition

1993 • 3 citations

Effect of cadmium on hepatic microsomal monooxygenase activities in guinea pigs with low and high ascorbic acid intake

1994 • 2 citations