Metal ion-catalyzed oxidation of proteins: Biochemical mechanism and biological consequences

[49] Determination of carbonyl content in oxidatively modified proteins

1990 • 5,654 citations

Protein damage and degradation by oxygen radicals. I. general aspects.

1987 • 1,618 citations

Glucose autoxidation and protein modification. The potential role of ‘autoxidative glycosylation’ in diabetes

1987 • 1,278 citations

Age-related changes in oxidized proteins.

1987 • 1,229 citations

Protein damage and degradation by oxygen radicals. II. Modification of amino acids.

1987 • 840 citations

Hydroxyl radical production and autoxidative glycosylation. Glucose autoxidation as the cause of protein damage in the experimental glycation model of diabetes mellitus and ageing

1988 • 787 citations

Oxidative damage to brain proteins, loss of glutamine synthetase activity, and production of free radicals during ischemia/reperfusion-induced injury to gerbil brain.

1990 • 787 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Inactivation of the enzyme

1975 • 777 citations

Measurement of superoxide-derived free radicals in the reperfused heart. Evidence for a free radical mechanism of reperfusion injury.

1988 • 629 citations

Protein damage and degradation by oxygen radicals. III. Modification of secondary and tertiary structure.

1987 • 572 citations

Free radicals, lipids and protein degradation

1986 • 556 citations

Conversion of Amino Acid Residues in Proteins and Amino Acid Homopolymers to Carbonyl Derivatives by Metal-catalyzed Oxidation Reactions

1989 • 488 citations

Protein damage and degradation by oxygen radicals. IV. Degradation of denatured protein.

1987 • 482 citations

Inactivation of key metabolic enzymes by mixed-function oxidation reactions: Possible implication in protein turnover and ageing

1983 • 467 citations

Protein oxidation and proteolysis during aging and oxidative stress

1989 • 396 citations

Tissue Destruction by Neutrophils

1989 • 389 citations

Measurement and characterization of postischemic free radical generation in the isolated perfused heart

1989 • 383 citations

Turnover of bacterial glutamine synthetase: oxidative inactivation precedes proteolysis.

1981 • 347 citations

Proteins damaged by oxygen radicals are rapidly degraded in extracts of red blood cells.

1987 • 336 citations

Methods for determination of aldehydic lipid peroxidation products

1989 • 330 citations

On the cytotoxicity of vitamin C and metal ions

1983 • 328 citations

Novel subunit—subunit interactions in the structure of glutamine synthetase

1986 • 310 citations

Oxidation of proteins by mixed-function oxidation systems: implication in protein turnover, ageing and neutrophil function

1986 • 290 citations

Determination of carbonyl groups in oxidatively modified proteins by reduction with tritiated sodium borohydride

1989 • 285 citations

Preferential degradation of the oxidatively modified form of glutamine synthetase by intracellular mammalian proteases.

1985 • 282 citations

Nonenzymatic cleavage of proteins by reactive oxygen species generated by dithiothreitol and iron.

1985 • 268 citations

Oxidative modification of glutamine synthetase. II. Characterization of the ascorbate model system.

1983 • 266 citations

Glucose and Aging

1987 • 244 citations

Purification of a liver alkaline protease which degrades oxidatively modified glutamine synthetase. Characterization as a high molecular weight cysteine proteinase.

1985 • 244 citations

Medical, biochemical and chemical aspects of free radicals

1990 • 229 citations

Oxygen Effect in the Radiolysis of Proteins

1984 • 220 citations

Detection of Inactive Enzyme Molecules in Ageing Organisms

1970 • 220 citations

Site-specific modification of albumin by free radicals. Reaction with copper(II) and ascorbate

1986 • 212 citations

Radiation Chemistry of Organic Compounds

1961 • 211 citations

Macroxyproteinase (M.O.P.): A 670 kDa Proteinase complex that degrades oxidatively denatured proteins in red blood cells

1989 • 182 citations

Hemin-mediated oxidative degradation of proteins.

1984 • 173 citations

The analogous mechanisms of enzymatic inactivation induced by ascorbate and superoxide in the presence of copper.

1983 • 165 citations

Sequence of a peptide susceptible to mixed-function oxidation. Probable cation binding site in glutamine synthetase.

1986 • 163 citations

Protein Modification in Aging

1988 • 160 citations

Effect of Reactive Oxygen Species on Myelin Membrane Proteins

1985 • 153 citations

Increased carbonyl content of proteins in synovial fluid from patients with rheumatoid arthritis.

1989 • 143 citations

Oxidation state of tissue thiol groups and content of protein carbonyl groups in chickens with inherited muscular dystrophy

1989 • 130 citations

Degradation of oxidatively denatured proteins in Escherichia coli

1988 • 126 citations

Radiation-Induced Oxidation of Protein in Aqueous Solution

1962 • 124 citations

Detection of hydroxyl radical in the mitochondria of ischemic-reperfused myocardium by trapping with salicylate

1989 • 123 citations

Role of site-specific, metal-catalyzed oxidation in lens aging and cataract: A hypothesis

1990 • 122 citations

Mitochondria contain a proteolytic system which can recognize and degrade oxidatively-denatured proteins

1988 • 122 citations

Metal-catalyzed oxidation of Escherichia coli glutamine synthetase: Correlation of structural and functional changes

1990 • 121 citations

Purification of a protease from Escherichia coli with specificity for oxidized glutamine synthetase.

1987 • 121 citations

Intracellular protein catabolism

1977 • 118 citations

Hydroperoxide-mediated fragmentation of proteins

1988 • 118 citations

Oxygen radicals in biology and medicine

1989 • 112 citations

Inactivation of enzymes and oxidative modification of proteins by stimulated neutrophils

1987 • 111 citations

Modification of hepatic proteins in rats exposed to high oxygen concentration

1987 • 108 citations

A Role of Mixed‐Function Oxidation Reactions in the Accumulation of Altered Enzyme Forms During Aging

1987 • 104 citations

Use of fluorescein hydrazide and fluorescein thiosemicarbazide reagents for the fluorometric determination of protein carbonyl groups and for the detection of oxidized protein on polyacrylamide gels

1987 • 94 citations

Inactivation of α₁ ‐antiproteinase by hydroxyl radicals The effect of uric acid

1989 • 87 citations

Manganese(II)-bicarbonate-mediated catalytic activity for hydrogen peroxide dismutation and amino acid oxidation: detection of free radical intermediates.

1990 • 87 citations

Structural changes in bovine lens crystallins induced by ascorbate, metal, and oxygen

1986 • 86 citations

Inactivation of Escherichia coli glutamine synthetase by xanthine oxidase, nicotinate hydroxylase, horseradish peroxidase, or glucose oxidase: Effects of ferredoxin, putidaredoxin, and menadione

1985 • 85 citations

Posttranslational Modifications of Enzymes

1978 • 82 citations

Studies on Ascorbic Acid. I. Factors Influencing the Ascorbate-Mediated Inhibition of Catalase^*

1967 • 81 citations

Derivatization of γ-glutamyl semialdehyde residues in oxidized proteins by fluoresceinamine

1989 • 81 citations

Studies of the limited degradation of mucus glycoproteins. The mechanism of the peroxide reaction

1985 • 79 citations

Modulation of the hydrophobicity of glutamine synthetase by mixed‐function oxidation

1988 • 74 citations

Studies of the limited degradation of mucus glycoproteins. The effect of dilute hydrogen peroxide

1983 • 70 citations

Mixed-function oxidation of histidine residues

1984 • 70 citations

Increased oxygen radical‐dependent inactivation of metabolic enzymes by liver microsomes after chronic ethanol consumption

1988 • 70 citations

Nonenzymatic peptide alpha-amidation. Implications for a novel enzyme mechanism.

1985 • 66 citations

Metabolic Interconversion of Enzymes

1972 • 66 citations

The effect of mixed-function oxidation of enzymes on their susceptibility to degradation by a nonlysosomal cysteine proteinase

1985 • 62 citations

A mechanism for accelerated degradation of intracellular proteins after limited damage by free radicals

1987 • 61 citations

Oxidative modification of proteins in the presence of ferrous ion and air. Effect of ionic constituents of the reaction medium on the nature of the oxidation products

1973 • 59 citations

Studies on Ascorbic Acid. II. Physical Changes in Catalase Following Incubation with Ascorbate or Ascorbate and Copper(II)^*

1967 • 56 citations

The Oxidative Modification of Lens Proteins

1988 • 52 citations

Inactivation of glutamine synthetase by a purified rabbit liver microsomal cytochrome P-450 system

1985 • 49 citations

Different selectivities of oxidants during oxidation of methionine residues in the α‐1‐proteinase inhibitor

1989 • 46 citations

Alteration of aminoacyl-tRNA synthetase with age: Heat-labilization of the enzyme by oxidative damage

1990 • 46 citations

The role of hydroxyl radicals in irreversible inactivation of lactoperoxidase by excess H2O2

1987 • 39 citations

Implication of Lysine Residues in the Loss of Enzymatic Activity in Rat Liver 6-Phosphogluconate Dehydrogenase Found in Aging

1989 • 37 citations

Implication of Protein Oxidation in Protein Turnover, Aging, and Oxygen Toxicity

1988 • 36 citations

Lipid peroxidation inactivates rat liver microsomal glycerol-3-phosphate acyl transferase. Effect of iron and copper salts and carbon tetrachloride.

1990 • 34 citations

Covalent modification of proteins by mixed-function oxidation: recognition by intracellular proteases.

1985 • 34 citations

Alkaline phosphatase inactivation by mixed function oxidation systems

1987 • 34 citations

Regulation of glutamine synthetase, aspartokinase, and total protein turnover in Klebsiella aerogenes

1985 • 31 citations

Protease So from Escherichia coli preferentially degrades oxidatively damaged glutamine synthetase.

1988 • 31 citations

Oxidation of Neurospora crassa glutamine synthetase

1986 • 29 citations

Vit C.Fe(III) induced loss of the covalently bound phosphate and enzyme activity of phosphoglucomutase.

1985 • 27 citations

Specific Oxidation of Peptides via Their Copper Complexes^*

1967 • 27 citations

Regulation of Glutamine Synthetase Degradation

1981 • 27 citations

Effect of oxygen radicals and hyperoxia on rat heart ornithine decarboxylase activity

1982 • 26 citations

Hydrogen peroxide mediates the oxidative inactivation of enzymes following the switch from anaerobic to aerobic metabolism in Klebsiella pneumoniae.

1990 • 26 citations

Oxidation of Neurospora crassa NADP-specific glutamate dehydrogenase by activated oxygen species

1989 • 23 citations

ENZYMATIC OXIDATION OF α-CHYMOTRYPSIN

1955 • 23 citations

Fenton Chemistry Revisited: Amino Acid Oxidation

1988 • 21 citations

Oxygen radical induced alterations in polyclonal IgG

1988 • 20 citations

Oxidative inactivation of an extramitochondrial acetyl-CoA hydrolase by autoxidation of l-ascorbic acid

1985 • 19 citations

Fe2+ oxidation of α-crystallin produces a 43,000 Da aggregate composed of A and B chains cross-linked by non-reducible covalent bonds

1988 • 18 citations

Proteolysis induced by metal-catalyzed oxidation.

1989 • 18 citations

Decay of hexokinase during reticulocyte maturation: Is oxidative damage a signal for destruction?

1989 • 13 citations

Mixed function oxidation and enzymes: Kinetic and structural properties of an oxidatively modified alkaline phosphatase

1988 • 11 citations

Benzyl viologen-mediated in vivo and in vitro inactivation of glutamine synthetase in Azotobacter chroococcum

1982 • 10 citations

Alterations of the microsomal glucose-6-phosphatase system evoked by ferrous iron- and haloalkane free-radical-mediated lipid peroxidation

1986 • 9 citations

Inactivation of mitochondrial carbamoyl phosphate synthetase induced by ascorbate, oxygen, and Fe3+ in the presence of acetylglutamate: Protection by ATP and HCO−3 and lack of inactivation of ornithine transcarbamylase

1987 • 7 citations

Oxidative inactivation of yeast fructose-1,6-bisphosphatase.

1985 • 2 citations

Rapid correction of severe hyponatremia results in myelinolysis, brain protein oxidation, and altered blood chemistries

1989 • 2 citations