Tumor-Induced Immune Dysfunctions Caused by Myeloid Suppressor Cells

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Immunobiology of Dendritic Cells

2000 • 6,653 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.

1992 • 1,849 citations

Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic Cells

2000 • 1,577 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Colony-Stimulating Factor 1 Promotes Progression of Mammary Tumors to Malignancy

2001 • 1,556 citations

Antigen-Specific Inhibition of Effector T Cell Function in Humans after Injection of Immature Dendritic Cells

2001 • 1,384 citations

Increased Production of Immature Myeloid Cells in Cancer Patients: A Mechanism of Immunosuppression in Cancer

2001 • 1,309 citations

MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis

2000 • 1,306 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

Dramatic increase in the numbers of functionally mature dendritic cells in Flt3 ligand-treated mice: multiple dendritic cell subpopulations identified.

1996 • 1,129 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 933 citations

Reactive oxygen and reactive nitrogen intermediates in innate and specific immunity

2000 • 923 citations

Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo

1998 • 828 citations

Interleukin-12: A Cytokine at the Interface of Inflammation and Immunity

1998 • 785 citations

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 • 733 citations

Infections as a major preventable cause of human cancer

2000 • 729 citations

Dendritic Cells in Cancer Immunotherapy

2000 • 698 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

Other Functions, Other Genes

1999 • 686 citations

Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

1999 • 650 citations

The role of nitric oxide in innate immunity

2000 • 642 citations

In Breast Carcinoma Tissue, Immature Dendritic Cells Reside within the Tumor, Whereas Mature Dendritic Cells Are Located in Peritumoral Areas

1999 • 540 citations

Mechanism of Immune Dysfunction in Cancer Mediated by Immature Gr-1+ Myeloid Cells

2001 • 536 citations

Vascular endothelial growth factor affects dendritic cell maturation through the inhibition of nuclear factor-kappa B activation in hemopoietic progenitor cells.

1998 • 524 citations

Identification of a CD11b+/Gr-1+/CD31+ myeloid progenitor capable of activating or suppressing CD8+T cells

2000 • 516 citations

Biology of the Interleukin-2 Receptor

1998 • 489 citations

Immature dendritic cells generated with low doses of GM-CSF in the absence of IL-4 are maturation resistant and prolong allograft survivalin vivo

2000 • 477 citations

Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway

1998 • 473 citations

Vascular Endothelial Growth Factor Affects Dendritic Cell Maturation Through the Inhibition of Nuclear Factor-κB Activation in Hemopoietic Progenitor Cells

1998 • 440 citations

Decreased antigen presentation by dendritic cells in patients with breast cancer.

1997 • 439 citations

Tumor-induced immune dysfunction: the macrophage connection

1998 • 433 citations

Nitrosation and oxidation in the regulation of gene expression

2000 • 422 citations

Flt3-Ligand and Granulocyte Colony-Stimulating Factor Mobilize Distinct Human Dendritic Cell Subsets In Vivo

2000 • 419 citations

Differences in dendritic cells stimulated in vivo by tumors engineered to secrete granulocyte-macrophage colony-stimulating factor or Flt3-ligand.

2000 • 418 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Gr-1+ Myeloid Cells Derived from Tumor-Bearing Mice Inhibit Primary T Cell Activation Induced Through CD3/CD28 Costimulation

2000 • 361 citations

Oxidative stress by tumor-derived macrophages suppresses the expression of CD3 ζ chain of T-cell receptor complex and antigen-specific T-cell responses

1996 • 341 citations

Immune suppression and skin cancer development: regulation by NKT cells

2000 • 327 citations

The role of different subsets of T regulatory cells in controlling autoimmunity

2000 • 323 citations

Apoptotic Death of CD8+ T Lymphocytes After Immunization: Induction of a Suppressive Population of Mac-1+/Gr-1+ Cells

1998 • 321 citations

Peroxynitrite Inhibits T Lymphocyte Activation and Proliferation by Promoting Impairment of Tyrosine Phosphorylation and Peroxynitrite-Driven Apoptotic Death

1999 • 307 citations

Angiogenesis and Metastasis

2002 • 294 citations

Mechanisms of immune suppression in patients with head and neck cancer: presence of CD34(+) cells which suppress immune functions within cancers that secrete granulocyte-macrophage colony-stimulating factor.

1995 • 272 citations

Suppressor macrophages in African trypanosomiasis inhibit T cell proliferative responses by nitric oxide and prostaglandins.

1993 • 249 citations

Nitric oxide negatively regulates c-Jun N-terminal kinase/stress-activated protein kinase by means ofS-nitrosylation

2000 • 244 citations

Tumor-induced immune dysfunction

1999 • 239 citations

Natural Suppressor (NS) Cells, Neonatal Tolerance, and Total Lymphoid Irradiation: Exploring Obscure Relationships

1984 • 231 citations

Chronic immune activation associated with intestinal helminth infections results in impaired signal transduction and anergy

2000 • 216 citations

Functions of nonclassical MHC and non-MHC-encoded class I molecules

1999 • 211 citations

Interleukin 12 Protects from a T Helper Type 1–mediated Autoimmune Disease, Experimental Autoimmune Uveitis, through a Mechanism Involving Interferon γ, Nitric Oxide, and Apoptosis

1999 • 210 citations

Postgrafting administration of granulocyte colony-stimulating factor impairs functional immune recovery in recipients of human leukocyte antigen haplotype–mismatched hematopoietic transplants

2001 • 189 citations

Production of Interleukin-10 by Granulocyte Colony-Stimulating Factor–Mobilized Blood Products: A Mechanism for Monocyte-Mediated Suppression of T-Cell Proliferation

1998 • 186 citations

Synergy between T-cell immunity and inhibition of paracrine stimulation causes tumor rejection.

1995 • 169 citations

The chemokine receptor switch paradigm and dendritic cell migration: its significance in tumor tissues

2000 • 169 citations

Signaling defects in T lymphocytes of patients with malignancy

1999 • 166 citations

Increased recurrence and metastasis in patients whose primary head and neck squamous cell carcinomas secreted granulocyte-macrophage colony-stimulating factor and contained CD34+ natural suppressor cells

1997 • 157 citations

Immortalized Myeloid Suppressor Cells Trigger Apoptosis in Antigen-Activated T Lymphocytes

2000 • 155 citations

Nitric oxide and thiol redox regulation of Janus kinase activity

1998 • 150 citations

Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-beta and nitric oxide.

1996 • 147 citations

Resection of Solid Tumors Reverses T Cell Defects and Restores Protective Immunity

2000 • 146 citations

Relationship between the expression of vascular endothelial growth factor and the density of dendritic cells in gastric adenocarcinoma tissue

1998 • 141 citations

Distinct mouse bone marrow macrophage precursors identified by differential expression of ER‐MP12 and ER‐MP20 antigens

1994 • 140 citations

Nitric oxide-producing CD11b+Ly-6G(Gr-1)+CD31(ER-MP12)+cells in the spleen of cyclophosphamide–treated mice: implications for T-cell responses in immunosuppressed mice

2000 • 139 citations

Vitamin A deficiency in mice causes a systemic expansion of myeloid cells

2000 • 137 citations

Inhibition of rat mixed lymphocyte cultures by suppressor macrophages

1977 • 129 citations

Immune Suppression by Recombinant Interleukin (rIL)-12 Involves Interferon γ Induction of Nitric Oxide Synthase 2 (iNOS) Activity: Inhibitors of NO Generation Reveal the Extent of rIL-12 Vaccine Adjuvant Effect

1998 • 129 citations

Activation of the Cell Death Program by Nitric Oxide Involves Inhibition of the Proteasome

1999 • 127 citations

Alternatively activated macrophages actively inhibit proliferation of peripheral blood lymphocytes and CD4⁺ T cells in vitro

1997 • 123 citations

Cytokine-secreting tumor cell vaccines

2000 • 119 citations

IL-2 enhances the function of recombinant poxvirus-based vaccines in the treatment of established pulmonary metastases.

1995 • 117 citations

Production of colony-stimulating factor by tumor cells and the factor-mediated induction of suppressor cells.

1988 • 112 citations

Increased presence of CD34+ cells in the peripheral blood of head and neck cancer patients and their differentiation into dendritic cells

1997 • 110 citations

Uses of granulocyte-macrophage colony-stimulating factor in vaccine development

2000 • 110 citations

Effect of Vascular Endothelial Growth Factor and FLT3 Ligand on Dendritic Cell Generation In Vivo

1999 • 107 citations

T-cell regulation of macrophage function

1995 • 100 citations

Cyclophosphamide Induces the Development of Early Myeloid Cells Suppressing Tumor Cell Growth by a Nitric Oxide-Dependent Mechanism

2001 • 94 citations

Superantigen-Induced CD4 T Cell Tolerance Mediated by Myeloid Cells and IFN-γ

2000 • 93 citations

Immunosuppression induced by attenuated Salmonella. Evidence for mediation by macrophage precursors.

1991 • 92 citations

Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages.

1999 • 92 citations

A Model for CD8+ CTL Tumor Immunosurveillance and Regulation of Tumor Escape by CD4 T Cells Through an Effect on Quality of CTL

1999 • 92 citations

Changes in Expression of Signal Transduction Proteins in T Lymphocytes of Patients with Leprosy

1998 • 89 citations

Membrane Molecules as Differentiation Antigens of Murine Macrophages

1998 • 84 citations

Wheat germ agglutinin-positive cells in a stem cell-enriched fraction of mouse bone marrow have potent natural suppressor activity.

1988 • 84 citations

Impaired Induction of the CD28-Responsive Complex in Granulocyte Colony-Stimulating Factor Mobilized CD4 T Cells

1998 • 81 citations

Recognition and function of Vα14 NKT cells

2000 • 80 citations

Mice Bearing Late-Stage Tumors Have Normal Functional Systemic T Cell Responses In Vitro and In Vivo

2000 • 79 citations

Endotoxin-Mediated S-Nitrosylation of p50 Alters NF-κB-Dependent Gene Transcription in ANA-1 Murine Macrophages

1999 • 76 citations

Radiation damage and immune suppression in splenic mononuclear cell populations

1997 • 74 citations

Cloned natural suppressor cell lines express the CD3+CD4-CD8- surface phenotype and the alpha, beta heterodimer of the T cell antigen receptor.

1989 • 73 citations

Treating tumor-bearing mice with vitamin D3 diminishes tumor-induced myelopoiesis and associated immunosuppression, and reduces tumor metastasis and recurrence

1995 • 72 citations

The role of tumor-derived cytokines on the immune system of mice bearing a mammary adenocarcinoma. I. Induction of regulatory macrophages in normal mice by the in vivo administration of rGM-CSF.

1991 • 65 citations

Primary chemically induced tumors induce profound immunosuppression concomitant with apoptosis and alterations in signal transduction in T cells and NK cells.

1999 • 64 citations

Aberrant antigen presentation by macrophages from tumor-bearing mice is involved in the down-regulation of their T cell responses.

1995 • 63 citations

Different Doses of Adenoviral Vector Expressing IL-12 Enhance or Depress the Immune Response to a Coadministered Antigen: the Role of Nitric Oxide

1999 • 63 citations

Myelopoiesis-associated immune suppressor cells in mice bearing metastatic Lewis lung carcinoma tumors: gamma interferon plus tumor necrosis factor alpha synergistically reduces immune suppressor and tumor growth-promoting activities of bone marrow cells and diminishes tumor recurrence and metastasis.

1992 • 58 citations

Graft-vs-host reactions (GVHR) across minor murine histocompatibility barriers. II. Development of natural suppressor cell activity.

1985 • 58 citations

Antibodies to colony-stimulating factors block Lewis lung carcinoma cell stimulation of immune-suppressive bone marrow cells

1991 • 57 citations

Transferable Anergy: Superantigen Treatment Induces CD4+ T Cell Tolerance That Is Reversible and Requires CD4−CD8− Cells and Interferon γ

1997 • 57 citations

HIV-1 infection induces a selective reduction in STAT5 protein expression.

1998 • 57 citations

Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.

1997 • 54 citations

Augmentation of the immune response with granulocyte-macrophage colony-stimulating factor and other hematopoietic growth factors

1999 • 50 citations

Early myeloid cells are high producers of nitric oxide upon CD40 plus IFN-γ stimulation through a mechanism dependent on endogenous TNF-α and IL-1α

2000 • 50 citations

Cutting Edge: HIV-1 Infection Induces a Selective Reduction in STAT5 Protein Expression

1998 • 48 citations

Augmentation of an Antitumor CTL Response In Vivo by Inhibition of Suppressor Macrophage Nitric Oxide

1999 • 46 citations

Mechanisms of Tumor-Induced Immunosuppression: Evidence for Contact-Dependent T Cell Suppression by Monocytes

1996 • 43 citations

Myelopoiesis‐associated suppressor‐cell activity in mice with lewis lung carcinoma tumors: Interferon‐γ plus tumor necrosis factor‐α synergistically reduce suppressor cell activity

1990 • 38 citations

Peritoneal macrophages exposed to purified macrophage colony-stimulating factor (M-CSF) suppress mitogen- and antigen-stimulated lymphocyte proliferation.

1986 • 35 citations

A partial characterization of suppressor cells in the spleens of mice conditioned with fractionated total lymphoid irradiation (TLI).

1983 • 34 citations

Inhibition of tumor cell proliferation by natural suppressor cells present in murine bone marrow.

1990 • 33 citations

Stimulation of immune-suppressive bone marrow cells by colony-stimulating factors.

1990 • 33 citations

Treating tumor-bearing mice with low-dose gamma-interferon plus tumor necrosis factor alpha to diminish immune suppressive granulocyte-macrophage progenitor cells increases responsiveness to interleukin 2 immunotherapy.

1995 • 33 citations

Vitamin D3 treatment of tumor bearers can stimulate immune competence and reduce tumor growth when treatment coincides with a heightened presence of natural suppressor cells

1996 • 33 citations

Natural suppressor cells in spleens of irradiated, bone marrow-reconstituted mice and normal bone marrow: Lack of SCA-1 expression and enrichment by depletion of MAC1-positive cells

1990 • 33 citations

Human prostate carcinoma cell lines secrete GM-CSF and express GM-CSF-receptor on their cell surface.

1996 • 33 citations

In vivo and in vitro suppression of primary B lymphocytopoiesis by tumor-derived and recombinant granulocyte colony-stimulating factor

1993 • 31 citations

Secretion of bioactive granulocyte-macrophage colony-stimulating factor by human colorectal carcinoma cells.

1994 • 31 citations

Inhibition of lymphocyte blastogenic response in healthy donors treated with recombinant human granulocyte colony-stimulating factor (rhG-CSF): possible role of lactoferrin and interleukin-1 receptor antagonist

1997 • 30 citations

Heterogeneity of splenic natural suppressor cells induced in mice by treatment with cyclophosphamide

1993 • 30 citations

Restoration of T and NK cell function in GM-CSF mobilized stem cell products from breast cancer patients by monocyte depletion

1997 • 29 citations

Prostaglandin E2 Production by Mac-2+ Macrophages: Tumor-Induced Population Shift

1987 • 27 citations

Up- and down-regulation of granulocyte/macrophage-colony stimulating factor activity in murine skin increase susceptibility to skin carcinogenesis by independent mechanisms.

2001 • 24 citations

Selection and use of chemotherapy with hematopoietic growth factors for mobilization of peripheral blood progenitor cells

2000 • 21 citations

Changes in Splenic Macrophage Mac Antigen Expression During Tumor Growth: A Kinetic Study of Accessory Cell Function and Antigen-Defined Phenotypes

1986 • 19 citations

Stimulation of immune suppressive CD34 + cells from normal bone marrow by Lewis lung carcinoma tumors

1998 • 18 citations

Bone marrow natural suppressor cells inhibit the growth of myeloid progenitor cells and the synthesis of colony-stimulating factors.

1992 • 16 citations

Induction and suppression of delayed-type hypersensitivity to non-MHC antigens during lethal graft-versus-host reaction.

1992 • 7 citations

Proliferation of natural suppressor cells in long-term cultures of spleen cells from normal adult mice.

1991 • 4 citations