Macrophage-Derived Nitric Oxide Regulates T Cell Activation via Reversible Disruption of the Jak3/STAT5 Signaling Pathway

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide.

1987 • 5,027 citations

The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide

1995 • 1,512 citations

Formation of nitric oxide from L-arginine in the central nervous system: a transduction mechanism for stimulation of the soluble guanylate cyclase.

1989 • 1,443 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

Cytokine Signaling Through Nonreceptor Protein Tyrosine Kinases

1995 • 713 citations

Suppression of arthritis by an inhibitor of nitric oxide synthase.

1993 • 662 citations

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease

1996 • 588 citations

Interaction of the IL-2 Receptor with thesrc-Family Kinase p56^lck: Identification of Novel Intermolecular Association

1991 • 576 citations

Nitric oxide and asthmatic inflammation

1995 • 514 citations

Pathogenesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals.

1996 • 496 citations

Inhibition of smooth muscle cell growth by nitric oxide and activation of cAMP-dependent protein kinase by cGMP

1994 • 467 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells

1994 • 377 citations

Peroxynitrite disables the tyrosine phosphorylation regulatory mechanism: Lymphocyte-specific tyrosine kinase fails to phosphorylate nitrated cdc2(6-20)NH2 peptide.

1996 • 341 citations

Nonspecific defence mechanism: the role of nitric oxide

1991 • 325 citations

Elevated levels of exhaled nitric oxide in bronchiectasis.

1995 • 308 citations

Generation of nitric oxide by human neutrophils

1989 • 298 citations

Production of nitric oxide in the synovial membrane of rheumatoid and osteoarthritis patients.

1996 • 285 citations

Regulation of Cytosolic Guanylyl Cyclase by Nitric Oxide: The NO-Cyclic GMP Signal Transduction System

1994 • 232 citations

[13] Nitric oxide-cyclic GMP signal transduction system

1996 • 183 citations

Inhibition of the immunosuppressive activity of resident pulmonary alveolar macrophages by granulocyte/macrophage colony-stimulating factor.

1993 • 170 citations

Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway.

1996 • 167 citations

Regulation of lymphocyte functions by nitric oxide

1995 • 166 citations

Rapamycin blocks cell cycle progression of activated T cells prior to events characteristic of the middle to late G₁ phase of the cycle

1993 • 154 citations

Tumor necrosis factor-alpha-dependent production of reactive nitrogen intermediates mediates IFN-gamma plus IL-2-induced murine macrophage tumoricidal activity.

1992 • 144 citations

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction.

1993 • 138 citations

Synergistic cooperation between T cell lymphokines for induction of the nitric oxide synthase gene in murine peritoneal macrophages.

1993 • 134 citations

Spontaneously increased production of nitric oxide and aberrant expression of the inducible nitric oxide synthase in vivo in the transforming growth factor beta 1 null mouse.

1996 • 115 citations

Regulation of immune response to inhaled antigen by alveolar macrophages: differential effects of in vivo alveolar macrophage elimination on the induction of tolerance vs. immunity

1991 • 105 citations

Alveolar macrophages from humans and rodents selectively inhibit T-cell proliferation but permit T-cell activation and cytokine secretion.

1995 • 85 citations

Nitric Oxide Facilitates Long-Term Potentiation, But Not Long-Term Depression

1997 • 83 citations

Regulation of T‐cell activation in the lung: alveolar macrophages induce reversible T‐cell anergy in vitro associated with inhibition of interleukin‐2 receptor signal transduction

1996 • 82 citations

Autotoxicity of Nitric Oxide in Airway Disease

1996 • 82 citations

Regulation of T-cell function in lung tissue by pulmonary alveolar macrophages.

1993 • 82 citations

In vitro correction of JAK3-deficient severe combined immunodeficiency by retroviral-mediated gene transduction.

1996 • 70 citations

Interleukin 2‐induced activation of JAK3: Possible involvement in signal transduction for c‐myc induction and cell proliferation

1994 • 55 citations

Inhibition of nitric oxide synthesis by interleukin‐4 may involve inhibiting the activation of protein kinase C epsilon

1994 • 48 citations

Inhibition of Glutamate Uptake and Proton Pumping in Synaptic Vesicles by S‐Nitrosylation

1996 • 45 citations

Dispensability of Jak1 tyrosine kinase for interleukin‐2‐induced cell growth signaling in a human T cell line

1996 • 45 citations

Regulation of T‐cell activation in the lung: isolated lung T cells exhibit surface phenotypic characteristics of recent activation including down‐modulated T‐cell receptors, but are locked into the G₀/G₁ phase of the cell cycle

1996 • 39 citations

Suppression of T-cell activation by pulmonary alveolar macrophages: dissociation of effects on TcR, IL-2R expression, and proliferation

1994 • 38 citations

Alveolar macrophages. VI. Regulation of alveolar macrophage-mediated suppression of lymphocyte proliferation by a putative T cell.

1981 • 23 citations

In vivo association between p56lck and MAP kinase during IL-2-mediated lymphocyte proliferation.

1995 • 17 citations

The action of NO and its role in autoimmune diabetes mellitus

1995 • 13 citations