Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

Dendritic cells and the control of immunity

1998 • 14,345 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

Homeostasis and Self-Tolerance in the Immune System: Turning Lymphocytes off

1998 • 989 citations

Nitric oxide production is required for murine resident peritoneal macrophages to suppress mitogen-stimulated T cell proliferation. Role of IFN-gamma in the induction of the nitric oxide-synthesizing pathway.

1991 • 384 citations

An Investigation of the Cause of the Eosinophilia–Myalgia Syndrome Associated with Tryptophan Use

1990 • 361 citations

Molecular basis of "suppressor" macrophages. Arginine metabolism via the nitric oxide synthetase pathway.

1991 • 344 citations

Quantitative assessment of the leukocyte infiltrate in ovarian cancer and its relationship to the expression of C-C chemokines.

1997 • 340 citations

1-methyl-dl-tryptophan, β-(3-benzofuranyl)-dl-alanine (the oxygen analog of tryptophan), and β-[3-benzo(b)thienyl]-dl-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

1991 • 279 citations

Nitric oxide in autoimmune disease: cytotoxic or regulatory mediator?

1998 • 262 citations

Nitric oxide inhibits indoleamine 2,3-dioxygenase activity in interferon-gamma primed mononuclear phagocytes.

1994 • 207 citations

Characteristics of interferon induced tryptophan metabolism in human cells in vitro

1989 • 191 citations

Characterization of "Peak E," a Novel Amino Acid Associated with Eosinophilia-Myalgia Syndrome

1990 • 182 citations

Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells.

1999 • 179 citations

The Multiplex Function of Nitric Oxide in (Auto)immunity

1998 • 175 citations

The invertebrate phagocytic immunocyte: clues to a common evolution of immune and neuroendocrine systems

1997 • 167 citations

Cooperative Role of Interferon Regulatory Factor 1 and p91 (STAT1) Response Elements in Interferon-γ-inducible Expression of Human Indoleamine 2,3-Dioxygenase Gene

1996 • 155 citations

Serum kynurenine-to-tryptophan ratio increases with progressive disease in HIV-infected patients

1998 • 155 citations

Development of a Scleroderma-like Illness during Therapy with L-5-Hydroxytryptophan and Carbidopa

1980 • 152 citations

Decreased plasma tryptophan in pregnancy

1996 • 151 citations

Role of IFN-γ-Induced Indoleamine 2,3 Dioxygenase and Inducible Nitric Oxide Synthase in the Replication of Human Cytomegalovirus in Retinal Pigment Epithelial Cells

1999 • 145 citations

Placental amino acid transport

1995 • 120 citations

Localization and developmental change of indoleamine 2,3-dioxygenase activity in the human placenta.

1991 • 113 citations

Regulation of indoleamine 2,3-dioxygenase activity in the small intestine and the epididymis of mice

1980 • 112 citations

Facilitation or attenuation of mixed leukocyte culture responsiveness by adherent cells

1976 • 104 citations

Differential Regulation of the Human, Interferon Inducible Tryptophanyl-tRNA Synthetase by Various Cytokines in Cell Lines

1995 • 101 citations

The Role of Alveolar Macrophages in Regulation of Lung Inflammation

1994 • 101 citations

Importance of the Two Interferon-stimulated Response Element (ISRE) Sequences in the Regulation of the Human Indoleamine 2,3-Dioxygenase Gene

1996 • 100 citations

Differential regulation of indoleamine 2,3-dioxygenase expression by nitric oxide and inflammatory mediators in IFN-gamma-activated murine macrophages and microglial cells.

1997 • 98 citations

THE role of indoleamine 2,3‐dioxygenase in the anti‐tumour activity of human interferon‐γ in vivo

1995 • 93 citations

Hypoxia down-regulates MCP-1 expression: implications for macrophage distribution in tumors

1998 • 92 citations

Inhibition of Nitric Oxide Synthase Expression and Activity in Macrophages by 3-Hydroxyanthranilic Acid, a Tryptophan Metabolite

1997 • 73 citations

Frontal cortex indoleamine-2,3-dioxygenase activity is increased in HIV-1-associated dementia

1995 • 67 citations

Much IDO about pregnancy

1998 • 62 citations

Antibodies to quinolinic acid and the determination of its cellular distribution within the rat immune system

1994 • 57 citations

Gene structure of human indoleamine 2,3-dioxygenase

1992 • 51 citations

Quinolinate Immunoreactivity in Experimental Rat Brain Tumors Is Present in Macrophages but Not in Astrocytes

1997 • 44 citations

Inducible anti-parasitic effector mechanisms in human uroepithelial cells: tryptophan degradation vs. NO production

1999 • 37 citations

Convergent evolution. The gene structure of Sulculus 41 kDa myoglobin is homologous with that of human indoleamine dioxygenase

1996 • 21 citations

Differential responsiveness of human and rat mesothelioma cell lines to recombinant interferon-gamma.

1997 • 13 citations

Scleroderma and autoimmune thrombocytopenia associated with ingestion of l-tryptophan

1993 • 9 citations