Uses of granulocyte-macrophage colony-stimulating factor in vaccine development

CpG motifs in bacterial DNA trigger direct B-cell activation

1995 • 3,543 citations

Heterologous Protection Against Influenza by Injection of DNA Encoding a Viral Protein

1993 • 2,330 citations

Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

1995 • 1,097 citations

The Granulocyte-Macrophage Colony-Stimulating Factors

1985 • 1,007 citations

Combination Immunotherapy of B16 Melanoma Using Anti–Cytotoxic T Lymphocyte–Associated Antigen 4 (Ctla-4) and Granulocyte/Macrophage Colony-Stimulating Factor (Gm-Csf)-Producing Vaccines Induces Rejection of Subcutaneous and Metastatic Tumors Accompanied by Autoimmune Depigmentation

1999 • 1,000 citations

Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo.

1996 • 922 citations

DEGRADATION OF CELL PROTEINS AND THE GENERATION OF MHC CLASS I-PRESENTED PEPTIDES

1999 • 898 citations

Peptide-pulsed dendritic cells induce antigen-specific CTL-mediated protective tumor immunity.

1996 • 746 citations

Gene inoculation generates immune responses against human immunodeficiency virus type 1.

1993 • 655 citations

Vaccination with irradiated autologous melanoma cells engineered to secrete human granulocyte–macrophage colony-stimulating factor generates potent antitumor immunity in patients with metastatic melanoma

1998 • 586 citations

Murine dendritic cells loaded in vitro with soluble protein prime cytotoxic T lymphocytes against tumor antigen in vivo.

1996 • 561 citations

Activation of Cutaneous Dendritic Cells by CpG-Containing Oligodeoxynucleotides: A Role for Dendritic Cells in the Augmentation of Th1 Responses by Immunostimulatory DNA

1998 • 543 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

A new foreign policy: MHC class I molecules monitor the outside world

1996 • 422 citations

Paracrine Cytokine Adjuvants in Cancer Immunotherapy

1995 • 373 citations

Bone marrow-generated dendritic cells pulsed with a class I-restricted peptide are potent inducers of cytotoxic T lymphocytes.

1995 • 372 citations

Generation of immunity to the HER-2/neu oncogenic protein in patients with breast and ovarian cancer using a peptide-based vaccine.

1999 • 339 citations

Induction of antitumor immunity using bone marrow-generated dendritic cells.

1996 • 323 citations

Idiotype/granulocyte-macrophage colony-stimulating factor fusion protein as a vaccine for B-cell lymphoma

1993 • 314 citations

DNA vaccines with single-chain Fv fused to fragment C of tetanus toxin induce protective immunity against lymphoma and myeloma

1998 • 303 citations

DNA immunization induces protective immunity against B–cell lymphoma

1996 • 252 citations

Tumor antigen presentation by murine epidermal cells.

1991 • 211 citations

A Plasmid Encoding Murine Granulocyte-Macrophage Colony-Stimulating Factor Increases Protection Conferred by a Malaria DNA Vaccine

1998 • 171 citations

Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation

1995 • 147 citations

Bone Marrow‐Derived Dendritic Cells Serve as Potent Adjuvants for Peptide‐Based Antitumor Vaccines

1997 • 144 citations

Idiotypic DNA Vaccines Against B‐cell Lymphoma

1995 • 134 citations

Immunostimulatory CpG Oligodeoxynucleotides Enhance the Immune Response to Vaccine Strategies Involving Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 124 citations

A nine-amino acid peptide from IL-1beta augments antitumor immune responses induced by protein and DNA vaccines.

1996 • 118 citations

A Universal Granulocyte-Macrophage Colony-Stimulating Factor-Producing Bystander Cell Line for Use in the Formulation of Autologous Tumor Cell-Based Vaccines

1999 • 116 citations

Enhancement of protective humoral (Th2) and cell-mediated (Th1) immune responses against herpes simplex virus-2 through co-delivery of granulocyte-macrophage colony-stimulating factor expression cassettes

1998 • 107 citations

DNA Vaccination Against the Idiotype of a Murine B Cell Lymphoma: Mechanism of Tumor Protection

1999 • 84 citations

A Phase I Clinical Trial of Lethally Irradiated Allogeneic Pancreatic Tumor Cells Transfected with the GM-CSF Gene for the Treatment of Pancreatic Adenocarcinoma. The Johns Hopkins Oncology Center, Baltimore, Maryland

1998 • 83 citations

Optimal Induction of Hepatitis C Virus Envelope-Specific Immunity by Bicistronic Plasmid DNA Inoculation with the Granulocyte-Macrophage Colony-Stimulating Factor Gene

1998 • 82 citations

Therapy of established tumour with a hybrid cellular vaccine generated by using granulocyte–macrophage colony‐stimulating factor genetically modified dendritic cells

1999 • 74 citations

Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.

1988 • 71 citations

Potential role of granulocyte-macrophage colony-stimulating factor as vaccine adjuvant

1994 • 69 citations

GM-CSF as a systemic adjuvant in a phase II prostate cancer vaccine trial

1999 • 69 citations

Facilitated DNA inoculation induces anti-HIV-1 immunity in vivo

1994 • 60 citations

Induction of tumor-specific in vivo protective immunity by immunization with tumor antigen-pulsed antigen-presenting cells.

1989 • 57 citations

A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. I. Vaccine characterization and efficacy studies in mice

1999 • 55 citations

Immunophenotypical and functional heterogeneity of dendritic cells generated from murine bone marrow cultured with different cytokine combinations: implications for anti‐tumoral cell therapy

1999 • 53 citations

Tumor Cell Surface Expression of Granulocyte-Macrophage Colony-Stimulating Factor Elicits Antitumor Immunity and Protects from Tumor Challenge in the P815 Mouse Mastocytoma Tumor Model

1999 • 47 citations

Enhanced cellular immunity to hepatitis C virus nonstructural proteins by codelivery of granulocyte macrophage-colony stimulating factor gene in intramuscular DNA immunization

1999 • 46 citations

Pulsing of dendritic cells with cell lysates from either B16 melanoma or MCA-106 fibrosarcoma yields equally effective vaccines against B16 tumors in mice

1998 • 45 citations

Broadened Clinical Utility of Gene Gun-Mediated, Granulocyte-Macrophage Colony-Stimulating Factor cDNA-Based Tumor Cell Vaccines as Demonstrated with a Mouse Myeloma Model

1998 • 44 citations

Third Keystone Symposium on Cellular Immunology and the Immunotherapy of Cancer Antigen Processing and Presentation Autologous Human Dendriphages Pulsed with Synthetic or Natural Tumor Peptides Elicit Tumor-Specific CTLs In Vitro

1998 • 44 citations

Cytokine-Based Tumor Cell Vaccine Is Equally Effective Against Parental and Isogenic Multidrug-Resistant Myeloma Cells: The Role of Cytotoxic T Lymphocytes

1999 • 43 citations

Immune Response to Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia Induced by Expression of CD80, Interleukin 2, and Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 42 citations

A novel influenza subunit vaccine composed of liposome-encapsulated haemagglutinin/neuraminidase and IL-2 or GM-CSF. II. Induction of TH1 and TH2 responses in mice

1999 • 41 citations

DNA inoculations with HIV-1 recombinant genomes that express cytokine genes enhance HIV-1 specific immune responses

1999 • 36 citations

Immunotherapy for Lung Metastases of Murine Renal Cell Carcinoma

1999 • 22 citations

A human immunodeficiency virus type 1 Env-granulocyte-macrophage colony-stimulating factor fusion protein enhances the cellular immune response to Env in a vaccinia virus-based vaccine.

1999 • 21 citations

Activated Dendritic Cells From Bone Marrow Cells of Mice Receiving Cytokine-Expressing Tumor Cells Are Associated With the Enhanced Survival of Mice Bearing Syngeneic Tumors

1999 • 19 citations

Reduced melanoma tumor formation in mice immunized with DNA expressing the melanoma-specific antigen gp100/pmel17

1999 • 19 citations

Clinical implications of the new biology in the development of melanoma vaccines

1999 • 15 citations

Vaccine Adjuvancy: A New Potential Area of Development for GM-CSF

1995 • 15 citations

Construction and Characterization of a Chimeric Fusion Protein Consisting of an Anti-idiotype Antibody Mimicking a Breast Cancer-Associated Antigen and the Cytokine GM-CSF

1999 • 13 citations